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Changes in extreme high temperature warning indicators over China under different global warming levels

Science China Earth Sciences 2024年第6期67卷 1895-1909页

作者： yuxia zhang Ying SUN Ting HU Chinese Academy of Meteorological Sciences Beijing 100081China National Climate Center Laboratory for Climate StudiesChina Meteorological AdministrationBeijing 100081China

High temperature warning indicators play a pivotal role in meteorological departments,serving as crucial criteria for issuing warnings that guide both social production and daily life.Despite their importance,limited studies have explored the relationship between different global warming levels and changes in high temperature warning indicators.In this study,we analyze data from 2,419 meteorological stations over China and utilize the Coupled Model Intercomparison Project Phase 6(CMIP6)models to examine historical changes in high temperature warning indicators used by the China Meteorological Administration.We evaluate model performance and estimate future changes in these indicators using an annual cycle bias correction method.The results indicate that since 1961,the number of high temperature days(TX35d and TX40d)and length of season(TX40d and TX40l)with daily maximum temperature reaching or exceeding 35℃ and 40℃ have increased over China.The intensity of high temperatures(TXx)has strengthened and the geographical extent affected by high temperatures has expanded.In 2022,the occurrence of 40℃ high temperatures surges,with Eastern China experiencing a two-day increase in TX40d and an extended seasonal length in TX40l by over five days.While CMIP6 models have underestimated the high temperature indictors associated with 35℃ during historical periods,notable difference is not observed between the models and observations for TX40d and TX40l,given their rare occurrence.However,future projections,after bias correction,indicate that the increasing trends for 35℃ and 40℃ high temperature days and length of season become more pronounced than the raw projection,suggesting a more severe increase than that anticipated originally.As global warming intensifies,the high temperature days and length of season are projected to increase non-linearly,while the intensity of high temperatures is expected to increase linearly.For every 1℃ increase in global temperature,the intensity is projected to rise by approximately 1.4℃.The impa

关键词： Extreme high temperatures Meteorological warning CMIP6 Global warming levels Future projection

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Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice

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Journal of Environmental Sciences 2024年第3期137卷 553-566页

作者： Xingpei Fan Xiaoyan Li Jiaxin Li yuxia zhang Xiangjuan Wei Hailong Hu Boya zhang Haining Du Meimei Zhao Ruijiao Zhu Daqian Yang Yuri Oh Ning Gu School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150006China Department of Medicine Renal Electrolyte and Hypertension DivisionDepartment of GeneticsPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia 19104USA Faculty of Education Wakayama UniversityWakayama 640-8441Japan

Nanoplastics-induced developmental and reproductive toxicity,neurotoxicity and immunotoxicity are a focus of widespread attention.However,the effects of nanoplastics(NPs)on glycolipid metabolism and the precise underlying mechanisms are unclear at present.Here,we showed that oral administration of polystyrene nanoparticles(PS-NPs)disrupts glycolipid metabolism,with reactive oxygen species(ROS)identified as a potential key signaling molecule.After PS-NPs treatment,excessive production of ROS induced the infammatory response and activated the antioxidant pathway through nuclear factor-erythroid factor 2-related factor 2.The activation of nuclear factor-κB(NFκB)signaling pathway induced the phosphorylation of the mitogen-activated protein kinases(MAPK)signaling pathway,which induced the activation of extracellular regulated kinases(ERK)and p38.Constitutive activation of the MAPK signaling proteins induced high continued phosphorylation of insulin receptor substrate-1,in turn,leading to decreased protein kinase B(Akt)activity,which weakened the sensitivity of liver cells to insulin signals and induced insulin resistance.In parallel,phosphorylation of Akt led to loss of control of Fo XO1,a key gene of gluconeogenesis,activating transcription of glucose-6-phosphatase(G6PC)and phosphoenolpyruvate carboxykinase(PEPCK)in a manner dependent on PGC1α.Moreover,the activated ERK promoted lipid accumulation through ERK-PPARγcascades.Therefore,sterol regulatory element-binding protein-1 and levels of its downstream lipogenic enzymes,ACC-1,were up-regulated.Upon treatment with the antioxidant resveratrol,PS-NPs-induced glucose and lipid metabolic disorders were improved by inhibiting ROS-induced activation of NFκB and MAPK signaling pathway in mice.Based on above,PS-NPs exposure disrupts glycolipid metabolism in mice,with ROS identified as a potential key signaling molecule.

