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Preparation and Characterization of Maltose-Pendant Polymer/Mica Nanocomposites and Their Application to Oxygen Gas Barrier Films

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Journal of Biomaterials and Nanobiotechnology 2014年第3期5卷 146-152页

作者： Hideo Sakurai Shoji Nagaoka Maki Horikawa Tomohiro Shirosaka Shuzou kubota Kazuhiro Hamada Makoto Takafuji Hirotaka Ihara Graduate School of Science and Technology Kumamoto University Kumamoto Japan Kumamoto Industrial Research Institute Kumamoto Japan Kumamoto Institute for Photo-Electro Organics (Phoenics) Kumamoto Japan

Maltose-pendant polymer/mica nanocomposites were prepared by a solution intercalation method. For organic composite part, 1) maltose-pendant polymer (homopolymer) and 2) the copolymer of maltose-pendant monomer and a small amount of N,N-Dimethylamino propylacrylamide, methyl chloride quartenary were used. The morphological studies (XRD and FE-SEM) revealed that the hybrid of maltose-pendant polymer was a conventional phase separated composite. On the other hand, the hybrid using the copolymer exhibited exfoliated structure. Both the conventional composite of maltose-pendant polymer and the nanocomposite of copolymer were applied to a coating material for oxygen gas barrier layer on a nylon-6 film, and oxygen transmission rates of the films were evaluated. Maltose-pendant polymer had a good oxygen barrier property under dry condition, and the barrier property under wet condition was improved by the hybridization with mica. In contrast, the barrier property of copolymer was slightly inferior to that of maltosependant polymer. However, under dry condition, it can be seen that the nanocomposite of copolymer improves the barrier property more effectively than the case of conventional composite of maltose-pendant polymer.

关键词： Maltose-Pendant Polymer Nanocomposite Mica Oxygen Gas Barrier Film Food Packaging

Association of Superior Vena Cava Syndrome with Sleep Apnea: Investigation Using an Impulse Oscillometry System

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International Journal of Clinical Medicine 2012年第4期3卷 270-275页

作者： Masanori Yokoba Naohito Ishii Tsuyoshi Ichikawa Mayuko Wada Hisashi Mitsufuji Masaru kubota Noriyuki Masuda Masato Katagiri Division of Respiratory Medicine Kitasato University HospitalKanagawa JAPAN Kitasato University Graduate School of Medical Sciences Kanagawa JAPAN Kitasato University School of Allied Health Sciences Kanagawa JAPAN

Superior vena cava syndrome (SVCS) patients sometimes show signs of obstructive sleep apnea (OSA). However, the mechanism causing hypoxia during sleep in SVCS patients is still uncertain. The aim of this study was to elucidate 1) the changes in central and peripheral respiratory resistance with SVCS, and 2) interpret the mechanism underlying the development of hypoxia during sleep in patients with SVCS related to OSA. Ten SVCS patients related to a neoplasm were recruited for this study. The degree of apnea hypopnea index (AHI) for OSA was evaluated by portable diagnosing device before and after SVCS treatment. We also analyzed the airway resistance and reactance quantitatively in the supine position by Master Screen impulse oscillometry system (MS-IOS?). After SVCS treatment, mean values of AHI were significantly decreased from 30.9 to 16.9 (/hour) (p = 0.001). Central respiratory resistance (R20) also decreased significantly from 0.40 to 0.33 kPa/L/s (p = 0.025) in the supine position. In contrast, peripheral respiratory resistance (R5-R20) and distal capacitive reactance (X5) did not change significantly. It is thought that the exacerbation of OSA due to SVCS is caused by increasing upper airway resistance related to reversible edema of the upper airway mucous or tissue. In contrast, SVCS may not cause peripheral respiratory tract and lung parenchyma edema.

关键词： Upper Airway Resistance Central Respiratory Resistance Peripheral Respiratory Resistance Impulse Oscillometry System Ios Pulmonary Neoplasm

学习策略对成效的中介作用 ——以项目式工程教育为例

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学习策略对成效的中介作用 ——以项目式工程教育为例

作者：窪田申平（kubota SHIMPEI）清华大学

学位级别：硕士

The New Molecular Entity Evolocumab, One Kind of PCSK9 Inhibitor, Reduce Plasma Small Size LDL-Cholesterol Levels by Using a New Standardized Method of Measuring LDL Size

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Open Journal of Molecular and Integrative Physiology 2017年第1期7卷 1-23页

作者： Ikuo Inoue Ryo kubota Shohan Yanagi Masumi Akita Takanari Nakano Shigehiro Katayama Akira Shimada Mistuhiko Noda Department of Endocrinology and Diabetology Saitama Medical University Saitama Japan Department of Health Sciences Saitama Prefectural University Saitama Japan Research and Development Department Advanced Materials Development Sector Tokyo Metropolitan Industrial Technology Research Institute Tokyo Japan Division of Morphological Science Biomedical Research Center Saitama Medical University Saitama Japan Department of Biochemistry Saitama Medical University Saitama Japan

