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Engineering vascularized organotypic tissues via module assembly

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International Journal of Extreme Manufacturing 2024年第1期6卷 155-175页

作者： Zhenzhen Zhou Changru Liu yuting guo Yuan Pang Wei Sun Biomanufacturing Center Department of Mechanical EngineeringTsinghua UniversityHaidian DistrictBeijing 100084People’s Republic of China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing 100084People’s Republic of China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084People’s Republic of China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104United States of America

Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult,greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

关键词： vascularized organotypic tissue module assembly regenerative medicine tissue engineering

Analysis of nonlinear multi-field coupling responses of piezoelectric semiconductor rods via machine learning

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International Journal of Smart and Nano Materials 2024年第1期15卷 62-74页

作者： Chuwei Wu Zhengguang Xiao yuting guo Chunli Zhang Department of Engineering Mechanics Zhejiang UniversityHangzhouZhejangChina Huanjiang Laboratory ZhujiChina

Piezoelectric semiconductors(PSs)have widespread applications in semiconductor devices due to the coexistence of piezoelec-tricity and semiconducting *** is very important to conduct a theoretical analysis of PS ***,the present of nonlinearity in the partial differential equations(PDEs)that describe those multi-feld coupling mechanical behaviors of PSs poses a significant mathematical challenge when studying these PS *** this paper,we present a novel approach based on machine learning for solving multi-field coupling problems in PS structures.A physics-informed neural networks(PINNs)is constructed for predicting the multi-field coupling behaviors of PS rods with extensional *** utilizing the proposed PINNs,we evaluate the multi-field coupling responses of a ZnO rod under static and dynamic axial *** results demonstrate that the proposed PINNs exhibit high accuracy in solving both static and dynamic problems associated with Ps *** provides an effective approach to predicting the nonlinear multi-feld coupling phe-nomena in PS structures.

关键词： PS rod multi-feld coupling response machine learning PINNs

Monitoring stratification of anode biofilms in bioelectrochemical laminar flow reactors using flow cytometry

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Environmental Science and Ecotechnology 2020年第4期4卷 18-25页

作者： yuting guo Luis FMRosa Susann Muller Falk Harnisch Department of Environmental Microbiology Helmholtz-Centre for Environmental Research e UFZPermoserstrasse 1504318LeipzigGermany

A laminar flow bioelectrochemical systems(BES)was designed and benchmarked using microbial anodes dominated with Geobacter *** reactor architecture was based on modeled flow fields,the resulting structure was 3D printed and used for BES *** of the substrate availability within the reactor channels led to heterogeneous biomass distribution,with the maximum biomass found mainly in the initial/middle *** anode performance was assessed for different hydraulic retention times while coulombic efficiencies of up to 100%(including also hydrogen recycling from the cathode)and current densities of up to 75 μA cm^(-2) at an anode surface to volume ratio of 1770 cm^(2) L^(-1) after 35 days were *** low current density can be clearly attributed to the heterogeneous distributions of biomass and the stratification of the microbial community ***,it was shown that time and space resolved analysis of the reactor microbiomes per channel is feasible using flow cytometry.

关键词： Microbial electrochemical technology Flow cytometry Laminar flow Microbial community Electroactive microorganisms

Reciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation

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Protein & Cell 2019年第7期10卷 510-525页

作者： Xin Zhou Xiaofang Huang yuting guo Dong Li Junjie Hu Department of Genetics and Cell Biology College of Life Sciences Nankai University and Tianjin Key Laboratory of Protein Sciences Tianjin 300071 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China University of Chinese Academy of Sciences Beijing 100101 China

Three-way junctions are characteristic structures of the tubular endoplasmic reticulum (ER) network. Junctions are formed through atlastin (ATL)-mediated membrane fusion and stabilized by lunapark (Lnp). However, how Lnp is preferentially enriched at three-way junctions remains elusiveHere, we showed that Lnp loses its junction localization when ATLs are deleted. Reintroduction of ATL1 R77A and ATL3, which have been shown to cluster at the junctions, but not wild-type ATL1, relocates Lnp to the junctions. Mutations in the Nmyristoylation site or hydrophobic residues in the coiled coil (CC1) of Lnp N-terminus (NT) cause mis-targeting of LnpConversely, deletion of the lunapark motif in the C-terminal zinc fin ger domain, which affects the homooligomerization of Lnp, does not alter its localizationPurified Lnp-NT attaches to the membrane in a myristoylation- dependent manner. The mutation of hydrophobic residues in CC1 does not affect membrane association, but compromises ATL interactionsIn addition, Lnp-NT inhibits ATL-mediated vesicle fusion in vitro. These results suggest that CC1 in Lnp-NT contacts junction-enriched ATLs for proper localization;subsequently, further ATL activity is limited by Lnp after the junction is formed. The proposed mechanism ensures coordinated actions of ATL and Lnp in generating and maintaining three-way junctions.

