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Data Science and Informetrics 2023年第2期3卷 91-97页

作者： Rui Zhang Jingjing Wu yutian Fu Management School Hangzhou Dianzi UniversityHangzhouChina

Informetrics:theory,methods and applications records the research contents of informetrics in different periods,reveals the development motivation of"Three Metrics"to"Five Metrics",and is of great significance to the future trend of *** article reviews the research and development history of Professor Qiu Junping's team of"Three Metrics"and"Five Metrics",and analyzes and summarizes their academic influence and contribution to the field of international informetrics in combination with the chapter content,innovation,and practicality of the *** can be seen that Informetrics:theory,methods and applications not only explains the complete research paradigm of informetrics,but also showed to the world the multi-dimensional breakthrough and innovation of Chinese informetrics research,and provided new ideas for the development of international informetrics.

关键词： Informetrics Three-Metrics Five-Metrics Informetrics:theory,methods and applications

Experimental evaluation of the salt dissolution in inter-salt shale oil reservoirs

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Petroleum Exploration and Development 2020年第4期47卷 803-809页

作者： YANG Zhengming LI Ruishan LI Haibo LUO yutian CheN Ting GAO Tiening ZHANG Yapu Institute of Porous Flow&Fluid Mechanics PetroChina Research Institute of Petroleum Exploration&DevelopmentBeijing 100083China University of Chinese Academy of Sciences Beijing 100493China Research Institute of Exploration and Development Jianghan Oilfield CompanyWuhan 430223China

By using salt dissolution experiment,imbibition experiment and high temperature and high pressure nuclear magnetic resonance(NMR)on-line test,the evaluation methods for salt dissolution of inter salt shale oil-bearing cores were established,and the effects of salt dissolution on spontaneous imbibition and permeability were *** intensity of salt dissolution is quantitatively evaluated by comparing the signal quantity and distribution characteristics of T2 spectrum(transverse relaxation time)measured at different *** salt dissolution experiment,salt in the core is gradually dissolved as the injected water is continuously immersed in the *** spontaneous imbibition experiment of inter-salt shale oil-bearing core can be divided into three stages:strong imbibition and weak salt dissolution,strong salt dissolution promoting imbibition,and weak salt dissolution and weak *** salt dissolution in spontaneous imbibition is very obvious,and the salt dissolution contributes more than 60%of *** micro-pore structure in different cross sections or different parts of inter-salt shale oil-bearing core isn’t uniform,and the pore volume,porosity and permeability increase after salt dissolution.

关键词： shale oil salt dissolution imbibition physical simulation nuclear magnetic resonance

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Innovations in 3D bioprinting and biomaterials for liver tissue engineering:Paving the way for tissue-engineered liver

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iLIVER 2024年第1期3卷 67-81页

作者： Qi Wang yutian Feng Anqi Wang Yuelei Hu Yannan Cao Jingjing Zheng Yinpeng Le Juan Liu hepato-Pancreato-Biliary Center Beijing Tsinghua Changgung HospitalBeijing 102218China School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of hepatobiliary and Pancreatic Surgery The First Hospital of Jilin UniversityChangchun 130021China Key Laboratory of Digital Intelligence hepatology(Tsinghua University) Ministry of EducationBeijing 102218China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Institute of Smart Biomedical Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

The liver is a pivotal organ that maintains internal homeostasis and actively participates in multiple physiological *** tissue engineering(LTE),by which in vitro biomimetic liver models are constructed,serves as a platform for disease research,drug screening,and cell replacement therapies.3D bioprinting is used in tissue engineering to create microenvironments that closely mimic authentic tissues with carefully selected functional *** functional biomaterials exhibit characteristics such as high biocompatibility,mechanical strength,flexibility,processability,and tunable *** can be categorized into natural and synthetic biomaterials,each with its own advantages and limitations,and their combinations serve as a primary source of 3D bioprinting *** is noteworthy that the liver decellularized extracellular matrix(dECM),obtained by removing cellular components from tissues,possesses traits such as bioactivity,biocompatibility,and non-immunogenicity,making it a common choice among functional ***,crosslinking of biomaterials significantly impacts the mechanical strength,physicochemical properties,and cellular behavior of the printed *** review covers the current utilization of biomaterials in LTE,focusing on natural and synthetic biomaterials as well as the selection and application of crosslinking *** aim is to enhance the fidelity of in vitro liver tissue models by providing a comprehensive coverage of functional biomaterials,thereby establishing a versatile platform for tissue-engineered livers.