Aims: There has been no evidence on the effects of evolocumab, protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, on small size LDL. We observationally investigated the efficacy and side effects of evolocumab on the LDL subfraction particle diameter using PAGE system for lipoprotein analysis. Methods: We defined 30 patients with high-risk hyperlipidemia. As for analysis of LDL subfraction profile, we used polyacrylamide gel electrophoresis three methods: 1) 3% nondenatured poly-acrylamide gel electrophoresis method (3%PAGE), 2) 2% - 16% nondenatured poly-acrylamide gradient gel electro-phoresis method (2% - 16% GGE) and 3) 2.7% - 5% GGE. Evolocumab 140 mg/day administered together with statin significantly improved serum total cholesterol (TC), triglyceride (TG), high-dense lipoprotein-cholesterol (HDL-C), and LDL-C after four-week treatment. Results: TC, TG, HDL-C and LDL-C levels were improved by, respectively, 33%, 20%, 10%, and 54%. The mean LDL size significantly increased from 25.6 ± 0.4 nm to 26.4 ± 0.8 nm. The small dense LDL-cholesterol (sdLDL-C), large buoyant LDL-cholesterol (lbLDL-C), and mid-band lipoprotein-cholesterol were reduced, respectively. Therefore, the preliminary study on this paper can be the first step into a new insight on the world of lipid metabolism. Conclusion: Short-term administration of evolocumab addedons to statin therapy, significantly reduced small size LDL levels.

关键词： PCSK9 Inhibitor Evolocumab LDL Heterogeneicity Small Size LDL 3% PAGE 2% - 16% GGE

Tumor characteristics of ductal carcinoma in situ of breast visualized on [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography: Results from a retrospective study

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World Journal of Radiology 2016年第8期8卷 743-749页

作者： Tomoyuki Fujioka Kazunori kubota Akira Toriihara Youichi Machida Kaori Okazawa Tsuyoshi Nakagawa Yukihisa Saida Ukihide Tateishi Department of Diagnostic Radiology Tokyo Medical and Dental University Department of Radiology Kameda Kyobashi Clinic Department of Breast Surgery Tokyo Medical and Dental University

AIM To clarify clinicopathological features of ductal carcinoma in situ(DCIS) visualized on [F-18] fluorodeoxyglucosepositron emission tomography/computed tomography(FDG-PET/CT).METHODS This study retrospectively reviewed 52 consecutive tumors in 50 patients with pathologically proven pure DCIS who underwent [F-18] FDG-PET/CT before surgery. [F-18] FDG-PET/CT was performed after biopsy in all patients. The mean interval from biopsy to [F-18] FDGPET/CT was 29.2 d. [F-18] FDG uptake by visual analysis and maximum standardized uptake value(SUVmax) was compared with clinicopathological ***[F-18] FDG uptake was visualized in 28 lesions(53.8%) and the mean and standard deviation of SUVmax was 1.63 and 0.90. On univariate analysis, visual analysis and the SUVmax were associated with symptomatic presentation(P = 0.012 and 0.002, respectively), palpability(P = 0.030 and 0.024, respectively), use of core-needle biopsy(CNB)(P = 0.023 and 0.012, respectively), ultrasound-guided biopsy(P = 0.040 and 0.006, respectively), enhancing lesion ≥ 20 mm on magnetic resonance imaging(MRI)(P = 0.001 and 0.010, respectively), tumor size ≥ 20 mm on histopathology(P = 0.002 and 0.008, respectively). However, [F-18] FDG uptake parameters were not significantly associated with age, presence of calcification on mammography, mass formation on MRI, presence of comedo necrosis, hormone status(estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), and nuclear grade. The factors significantly associated with visual analysis and SUVmax were symptomatic presentation(P = 0.019 and 0.001, respectively), use of CNB(P = 0.001 and 0.031, respectively), and enhancing lesion ≥ 20 mm on MRI(P = 0.001 and 0.049, respectively) on multivariate *** Although DCIS of breast is generally non-avid tumor, symptomatic and large tumors(≥ 20 mm) tend to be visualized on [F-18] FDG-PET/CT.

