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Acta Metallurgica Sinica(English Letters) 2013年第5期26卷 497-502页

作者： Feng shi Xiaowu LI yutong HU Chuan SU Chunming LIU Institute of Materials Physics and Chemistry College of Sciences Northeastern University School of Materials and Metallurgy Northeastern University

Grain boundary engineering（GBE） is a practice of improving resistance to grain boundary failure of the material through increasing the proportion of low Σ coincidence site lattice（CSL） grain boundaries（special grain boundaries） in the grain boundary character distribution（GBCD）. The GBCD in a cold rolled and annealed Fe-18Cr-18Mn-0.63N high-nitrogen austenitic stainless steel was analyzed by electron back scatter difraction（EBSD）. The results show that the optimization process of GBE in the conventional austenitic stainless steel cannot be well applied to this high-nitrogen austenitic stainless steel. The percentage of low ΣCSL grain boundaries could increase from 47.3% for the solid solution treated high-nitrogen austenitic stainless steel specimen to 82.0% for the specimen after 5% cold rolling reduction and then annealing at 1423 K for 10 *** special boundaries of high proportion efectively interrupt the connectivity of conventional high angle grain boundary network and thus achieve the GBCD optimization for the high-nitrogen austenitic stainless steel.

关键词： High nitrogen austenitic stainless steel Grain boundary character distri-bution CSL grain boundary EBSD

ZL205A合金凝固过程本构模型及其在筒形件中的应用

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特种铸造及有色合金 2021年第5期41卷 570-574页

作者：王明杰张建兵吴士平黄西西戴贵鑫张晓东慕岩史玉童哈尔滨工业大学材料科学与工程学院哈尔滨150001 首都航天机械有限公司

ZL205A合金在凝固过程中极易产生热裂缺陷,由于其高温阶段本构模型的缺失,使铸件热裂的预测十分困难。借助ProCAST软件研究了适用于ZL205A合金的线弹性、弹塑性及粘弹塑性本构模型,在此基础上与热裂实际浇注试验进行对比分析,发现粘弹... 详细信息

ZL205A合金在凝固过程中极易产生热裂缺陷,由于其高温阶段本构模型的缺失,使铸件热裂的预测十分困难。借助ProCAST软件研究了适用于ZL205A合金的线弹性、弹塑性及粘弹塑性本构模型,在此基础上与热裂实际浇注试验进行对比分析,发现粘弹塑性本构模型更适合于ZL205A合金。将该模型应用于大型薄壁筒形件中,结果发现,应力主要集中在法兰与薄壁的交界处,当筋高由19 mm增加至48 mm时,能够有效地改善筒形件的变形情况。

关键词： ZL205A合金粘弹塑性本构模型薄壁筒形件

基于CiteSpace的腰椎黄韧带有限元模型国内研究的可视化分析

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中国医药导报 2024年第12期21卷 84-89页

作者：李永辉贾露露齐娇李滕朱雨桐张欲翔师梦雅王鹏河北中医药大学第一附属医院骨伤二科河北石家庄050011 石家庄市第一医院麻醉科河北石家庄050011 河北中医药大学中西医结合学院河北石家庄050200

目的基于Cite Space探讨腰椎黄韧带有限元模型研究的热点与趋势。方法检索1990年1月至2023年8月中国知网、维普网、万方数据知识服务平台3大数据库中,腰椎黄韧带有限元模型的相关中文文献;运用Cite Space 5.7.R5软件生成作者、机构合作... 详细信息

目的基于Cite Space探讨腰椎黄韧带有限元模型研究的热点与趋势。方法检索1990年1月至2023年8月中国知网、维普网、万方数据知识服务平台3大数据库中,腰椎黄韧带有限元模型的相关中文文献;运用Cite Space 5.7.R5软件生成作者、机构合作、关键词等图谱。结果共纳入文献1395篇,发文量总体呈增长趋势;核心作者丁宇发文最多;发文量最多机构为上海大学期刊社;关键词中“生物力学”出现频次最高;生成了“生物力学”等9个聚类;时间线路图中,最大的节点为“姿势性脊柱后凸”;突现图中“活动度”的研究持续至今。结论腰椎黄韧带有限元模型领域的研究总体增加,主要热点是“生物力学”,“脊柱”将是未来有限元领域的研究重点。

关键词：腰椎黄韧带有限元模型可视化分析 CiteSpace

Steady formation analysis onmulti-robot systems

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Journal of Control and Decision 2017年第1期4卷 12-31页

作者： yutong Liu Hongjun Yu Cheng-Chew Lim Peng shi School of Electrical and Electronic Engineering University of AdelaideAdelaideAustralia

In this paper,a controller is designed for a group of cooperative robots to achieve the stable *** network among the robots is assumed unavailable and each robot can only measure the displacements relative to their *** controller will enable the robots to move to a predefined formation or a special formation under a suitable protocol which we will *** will discuss the effect of different sizes of the multi-vehicle system and conduct simulations to verify the effectiveness of the proposed controller and the formation protocols.

