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Formulation,characterization and in vivo and in vitro evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement

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Journal of Traditional Chinese Medicine 2024年第1期44卷 54-62页

作者： LI Xiuyan luo yuting WANG Jinhui DU Zhimin Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese MedicineMinistry of EducationHarbin 150040China College of Pharmacy Harbin Medical UniversityHarbin 150081China Institute of Clinical Pharmacology the Second Affliated Hospital of Harbin Medical University(University Key aboratory of Drug ResearchHeilongjiang Province)Harbin 150086China Department of Clinical Pharmacology College of Pharmacy Harbin Medical UniversityHarbin 150081China State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacao 999078China

OBJECTIVE:To prepare aloe-emodin solid dispersion(AE-SD)and determine the metabolic process of AE and AE-SD in ***:AE-SD was prepared via solvent evaporation or solvent melting using PEG-6000 and PVP-K30 as *** analysis,X-ray diffraction spectroscopy,differential scanning calorimetry,Fourier transform infrared spectroscopy and scanning electron microscopy were used to identify the physical state of *** prescriptions were screened via the dissolution degree determination *** Phoenix software,AE suspension and AE-SD were subjected to a pharmacokinetic comparison study analyzing the alteration of behavior in vivo after AE was prepared as a solid *** toxicity was assessed in mice,and the physiological toxicity was used as the determination criterion for ***:AE-SD showed that AE existed in the carrier in an amorphous *** with polyethylene glycol,polyvinylpyrrolidone(PVP)inhibited AE crystallization,causing the drug to transform from a dense crystalline state to an amorphous form and increasing the degree of drug ***,it was more suitable as a carrier material for *** addition of poloxamer(POL)was more beneficial to the stability of solid dispersions and could reduce the amount of *** dissolution test confirmed that the optimal ratio of AE to the composite vector AE-PVP-POL was 1:2:2,and its dissolution effect was also *** on the pharmacokinetic comparison,the drug absorption was faster and quickly reached the peak of blood drug concentration in AE-SD compared to AE,the Cmax of AE-SD was greater than that of AE,and t1/2 and mean residence time of AE-SD were less than *** results showed that the drug metabolism in AE-SD was better,and the residence time was *** toxicology study showed that both AE and AE-SD had no ***:This paper established that the solubility of the drug could be increased after preparing a solid dispersion,

关键词： aloe-emodin solid dispersion solvent evaporation drug liberation pharmacokinetics

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A deep learned nanowire segmentation model using synthetic data augmentation

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npj Computational Materials 2022年第1期8卷 845-856页

作者： Binbin Lin Nima Emami David A.Santos yuting luo Sarbajit Banerjee Bai-Xiang Xu Mechanics of Functional Materials Division Institute of Materials ScienceTechnische Universität Darmstadt64287DarmstadtGermany Department of Chemistry Texas A&M UniversityCollege StationTX77843USA

Automated particle segmentation and feature analysis of experimental image data are indispensable for data-driven material *** learning-based image segmentation algorithms are promising techniques to achieve this goal but are challenging to use due to the acquisition of a large number of training *** the present work,synthetic images are applied,resembling the experimental images in terms of geometrical and visual features,to train the state-of-art Mask region-based convolutional neural networks to segment vanadium pentoxide nanowires,a cathode material within optical density-based images acquired using *** results demonstrate the instance segmentation power in real optical intensity-based spectromicroscopy images of complex nanowires in overlapped networks and provide reliable statistical *** model can further be used to segment nanowires in scanning electron microscopy images,which are fundamentally different from the training dataset known to the *** proposed methodology can be extended to any optical intensity-based images of variable particle morphology,material class,and beyond.

关键词： nanowires networks particle

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Achieving highly selective electrochemical CO_(2) reduction to C_(2)H_(4) on Cu nanosheets

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Journal of Energy Chemistry 2023年第4期79卷 312-320页

作者： Huan Xie Ruikuan Xie Zhiyuan Zhang Yongyu Pang yuting luo Jiong Li Bilu Liu Maria-Magdalena Titirici Guoliang Chai State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037JiangsuChina Shenzhen Geim Graphene Center(SGC) Tsinghua-Berkeley Shenzhen Institute(TBSI)and Tsinghua Shenzhen International Graduate School(TSIGS)Tsinghua UniversityShenzhen 518055GuangdongChina School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Department of Chemical Engineering Imperial College LondonSW72AZUK

