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The role of ubiquitination and deubiquitination in the regulation of cell junctions

Protein & Cell 2018年第9期9卷 754-769页

作者： Junting Cai Miranda K. Culley yutong zhao Jing zhao Acute Lung Injury Center of Excellence Division of Pulmonary Asthma and Critical Care Medicine Department of Medicine The University of Pittsburgh Pittsburgh PA 15213 USA Xiangya Hospital of Central South University Changsha 410008 China

Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death. Disruption of cell junctions is implicated in a variety of human disorders, such as inflammatory diseases and cancers. Understanding molecular regulation of cell junctions is important for development of therapeutic strategies for intervention of human diseases. Ubiquitination is an important type of post-translational modification that primarily regulates endogenous protein stability, recep- tor internalization, enzyme activity, and protein-protein interactions. Ubiquitination is tightly regulated by ubiq- uitin E3 ligases and can be reversed by deubiquitinating enzymes. Recent studies have been focusing on inves- tigating the effect of protein stability in the regulation of cell-cell junctions. Ubiquitination and degradation of cadherins, claudins, and their interacting proteins are implicated in epithelial and endothelial barrier disruption. Recent studies have revealed that ubiquitination is involved in regulation of Rho GTPases＇ biological activities. Taken together these studies, ubiquitination plays a critical role in modulating cell junctions and motility. In this review, we will discuss the effects of ubiquitination and deubiquitination on protein stability and expression of key proteins in the cell-cell junctions, including junction proteins, their interacting proteins, and small Rho GTPases. We provide an overview of protein stability in modulation of epithelial and endothelial barrier integrity and introduce potential future search directions to better understand the effects of ubiquitination on human disorders caused by dysfunction of cell junctions.

关键词： cell-cell junctions protein stability ubiquitination deubiquitination Rho GTPases

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Synergistic Effect between Zr-MOF and Phosphotungstic Acid for Oxidative Desulfurization

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China Petroleum Processing & Petrochemical Technology 2020年第4期22卷 56-62页

作者： Zong Mengya zhao yutong Fan Cunzheng Wang Danhong TKL of Metal and Molecule Based Material Chemistry National Institute for Advanced MaterialsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350 Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023 Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071

PTA/UiO-66 composites were successfully synthesized by the hydrothermal *** results showed that the synergistic effect between phosphotungstic acid(PTA)and UiO-66 could enhance the oxidative desulfurization(ODS)*** XRD results proved that UiO-66 retained its structure in the PTA/UiO-66 *** SEM results showed that the PTA/UiO-66 catalysts exhibited regular octahedral *** Raman spectra revealed that PTA in the composites retained the Keggin *** XPS results showed that the electron transfer occurred from Zr-MOF to *** ODS reaction mechanism was *** transfer from Zr-MOF to PTA can promote the generation of active species(·OH)and thus enhance the ODS *** explanation can be confirmed by the formation of oxygen vacancy and W0 as revealed by the XPS analysis.

关键词： phosphotungstic acid Zr-MOF oxidative desulfurization synergistic effect oxygen vacancy

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Deciphering impacts of climate extremes on Tibetan grasslands in the last fifteen years

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Science Bulletin 2019年第7期64卷 446-454页

作者： Dan Liu Tao Wang Tao Yang Zhengjie Yan Yongwen Liu yutong zhao Shilong Piao Key Laboratory of Alpine Ecology Institute of Tibetan Plateau Research Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences School of Life Sciences Lanzhou University College of Urban and Environmental Sciences and Sino-French Institute for Earth System Science Peking University