关键词： Formation control limited sensing range controller design size of multi-vehicle system

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博尔德创业园对我国创业生态系统建设的启示

科技创业月刊 2021年第3期34卷 148-152页

作者：雷雪霏王雷张洗月张翰林史宇彤郭润萍(指导) 吉林大学管理学院吉林大学机械与航空航天学院吉林长春130022

美国顶级创业孵化器TechStars公司的创始人布拉德·费尔德在其出版的《创业园——创业生态系统构建指南》著作中对博尔德创业园的地缘优势和发展动力进行了阐述。基于博尔德创业生态系统的成功模式,从创新意识和创业网络理论视角,就企... 详细信息

美国顶级创业孵化器TechStars公司的创始人布拉德·费尔德在其出版的《创业园——创业生态系统构建指南》著作中对博尔德创业园的地缘优势和发展动力进行了阐述。基于博尔德创业生态系统的成功模式,从创新意识和创业网络理论视角,就企业家、投资者、导师和高校等不同角色在博尔德创业园典型活动案例中的行为特点进行剖析,为推动我国科技园区创业网络建设提供参考。

关键词：创业园活动案例创业生态系统

Continuation,reduction,or withdrawal of tofacitinib in patients with rheumatoid arthritis achieving sustained disease control:a multicenter,open-label,randomized controlled trial

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Chinese Medical Journal 2023年第3期136卷 331-340页

作者： Mengyan Wang Yu Xue Fang Du Lili Ma Liang-jing Lu Lindi Jiang Yi-Li Tao Chengde Yang Hui shi Honglei Liu Xiaobing Cheng Junna Ye yutong Su Dongbao Zhao Sheng-Ming Dai Jialin Teng Qiongyi Hu Department of Rheumatology and Immunology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Rheumatology and Immunology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Rheumatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Rheumatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Rheumatology and Immunology Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China Department of Rheumatology and Immunology Changhai HospitalNaval Medical UniversityShanghai 200433China

Background:Rheumatoid arthritis(RA),a chronic systemic autoimmune disease,is characterized by synovitis and progressive damage to the bone and cartilage of the joints,leading to disability and reduced quality of *** study was a randomized clinical trial comparing the outcomes between withdrawal and dose reduction of tofacitinib in patients with RA who achieved sustained disease ***:The study was designed as a multicenter,open-label,randomized controlled *** patients who were taking tofacitinib(5 mg twice daily)and had achieved sustained RA remission or low disease activity(disease activity score in 28 joints[DAS28]≤3.2)for at least 3 months were enrolled at six centers in Shanghai,*** were randomly assigned(1:1:1)to one of three treatment groups:continuation of tofacitinib(5 mg twice daily);reduction in tofacitinib dose(5 mg daily);and withdrawal of *** and safety were assessed up to 6 ***:Overall,122 eligible patients were enrolled,with 41 in the continuation group,42 in the dose-reduction group,and 39 in the withdrawal *** 6 months,the percentage of patients with a DAS28-erythrocyte sedimentation rate(ESR)of<3.2 was significantly lower in the withdrawal group than that in the reduction and continuation groups(20.5%,64.3%,and 95.1%,respectively;P<0.0001 for both comparisons).The average flare-free time was 5.8 months for the continuation group,4.7 months for the dose reduction group,and 2.4 months for the withdrawal ***:Withdrawal of tofacitinib in patients with RA with stable disease control resulted in a rapid and significant loss of efficacy,while standard or reduced doses of tofacitinib maintained a favorable *** Registration:***,ChiCTR2000039799.

关键词： Tofacitinib Rheumatoid arthritis Withdrawal Dose reduction

A Performance Fault Diagnosis Method for SaaS Software Based on GBDT Algorithm

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Computers, Materials & Continua 2020年第3期62卷 1161-1185页

作者： Kun Zhu shi Ying Nana Zhang Rui Wang yutong Wu Gongjin Lan Xu Wang School of Computer Science Wuhan UniversityWuhan430072China Department of Computer Science Vrije University AmsterdamAmster-dam1081HVThe Netherlands

SaaS software that provides services through cloud platform has been more widely used ***,when SaaS software is running,it will suffer from performance fault due to factors such as the software structural design or complex *** is a major challenge that how to diagnose software quickly and accurately when the performance fault *** this challenge,we propose a novel performance fault diagnosis method for SaaS software based on GBDT(Gradient Boosting Decision Tree)*** particular,we leverage the monitoring mean to obtain the performance log and warning log when the SaaS software system runs,and establish the performance fault type set and determine performance log *** also perform performance fault type annotation for the performance log combined with the analysis result of the warning ***,we deal with the incomplete performance log and the type non-equalization problem by using the mean filling for the same type and combination of SMOTE(Synthetic Minority Oversampling Technique)and undersampling ***,we conduct an empirical study combined with the disaster reduction system deployed on the cloud platform,and it demonstrates that the proposed method has high efficiency and accuracy for the performance diagnosis when SaaS software system runs.