关键词： Tissue engineered liver Natural biomaterials Synthetic biomaterials Crosslinking 3D bioprinting

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利用光场合成与弥散圆渲染的单幅图像重聚焦

光学学报 2020年第1期40卷 275-283页

作者：王奇傅雨田中国科学院红外探测与成像技术重点实验室上海200083 中国科学院上海技术物理研究所上海200083 中国科学院大学北京100049

提出一种单幅图像动态重聚焦方法,结合基于深度学习的光场合成与基于几何结构的弥散圆渲染方法,模拟出光场重聚焦效果。该方法仅输入单幅图像,首先进行深度估计,然后将深度图转换为视差,最后在不同深度确定弥散圆直径以进行像素重采样... 详细信息

提出一种单幅图像动态重聚焦方法,结合基于深度学习的光场合成与基于几何结构的弥散圆渲染方法,模拟出光场重聚焦效果。该方法仅输入单幅图像,首先进行深度估计,然后将深度图转换为视差,最后在不同深度确定弥散圆直径以进行像素重采样。设计两种神经网络结构,分别以光场相机的多视角子图和重聚焦图像为样本进行有监督的深度学习。在多个数据集和实际场景中的实验结果表明,本文方法在可接受的计算成本下能获得优于其他方法的视觉效果与评价指标,峰值信噪比达到了34.55,结构相似度达到了0.937。

关键词：成像系统计算成像光场重聚焦深度估计弥散圆渲染

MosaicBase:A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and healthy Human Individuals

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 140-149页

作者： Xiaoxu Yang Changhong Yang Xianing Zheng Luoxing Xiong yutian Tao Meng Wang Adam Yongxin Ye Qixi Wu Yanmei Dou Junyu Luo Liping Wei August Yue Huang Center for Bioinformatics State Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing 100871China Department of Bioinformatics Chongqing Medical UniversityChongqing 400016China College of Life Sciences Beijing Normal UniversityBeijing 100875China National Institute of Biological Sciences Beijing 102206China Peking-Tsinghua Center for Life Sciences(CLS) Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730China School of Life Sciences Peking UniversityBeijing 100871China

Mosaic variants resulting from postzygotic mutations are prevalent in the human genome and play important roles in human ***,except for cancer-related variants,there is no collection of postzygotic mosaic variants in noncancer disease-related and healthy ***,we present MosaicBase,a comprehensive database that includes 6698 mosaic variants related to 266 noncancer diseases and 27,991 mosaic variants identified in 422 healthy *** and phenotypic information of each variant was manually extracted and curated from 383 *** supports the query of variants with Online Mendelian Inheritance in Man(OMIM)entries,genomic coordinates,gene symbols,or Entrez *** also provide an integrated genome browser for users to easily access mosaic variants and their related annotations for any genomic *** analyzing the variants collected in MosaicBase,we find that mosaic variants that directly contribute to disease phenotype show features distinct from those of variants in individuals with mild or no phenotypes,in terms of their genomic distribution,mutation signatures,and fraction of mutant *** will not only assist clinicians in genetic counseling and diagnosis but also provide a useful resource to understand the genomic baseline of postzygotic mutations in the general human *** is publicly available at http://***/or http://49.***.21.8:8000.