Climate extremes have emerged as a crucial driver of changes in terrestrial ecosystems. The Tibetan Plateau, facing a rapid climate change, tends to favor climate extremes. But we lack a clear understanding of the impacts of such extremes on alpine grasslands. Here we show that extreme events(drought,extreme wet, extreme cold and extreme hot) occurred at a frequency of 0.67–4 months decade^(-1) during2001–2015, with extreme precipitation predominantly occurring in June-to-August and extreme temperatures in May. Drought and extreme wet cause opposite and asymmetric effects on grassland growth,with drought-induced reductions greater than increases due to extreme wet. Grassland responses to extreme temperatures, which predominantly occur in May, show a dipole-like spatial pattern, with extreme hot(cold) events enhanced(reduced) growth in the eastern plateau but slightly reduced(enhanced) growth in the western plateau. These opposite responses to extreme temperatures over the eastern plateau are explained by the possibility that the occurrence of extreme cold slows the preseason temperature accumulation, delaying the triggering of spring phenology, while extreme hot hastens the accumulation. In the western plateau, in contrast, positive responses to extreme cold are induced by accompanying high precipitation. Furthermore, high extremeness of climate events generally led to a much lower extremeness in growth response, implying that the Tibetan grasslands have a relatively high resistance to climate extremes. The ecosystem models tested could not accurately simulate grassland responses to drought and extreme temperatures, and require re-parameterization before trust can be placed in their output for this region.

关键词： Drought Extreme cold Extreme hot Growth response Alpine grasslands Tibetan Plateau

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Electrochemical reconstruction of non-noble metal-based heterostructure nanorod arrays electrodes for highly stable anion exchange membrane seawater electrolysis

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Journal of Energy Chemistry 2024年第4期91卷 370-382页

作者： Jingchen Na Hongmei Yu Senyuan Jia Jun Chi Kaiqiu Lv Tongzhou Li Yun zhao yutong zhao Haitao Zhang Zhigang Shao Fuel Cell System and Engineering Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Direct seawater electrolysis for hydrogen production has been regarded as a viable route to utilize surplus renewable energy and address the climate ***,the harsh electrochemical environment of seawater,particularly the presence of aggressive Cl^(-),has been proven to be prone to parasitic chloride ion oxidation and corrosion reactions,thus restricting seawater electrolyzer ***,hierarchical structure(Ni,Fe)O(OH)@NiCoS nanorod arrays(NAs)catalysts with heterointerfaces and localized oxygen vacancies were synthesized at nickel foam substrates via the combination of hydrothermal and annealing methods to boost seawater *** hiera rchical nanostructure of NiCoS NAs enhanced electrode charge transfer rate and active surface area to accelerate oxygen evolution reaction(OER)and generated sulfate gradient layers to repulsive aggressive Cl^(-).The fabricated heterostructure and vacancies of(Ni,Fe)O(OH)tuned catalyst electronic structure into an electrophilic state to enhance the binding affinity of hydroxyl intermediates and facilitate the structural transformation into amorphousγ-NiFeOOH for promoting ***,through operando electrochemistry techniques,we found that theγ-NiFeOOH possessing an unsaturated coordination environment and lattice-oxygen-participated OER mechanism can minimize electrode Cl^(-)corrosion enabled by stabilizing the adsorption of OH*intermediates,making it one of the best OER catalysts in the seawater medium reported to ***,these catalysts can deliver current densities of 100 and 500 mA cm-2for boosting OER at minimal overpotentials of 245and 316 mV,respectively,and thus prevent chloride ion oxidation ***,a highly stable anion exchange membrane(AEM)seawater electrolyzer based on the non-noble metal heterostructure electrodes reached a record low degradation rate under 100μV h-1at constant industrial current densities of 400 and 600 mA cm-2over 300 h,which exhibits a promi

关键词： Direct seawater electrolysis Anion exchange membrane water electrolysis Oxygen evolution reaction Oxygen vacancies Operando electrochemistry techniques

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Effect of Doped Vanadium Dioxide on Oxidative Desulfurization Reaction

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China Petroleum Processing & Petrochemical Technology 2019年第4期21卷 42-48页

作者： zhao yutong Zong Mengya Fan Cunzheng Chen Kun Wang Danhong Zhang Minghui TKL of Metal and Molecule Based Material Chemistry National Institute for Advanced MaterialsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350 Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071

VO2(M) doped with different metals(Ti, Ce, Nb, Zr, W, and Mo) was successfully synthesized by the hydrothermal reduction process using oxalic acid as the reductant. The results showed that doping metals in the VO2(M) lattice could enhance the oxidative desulfurization(ODS) activity. The DSC and Raman spectra revealed that VO2(M) retained its monoclinic structure after doping. Mechanism for the improvement of ODS activity by doping was investigated. Electron transfer to V(V) atom occurs upon doping, and then V(V) changes into V(IV), which can promote the ODS reaction. This explanation can be confirmed by the fact that doping can promote the proportion of V(Ⅳ) after doping as revealed by the XPS analysis.

