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Comprehensive analysis identifies as a critical prognostic prediction gene in breast cancer

Chinese Medical Journal 2022年第18期135卷 2218-2231页

作者： Ting Hu Xu Wang Yun Xia lu Wu yuxi Ma Rui Zhou Yanxia Zhao Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Background:Aurora kinases(AURKs)family plays a vital role not only in cell division but also in ***,there are still rare systematic analyses of the diverse expression patterns and prognostic value of the AURKs family in breast cancer(BC).Systematic bioinformatics analysis was conducted to explore the biological role,prognostic value,and immunologic function of AURKs family in ***:The expression,prognostic value,and clinical functions of AURKs family in BC were evaluated with several bioinformatics web portals:ONCOMINE Gene Expression Profiling Interactive Analysis,Kaplan-Meier plotter,cBioPortal,Metascape,GeneMANIA,and LinkedOmics;and the result was verified using human ***:The expression of AURKA and AURKB were upregulated in BC in subgroup analyses based on tumor stage(all P<0.05).BC patients with high AURKA and AURKB expression had a worse overall survival,relapse-free survival,and distant metastasisfree survival(all P<0.05).Verification experiment revealed that AURKA and AURKB were upregulated in BC(P<0.05).AURKA and AURKB were specifically associated with several tumor-associated kinases(polo-like kinase 1 and cyclin-dependent kinase 1),miRNAs(miR-507 and miR-381),and E2F transcription factor ***,AURKA and AURKB were correlated with immune cell *** enrichment analysis revealed that AURKA and AURKB were involved in the cell cycle signaling pathway,platinum drug resistance signaling pathway,ErbB signaling pathway,Hippo signaling pathway,and nucleotide-binding and oligomerization domain-like receptor signaling ***:Aurora kinases AURKA and AURKB could be employed as novel prognostic biomarkers or promising therapeutic targets for BC.

关键词： Aurora kinases AURKs Breast cancer Prognosis Bioinformatics analysis

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新疆塔什库尔干塔吉克自治县牦牛产业发展技术研讨与援疆工作

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中国畜禽种业 2024年第10期20卷 129-134页

作者：卢宇曦孔大帅常荣荣田蕴涵李晨莹包鹏甲郭宪李家奎张丽张玉波阎萍孔思远中国农业科学院深圳农业基因组研究所广东深圳518120 中国农业科学院兰州畜牧与兽药研究所甘肃兰州730050 华中农业大学湖北武汉430070 甘肃农业大学甘肃兰州730070

塔县牦牛是在帕米尔高原独特的自然环境与气候条件下形成的特有牦牛种群,是新疆塔什库尔干塔吉克自治县(简称塔县)高寒牧区重要生产、生活材料。该文主要介绍了塔县牦牛产业发展现状及提质增效技术、牦牛疾病防控概况及发展方向、牦牛... 详细信息

塔县牦牛是在帕米尔高原独特的自然环境与气候条件下形成的特有牦牛种群,是新疆塔什库尔干塔吉克自治县(简称塔县)高寒牧区重要生产、生活材料。该文主要介绍了塔县牦牛产业发展现状及提质增效技术、牦牛疾病防控概况及发展方向、牦牛肉及副产物精深加工技术,并对多次赴塔县科技援疆工作的内容进行思考和总结,为改良塔县牦牛种群,提高当地畜牧业发展水平,助力科技脱贫提供参考。

关键词：新疆塔什库尔干塔吉克自治县养殖牦牛畜牧业

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Julolidine functionalized benzimidazoline-doped fullerene derivatives for efficient and stable perovskite solar cells

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Interdisciplinary Materials 2024年第3期3卷 369-379页

作者： Yanqing Zhu Chenglong Li JiaHui Chen yuxi Zhang Jianfeng lu Min Hu Wangnan Li Fuzhi Huang Yi-Bing Cheng Hyesung Park Shengqiang Xiao State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhanChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina School of Electronic and Electrical Engineering Hubei Province Engineering Research Centre for Intelligent Micro-Nano Medical Equipment and Key TechnologiesWuhan Textile UniversityWuhanChina Hubei Key Laboratory of Low Dimensional Optoelectronic Material and Devices Hubei University of Arts and ScienceXiangyangHubeiChina KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulRepublic of Korea Department of Integrative Energy Engineering Korea UniversitySeoulRepublic of Korea Hubei Key Laboratory of Fuel Cell WuhanChina

Fullerene derivatives are highly attractive materials in solar cells,organic thermoelectrics,and other ***,the intrinsic low electron mobility and electrical conductivity restrict their potential device performance,such as perovskite solar cells(PSCs).Herein,we successfully enhanced the electric properties and morphology of phenyl-C61-butyric acid methyl ester(PCBM)by n-doping it with a benzimidazoline derivative,9-(1,3-dimethyl-2,3-dihydro-1H-benzoimidazol-2-yl)-julolidine(JLBI-H)via a solution *** found the n-doping can not only improve the conductivity and optimize the band alignment but also enable the PCBM to have a constantly strong charge extraction ability in a wide temperature from 173 to 373 K,which guarantees a stable photovoltaic performance of the corresponding PSCs under a wide range of operating *** the JLBI-H-doped PCBM,we improved the efficiency from 17.9%to 19.8%,along with enhanced stability of the nonencapsulated devices following the aging protocol of ISOS-D-1.

