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16例急性有机磷中毒致呼吸肌麻痹的护理

天津护理 1999年第4期7卷 142-144页

作者：邵玉文天津市汉沽医院急症科 300480

通过对16例急性有机磷中毒致呼吸肌麻痹患者救治成功的护理,我们制定了有效的护理措施:呼吸道护理;病情观察;心理护理。防止或减少了并发症的发生,对提高抢救成功率起到了重要作用。

关键词：有机磷中毒呼吸肌麻痹护理

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中小型燃气企业网络安全等级保护实践与探索

天津科技 2024年第9期51卷 52-55页

作者：戴绘邵郁文天津市赛达燃气有限公司天津300385

随着信息化技术的发展及政策要求,燃气企业网络安全形势日益严峻,网络安全等级保护的需求迫在眉睫。以燃气企业为研究对象,分析燃气企业网络安全的现状和面临的主要威胁,结合网络安全等级保护实践,从物理安全、区域边界安全、通信网络... 详细信息

随着信息化技术的发展及政策要求,燃气企业网络安全形势日益严峻,网络安全等级保护的需求迫在眉睫。以燃气企业为研究对象,分析燃气企业网络安全的现状和面临的主要威胁,结合网络安全等级保护实践,从物理安全、区域边界安全、通信网络安全、计算环境安全等方面提出具体的防护措施,以期通过建立安全管理体系和应急响应机制,加强员工培训和意识教育,有效提升燃气企业的网络安全防护能力,降低网络安全风险,保障燃气企业稳定运行。

关键词：燃气企业网络安全等级保护防护措施安全管理

KMBox:基于Linux内核改造的进程异构冗余执行系统

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信息安全学报 2023年第1期8卷 14-25页

作者：马博林张铮邵昱文李秉政潘传幸蒋鹏邬江兴中国人民解放军战略支援部队信息工程大学郑州450001 网络通信与安全紫金山实验室南京211100

随机化技术防御进程控制流劫持攻击,是建立在攻击者无法了解当前内存地址空间布局的基础之上,但是,攻击者可以利用内存信息泄露绕过随机化防御获得gadget地址,向程序注入由gadget地址构造的payload,继续实施控制流劫持攻击,窃取敏感数... 详细信息

随机化技术防御进程控制流劫持攻击,是建立在攻击者无法了解当前内存地址空间布局的基础之上,但是,攻击者可以利用内存信息泄露绕过随机化防御获得gadget地址,向程序注入由gadget地址构造的payload,继续实施控制流劫持攻击,窃取敏感数据并夺取或破坏执行软件的系统。目前,异构冗余执行系统是解决该问题的方法之一,基本思想是同一程序运行多个多样化进程,同时处理等效的程序输入。随机化技术使冗余的进程对恶意输入做出不同的输出,同时正常功能不受影响。近年来,一些符合上述描述的系统已经被提出,分析进程异构冗余执行系统的表决设计可以发现,基于ptrace的实现方法会引入大量的上下文切换,影响系统的执行效率。率先直接修改内核设计出一种进程异构冗余执行系统,表决过程完全在内核中完成,冗余的进程独立地采用内存地址空间随机化技术,构建相互异构的内存地址空间布局,在与内存信息泄露相关的系统调用处进行表决,发现泄露信息不一致,阻断进程控制流劫持攻击。即使攻击者跳过内存信息泄露进行漏洞利用,异构内存空间布局也使得注入由gadget地址构造的payload无法同时在冗余的进程中有效,阻断进程控制流劫持攻击。实现了原型系统KMBox,实验证明该系统能够有效抵御进程控制流劫持攻击,性能相较于基于ptrace的进程异构冗余执行系统有所提高。

关键词：控制流劫持攻击异构冗余执行系统随机化

MSC-EV通过抑制中性粒细胞胞外诱捕网的生成减轻脓毒症相关急性肺损伤

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国际麻醉学与复苏杂志 2024年第11期45卷 1121-1126页

作者：邵毓雯吴丹施雨鑫王杨寒召张浩缪长虹上海200032 上海市围手术期应激与保护重点实验室200032

目的探讨间充质干细胞（MSC）来源的细胞外囊泡（EV）（MSC-EV）在脓毒症相关急性肺损伤（SI-ALI）中对中性粒细胞胞外诱捕网（NET）的影响及其相关机制。方法将提取的MSC-EV进行表征鉴定，采用纳米流式检测仪检测其粒径范围，电镜... 详细信息