关键词： endoplasmic reticulum three-way junction membrane fusion lunapark atlastin amphipathic helix myristoylation

GENERALIZED FORELLI-RUDIN TYPE OPERATORS BETWEEN SEVERAL FUNCTION SPACES ON THE UNIT BALL OF C^(N)

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Acta Mathematica Scientia 2024年第4期44卷 1301-1326页

作者： Xuejun ZHANG yuting guo Hongxin CHEN Pengcheng TANG College of Mathematics and Statistics Hunan Normal University.Changsha 410081China School of Mathematics Hunan UniversityChangsha 410082China School of Mathematics and Computational Science Hunan University of Science and TechnologyXiangtan 411201China

In this paper,we investigate sufficient and necessary conditions such that generalized Forelli-Rudin type operators T_(λ,τ,k),S_(λ,τ,k),Q_(λ,τ,k)and R_(λ,τ,k)are bounded between Lebesgue type *** order to prov... 详细信息

关键词： Forelli-Rudin type operator L^(p,q,s,k)(B_(n))space boundedness unit ball

Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis

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Nano Research 2023年第4期16卷 5311-5321页

作者： Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai Li yuting Zhu Qiang Zhang Tingting Li Zhongxian Li Xiaohan Zhou yuting guo Yinglu Ji Xiaoli Shi Dong Han College of Life Science Beijing University of Chinese MedicineBeijing 100029China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China College of Pharmacy Baotou Medical CollegeBaotou 10040China Hebei Key Laboratory of Nanobiotechnology Yanshan UniversityQinhuangdao 066004China University of Chinese Academy of Sciences Beijing 100049China

Intervaginal space injection(ISI)is a novel mode of administration investigated over the last *** injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial *** transport has a certain delivery direction,and site-specific injection can work on specific organs or *** this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was *** prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to *** 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous ***,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the ***,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic *** proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly *** vascular elastic fibers at the plaque site were thickened,and fractures were *** was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques.

关键词： thoracic intervaginal space injection(tISI) gold nanoparticle(AuNP) tanshinone IIa sodium sulfonate liposome atherosclerosis adventitia

Spatiotemporally-regulated multienzymatic polymerization endows hydrogel continuous gradient and spontaneous actuation

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Science China Chemistry 2022年第1期65卷 153-161页

作者： Saiji Shen Chu Wu Yinghui Shang Hongdou Shen Yue Liao yuting guo Min Hu Xia Wang Gang Li Qigang Wang School of Chemical Science and Engineering Tongji UniversityShanghai 200092China College of Electronics and Information Engineering Tongji UniversityShanghai 201804China

There are several natural materials which have evolved functional gradients,ingeniously attaining maximal efficacy from limited ***,we utilized the spatiotemporal distribution of initiator acetylacetone to regulate the multienzyme polymerization and fabricate a chitosan-polymer *** temporal priority order of acetylacetone was higher than phenolmodified chitosan by density functional theory *** acetylacetone within the gelatin could gradually diffuse spatially into the chitosan hydrogel to fabricate the composite hydrogel with gradient network *** gradient hydrogel possessed a transferring topography from the two-dimensional pattern.A continuously decreased modulus along with acetylacetone diffusion was confirmed by atomic force microscope-based force mapping *** water-retaining ability of various regions was confirmed by low-field nuclear magnetic resonance(NMR)and thermogravimetric analysis(TG)analysis,which led to the spontaneous actuation of gradient hydrogel with maximum 1821°/h curling speed and 227°curling ***,the promising gradient hydrogels could be applied as intelligent actuators and flexible robots.

关键词： bionic materials multienzymatic polymerization continuous gradient 3D printing spontaneous actuation

Mild and efficient recovery of lithium-ion battery cathode material by deep eutectic solvents with natural and cheap components

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Green Chemical Engineering 2023年第3期4卷 303-311页

作者： Yu Chen Yanlong Wang Yue Bai Minghui Feng Fengyi Zhou Yanhong Lu yuting guo Yixuan Zhang Tiancheng Mu Department of Chemistry and Material Science Langfang Normal UniversityLangfang065000China Hebei Regional Geological Survey Institute Langfang065000China Department of Chemistry Renmin University of ChinaBeijing100872China

Dissolution of lithium cobalt oxide(LCO)is the key step for the recovery of valuable metals(e.g.,Co and Li)from spent LCO-based lithium-ion batteries(LIBs).However,the dissolution process of LCO either needs toxic solvents,and high temperature,or shows low *** eutectic solvents(DESs)are potential green solvents to dissolve ***,DESs with polyethylene glycol(PEG)as hydrogen bond acceptor and ascorbic acid(AA)as hydrogen bond donor are found to dissolve LCO with 84.2%Co leaching efficiency at 80℃ and 72 h,which is higher than that from the reported references by common ***,both DESs components(i.e.,PEG and AA)are cheap,biodegradable,and *** could be easily and abundantly extracted from natural fruits or *** provides a new guide for the green,mild,and efficient dissolution of LCO aiming at sustainable recovery of spent LIBs.

关键词： Low cost Mild condition New energy Green chemistry Green solvents Ascorbic acid

Changepoint Detection with Outliers Based on RWPCA

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Journal of Applied Mathematics and Physics 2024年第7期12卷 2634-2651页

作者： Xin Zhang Sanzhi Shi yuting guo School of Mathematics and Statistics Changchun University of Science and Technology Changchun China

Changepoint detection faces challenges when outlier data are present. This paper proposes a multivariate changepoint detection method which is based on the robust WPCA projection direction and the robust RFPOP method, RWPCA-RFPOP method. Our method is double robust which is suitable for detecting mean changepoints in multivariate normal data with high correlations between variables that include outliers. Simulation results demonstrate that our method provides strong guarantees on both the number and location of changepoints in the presence of outliers. Finally, our method is well applied in an ACGH dataset.

关键词： RWPCA-RFPOP Double Robust Outlier Detection Biweight Loss