关键词： Nanoplastics Resveratrol Hyperglycemia Lipid metabolism Infammatory response Reactive oxygen species(ROS)

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Upper bound of Kahler angles on the β-symplectic critical surfaces

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Frontiers of Mathematics in China 2022年第4期17卷 511-519页

作者： yuxia zhang Xiangrong ZHU College of Mathematics and Computer Science Zhejiang Normal UniversityJinhua321004China

Let(M,g)be a Kähler surface andΣbe aβ-symplectic critical surface in M.If L_(q)(Σ)is bounded for some q>3,then we give a uniform upper bound for the Kähler angle onΣ.This bound only depends on M,q,βand the Lq fun... 详细信息

关键词： Kähler surface β-symplectic critical surfaces Kähler angle L_(β)functional

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Recovery of Flavor Perception and Umami Taste Sensitivity in Young Chinese Adults Following SARS-CoV-2 Omicron Infection: A Case-Control Series

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Food Science and Human Wellness 2024年

作者： Yiwen Zhu Xiaoxiao Feng yuxia Fan Yin zhang Ye Liu Yuan Liu Department of Food Science & Technology School of Agriculture & Biology Shanghai Jiao Tong University Key Laboratory of Meat Processing of Sichuan Chengdu University Beijing Engineering and Technology Research Center of Food Additives School of Food and Health Beijing Technology and Business University School of Food and Health Beijing Technology and Business University

SARS-CoV-2， particularly the Omicron variant， often leads to flavor perception dysfunction in infected individuals， making a comprehensive understanding of its duration and recovery patterns a critical part of disease management. This study surveyed a cohort of 199 mildly-to-moderately affected SARS-CoV-2 Omicron-infected patients， focusing on the alterations in their olfaction， taste， and chemesthesis perception. Further， a subset of 36 participants (18 healthy and 18 infected) underwent sensory evaluations to check the variation of umami taste sensitivity. The results demonstrated that most of the infected cohort experienced chemosensory disorders， with the recovery period varying between one week and over a month. Intriguingly， the severity of flavor perception changes during infection significantly correlated with the length of the recovery period. Furthermore， this study explored the specific manifestations of flavor perception dysfunction， potential contributing factors， and potential mechanistic explanations for chemosensory disorders. These include local damage， inflammatory responses， and virus-induced neural damage. However， this study revealed no significant change (P > 0.05) in umami taste sensitivity among infected patients 55 days post-infection. While this research faces limitations related to its self-reported， cross-sectional design， and regional focus， it offers valuable insights into the multifaceted impact of COVID-19， particularly the Omicron variant， on chemosensory perception.

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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu zhang Shicheng Yu Hongyan Li Shaohong Chen Jingting Luo Haibo Wang yuxia Guan Haihan zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying Sha Chuan zhang Yuhang Yang Xuan Yang Xifang zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available treatment.Here,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 days.This open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/8-hCYP4V2.Overall,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were observed.Compared with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the treatment.We conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

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Hepatic transcriptome profiling reveals early signatures associated with disease transition from non-alcoholic steatosis to steatohepatitis

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Liver Research 2022年第4期6卷 238-250页

作者： Nancy Magee Forkan Ahamed Natalie Eppler Elizabeth Jones Priyanka Ghosh Lily He yuxia zhang Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKSUSA Liver Center University of KansasKansas CityKSUSA

Background and aim:Non-alcoholic fatty liver disease(NAFLD)is becoming a leading cause of chronic liver disease worldwide.The molecular events that influence disease progression from non-alcoholic fatty liver(NAFL)to aggressive non-alcoholic steatohepatitis(NASH)remain incompletely understood,leading to lack of mechanism-based targeted treatment options for NASH.This study aims to identify early signatures associated with disease progression from NAFL to NASH in mice and humans.Materials and methods:Male C57BL/6J mice were fed a high-fat,-cholesterol,and-fructose(HFCF)diet for up to 9 months.The extent of steatosis,inflammation,and fibrosis was evaluated in liver tissues.Total RNA sequencing(RNA-seq)was conducted to determine liver transcriptomic changes.Results:After being fed the HFCF diet,mice sequentially developed steatosis,early steatohepatitis,steatohepatitis with fibrosis,and eventually spontaneous liver tumor.Hepatic RNA-seq revealed that the key signatures during steatosis progression to early steatohepatitis were pathways related to extracel-lular matrix organization and immune responses such as T cell migration,arginine biosynthesis,C-type lectin receptor signaling,and cytokine-cytokine receptor interaction.Genes regulated by transcription factors forkhead box M1(FOXM1)and negative elongation factor complex member E(NELFE)were significantly altered during disease progression.This phenomenon was also observed in patients with NASH.

关键词： Liver Transcriptome Steatosis Inflammation Fibrosis Non-alcoholic steatohepatitis(NASH)

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Recent insights into the pathogeneses and therapeutic targets of liver diseases: Summary of the 4th Chinese American liver Society/Society of Chinese Bioscientists in America Hepatology Division Symposium in 2021

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Liver Research 2022年第1期6卷 50-57页

作者： Wen-Xing Ding Hua Wang yuxia zhang On behalf of the Chinese American Liver Society Symposium Organizing Committee Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKSUSA Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina 不详

The 4th Chinese American Liver Society(CALS)/Society of Chinese Bioscientists in America(SCBA)Hepatology Division Annual Symposium was held virtually on October 29e30,2021.The goal of the CALS Symposium was to present and discuss the recent research data on the pathogenesis and therapeutic targets of liver diseases among the CALS members,trainees and invited speakers.Here we briefly introduce the history of the CALS/SCBA Hepatology Division and highlight the presentations that focus on the current progresses on basic and translational research in liver metabolism,bile acid biology,alcohol-related liver disease,drug-induced liver injury,cholestatic liver injury,non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and liver cancer.