The conversion of CO_(2)into value-added chemicals coupled with the storage of intermittent renewable electricity is *** nanosheets with an average size and thickness of~30 and~20 nm have been developed,which are in situ reduced into Cu nanosheets during electrochemical CO_(2)reduction reaction(ECO_(2)RR).The derived Cu nanosheets demonstrate much higher selectivity for C2H4production than commercial CuO derived Cu powder,with an optimum Faradaic efficiency of 56.2%and a partial current density of C_(2)H_(4)as large as 171.0 mA cm^(-2)in a gas diffusion flow *** operando attenuated total reflectance-Fourier transform infrared spectra measurements and density functional theory simulations illustrate that the high activity and selectivity of Cu nanosheets originate from the edge sites on Cu nanosheets with a coordinate number around 5(4–6),which facilitates the formation of^(*)CHO rather than^(*)COH intermediate,meanwhile boosting the C-C coupling reaction of^(*)CO and^(*)CHO intermediates,which are the critical steps for C_(2)H_(4)formation.

关键词： Electrochemical CO_(2)reduction Cu nanosheets C_(2)H_(4) High selectivity Coordination number

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Adhering to Correct Political Orientation, Building the Chinese Human Right Discourse System

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The Journal of Human Rights 2014年第5期13卷 15-16页

作者： luo yuting the CPC committee of Wuhan University

The Human Rights Research Academy of Wuhan University being named a national human rights education and training base is an affirmation and sign of trust in the university as well as a glorious re- sponsibility. We are going to work hard to build the academy into a world-recognized education and research platform with Chinese characteristics, making its necessary contribution to human rights devel- opment in China.

关键词： CPC work Building the Chinese Human Right Discourse System

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Confined van der Waals Epitaxial Growth of Two-Dimensional Large Single-Crystal In_(2)Se_(3) for Flexible Broadband Photodetectors

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Research 2019年第1期2019卷 1096-1105页

作者： Lei Tang Changjiu Teng yuting luo Usman Khan Haiyang Pan Zhengyang Cai Yue Zhao Bilu Liu Hui-Ming Cheng Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua UniversityShenzhen 518055China Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Quantum Science and Engineering Shenzhen 518055China Shenyang National Laboratory for Materials Sciences Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The controllable growth of two-dimensional(2D)semiconductors with large domain sizes and high quality is much needed in order to reduce the detrimental efect of grain boundaries on device performance but has proven to be ***,we analyze the precursor concentration on the substrate surface which signifcantly infuences nucleation density in a vapor deposition growth process and design a confned micro-reactor to grow 2D In_(2)Se_(3) with large domain sizes and high *** uniqueness of this confned micro-reactor is that its size is∼102-103 times smaller than that of a conventional *** a remarkably small reactor causes a very low precursor concentration on the substrate surface,which reduces nucleation density and leads to the growth of 2D In_(2)Se_(3) grains with sizes larger than 200�*** experimental results show large domain sizes of the 2D In_(2)Se_(3) with high *** fexible broadband photodetectors based on the as-grown In_(2)Se_(3) show rise and decay times of 140 ms and 25 ms,efcient response(5.6 A/W),excellent detectivity(7×10^(10) Jones),high external quantum efciency(251%),good fexibility,and high *** study,in principle,provides an efective strategy for the controllable growth of high quality 2D materials with few grain boundaries.

关键词： stability grain sizes

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New insights into the correlations between circulating tumor cells and target organ metastasis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 211-233页

作者： Qinru Zhan Bixia Liu Xiaohua Situ yuting luo Tongze Fu Yanxia Wang Zhongpeng Xie Lijuan Ren Ying Zhu Weiling He Zunfu Ke Department of Pathology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Zhongshan School of Medicine Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Radiology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Microbiology and Immunology Weill Cornell MedicineNew YorkNY 10065USA School of Medicine Xiang’an Hospital of Xiamen UniversityXiamen University361000 XiamenFujianP.R.China

Organ-specific metastasis is the primary cause of cancer patient *** distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their *** an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic *** harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further *** the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et ***,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific *** on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced ***,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical *** the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs.