关键词： GBDT algorithm SaaS software performance log performance fault diagnosis

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中药用蕨类植物孢子繁殖技术研究进展

亚太传统医药 2018年第6期14卷 80-83页

作者：刘欣薛萌许亮梁勇满史羽桐唐齐辉王伟强辽宁中医药大学辽宁大连116600

中药蕨类植物大多生长在温暖潮湿的林下,是植物发展史上一个独特的分支。因为在种质、遗传和代谢产物中均具备多样性,现今被国内外作为模式植物广泛应用。当前中药蕨类植物的孢子繁殖技术尚不完善,这一局限性成为其无法在市场上推广的... 详细信息

中药蕨类植物大多生长在温暖潮湿的林下,是植物发展史上一个独特的分支。因为在种质、遗传和代谢产物中均具备多样性,现今被国内外作为模式植物广泛应用。当前中药蕨类植物的孢子繁殖技术尚不完善,这一局限性成为其无法在市场上推广的制约因素,因此有必要进行人工栽培与繁育。采用孢子及茎、叶等作为繁殖材料人工繁育培养,梳理蕨类植物孢子繁殖的规律,为进一步研究其育种方法和繁殖技术提供参考依据。

关键词：蕨类植物孢子繁殖技术研究进展

How Well Informed of Participants in Clinical Trials: A Case Study of China

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International Journal of Clinical Medicine 2022年第4期13卷 167-179页

作者： yutong Jiang Zhifan Huang Lei Chen Yukang Cui Hong Zhu Tongjun shi Zaixiang Tan The Second Clinical College Xuzhou Medical University Xuzhou China Drug Clinical Trial Institution The Affiliated Hospital of Xuzhou Medical University Xuzhou China College of Marxism Xuzhou Medical University Xuzhou China College of Management Xuzhou Medical University Xuzhou China The Affiliated Hospital of Xuzhou Medical University Xuzhou China

Background: With the development of globalization, the rising cost of clinical trials in Europe and the United States, and the huge drug consumption market in developing countries, multinational pharmaceutical giants have set their sights on emerging developing countries. As a leader in developing countries, China has unparalleled advantages, so more and more clinical trials are registered and carried out in China. Objective: The objective of the study is to understand the current practice of informed consent in clinical trials in public hospitals in Xuzhou. Methods: In this study, a 15-question questionnaire was distributed to 369 subjects in the affiliated hospital of Xuzhou medical university. Each question was graded on a 3-point scale (1 = no, 2 = unsure, 3 = yes). The sum of the scores for the 15 questions represented the level of awareness of clinical trials. Results: Valid questionnaires were received from 300 subjects. A considerable number of subjects still had insufficient understanding of clinical trials, especially concerning the nature of clinical trials, understanding of informed consent forms, contact with researchers, and ethics committee. (The “yes” rate was around or below 50%). Factors associated with responses to the survey include education, occupation, and source of medical expenses. Conclusion: Overall, this study showed that the implementation of informed consent in China remained room for improvement. Legislators, ethics officers, and researchers should work together to protect the interests of subjects.

关键词： Clinical Trials Informed Consent Ethics-Research China

SULT1E1、ERβ在子宫内膜腺癌组织中的表达及其相关性

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现代肿瘤医学 2015年第2期23卷 256-261页

作者：佟芳时瑜彤周莹莹双婷闫效宇冷旭王敏中国医科大学附属盛京医院妇产科辽宁沈阳110004 大连医科大学附属第一医院妇产科辽宁大连116000

目的:探讨SULT1E1及ERβ蛋白与子宫内膜腺癌的发生、发展之间的关系。方法:采用Western blot方法检测正常增生期子宫内膜组织、不典型增生子宫内膜组织及子宫内膜腺癌组织中SULT1E1和ERβ蛋白的表达含量。结果:SULT1E1和ERβ蛋白在正常... 详细信息

目的:探讨SULT1E1及ERβ蛋白与子宫内膜腺癌的发生、发展之间的关系。方法:采用Western blot方法检测正常增生期子宫内膜组织、不典型增生子宫内膜组织及子宫内膜腺癌组织中SULT1E1和ERβ蛋白的表达含量。结果:SULT1E1和ERβ蛋白在正常增生期子宫内膜组织、不典型增生子宫内膜组织及子宫内膜腺癌组织中的表达含量逐渐降低,三者比较差异有统计学意义(P0.05)。在子宫内膜腺癌组织中,SULT1E1蛋白与ERβ蛋白表达呈明显正相关(r=0.66,P0.05;r=0.466,P>0.05)。结论:在子宫内膜腺癌的渐近演变过程中,SULT1E1、ERβ表达降低或缺失可能与子宫内膜癌的早期形成有一定的关系,ERβ蛋白含量越多,SULT1E1蛋白对雌激素的调节作用越强,但不能作为子宫内膜腺癌病情严重程度和预后进行评价的指标。

关键词：子宫内膜腺癌雌激素受体亚型β(ERβ) 雌激素代谢雌激素硫酸基转移酶(SULT1E1)