关键词： charge extraction electron mobility n-doping PSCs wide operation temperature

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Research on FBG-Based CFRP Structural Damage Identification Using BP Neural Network

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Photonic Sensors 2018年第2期8卷 168-175页

作者： Xiangyi GENG Shizeng lu Mingshun JIANG Qingmei SUI Shanshan LV Hang XIAO yuxi JIA Lei JIA School of Control Science and Engineering Shandong University Jinan 250061 China School of Electrical Engineering University of Jinan Jinan 250022 China Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education) Shandong University Jinan 250061 China

A damage identification system of carbon fiber reinforced plastics （CFRP） structures is investigated using fiber Bragg grating （FBG） sensors and back propagation （BP） neural network. FBG sensors are applied to construct the sensing network to detect the structural dynamic response signals generated by active actuation. The damage identification model is built based on the BP neural network. The dynamic signal characteristics extracted by the Fourier transform are the inputs, and the damage states are the outputs of the model. Besides, damages are simulated by placing lumped masses with different weights instead of inducing real damages, which is confirmed to be feasible by finite element analysis （FEA）. At last, the damage identification system is verified on a CFRP plate with 300mm × 300mm experimental area, with the accurate identification of varied damage states. The system provides a practical way for CFRP structural damage identification.

关键词： Carbon fiber reinforced polymer damage identification FBG sensors neural network finite elementanalysis

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Investigation and Optimization of the Current Situation of Temporary Pedestrian Crossing in Nanchang City

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Journal of Landscape Research 2020年第2期12卷 23-25页

作者： ZENG Yan SUN yuxi XIE Kelu lu Sen College of City Construction Jiangxi Normal UniversityNanchangJiangxi 330022China

A temporary pedestrian crossing has been set up for the first time in Nanchang City to facilitate the passage of residents,which has brought great convenience to surrounding residents and *** author made an in-depth investigation on the temporary pedestrian crossing,analyzed its advantages and existing problems through field investigation,questionnaire survey,resident interview and other forms and put forward relevant suggestions by considering the current operation mode of the facilities,to provide reference for relevant departments to optimize the temporary pedestrian crossing and provide reliable and efficient solutions for other regions.

关键词： Nanchang City Temporary pedestrian crossing Investigation of current situation Optimization

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Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

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Bone Research 2023年第1期11卷 136-147页

作者： Aoyuan Fan Genbin Wu Jianfang Wang Laiya lu Jingyi Wang Hanjing Wei yuxi Sun Yanhua Xu Chunyang Mo Xiaoying Zhang Zhiying Pang Zhangyi Pan Yiming Wang Liangyu lu Guojian Fu Mengqiu Ma Qiaoling Zhu Dandan Cao Jiachen Qin Feng Yin Rui Yue Department of Joint Surgery Shanghai East HospitalTongji University School of MedicineShanghai200092China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200240China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai200092China Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai200072China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai200120China Shanghai Clinical Research Center for Aging and Medicine Shanghai200040China

Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and *** is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly ***,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in ***,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col ***-articular injection of r Fap significantly accelerated Col II degradation and OA *** contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in *** deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or ***-articular injection of r Oln significantly ameliorated OA *** together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation.

关键词： cartilage superficial inhibited

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Analysis of the immune mechanism of three traditional Chinese medicines fermented by Lactobacillus plantarum in mouse models of specific diseases by omics

Analysis of the immune mechanism of three traditional Chines...