关键词： metastasis organs insight

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scPlant:A versatile framework for single-cell transcriptomic data analysis in plants

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Plant Communications 2023年第5期4卷 1-14页

作者： Shanni Cao Zhaohui He Ruidong Chen yuting luo Liang-Yu Fu Xinkai Zhou Chao He Wenhao Yan Chen-Yu Zhang Dijun Chen State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhanChina

Single-cell transcriptomics has been fully embraced in plant biological research and is revolutionizing our understanding of plant growth,development,and responses to external ***,single-cell tran-scriptomic data analysis in plants is not trivial,given that there is currently no end-to-end solution and that integration of various bioinformatics tools involves a large number of required ***,we pre-sent scPlant,a versatile framework for exploring plant single-cell atlases with minimuminput data provided by *** scPlant pipeline is implemented with numerous functions for diverse analytical tasks,ranging from basic data processing to advanced demands such as cell-type annotation and deconvolution,trajec-tory inference,cross-species data integration,and cell-type-specific gene regulatory network *** addition,a variety of visualization tools are bundled in a built-in Shiny application,enabling explo-ration of single-cell transcriptomic data on the fly.

关键词： versatile Plant integration

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论立场

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马克思主义研究 2020年第9期 5-18,159页

作者：骆郁廷武汉大学马克思主义学院湖北武汉430072 教育部高等学校马克思主义理论类专业教学指导委员会

立场,是人们观察、认识和处理问题的立足点。立场问题,是一个根本性的问题。立场说到底是一种阶级立场,它是阶级利益的反映,从根本上决定着人们的思想观点、情感体验和价值取向。立场决定人们思维与实践活动的方向,甚至决定人生、社会... 详细信息

立场,是人们观察、认识和处理问题的立足点。立场问题,是一个根本性的问题。立场说到底是一种阶级立场,它是阶级利益的反映,从根本上决定着人们的思想观点、情感体验和价值取向。立场决定人们思维与实践活动的方向,甚至决定人生、社会、国家的前途命运。面对当前社会领域多元多样、纷繁复杂的价值观念和社会思潮,更要引导人们高度重视立场、善于辨析立场、正确选择立场,这不仅是人们坚持马克思主义立场、观点、方法和正确政治方向的客观需要,更是坚定走中国特色社会主义道路,实现最广大人民群众根本利益的必然要求。新时代我们要始终坚持马克思主义立场,实现好、维护好、发展好人民群众的根本利益。

关键词：马克思主义立场政治立场认识立场价值立场

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论思想政治教育的普遍贯通

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马克思主义研究 2022年第9期 74-84,156页

作者：骆郁廷武汉大学思想政治教育研究院武汉大学马克思主义学院湖北武汉430072

思想政治教育贯通问题,是新时代思想政治教育的重大课题。思想政治教育贯通是全方位、全过程、全员性的普遍贯通,是一切社会实践领域客观存在的普遍现象。思想政治教育贯通要解决的根本问题是思想政治教育与社会实践的关系问题,思想政... 详细信息

思想政治教育贯通问题,是新时代思想政治教育的重大课题。思想政治教育贯通是全方位、全过程、全员性的普遍贯通,是一切社会实践领域客观存在的普遍现象。思想政治教育贯通要解决的根本问题是思想政治教育与社会实践的关系问题,思想政治教育贯通的本质体现为思想政治教育融入、融合、融通社会实践的有机统一。思想政治教育贯通具有横向贯通、纵向贯通、动态贯通、网络贯通和全员贯通等基本样态。思想政治教育贯通要因人而贯、因事而贯、因时而贯、因势而贯,不断提高贯通的整体实效。新时代思想政治教育贯通的探索和深化,具有重要的时代价值。

关键词：思想政治教育贯通普遍贯通社会实践

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“小我”与“大我”:价值引领的根本问题

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马克思主义研究 2019年第12期 64-74,149页

作者：骆郁廷武汉大学思想政治教育研究院武汉大学马克思主义学院

对“小我”与“大我”价值关系的认识和处理是价值引领的根本问题。无论价值导向、价值评判还是价值实践,从根本上来说,就是要引导人们正确认识和处理“小我”与“大我”之间的价值关系问题。在“小我”与“大我”的价值关系上,“大我... 详细信息

对“小我”与“大我”价值关系的认识和处理是价值引领的根本问题。无论价值导向、价值评判还是价值实践,从根本上来说,就是要引导人们正确认识和处理“小我”与“大我”之间的价值关系问题。在“小我”与“大我”的价值关系上,“大我”背离“小我”,抑或“小我”背离“大我”,都是错误的价值偏向。新时代,加强全社会的价值引领,就要引导人们尤其是青少年始终坚持“小我”与“大我”相结合,自觉将个体的“小我”融入国家、人民的“大我”中,积极推进个体价值与社会价值、个人利益与集体利益、个人理想与共同理想的相互融合与共同实现。

关键词： “小我” “大我” 价值取向价值引领

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