关键词： Postzygotic Mosaicism Noncancer Mutation MosaicBase

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用于高轨卫星精密稳像的拖尾星斑复原

光学学报 2020年第13期40卷 66-73页

作者：王奇傅雨田中国科学院红外探测与成像技术重点实验室上海200083 中国科学院上海技术物理研究所上海200083 中国科学院大学北京100049

为了提高复杂动态环境下精密稳像系统的质心定位精度,提出了一种基于生成对抗网络(GAN)的方法,以解决载体运动引起的星斑拖尾问题。传统的高斯模型先验方法对噪声敏感,盲反卷积方法采用简化模型估计模糊核,与真实值误差较大。所提方法... 详细信息

为了提高复杂动态环境下精密稳像系统的质心定位精度,提出了一种基于生成对抗网络(GAN)的方法,以解决载体运动引起的星斑拖尾问题。传统的高斯模型先验方法对噪声敏感,盲反卷积方法采用简化模型估计模糊核,与真实值误差较大。所提方法结合了运动流图的运动方向和GAN的优化细节,将运动流图与模拟星点作为监督信号,采用端到端的形式复原星斑图,无需先验信息与迭代计算,并且可以抑制噪声。实验结果表明,相较于R-L方法,所提方法复原星斑后峰值信噪比提升了30.5%,质心定位精度提高了33.4%。

关键词：成像系统运动模糊星斑复原生成对抗网络流估计

N-methyl-D-aspartate glutamate receptors (NMDARs) in stroke pathogenesis and treatments

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Journal of Translational Neuroscience 2019年第4期4卷 1-12页

作者： Wenlin Chen Yang Ge yutian Wang Djavad Mowafaghian Centre for Brain health and Department of Medicine University of British ColumbiaVancouverV6T 2B5Canada

N-methyl-D-aspartate glutamate receptors(NMDARs)play crucial roles in the pathogenesis of neuronal injuries following a stroke insult;therefore,a plethora of preclinical studies focus on better understanding functions of NMDARs and their associated signaling *** the past decades,NMDARs have been found to exert dual effects in neuronal deaths signaling and neuronal survival signaling during cerebral ***,many complex intracellular signaling pathways downstream of NMDAR activation have been elucidated,which provide novel targets for developing much-needed neuro-protectants for patients with *** this review,we will discuss the recent progress in understanding the underlying mechanisms of stroke related to NMDAR activation and the potential therapeutic strategies based on these discoveries.

关键词： N-methyl-D-aspartate glutamate receptors(NMDARs) stroke treatments neuronal survival signaling complex(NSC) neuronal death signaling complex(NDC)

Chaos in Fractional Difference Equation

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Chaos in Fractional Difference Equation

A Prognostic Nomogram with High Accuracy Based on 2D-SWE in Patients with Acute-on-chronic Liver Failure

第一届全国神经动力学学术会议

作者： Huang Xiao yutian Ma Changpin Li Department of Mathematics Shanghai University

Starting from the kicked equations of motion with fractional derivatives, we obtain the fractional discrete maps, which have memories. In this paper, we mainly display the fractional discrete maps: Zaslavsky map and L... 详细信息

关键词： Fractional derivatives Chaos Zaslavsky map Logistic map Difference equation

来源： cnki会议评论

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Journal of Clinical and Translational hepatology 2022年第5期10卷 803-813页

作者： Lili Wu Jieyang Jin Taicheng Zhou Yuankai Wu Xinhua Li Xiangyong Li Jie Zeng Jinfen Wang Jie Ren yutian Chong Rongqin Zheng Department of Medical Ultrasonics Third Affiliated Hospital of Sun Yat-Sen UniversityGuangdong Key Laboratory of Liver Disease ResearchGuangzhouGuangdongChina Department of Gastroenterological Surgery and hernia Center Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesSupported by National Key Clinical DisciplineGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina

