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Ligand effect in surface atomic sites of group VI B transition metals on ultrathin Pt nanowires for enhanced oxygen reduction

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Nano Research 2024年第6期17卷 5298-5304页

作者： yuwei he Yueguang Chen Renjie Wu Zhihe Xiao Mengxian Li Chunfeng Shi Leyu Wang State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Petroleum Molecular and Process Engineering SINOPEC Research Institute of Petroleum Processing Co.Beijing 100083China

Increasing the utilization efficiency of platinum is critical for advancing proton exchange-membrane fuel cells(PEMFCs).Despite extensive research on catalysts for the cathodic oxygen reduction reaction(ORR),developing highly active and durable Pt-based catalysts that can suppress surface dealloying in corrosive acid conditions remains ***,we report a facile synthesis of bimetallic ultrathin PtM(M=Mo,W,and Cr)nanowires(NWs)composed of group VI B transition metal atomic sites anchored on the *** NWs possess uniform sizes and well-controlled atomic *** to PtW and PtCr catalysts,the PtMo0.05 NWs exhibit the highest half-wave potential of 0.935 V and a mass activity of 1.43 A·mgPt^(−1).Remarkably,they demonstrate a remarkable 23.8-fold enhancement in mass activity compared to commercial Pt/C for ORR,surpassing previously reported Pt-based ***,the PtMo NWs cathode in membrane electrode assembly tests achieves a remarkable peak power density of 1.443 W·cm^(−2)(H_(2)-O_(2)conditions at 80℃),which is 1.09 times that of commercial Pt/*** ligand effect in the bimetallic surface not only facilitates strong coupling between Mo(4d)and Pt(5d)atomic orbitals to hinder atom leaching but also modulates the d-states of active site,significantly optimizing the adsorption of key oxygen(*O and*OH)species and accelerating the rate-determining step in ORR pathways.

关键词： ligand effect oxygen reduction reaction group VI B transition metal ultrathin nanowires multiple oxygen species

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针灸治疗帕金森病验案

中国民间疗法 2024年第12期32卷 109-112页

作者：何玉伟北京中医药大学附属护国寺中医医院北京100035

帕金森病是一种常见于中老年人群的神经系统疾病。该文介绍针灸治疗帕金森病验案1则,帕金森病病机多以肝肾亏虚、阴虚风动为主,阳气亏虚亦为重要病机,采用针灸治疗该病时应充分考虑肝肾阴虚、阴虚风动、阳气虚衰对本病的致病作用,运用... 详细信息

帕金森病是一种常见于中老年人群的神经系统疾病。该文介绍针灸治疗帕金森病验案1则,帕金森病病机多以肝肾亏虚、阴虚风动为主,阳气亏虚亦为重要病机,采用针灸治疗该病时应充分考虑肝肾阴虚、阴虚风动、阳气虚衰对本病的致病作用,运用经络诊察的方法以明确患者的病变经络特点,从异常经络着手治疗。

关键词：帕金森病针灸肝肾阴虚阴虚风动阳气虚衰经络诊察

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考虑各向异性空间变异性的边坡可靠度分析

土木与环境工程学报（中英文） 2024年第4期46卷 60-74页

作者：明思成仉文岗何昱苇陈龙龙覃长兵重庆大学土木工程学院重庆400045 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 重庆大学库区环境地质灾害防治国家地方联合工程研究中心重庆400045

在边坡可靠度分析中,通常采用横观各向异性或各向同性随机场来刻画土体参数的空间变异特性,而忽略了土体参数的各向异性空间变异性,从而可能会得出错误的可靠度评价结果。为此,建立考虑各向异性空间变异性的边坡可靠度随机有限差分方法(... 详细信息