目的探讨间充质干细胞（MSC）来源的细胞外囊泡（EV）（MSC-EV）在脓毒症相关急性肺损伤（SI-ALI）中对中性粒细胞胞外诱捕网（NET）的影响及其相关机制。方法将提取的MSC-EV进行表征鉴定，采用纳米流式检测仪检测其粒径范围，电镜检测其形态，免疫印迹法（Western blot）检测EV标记物[凋亡诱导因子6相互作用蛋白抗体（Alix）、溶酶体相关膜蛋白3（CD63）、细胞分化抗原9（CD9）、钙联蛋白（Calnexin）]。将18只野生型C57BL/6J小鼠按随机数字表法分为3组（每组6只）：假手术组（S组）、盲肠结扎穿孔术（CLP）组、治疗组（CME组）。S组小鼠开腹后关腹，CLP组进行CLP，CME组CLP前1 h尾静脉注射MSC-EV（200 μg/只）；苏木精-伊红（H-E）染色比较3组小鼠肺组织病理改变，免疫荧光染色法比较肺组织髓过氧化物酶（MPO）、瓜氨酸化组蛋白H3（CitH3）水平。取人外周血中的中性粒细胞按随机数字表法分为3组：对照组（C组）、丙二醇甲醚醋酸酯组（PMA组）、细胞治疗组（PME组）。C组给予磷酸盐缓冲液（PBS）对照处理，PMA组给予PMA 50 nmol/L，PME组在PMA刺激前1 h给予MSC-EV 20 mg/L；免疫荧光染色法比较3组细胞CitH3水平，活性氧（ROS）染色法比较细胞ROS水平。结果纳米流式检测结果显示MSC-EV粒径范围为60~100 nm；透射电镜显示杯状的囊泡图像；Western blot显示MSC-EV表达EV的标志蛋白Alix、CD63、CD9，不表达Calnexin。与S组比较，CLP组肺组织肺泡壁较厚、出血较多、炎症细胞浸润较多，肺组织MPO、CitH3水平较高（均 P <0.05）；与CLP组比较，CME组肺组织肺泡壁较薄、出血较少、炎症细胞浸润较少，肺组织MPO、CitH3水平较低（均 P <0.05）。与C组比较，PMA组CitH3、ROS水平较高（均 P <0.05）；与PMA组比较，PME组CitH3、ROS水平较低（均 P <0.05）。结论 MSC-EV可以通过减少ROS从而抑制NET生成，进而缓解SI-ALI。

关键词：脓毒症急性肺损伤间充质干细胞细胞外囊泡中性粒细胞胞外诱捕网

Inter-comparisons of VOC oxidation mechanisms based on box model:A focus on OH reactivity

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Journal of Environmental Sciences 2022年第4期34卷 286-296页

作者： Xiaoyun Yang Bin Yuan Zhe Peng yuwen Peng Caihong Wu Suxia Yang Jin Li Min shao Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 511443China Department of Chemistry and Cooperative Institute for Research in Environmental Sciences University of ColoradoBoulderCO 80309USA

Volatile organic compounds(VOCs)oxidation processes play a very important role in atmospheric chemistry,and the chemical reactions are expressed in various manners in chemical *** gain an improved understanding of VOCs evolution during oxidation processes and evaluate the discrepancies of VOCs oxidation schemes among different mechanisms,we used the total VOC reactivity as a diagnostic and evaluated tool to explore the differences for six widely used chemical *** compared the total VOC reactivity evolution under high-NO_(x)xconditions for several sets of precursors,including n-pentane,toluene,ethene,isoprene and a mixture of 57 Photochemical Assessment Monitoring Stations(PAMS)species in a 0-D photochemical box ***-comparison of total VOC reactivity of individual precursor simulations showed discrepancies to different extent of the oxidation schemes among the studied mechanisms,which are mainly attributed to the different lumping approaches for organic *** PAMS simulation showed smaller discrepancy than individual precursor cases in terms of total VOC ***07 and RACM2 performances are found to better match the MCM for simulation of total VOC *** suggest that the performance in simulating secondary organic products,OH concentrations and NO_(x)concentrations are related to the OH reactivity discrepancies among various chemical *** in this study can be used in selection of chemical mechanisms to better model OH reactivity in different *** results in this study also provide directions to further improve the ability in modelling total VOC reactivity with the chemical mechanisms.

关键词： VOCs Box model Chemical mechanism Total VOC reactivity VOC oxidation

Coherence of Superposition States

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Communications in Theoretical Physics 2019年第9期71卷 1084-1088页

作者： Shan-Shan yuwen Lian-He shao Zheng-Jun Xi College of Computer Science Shaanxi Normal UniversityXi'an710062China School of Computer Science Xi'an Polytechnic UniversityXi'an710048China

We find tight upper bound on the coherence of a superposition of two states in terms of the coherence of the two states constituting the superposition with l1-norm of coherence. Our upper bound is tighter than the one presented by Liu, et al. [Quantum Inf. Process. 15(2016) 4209.] We also generalize the results to the case that the superposition is constituted with more than two states in high dimension, and we give the corresponding upper bounds.