Background and Aims:Acute-on-chronic liver failure(ACLF)is associated with very high *** prediction of prognosis is critical in navigating optimal treatment decisions to improve patient *** study was aimed to develop a new nomogram integrating two-dimensional shear wave elastography(2D-SWE)values with other independent prognostic factors to improve the precision of predicting ACLF patient ***:A total of 449 consecutive patients with ACLF were recruited and randomly allocated to a training cohort(n=315)or a test cohort(n=134).2D-SWE values,conventional ultrasound features,laboratory tests,and other clinical characteristics were included in univariate and multivariate *** with prognostic value were then used to construct a novel prognostic *** operating curves(ROCs)were generated to evaluate and compare the performance of the novel and published models including the Model for EndStage Liver Disease(MELD),MELD combined with sodium(MELD-Na),and Jin’s *** model was validated in a prospective cohort(n=102).Results:A ACLF prognostic nomogram was developed with independent prognostic factors,including 2D-SWE,age,total bilirubin(TB),neutrophils(Neu),and the international normalized ratio(INR).The area under the ROC curve(AUC)was 0.849 for the new model in the training cohort and 0.861 in the prospective validation cohort,which were significantly greater than those for MELD(0.758),MELD-Na(0.750),and Jin’s model(0.777,all phe predicted and observed *** new nomogram had superior overall net benefit and clinical ***:We established and validated a 2D-SWE-based noninvasive nomogram to predict the prognosis of ACLF patients that was more accurate than other prognostic models.

关键词： Acute-on-chronic liver failure Two-dimensional shear wave elastography hepatitis B virus Prognosis

Evaluation of degree of nerve root injury by dermatomal somatosensory evoked potential following lumbar spinal stenosis

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Neural Regeneration Research 2008年第11期3卷 1249-1252页

作者： Ningjiang Shen Guangji Wang Jian Chen Xiaoli Wu yutian Wang Department of Orthopaedic Surgery Hainan People＇s Hospital Haikou 570311 Hainan Province China

BACKGROUND： Computed Tomography （CT） and Magnetic Resonance Imaging （MRI） can display the site of lumbar spinal stenosis and predict nervous compression at the morphological level; however, pure morphological changes cannot reflect functional alterations in a compressed nerve root. Dermatomal somatosensory evoked potential （DSEP） provides a means to assess the functional state of a nerve root. OBJECTIVE： To evaluate the clinical significance of DSEP, assessing the degree of nerve root injury following lumbar spinal stenosis. DESIGN, TIME AND SETTING： A case-control study was performed in the Department of Orthopaedic Surgery, Hainan People＇s Hospital, China, between September 2004 and December 2007. PARTICIPANTS： Forty-seven patients diagnosed with lumbar spinal stenosis by CT or MRI were selected as the case group; fifty healthy subjects were collected as the control group. METHODS： A KEYPOINT myoelectric evoked potential apparatus （DANTEC Company, Denmark） was used to measure DSEP, and stimulative spots were determined in accordance with the skin key sensory spot standards established by The American Spinal Injury Association： L4 in the medial malleolus, L5 in the third metatarsophalangeal joint of the dorsum of foot and S1 in the lateral heel. The needle electrode used as the recording electrode was located at the Cz point of the cranium, and the reference electrode at the Fz point. MAIN OUTCOME MEASURES： Latency of the P40 peak of DSEP, P1-N1 amplitude, P40 waveform and differentiation and disappearance of various waves. RESULTS： The sensitivity and diagnostic concurrence with surgery of nerve root injury following lumbar spinal stenosis evaluated by DSEP was 95.7 %. P40 latencies at L4, L5 and S1 in the case group were significantly longer than in the control group （P 〈 0.05）, and the P1-N1 amplitude in the case group was significantly lower than the control group （P 〈 0.05-0.01）. Nerve root injury was categorized according to DSEP latency as follows： severe da

关键词： dermatomal somatosensory evoked potential lumbar spinal stenosis nerve root injury