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Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing

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National Science Review 2024年第4期11卷 254-270页

作者： yutong Yang Jiaxin Wang Shengfei Huang Meng Li Jueying Chen Dandan Pei Zhen Tang Baolin guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology and Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of Stomatology Xi'an Jiaotong University Department of Orthopedics Tangdu Hospital Fourth Military Medical University Department of Orthopedics The First Affiliated Hospital of Xi'an Jiaotong University

There is still an urgent need to develop hydrogels with intelligent antibacterial ability to achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy of hydrogel wound dressing with bacteria-responsive self-activating antibacterial property and multiple nanozyme activities to remodel the regeneration microenvironment in order to significantly promote infected wound healing. Specifically, p H-responsive H2O2self-supplying composite nanozyme（MSCO） and p H/enzyme-sensitive bacteria-responsive triblock micelles encapsulated with lactate oxidase（PPEL） were prepared and encapsulated in hydrogels composed of L-arginine-modified chitosan（CA） and phenylboronic acid-modified oxidized dextran（ODP） to form a cascade bacteria-responsive self-activating antibacterial composite hydrogel platform. The hydrogels respond to multifactorial changes of the bacterial metabolic microenvironment to achieve on-demand antibacterial and biofilm eradication through transformation of bacterial metabolites, and chemodynamic therapy enhanced by nanozyme activity in conjunction with self-driven nitric oxide（NO） release. The composite hydrogel showed 'self-diagnostic' treatment for changes in the wound *** self-activating antibacterial therapy in the infection stage to self-adaptive oxidative stress relief and angiogenesis in the post-infection stage, it promotes wound closure, accelerates wound collagen deposition and angiogenesis, and completely improves the microenvironment of infected wound regeneration, which provides a new method for the design of intelligent wound dressings.

关键词： bacterial response hydrogel dressing multiple nanozyme activity biofilm elimination infected motion wound healing

iHypoxia:An Integrative Database of Protein Expression Dynamics in Response to Hypoxia in Animals

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Genomics, Proteomics & Bioinformatics 2023年第2期21卷 267-277页

作者： Ze-Xian Liu Panqin Wang Qingfeng Zhang Shihua Li Yuxin Zhang yutong guo Chongchong Jia Tian Shao Lin Li Han Cheng Zhenlong Wang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterSun Yat-sen UniversityGuangzhou 510060China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China

Mammals have evolved mechanisms to sense hypoxia and induce hypoxic ***,high-throughput techniques have greatly promoted global studies of protein expression changes during hypoxia and the identification of candidate genes associated with hypoxiaadaptive evolution,which have contributed to the understanding of the complex regulatory networks of *** this study,we developed an integrated resource for the expression dynamics of proteins in response to hypoxia(iHypoxia),and this database contains 2589 expression events of 1944 proteins identified by low-throughput experiments(LTEs)and 422,553 quantitative expression events of 33,559 proteins identified by high-throughput experiments from five mammals that exhibit a response to *** experimental details,such as the hypoxic experimental conditions,expression patterns,and sample types,were carefully collected and ***,8788 candidate genes from diverse species inhabiting low-oxygen environments were also *** addition,we conducted an orthologous search and computationally identified 394,141 proteins that may respond to hypoxia among 48 *** enrichment analysis of human proteins identified from LTEs shows that these proteins are enriched in certain drug targets and cancer *** of known posttranslational modification(PTM)sites in the proteins identified by LTEs reveals that these proteins undergo extensive PTMs,particularly phosphorylation,ubiquitination,and *** provides a convenient and user-friendly method for users to obtain hypoxia-related information of interest.