关键词： quantum coherence superposition states l1-norm of coherence

Long‐life lithium batteries enabled by a pseudo‐oversaturated electrolyte

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Carbon Energy 2024年第4期6卷 115-127页

作者： Youchun Yu Simeng Wang Juyan Zhang Weiwei Qian Nana Zhang Guangjie shao Haiyan Bian yuwen Liu Lan Zhang Hebei Key Laboratory of Applied Chemistry College of Environmental and Chemical EngineeringYanshan UniversityQinhuangdaoChina Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijingChina Haike Group Research Institute of Innovation&Technology DongyingChina Langfang Green Industrial Technology Center LangfangChina

The specific energy of Li metal batteries(LMBs)can be improved by using high‐voltage cathode materials;however,achieving long‐term stable cycling performance in the corresponding system is particularly challenging for the liquid ***,a novel pseudo‐oversaturated electrolyte(POSE)is prepared by introducing 1,1,2,2‐tetrafluoroethyl‐2,2,3,3‐tetrafluoropropyl ether(TTE)to adjust the coordination structure between diglyme(G2)and lithium bis(trifluoromethanesulfonyl)imide(LiTFSI).Surprisingly,although TTE shows little solubility to LiTFSI,the molar ratio between LiTFSI and G2 in the POSE can be increased to 1:1,which is much higher than that of the saturation state,1:*** and experimental results prove that TTE promotes closer contact of the G2 molecular with Li^(+)in the ***,it also participates in the formation of electrolyte/electrode *** electrolyte shows outstanding compatibility with both the Li metal anode and typical high‐voltage ***||Li symmetric cells show a long life of more than 2000 h at 1 mA cm^(−2),1 mAh cm^(−2).In the meantime,Li||LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cell with the POSE shows a high reversible capacity of 134.8 mAh g^(−1 )after 900 cycles at 4.5 V,1 C *** concept of POSE can provide new insight into the Li^(+)solvation structure and in the design of advanced electrolytes for LMBs.

关键词： high voltage lithium metal batteries pseudo‐oversaturated electrolyte solid electrolyte interphases(SEI) solvation structure

Investigation of transfer ionization processes in the collision of partially stripped carbon ions on Argon

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Science China(Physics,Mechanics & Astronomy) 2008年第7期51卷 750-754页

作者： WANG Jun CHEN XiMeng DING BaoWei FU HongBin CUI Ying shao JianXiong LU YanXia GAO ZhiMin LIU yuwen Du Juan SUN GuangZhi CHEN Lin Department of Nuclear Science and Technology Lanzhou UniversityLanzhou 73000China

The ratios of the cross section of the transfer-ionization to the single-electron-capture of Argon induced by Cq+ (q=1,2,3) ions are measured by means of position sensitive and time-of-flight techniques. Our experimental results are compared with the data of Heq+ (q=1,2)-Ar of DuBois. A qualitative interpretation is presented based on the Classical-Over-Barrier Model of Bohr.

关键词： ion-atom collision transfer-ionization single-electron-capture over barrier model

Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma

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Bioactive Materials 2023年第10期28卷 376-385页

作者： Dafu Chen Chengyue Lei Weifeng Liu Meiyu shao Meizhou Sun Jianxun Guo Jingjing Cao Jing-Jun Nie Peng Luo yuwen Luo Bingran Yu Renxian Wang Shun Duan Fu-Jian Xu Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology)Ministry of EducationBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Orthopaedic Oncology Surgery Beijing Jishuitan HospitalPeking UniversityBeijing100035China JST Sarcopenia Research Centre Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China

miRNAs are important regulators of gene expression and play key roles in the development of cancer, including osteosarcoma. During the development of osteosarcoma, the expression of miR-22 is significantly downregulated, making miR-22 as a promising therapeutic target against osteosarcoma. To design and fabricate efficient delivery carriers of miR-22 into osteosarcoma cells, a hydroxyl-rich reduction-responsive cationic polymeric nanoparticle, TGIC-CA (TC), was developed in this work, which also enhanced the therapeutic effects of Volasertib on osteosarcoma. TC was prepared by the ring-opening reaction between amino and epoxy groups by one-pot method, which had the good complexing ability with nucleic acids, reduction-responsive degradability and gene transfection performance. TC/miR-22 combined with volasertib could inhibit proliferation, migration and promote apoptosis of osteosarcoma cells in vitro. The anti-tumor mechanisms were revealed as TC/ miR-22 and volasertib could inhibit the PI3K/Akt signaling pathway synergistically. Furthermore, this strategy showed outstanding tumor suppression performance in animal models of orthotopic osteosarcoma, especially in patient-derived chemo-resistant and chemo-intolerant patient-derived xenograft (PDX) models, which reduced the risk of tumor lung metastasis and overcame drug resistance. Therefore, it has great potential for efficient treatment of metastasis and drug resistance of osteosarcoma by the strategy of localized, sustained delivery of miR-22 using the cationic nanocarriers combined with non-traditional chemotherapy drugs.

关键词： Nucleic acid delivery Nanoparticle Gene therapy Osteosarcoma Responsive Patient-Derived Xenograft(PDX)