在边坡可靠度分析中,通常采用横观各向异性或各向同性随机场来刻画土体参数的空间变异特性,而忽略了土体参数的各向异性空间变异性,从而可能会得出错误的可靠度评价结果。为此,建立考虑各向异性空间变异性的边坡可靠度随机有限差分方法(RFDM)计算框架,并以一般各向异性空间变异性边坡为参考边坡,从波动范围方向结构、互相关系数、变异系数和波动范围等方面系统地探讨各向异性空间变异性对边坡可靠度的影响。结果表明:基于坐标转换的各向异性随机场模拟方法可以有效地刻画土体参数各向异性空间变异性;应变聚类边坡临界滑面搜索算法适用于复杂临界滑面的精确搜索;相比一般各向异性空间变异性,旋转各向异性空间变异性会高估边坡失效概率,横观各向异性空间变异性会严重低估边坡失效概率,而各向同性空间变异性会在较大和较小的波动范围内分别高估和低估边坡失效概率。

关键词：随机有限差分边坡可靠度蒙特卡洛模拟各向异性空间变异性临界滑面

多种冲击电流下金属氧化物压敏电阻动态模型准确性分析

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高压电器 2024年第10期60卷 137-146页

作者：王伟芳何雨微徐真刘政国刘亚坤上海交通大学电力传输与功率变换控制教育部重点实验室上海200030 国网浙江省电力有限公司杭州供电公司杭州310009 上海雷霸电气科技有限公司上海201400

为研究IEEE模型和Pinceti模型对金属氧化物压敏电阻(metal-oxide varistor,MOV)的仿真准确性,以额定电压为150~750 V的6种MOV为对象,理论和试验分析了不同幅值4/10μs、8/20μs雷电冲击电流和30/60μs操作冲击电流下的残压及吸收能量。... 详细信息

为研究IEEE模型和Pinceti模型对金属氧化物压敏电阻(metal-oxide varistor,MOV)的仿真准确性,以额定电压为150~750 V的6种MOV为对象,理论和试验分析了不同幅值4/10μs、8/20μs雷电冲击电流和30/60μs操作冲击电流下的残压及吸收能量。结果表明,在IEEE模型参数确定中,随操作冲击电流幅值的增大,非线性电阻参考电压取值增大但电感取值减小;在残压预测中,IEEE模型误差为2.6%,较Pinceti模型误差4.6%更准确;在MOV吸收能量估算中,IEEE模型在低于10 kA电流幅值下的准确性高于Pinceti模型,且IEEE模型对30/60μs操作冲击电流的准确性较高,对8/20μs雷电冲击电流准确性较低。

关键词：冲击电流试验金属氧化物压敏电阻动态模型残压吸收能量

Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

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Acta Pharmaceutica Sinica B 2018年第1期8卷 14-22页

作者： Ruixiang Li yuwei he Shuya Zhang Jing Qin Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University Key Laboratory of Smart Drug Delivery Ministry of Education Institute of Materia Medica Academy of Chinese and Western Integrative Medicine Fudan University

Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells. The cell membrane-coating technology has pushed the limits of common nano-systems(fast elimination in circulation) to more effectively navigate within the body. Moreover, because of the various functional molecules on the surface, cell membrane-based nanoparticles(CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor. Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy. In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field.

关键词： Cell membrane Biomimetic nanoparticle Drug delivery Cancer targeting Circulation Molecular recognition

Recent advances in cardiovascular stent for treatment of in-stent restenosis:Mechanisms and strategies

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Chinese Journal of Chemical Engineering 2021年第9期34卷 12-29页

作者： Hang Yao yuwei he Jinrong Ma Lang Jiang Jingan Li Jin Wang Nan Huang Key Laboratory of Advanced Technology for Materials of the Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Department of Chemical Engineering University of WashingtonSeattle 98195USA Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450000China