关键词： Hypoxia Expression dynamics Low-throughput experiment High-throughput experiment Functional annotation

Sparse identification-assisted exploration of the atomic-scale deformation mechanism in multiphase CoCrFeNi high-entropy alloys

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Science China(Technological Sciences) 2024年第4期67卷 1124-1132页

作者： XIAO Lu guo XiaoXiang SUN yutong WANG Gang LONG WeiMin LIAW Peter K. REN JingLi School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Institute of Materials Shanghai UniversityShanghai 200444China SKL of Advanced Brazing Metals&Technology Zhengzhou Research Institute of Mechanical EngineeringZhengzhou 450001China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA

This study investigated the atomic-scale deformation mechanism of multiphase CoCrFeNi high-entropy alloys(HEAs)at liquid helium,liquid nitrogen,and room temperatures.A million-atom multiphase HEA was prepared using molecular dynamics simulation involving melt and quench *** HEA exhibited high-density dislocations and some twins,consistent with experimental *** analysis revealed an inconsistent evolution of the microstructure under tensile *** particular,the elastic and initial plastic stages exhibited an increase in the disordered structure at the expense of the face-centered cubic and hexagonal close-packed structures,followed by a subsequent transformation involving multiple structural ***,through sparse identification,a model depicting microstructural evolution during tension was extracted for the CoCrFeNi HEA at three typical temperatures and three tensile *** model highlighted the importance of the body-centered cubic structure in the evolutionary process.

关键词： high-entropy alloy data-driven method microstructure evolution multiphase structure molecular dynamics simulation

Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure

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Journal of Environmental Sciences 2024年第2期136卷 270-278页

作者： Tingting Ku Jindong Hu Mengmeng Zhou Yuanyuan Xie yutong Liu Xin Tan Lin guo Guangke Li Nan Sang College of Environmental Science and Resources Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China

Tebuconazole exposure has been described as an increasing hazard to human *** increasing number of recent studies have shown a positive association between tebuconazole exposure and cardiovascular disease risk,which is characterized by the reduction of adenosine triphosphate(ATP)***,researches on the damage of tebuconazole exposure to energy metabolism and the related molecular mechanisms are *** the present study,male C57BL/6 mice were treated with tebuconazole at different low concentrations for 4 *** results indicated that tebuconazole could accumulate in the heart and further induce the decrease of ATP content in the mouse ***,tebuconazole induced an obvious shift in substrate utilization of fatty acid and glucose by disrupting their corresponding transporters(GLUT1,GLUT4,CD36,FABP3 and FATP1)expression,and significantly repressed the expression of mitochondrial biogenesis(Gabpa and Tfam)and oxidative phosphorylation(CS,Ndufa4,Sdhb,Cox5a and Atp5b)related genes in a dosedependent *** investigation revealed that these alterations were related to the IRS1/AKT and PPARγ/RXRα*** findings contribute to a better understanding of triazole fungicide-induced cardiovascular disease by revealing the key indicators associated with this phenomenon.

关键词： Tebuconazole Cardiotoxicity Energy metabolic disorders Energy substrate Mitochondrial damage

Exploring tumor immunity through a high-throughput,high-sensitivity micro-proteomics method

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Exploring tumor immunity through a high-throughput,high-sens...

Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing

第三届全国系统生物学大会

作者： Sun Liming guo yutong Li Qingrun Zeng Rong

Proteins are the main functional molecules of cells,and the tumor proteome offers valuable insights into the signaling transduction between the tumor microenvironment and cancer *** tumor proteome research has two directions:non-targeted protein mass spectrometry and antibody-based ***,the complexity and heterogeneity of tumor tissue pose significant challenges to analyzing tumor-driving related biomarkers at a global level and to accurately determining the immune cell status of tumors using limited target protein *** work innovatively choose an organic solution system for the lysis of a small number of cells,which,combined with a rapid enzymatic digestion process,allowed the identification of 2300 and 6700 proteins from 50 and 3000 cells within a mass spectrometry analysis time of 60 *** system's advantages can be used for in-depth proteomic analysis of immune *** characterized immune cell subpopulations from fresh tumor tissue,adjacent cancer tissue,and peripheral blood mononuclear cells(PBMC) using flow cytometry ***-proteome mass spectrometry analyzed immune cell protein expression variations across individuals and tissue *** aim to continue searching for tumor immune-related biomarkers,exploring the relevance of immune-related proteins in tumor tissue,adjacent tissue,and blood,further linking histological tissue tumor subtyping and clinical information,and developing personalized detection and treatment plans that are faster,more accurate,sensitive,and efficient.