关键词： doped VO2 hydrothermal reduction method oxidative desulfurization mechanism electron transfer

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Phosphorylated E2F1 ts stabilized by nuclear USPll to drive PeglO gene expression and activate lung epithelial cells

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Journal of Molecular Cell Biology 2018年第1期10卷 60-73页

作者： Dan Wang Jing zhao Shuang Li Jianxin Wei Ling Nan Rama K. Mallampalli Nathaniel M. Weathington Haichun Ma yutong zhao Department of Anesthesia the First Affiliated Hospital of Jilin University Changchun China Department of Medicine Division of Pulmonary Allergy and Critical Care Medicine University of Pittsburgh Pittsburgh USA Department of General Surgery the First Affiliated Hospital of Dalian Medical University Dallan China Acute Lung injury Center of Excellence and Vascular Medical Institute University of Pittsburgh Pittsburgh USA

Phosphorylation affects ubiquitination, stability, and activity of transcriptional factors, thus regulating various cellular functions. E2F transcriptional factor I （E2F1） regulates paternally expressed imprinted gene 10 （Peg10） expression, thereby promoting cell proliferation. However, the effect of E2FZ stability on PeglO expression and the molecular regulation of E2FZ stability by its phos- phorylation have not been well demonstrated. Here, we describe a new pathway in which phosphorylation of E2F1 by GSK3p increases E2FZ association with the deubiquitinating enzyme, ubiquitin-specific protease 11 （USPll）, which removes K63-1inked ubiquitin chains thereby preventing E2FZ degradation in the nuclei. Downregulation of USPlZ increases E2FZ ubiquitination and reduces E2F1 stability and protein levels, thereby decreasing PeglO mRNA levels. Physiologically, USPll depletion suppresses cell proliferation and wound healing in lung epithelial cells, and these effects are reversed by E2F1 and PEGIO overexpression. Thus, our study reveals a new molecular model that phosphorylation promotes substrate stability through increasing its associ- ation with a deubiquitinating enzyme. The data suggest that GSK3p and USPll act in concert to modulate E2FZ abundance and PEGIO expression in lung epithelial celts to affect cell wound healing. This study provides new therapeutic targets to lessen lung injury by improving lung epithelial cell repair and remodeling after injury.

关键词： deubiquitination E2F1 phosphorylation USP11 cell proliferation wound healing

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Short-Term Household Load Forecasting Based on Attention Mechanism and CNN-ICPSO-LSTM

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Energy Engineering 2024年第6期121卷 1473-1493页

作者： Lin Ma Liyong Wang Shuang Zeng yutong zhao Chang Liu Heng Zhang Qiong Wu Hongbo Ren New Energy Technology Center State Grid Beijing Electric Power Research InstituteBeijing100075China College of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai200090China

Accurate load forecasting forms a crucial foundation for implementing household demand response plans andoptimizing load scheduling. When dealing with short-term load data characterized by substantial fluctuations,a single prediction model is hard to capture temporal features effectively, resulting in diminished predictionaccuracy. In this study, a hybrid deep learning framework that integrates attention mechanism, convolution neuralnetwork (CNN), improved chaotic particle swarm optimization (ICPSO), and long short-term memory (LSTM), isproposed for short-term household load forecasting. Firstly, the CNN model is employed to extract features fromthe original data, enhancing the quality of data features. Subsequently, the moving average method is used for datapreprocessing, followed by the application of the LSTM network to predict the processed data. Moreover, the ICPSOalgorithm is introduced to optimize the parameters of LSTM, aimed at boosting the model’s running speed andaccuracy. Finally, the attention mechanism is employed to optimize the output value of LSTM, effectively addressinginformation loss in LSTM induced by lengthy sequences and further elevating prediction accuracy. According tothe numerical analysis, the accuracy and effectiveness of the proposed hybrid model have been verified. It canexplore data features adeptly, achieving superior prediction accuracy compared to other forecasting methods forthe household load exhibiting significant fluctuations across different seasons.