关键词： Ductal carcinoma in situ Positron emission tomography Breast cancer [F-18] fluorodeoxyglucosepositron emission tomography/computed tomography

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日本火山灰土壤的侵蚀

水土保持科技情报 1992年第1期10卷 13-18页

作者： Torn kubota AkiraIshihara 张培虎

过去对日本火山灰土壤的水蚀研究表明,火山灰土壤持水量大,团聚体稳定性强、渗透率高,其土壤侵蚀程度通常相对较低.然而近年来的研究发现,受农业机械化的影响,火山灰土壤的侵蚀程度较高,很显然,是由于亚表层土壤被压实后会产生亚表层流... 详细信息

过去对日本火山灰土壤的水蚀研究表明,火山灰土壤持水量大,团聚体稳定性强、渗透率高,其土壤侵蚀程度通常相对较低.然而近年来的研究发现,受农业机械化的影响,火山灰土壤的侵蚀程度较高,很显然,是由于亚表层土壤被压实后会产生亚表层流,从而导致表层土分离的结果.对火山灰土壤物理性质的测定表明:受压土壤的孔隙容积在压力解除后并不能恢复原状,且在近乎饱和条件下,由于土壤中存在密闭的充气孔隙,土壤的湿容重较小.这种特性是火山灰土壤所特有的,黄壤或灰色低地的土壤不存在这种现象.本文通过对非限定水域的测定,对火山灰土壤结构状况进行了评价,评价结果表明:由于土壤通气性差、硬度大,大多数亚表层土壤中的作物根系生长受到抑制.据此我们断定:由于表土的易碎性可使渗透力降低,受压火山灰土壤的水蚀会加剧,因此,应当采取以土壤特性为基础的土壤改良措施.

关键词：火山灰土壤侵蚀日本

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旱地土释放的亚硝酸的来源

核农学通报 1986年第4期 33-34页

作者： Masatsugu kubota 张勤争

用15N示踪法测定两种旱地土中释放的亚硝酸的来源和硝化抑制剂硫脲对亚硝酸释放的影响。试验证实了大部分释放的亚硝酸来源于氨态氮。氨态氮对释放的亚硝酸态氮的贡献在Taki土中为63—64％,在Matsuzawa土中为61—69％,硝态氮的贡献分别... 详细信息

用15N示踪法测定两种旱地土中释放的亚硝酸的来源和硝化抑制剂硫脲对亚硝酸释放的影响。试验证实了大部分释放的亚硝酸来源于氨态氮。氨态氮对释放的亚硝酸态氮的贡献在Taki土中为63—64％,在Matsuzawa土中为61—69％,硝态氮的贡献分别为23—26％和15—18％。从土壤中15N的回收率为92—96％。两种土壤中,亚硝态氮的释放随加入硫脲而减少,当硫脲的浓度为所加铵态氮的10％时,受到抑制。铵态氮可完全氧化为硝态氮和亚硝态氮。

关键词：原子百分超土中原子%超旱地耕地 NH 亚硝酸氮化合物亚硝态氮

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HMX推进剂燃速的温度敏感性

固体火箭技术 1987年第2期 20-26页

作者： N.kubota 唐菊花

为了阐明双基推进剂基体内HMX粒子的作用,研究了HMX基复合改性双基推进剂燃速的温度敏感性。虽然单位质量推进剂中包含的能量随着HMX重量分数ξ的增加而提高。但是,当ξ～0.5时,燃速又随着ξ而提高。换句话说,在定压下,ξ≌0.5时,燃速... 详细信息

为了阐明双基推进剂基体内HMX粒子的作用,研究了HMX基复合改性双基推进剂燃速的温度敏感性。虽然单位质量推进剂中包含的能量随着HMX重量分数ξ的增加而提高。但是,当ξ～0.5时,燃速又随着ξ而提高。换句话说,在定压下,ξ≌0.5时,燃速为最小值。温度敏感系数随着ξ上升而单调地下降。测试结果表明,当ξ上升时,嘶嘶区的反应速率单调下降,燃烧表面的反应热单调地增加。HMX—CMDB推进剂的这种燃烧模式证明了实测的燃速和温度敏感特性。

关键词：复合改性双基推进剂推进剂燃速奥克托今温度系数硝胺推进剂燃烧波

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为创意设计创意

建筑实践 2014年第2期 58-61页

作者：常号 Naho kubota

好的设计不仅要满足功能性的要求,同时也要创造一种空间的品质。当这种品质得到使用者的认同时,自身就会产生与空间共鸣的感受,潜移默化中"被设计"了生活的方式。设计团队All of the Above and First Office最近完成了网络公司Pinteres... 详细信息

好的设计不仅要满足功能性的要求,同时也要创造一种空间的品质。当这种品质得到使用者的认同时,自身就会产生与空间共鸣的感受,潜移默化中"被设计"了生活的方式。设计团队All of the Above and First Office最近完成了网络公司Pinterest旧金山总部的设计项目。为一个充满创意的团队设计一个创意的空间,让我们来看看All of the Above and First Office对此是如何理解的。工作室的选址本是在帕洛阿尔托地区,后由于Pinterest团队人员的迅速增幅,原本为12选用的工作室显然不再满足要求,于是客户重新选择了这所

关键词：建筑东西