检索结果-南通市图书馆

Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： Toshiaki Tsurui Yuya Hirasawa yutaro kubota Kiyoshi Yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

Right colon cancer presenting as hemorrhagic shock

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2011年第1期2卷 15-18页

作者： Tomoyuki Iwata Kazuo Konishi Takahisa Yamazaki Katsuya Kitamura Atsushi Katagiri Takashi Muramoto yutaro kubota Yuichiro Yano Yoshiya Kobayashi Toshiko Yamochi Nobuyuki Ohike Masahiko Murakami Takehiko Gokan Nozomi Yoshikawa Michio Imawari Division of Gastroenterology Department of MedicineShowa University School of Medicine Second Department of Pathology Showa University School of Medicine First Department of Pathology Showa University School of Medicine Division of Gastroenterogical Surgery Department of SurgeryShowa University School of Medicine Department of Radiology Showa University School of Medicine Endoscopic Center Showa University HospitalShowa University School of Medicine

A 67-year-old man visited our hospital with a history of continuous hematochezia leading to hemorrhagic *** abdominal computed tomography scan re-vealed a large mass in the ascending colon invading the duodenum and pancreatic head as well as extra-vasation of blood from the gastroduodenal artery(GDA) into the *** revealed an irregular ulcerative lesion and stenosis in the ascending ***,right hemicolectomy combined with pylorus-preser ving pancreaticoduodenectomy was ***,the tumor was classified as a moderately differentiated ***,cancer cells were mainly located in the colon but had also invaded the duode-num and pancreas and involved the ***,the tumor cells were positive for cytokeratin(CK)20 and carcinoembryonic antigen(CEA)but not forCK7 and carbohydrate antigen(CA)*** patient died 23 d after the surgery because he had another episode of arterial bleeding from the anastomosis *** En bloc resection of the tumor with pancreatico duodenectomy and colectomy performed for locally advanced colon cancer can ensure long-term survival,patients undergoing these procedures should be carefully monitored,particularly when the tumor involves the main artery.

关键词： Colon cancer Hemorrhagic shock Adjacent organs invasion En bloc resection Complication

NUMERICAL PREDICTION OF DYNAMIC PERFORMANCE OF PELTON TURBINE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2007年第3期19卷 356-364页

作者： kubota Takashi College of Electric Power South China University of Technology Guangzhou 510640 China

Different from the reaction turbines, the hydraulic performance of Pelton turbine is dynamic due to the unsteady flow in the rotating buckets in time and space. The dynamic energy efficiency of bucket ηεB and power efficiency of bucket ηPB within a short period can be predicted from the dynamic flow pattern of the free-surface sheet flow in the rotating bucket, whereas the dynamic discharge efficiency of bucket ηQB is defined as the resident discharge in the bucket at the respective moment. Under the operation of higher unit speed non than the optimum one, the power efficiency of bucket is deteriorated by the jet interference with the rear surface of bucket △Prear at the first stage of the dynamic performance, as well as the loss power due to the spilt flow from the cutout of bucket at the later stage of performance. Based on the dynamic performance prediction presented, the future possibility of the quantitative investigation for the negative scale effect of Pelton turbines was discussed.

关键词： dynamic energy efficiency dynamic discharge efficiency dynamic power efficiency rotating bucket Pelton turbine

Unsteady separation of jet branch by cutout of rotating Pelton bucket

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2011年第2期54卷 302-310页

作者： kubota Takashi College of Electric Power South China University of Technology

As a part of boundaries for a free curved surface of a Pelton bucket,the cutout is indispensable to secure the smooth entrance of the unsteady inflow of water jet into the rotating *** cutout of the rotating bucket unsteadily separates a free jet into two branches in both space and time:the impinging branch landing on the relevant bucket surface,and the flow-off branch separated by the cutout toward the preceding *** order to investigate the unsteady jet separation by the cutout three-dimensionally,a semicircular free jet was discretized into 641 nodes of boundary-fitted *** position P of impinging jet branch landing on the bucket surface was acquired with the relative velocity W and the water depth D at each *** trailing edge surface of the flow-off jet branch was simultaneously computed *** complicate unsteady interaction of the bucket cutout with the branched free jets was clarified visually with the 3D view of illustrations in order to research the unsteady hydraulic performance of Pelton turbines in space and time.