Treatments of atherogenesis,one of the most common cardiovascular diseases(CVD),are continuously being made thanks to innovation and an increasingly in-depth knowledge of percutaneous transluminal coronary angioplasty(PTCA),the most revolutionary medical procedure used for vascular *** with an expanding balloon,vascular stents used at stricture sites enable the long-time restoration of vascular ***,complication after stenting,in-stent restenosis(ISR),hinders the advancement of vascular stents and are associated with high medical costs for patients for decades ***,the development of a high biocompatibility stent with improved safety and efficiency is urgently *** review provides an overview of current advances and potential technologies for the modification of stents for better treatment and prevention of *** particular,the mechanisms of in-stent restenosis are investigated and summarized with the aim to comprehensively understanding the pathogenesis of stent ***,according to different therapeutic functions,the current stent modification strategies are reviewed,including polymeric drug eluting stents,biological friendly stents,prohealing stents,and gene ***,the review provides an outlook of the challenges in the design of stents with optimal ***,this review is a valuable and practical guideline for the development of cardiovascular stents.

关键词： Cardiovascular stent modification In-stent restenosis Late stent thrombosis Re-endothelialization Inflammatory modulation

A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver

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Nano Research 2018年第9期11卷 4507-4523页

作者： Jianming Liang Ruixiang Li yuwei he Chengli Ling Qi Wang Yongzhuo Huang Jing Qin Weigen Lu Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Rd. Shanghai201203 China Shanghailnstitute of Pharmaceuticallndustry China State Institute of Pharmaceutical Industry 285 Gebaini Rd. Shanghai201203 China School of Pharmacy Chengdu University of Traditional Chinese Medicine No 1166 Liu TaiAvenue Wenjiang District Chengdu 610072 China

Although nanotechnology has been rapidly developed and applied in tumor targeting, the outcome of chemotherapy remains greatly restricted by the toxicity of cytotoxic drugs in normal tissues and cells. Therefore, the development of alternative delivery systems, with few side effects in normal cells, has attracted increasing attention. Energy restriction is a novel and promising approach to cancer treatment, which can restrict tumor growth via inhibition of cellular energy metabolism. In this study, a novel tumor targeting system, based on folate-conjugated bovine serum albumin （BSA）, was developed to co-deliver albendazole and nanosilver simultaneously, to restrain the energy metabolism of tumor cells. This nanosystem showed stronger anti-tumor efficacy than those using nanoparticles without folic acid modification, nanosilver, or albendazole, both in vitro and in vivo. This nanosystem depleted cellular ATP via direct inhibition of glycolytic enzymes and mitochondrial damage, resulting in inhibition of proliferation, cell-cycle arrest, and apoptosis of tumor cells. The enhanced anti-tumor activity contributed to the tumor-targeting ability of this system, resulting in specific energy inhibition in tumor cells. Toxicity evaluation was performed to confirm the safety of this system. This nanosystem provides an efficient and safe strate~ for tumor therapy.

关键词： albendazole nano silver co-delivery tumor targeting energy metabolism

Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

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Nano Research 2018年第11期11卷 6086-6101页

作者： yuwei he Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China

The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification, are complex, laborious, and inefficient. Inspired by the intrinsic relationship between platelets and RA, platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA. Through platelet receptor-mediated adhesion, an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanoparticles, endowing the resulting PNPs with various functional receptors. By coating with platelet membranes, the nanoparticles were stabilized and had a better circulation profile, providing a benefit for passive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition, indicating that the PNPs could effectively target to RA tissues through multiple mechanisms, similar to natural platelets. Moreover, FK506, a model drug, was loaded into the PNPs and used to treat RA. Pharmacodynamic studies demonstrated that the FK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides a new biomimetic targeting strategy with great potential for the treatment of RA.

关键词： biomimetic nanoparticles platelet membrane rheumatoid arthritis targeted drug delivery

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数字绘画作品

湖南包装 2024年第4期39卷 219-222页

作者：毛淑婷汪丹(指导) 何雨微乐梦王泉灵武汉商学院

以中国传统节日为主题,以人物形象为刻画重点,选择端午、中秋、春节节庆期间的代表元素,运用现代插画风格表现中国的传统文化。现代风格与传统元素相互融合,画面丰富有趣,使传统节日更具现代美感。

关键词：现代风格传统元素中国传统节日插画风格现代美感人物形象数字绘画作品