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第十四届全国免疫学学术大会

作者： Chunjiang Zhang yuxi LI Xuerui lu Yun Yang Zeqi Huo Lanzhou University

Background: Licorice, angelica and astragalus have been used in China for thousands of years as traditional Chinese medicines. However, the existing Methods of processing herbal medicines in clinical practice often fail to fully utilize the advantages of herbal medicines. Some relevant studies have shown that fermented herbs can improve their efficacy and reduce ***&Results: In this study, we used Lactobacillus plantarum isolated from yak yogurt and northwestern specialtiesJiangshui, and for the different therapeutic effects of three herbal medicines,three experimental combinations of in vitro fermented licorice for acute alcoholic liver injury mouse model, in vitro fermented angelica against D-galactose-induced aging mouse model, and in vitro fermented astragalus to alleviate lipopolysaccharide-induced acute lung injury in mice were designed. After exploring the optimal fermentation conditions, the fermentation solution was given to model mice to compare the changes in antioxidant activity and histopathology before and after fermentation and to measure the biochemical indexes, so as to elucidate the alleviating effect of fermented herbs on the *** an in vitro fermented licorice model for the treatment of acute alcoholic liver injury, the fermented licorice solution was found to have strong in vitro antioxidant activity. By evaluating the liver index, liver histopathology score, AST, ALT and antioxidant enzymes in mice, it was found that licorice fermentation solution could significantly increase the activity of antioxidant enzymes in liver tissues of mice with alcoholic liver injury as a way to alleviate acute alcoholic liver *** vitro fermentation of Angelica sinensis significantly increased the antioxidant activity. Administration of fermentation broth to D-galactose-induced senescent mice significantly increased the activity of antioxidant enzymes in the liver tissues of senescent mice, reduced oxidative products, inhibited the release o

关键词： Licorice Angelica Astragalus Lactobacillus plantarum Metabolomics Fermentation gut microbiota

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弹体低速撞击下蓄液结构毁伤特性研究

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振动与冲击 2018年第15期37卷 84-89页

作者：刘雨曦任鹏拾路江苏科技大学船舶与海洋工程学院江苏镇江212000

为了研究蓄液结构在弹体低速侵彻作用下的损伤失效特性,利用轻气炮结合高速摄影技术对蓄液结构进行了两种不同形状弹头的低速撞击实验。对两种弹体入水后的速度衰减及空泡扩展分别进行了分析,进而获得了蓄液结构内空泡扩展及溃灭的典型... 详细信息

为了研究蓄液结构在弹体低速侵彻作用下的损伤失效特性,利用轻气炮结合高速摄影技术对蓄液结构进行了两种不同形状弹头的低速撞击实验。对两种弹体入水后的速度衰减及空泡扩展分别进行了分析,进而获得了蓄液结构内空泡扩展及溃灭的典型作用过程及蓄液结构前后面板的典型失效模式,并在此基础上讨论了弹速及弹头形状对结构损伤的影响。研究结果表明:相同速度条件下,半球形弹在水中的速度衰减及产生的空泡半径均弱于平头弹,平头弹对蓄液结构造成的毁伤程度更大,在该研究速度范围内,靶板的局部变形量与弹速成线性关系。

关键词：蓄液结构低速撞击水锤效应失效模式

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Hybrid femtosecond laser system based on a Yb:KGW regenerative amplifier for N_P polarization

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Chinese Optics Letters 2019年第4期17卷 71-74页

作者： Dongyu Yan Bowen Liu yuxi Chu Huanyu Song lu Chai Minglie Hu Chingyue Wang Ultrafast Laser Laboratory Key Laboratory of Opto-electronic Information Science and Technology of Ministry of Education School of Precision Instruments and Opto-electronics Engineering Tianjin University

We report a hybrid femtosecond laser system based on a femtosecond Yb-doped fiber laser and a Yb-doped potassium gadolinium tungstate(Yb:KGW) regenerative amplifier. To match the central wavelength of the seed source, a Yb:KGW crystal is used in the regenerative amplifier for N_p polarization. We study and optimize the dynamics of nonlinear amplification to alleviate the gain narrowing effect. With optimization, the system can output 270 fs pulses with 21 μJ pulse energy at a 60 kHz repetition rate.

关键词： hybrid femtosecond femtosecond Yb-doped 60 kHz repetition

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Overview of chemical constituents and pharmacological activities of Piper longum Linn.

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Asian Journal of Traditional Medicines 2019年第3期14卷 147-154页

作者： Liwei lu Le Zhou yuxi Wang Zhuoyang Cheng Jie Wang Xiaoxiao Huang Shaojiang Song Department of Natural Products Chemistry Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 PR China

Piper longum Linn. is a native of the Indo-Malaya region, belongs to the family Piperaceae. It is a slender aromatic climber widely distributed in the tropical and subtropical regions. As a traditional ethnic drug, P. longum contains various chemical constituents such as alkaloids, volatile oil and lignans. The extract of P. longum has been reported to show various activities like antitumor, antioxidant and hepatoprotective activity. Hence, this paper is presented as a review centered on the main chemical constituents and pharmacological effects of P. longum, aiming at its further development and potential value.

关键词： Piper longum Linn. chemical constituents pharmacological effects research review

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