关键词： cutout rotating bucket jet branch trailing edge surface of jet unsteady in space and time

Long-term outcomes of postgastrectomy syndrome after total laparoscopic distal gastrectomy using the augmented rectangle technique

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2022年第2期14卷 120-131页

作者： Suguru Yamauchi Hajime Orita Jun Chen Hiroki Egawa yutaro Yoshimoto Akira kubota Ryota Matsui Yukinori Yube Sanae Kaji Shinichi Oka Malcolm V Brock Tetsu Fukunaga Department of Gastroenterology and Minimally Invasive Surgery Juntendo University HospitalTokyo 113-8431Japan Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21205-2196United States

BACKGROUND For total laparoscopic distal gastrectomies for gastric cancer,the reconstruction method is critical to the clinical outcome of the ***,which reconstruction technique is optimal remains *** originally reported the augmented rectangle technique(ART)as a reconstruction option for total laparoscopic Billroth I ***,little is known about its effect on long-term outcomes,specifically the incidence of postgastrectomy syndrome and its impact on quality of *** To analyze postgastrectomy syndrome and quality of life after ART using the Postgastrectomy Syndrome Assessment Scale-37(PGSAS-37)*** At Juntendo University,a total of 94 patients who underwent ART for Billroth I reconstruction with total laparoscopic distal gastrectomies for gastric cancer between July 2016 and March 2020 completed the PGSAS-37 *** analysis was performed,comparing those 94 ART cases from our institution(ART group)to 909 distal gastrectomy cases with a Billroth I reconstruction from other Japanese institutions who also completed the PGSAS-37 as part of a larger national database(PGSAS group).RESULTS Patients in the ART group had significantly better total symptom scores in all the symptom subscales(i.e.,esophageal reflux,abdominal pain,meal-related distress,indigestion,diarrhea,constipation,and dumping).The loss of body weight was marginally greater for those in the ART group than in the PGSAS group(-9.3%vs-7.9%,P=0.054).The ART group scored significantly lower in their dissatisfaction of ongoing symptoms,during meals,and with daily *** ART for Billroth I reconstruction provided beneficial long-term results for postgastrectomy syndrome and quality of life in patients undergoing total laparoscopic distal gastrectomies for gastric cancer.

关键词： Laparoscopic distal gastrectomy Postgastrectomy syndrome Augmented rectangle technique Billroth I Postgastrectomy Syndrome Assessment Scale-37

Existence and Asymptotic Behavior of Radially Symmetric Solutions to a Semilinear Hyperbolic System in Odd Space Dimensions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2006年第5期27卷 507-538页

作者： Hideo KUBO Kji kubota Department of Mathematics Osaka University Machikaneyama 1-1ToyonakaOsaka 560-0043Japan Department of Mathematics Hokkaido University Sapporo 060-0810Japan

This paper is concerned with a class of semilinear hyperbolic systems in odd space dimensions. Our main aim is to prove the existence of a small amplitude solution which is asymptotic to the free solution as t →-∞ in the energy norm, and to show it has a free profile as t →＋∞. Our approach is based on the work of [11]. Namely we use a weighted L^∞ norm to get suitable a priori estimates. This can be done by restricting our attention to radially symmetric solutions. Corresponding initial value problem is also considered in an analogous framework. Besides, we give an extended result of [14] for three space dimensional case in Section 5, which is prepared independently of the other parts of the paper.

关键词： Semilinear wave equations Asymptotic behavior Radially symmetric solution

Evolution of Dentary Diastema in Iguanodontian Dinosaurs

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2009年第1期83卷 39-45页

作者： Katsuhiro kubota Yoshitsugu KOBAYASHI Kanna Dinosaur Center Hokkaido University Museum Hokkaido University