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Biomedical and Environmental Sciences 2024年第8期37卷 876-886页

作者： yutong Wang Jing Li Shirong Xu Shengli Lin Zhenchen Hou Linlin Wang Yali Huang Yue Sun Wei guo Lailai Yan Ying Wang Chan Tian State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Medical Genetics Peking UniversityBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Central Laboratory of School of Public Health Peking UniversityBeijing 100191China School of Basic Medical Sciences Peking UniversityBeijing 100191China

Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from *** A total of 141 couples were *** and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,*** models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET *** Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization ***,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical *** Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy *** is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive ***,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity.

关键词： Rare earth elements In vitro fertilization Pregnancy outcomes Mixture exposure analysis

Selective laser trabeculoplasty:a review of repeatability

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Annals of Eye Science 2019年第1期4卷 74-77页

作者： yutong guo Ariadni Ioannidou Philip Jute Department of Ophthalmology Sunderbyn HospitalLuleåSweden

The efficacy of selective laser trabeculoplasty(SLT)to treat open-angle glaucoma(OAG)and ocular hypertension(OHT)has been increasingly substantiated *** SLT is usually needed to control intraocular pressure(IOP),be it as primary or adjunctive *** review the studies available,in terms of SLT repeatability;and conclude comparable efficacy,with success rate,duration and complications similar to those in initial SLT.

关键词： Selective laser trabeculoplasty(SLT) repeatability repeat glaucoma

Proteomics analysis of dynamic lung cancer microenvironment

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Proteomics analysis of dynamic lung cancer microenvironment

第三届全国系统生物学大会

作者： Xu Keren guo yutong Li Qingrun Wu Qingqing Luo Xiaoyang Zeng Rong

The changes in the extracellular matrix(ECM) within tumor microenveironment play a crucial role in lung cancer tumorigenesis and progression,whose mechanisms are highly *** to the existing limitations in identifying ECM proteins in human lung tissue,our study compared and improved ECM enrichment methods,optimized mass spectrometry loading conditions,and refined searching parameters,thereby establishing a high-coverage ECM proteomics identification protocol.A total of 10,299proteins,including 619 annotated as Matrisome proteins,corresponding to 470 ECM genes were identified among 29 paired lung tumor tissues and adjacent normal *** represents the most extensive protein identification and the highest ECM coverage in ECM proteomic research to *** mass spectrometry was also applied to tissue proteomes and cell membrane *** three proteomics analyses consistently highlighted glycoproteins and ECM-related pathway enrichment in lung *** integrating the ECM and cell membrane proteomics data,we unveiled ECM interaction network changes in lung ***,integrating ECM proteomics with tissue proteomics data and clinical features,we constructed a predictive model to assess patient drug responsiveness to four targeted therapeutic *** model demonstrated overall good predictive performance(***=0.10),with individual drug prediction accuracies all exceeding ***,14 genes and 4proteins involved in the prediction model were associated with the overall prognosis of lung *** conclusion,our study provided a valuable guidance for clinical drug administration and patient prognosis outcomes prediction.

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多场景海上风电场关键设备技术经济性分析

中国电力 2021年第7期54卷 178-184,216页

作者：唐巍郭雨桐闫姝郭小江史绍平中国华能集团清洁能源技术研究院有限公司北京102209

中国海上风电正在走向深远海。离岸距离和水深的增大对海上风电场关键设备的技术选择和成本造价影响很大,海上风电场单位千瓦投资也相应变化。对海上风电场基础结构、海缆等关键设备费用在不同离岸距离和水深条件下的变化进行分析,探讨... 详细信息

中国海上风电正在走向深远海。离岸距离和水深的增大对海上风电场关键设备的技术选择和成本造价影响很大,海上风电场单位千瓦投资也相应变化。对海上风电场基础结构、海缆等关键设备费用在不同离岸距离和水深条件下的变化进行分析,探讨登陆送出、场内集电、基础结构等技术发展对投资的影响。远海风电场通过采用柔性直流和高电压场内集电技术,关键设备的单位千瓦投资可以低于目前在建的近海风电场。对于未来将采用8 MW风电机组的深远海风电场,采用先进的基础结构和输电技术,关键设备投资成本将比现有技术下降2 200元/kW,大幅降低深远海风电场开发投资。

关键词：深远海海上风电关键设备技术经济性电气系统基础结构