关键词： Short-term household load forecasting long short-term memory network attention mechanism hybrid deep learning framework

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基于行业内部的企业社会责任评价指标体系构建

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同济大学学报（自然科学版） 2012年第4期40卷 650-656页

作者：赵红孙键胡锋赵宇彤中国科学院研究生院管理学院北京100190 中国石化石油工程技术研究院北京100101

在我国,企业社会责任(CSR)理念的发展刚刚起步,促进CSR理念发展的重要因素之一是CSR评价.目前存在的CSR评价方法过于理性,这些理性的评价方法和模型没有充分考虑到行业的特性和行业内部人员对CSR的评价,而且可操作性、可比性不强.为此,... 详细信息

在我国,企业社会责任(CSR)理念的发展刚刚起步,促进CSR理念发展的重要因素之一是CSR评价.目前存在的CSR评价方法过于理性,这些理性的评价方法和模型没有充分考虑到行业的特性和行业内部人员对CSR的评价,而且可操作性、可比性不强.为此,从行业内部评价的视角出发,选取煤炭行业作为研究对象,构建了一套CSR指标体系,这套评价指标体系能够反映出煤炭行业对承担企业社会责任的态度并且具有实际可操作性和可比性.研究结果显示,该评价体系包含经济、员工、社区、法律、环境、客户责任和责任管理等7个部分.此外,还对这7个指标的关系进行了探索性研究.

关键词：企业社会责任因子分析评价指标体系行业内部视角

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基于交流电流下垂特性控制的VSC建模和稳定性分析

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电力自动化设备 2021年第5期41卷 50-55页

作者：赵雨童高飞张博深上海交通大学电力传输与功率变换控制教育部重点实验室上海200240

在直流微电网中,下垂控制常被用来实现直流母线电压的稳定和电压源型换流器(VSC)功率的准确分配,已有的下垂控制特性大多基于直流变量,响应速度慢且结构复杂。为此提出了一种基于交流侧电流的Id-V下垂特性,其与单闭环控制VSC结合,系统... 详细信息

在直流微电网中,下垂控制常被用来实现直流母线电压的稳定和电压源型换流器(VSC)功率的准确分配,已有的下垂控制特性大多基于直流变量,响应速度慢且结构复杂。为此提出了一种基于交流侧电流的Id-V下垂特性,其与单闭环控制VSC结合,系统结构简单、成本低、响应速度快,可以实现直流母线电压的快速稳定,并设计了自适应下垂系数以实现准确的功率分配。建立了传统I-V下垂控制系统和Id-V下垂控制系统的状态空间平均模型,并基于建立的模型绘制特征根轨迹分析系统的小信号稳定性。通过仿真验证了稳定性分析结果的正确性。仿真结果表明Id-V下垂控制系统能够实现准确的功率分配和直流母线电压的稳定,且响应速度相比传统I-V下垂控制系统更快。

关键词：直流微电网下垂特性电压源型换流器功率分配状态空间法特征根轨迹响应速度

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Exosome-mediated cell-cell communication within pancreatic cancer tumor microenvironment: a narrative review

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Journal of Pancreatology 2022年第1期5卷 177-213页

作者： Cheng Qin Bangbo zhao Yuanyang Wang Tianhao Li Zeru Li Tianyu Li yutong zhao Weibin Wang Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The significance of exosomes has emerged in a variety of physiological processes and *** cancer remains one of the most lethal diseases at ***,increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment,contributing to activating pancreatic stellate cells and cancer-associated fibroblasts,compromising immune cells,and enhancing *** their natural and intrinsic roles,exosomes may provide a novel potential way for pancreatic cancer management and therapy as ***,exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and *** comprehensively summarize the role of exosomes in pancreatic cancer,we searched the PubMed database and reviewed all relevant original studies.

关键词： cancer-associated fibroblasts exosomes extracellular vesicles pancreatic cancer review tumor microenvironment

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