The dentary diastema of iguanodontians has been considered to be related to its unique jaw mechanism for herbivorous adaptation. The dentary and diastema lengths of iguanodontians were measured and compared to elucidate the evolution of iguanodontian diastema. A gap in ratios between most non-hadrosaurid iguanodontians and hadrosaurids was observed, suggesting that all non- hadrosaurid iguanodontians, expect for Ouranosaurus nigeriensis and Protohadros byrdi, lack a diastema or have a short diastema, although some other taxa have been considered to have a long diastema in previous studies. In non-hadrosaurid iguanodontians, some large-sized forms, such as Iguanodon bernissartensis, Shuangmiaosaurus gilmorei, and possibly Eolambia caroljonesa, had a short diastema through ontogeny, whereas Ouranosaurus nigeriensis and Protohadros byrdi developed a long diastema convergently. The development of a long diastema of hadrosaurine hadrosaurids may be different from that of lambeosaurine hadrosaurids. Some hadrosaurines （Edmontosaurus annectens, Edmontosaurus regalis, and Saurolophus angustirostris） may have developed a long diastema in the subadult stage and showed little elongation of dentary diastema through ontogeny. Lambeosaurines （Corythosaurus casuarius and Lambeosaurus lambei） tend to have a short diastema in the embryonic and subadult stages, and an elongated diastema from the subadult to adult stages.

关键词： Cretaceous dentary diastema dinosaur iguanodontian ontogeny

Microbial characteristics in anaerobic membrane bioreactor treating domestic sewage:Effects of HRT and process performance

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2022年第1期34卷 392-399页

作者： Jialing Ni Jiayuan Ji Yu-You Li Kengo kubota Department of Civil and Environmental Engineering Graduate School of EngineeringTohoku University6-6-06 AobaAramakiAoba-ku 980-8579SendaiJapan Department of Frontier Science for Advanced Environment Graduate School of Environmental StudiesTohoku University6-6-06 AobaAramakiAoba-ku 980-8579SendaiJapan

Two anaerobic membrane bioreactors(AnMBRs)equipped with different membrane pore size(0.4 or 0.05μm)were operated at 25℃and fed with domestic *** hydraulic retention time(HRT)of the reactors was *** microbial communities of the two AnMBRs were investigated by 16S rRNA gene amplicon sequencing to see the effects of *** predominant Archaea was an aceticlastic methanogen *** composition of hydrogenotrophic methanogens changed with the HRTs:the population of Methanobacterium was higher for longer HRTs,whereas the population of unclassified Methanoregulaceae was higher for shorter *** Anaerolineae,Bacteroidia and Clostridia bacteria were dominant in both of the reactors,with a combined relative abundance of over 55%.The relative abundance of Anaerolineae was proportional to the biogas production *** change in the population of hydrogenotrophic methanogens or Anaerolineae can be used as an indicator for process *** sum of the relative abundance of Anaerolineae and Clostridia fluctuated slightly with changes in the HRT in both AnMBRs when the reactor was stably *** co-occurrence analysis revealed the relative abundance of the operational taxonomic units belonging to Anaerolineae and Clostridia was functionally equivalent during the treatment of real domestic sewage.A principal coordination analysis revealed that the changes in the microbial community in each reactor were consistent with the change of *** addition,both the HRT and the stability of the process are important factors for maintaining microbial community structures.

关键词： Anaerobic membrane bioreactor Co-occurrence analysis Hydrogenotrophic methanogen HRT Microbial community structure Principal coordinate analysis

Optimization of causative factors using logistic regression and artificial neural network models for landslide susceptibility assessment in Ujung Loe Watershed, South Sulawesi Indonesia

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2019年第2期16卷 383-401页

作者： Andang Suryana SOMA Tetsuya kubota Hideaki MIZUNO Faculty of Forestry Hasanuddin University Faculty of Agriculture Kyushu University

Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(ANN) to produce a LSM. The LSM is produced with 11 causative factors and then optimized using forward-stepwise LR(FSLR), ANN, and their combination(FSLR-ANN) until eight causative factors were found for each method. The ANN method produced superior validation results compared with LR. The ROC values for the training data set ranges between 0.8 and 0.9. On the other hand, validation with the percentage of landslide fall into LSM class high and very high, ANN method was higher(92.59%) than LR(82.12%). FSLR-ANN with nine causative factors gave the best validation results with respect to area under curve(AUC) values, and validation with the percentage of landslide fall into LSM class high and very high. In conclusion, ANN was found to be better than LR when producing LSMs. The best Optimization was combination of FSLR-ANN with nine causative factors and AUC success rate 0.847, predictive rate 0.844 and validation with landslide fall into high and very high class with 91.30%. It is an encouraging preliminary model towards a systematic introduction of FSLR-ANN model for optimization causative factors in landslide susceptibility assessment in the mountainous area of Ujung Loe Watershed.

关键词： Optimized causative factor Landslide, Logistic Regression Artificial neural network Indonesia