关键词： Liver diseases Alcohol-related liver disease(ALD) Cholestasis Drug-induced liver injury(DILI) Hepatocellular carcinoma(HCC) Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) Symposium

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Subjective cognitive decline domain improves accuracy of plasma Aβ42/Aβ40for preclinical Alzheimer’s disease diagnosis: The SILCODE study

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中华医学杂志(英文版) 2024年第9期137卷 2023 Nov 10页

作者： zhang Mingkai Wang Xiaoni Zhao Weina Li yuxia Ying Chao Jiang Jiehui Cai Yanning Lu Jie Han Ying Key Laboratory of Neurodegenerative Diseases Ministry of Education Beijing China School of Biomedical Engineering Hainan University Haikou Hainan China Center of Alzheimer’s Disease Beijing Institute for Brain Disorders Beijing China National Clinical Research Center for Geriatric Disorders Beijing China Institute of Biomedical Engineering Shenzhen Bay Laboratory Shenzhen Guangdong China Department of Neurology Xuanwu Hospital of Capital Medical University Beijing China Department of Neurology Sir Run Run Shaw Hospital Affiliated with School of Medicine Zhejiang University Hangzhou Zhejiang China Department of Neurology Hongqi Hospital Affiliated to Mudanjiang Medical University Mudanjiang Heilongjiang China Heilongjiang Key Laboratory of Ischemic Stroke Prevention and Treatment Mudanjiang Heilongjiang China Department of Neurology Tangshan Central Hospital Tangshan Hebei China Department of Neurobiology Xuanwu Hospital of Capital Medical University Key Laboratory for Neurodegenerative Diseases of the Ministry of Education Beijing China Institute for Advanced Communication and Data Science Shanghai University Shanghai China Department of Radiology and Nuclear Medicine Xuanwu Hospital Capital Medical University Beijing China Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics Beijing China

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智能技术具身下审美教育锚定人工智能素养的理路演进

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中国电化教育 2024年第5期 120-127页

作者：张岩罗旭国玉霞张辉沈阳师范大学基础教育信息化研究中心辽宁沈阳110034 沈阳师范大学新闻与传播学院辽宁沈阳110034 闽南师范大学艺术学院福建漳州363000

人工智能的具身化发展升级了技术具身的概念,“智能技术中的身体”和“智能技术身体”深刻变革人类认知方式转向人机共创的模式。审美教育具有学科共通性,智能技术具身演化了审美教育的新生态,形成了包括智能环境、人机协同融合模式、... 详细信息

人工智能的具身化发展升级了技术具身的概念,“智能技术中的身体”和“智能技术身体”深刻变革人类认知方式转向人机共创的模式。审美教育具有学科共通性,智能技术具身演化了审美教育的新生态,形成了包括智能环境、人机协同融合模式、智能代理机制和大脑智能的新型智能架构。智能技术具身下审美教育目标就是找到提高学生审美认知的可行方法和有效方式。审美认知表现在以身体为中心的智能技术和学生心智的协同与耦合,相应地审美教育的目标就锚定了人工智能素养。人工智能素养导向的审美教育可以为学生审美认知赋能赋权,有力支撑学生知情意行和谐统一的教育总体目标,铺设学生思维升级的路径。智能技术具身下的审美教育成为培育学生人工智能素养的新范式,即以自动化实现为审美理念引导智能通识技能的升格、以解决问题为审美目标引导计算思维的提升、以协同创造为审美理想引导高阶思维的跃迁。

关键词：审美教育审美认知智能技术具身计算思维高阶思维

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Decoding the role of extracellular vesicles in liver diseases

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Liver Research 2017年第3期1卷 147-155页

作者： Fengyan Deng Nancy Magee yuxia zhang Department of Pharmacology Toxicology&TherapeuticsUniversity of Kansas Medical CenterKansas CityKSUSA

Cell-to-cell communication is a fascinating process that is essential for maintaining tissue and wholebody homeostasis.Extracellular vesicles(EVs)are cell-derived membrane-bound nanoparticles that are a means of communication between cells.Accumulating evidence indicates that EVs can render either beneficial or harmful outcomes,depending on the specific cargos(e.g.,proteins,lipids,RNAs)transferred between cells.EVs also have great value as diagnostic and prognostic markers of disease because they are present in a variety of biological fluids and carry bioactive molecules from their cells or tissues of origin.Liver cells can both release and receive EVs derived from other cells and emerging evidence indicates that liver EVs play important roles in the pathogenesis of various liver diseases,including liver cancer,viral hepatitis,non-alcoholic fatty liver disease,and alcoholic liver disease.This review provides an overview of the biogenesis and secretion of EVs and summarizes the most recent advances in understanding the role of EVs in liver physiology and diseases.Additionally,we discuss potential applications of liver EVs as biomarkers and in therapeutic approaches to treat liver diseases.

关键词： Extracellular vesicles(EVs) Liver Disease Metabolism Biomarker

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