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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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Carbon-supported CeNCl as an efficient catalyst for CO_(2)cycloaddition

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Nano Research 2025年第1期18卷 157-163页

作者： Li Liu Lingling Zhang xiang Chu Baokang Geng Huilin Wang Zongxiang Li Xiao Wang Shuyan Song Hongjie Zhang School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Sinocare Incorporation Changsha 410221China Department of Chemistry Tsinghua UniversityBeijing 100084China

The cycloaddition reaction of CO_(2)with epoxide not only effectively reduces the concentration of CO_(2)in the atmosphere,but also has excellent industrial application value and up to 100%atom utilization,but there are difficulties in separation and recovery of traditional homogeneous catalysts,harsh reaction conditions of traditional heterogeneous catalysts,and activation of CO_(2)*** this paper,an easily synthesized heterogeneous catalyst CeNCl/C was used to catalyze the cycloaddition reaction of CO_(2)with styrene oxide,with a high yield of 92.7%,a high selectivity of 96.7%,a turnover numbers(TON)value of 349,and a good stability demonstrated in six cycle tests(equivalent to 216 h of testing).Through comprehensive studies,it was shown that CeNCl/C contains Lewis acid-base centers as active centers,which can effectively reduce the energy barrier required for ring opening of the reaction substrate,enhance the adsorption and activation of CO_(2),and promote the formation of intermediates,which led to the acquisition of excellent catalytic activity.

关键词： CO_(2)cycloaddition heterogeneous catalysis CeNCl Lewis acid/base

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Spatial distribution pattern of Picea schrenkiana population in the Middle Tianshan Mountains and the relationship with topographic attributes

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Journal of Arid Land 2012年第4期4卷 457-468页

作者： yutao ZHANG JiMei LI ShunLi CHANG xiang LI JianJiang LU Institute of Forest Ecology Xinjiang Academy of Forestry Urumqi 830000 China Key Laboratory of Oasis Ecology of Ministry of Education Xinjiang University Urumqi 830046 China

The spatial distribution of plant populations is an important feature of population structure and it de- termines the population＇s ecological preferences, biological characteristics and relationships with environmental factors. The point pattern analysis method was adopted to study the distribution pattern of Picea schrenkiana indi- viduals of different size classes and the correlations between two size classes as well as the impact of topog- raphical attributes on the population distribution. With increasing diameter at breast height, the plant density of the P. schrenkiana population showed a declining trend. Old trees showed a random distribution at a small spatial scale （0-12 m）, whereas saplings, small trees and big trees all had an aggregated distribution at all scales. With the increase of tree age, the scales at which maximal aggregation occurred gradually increased and the aggregation strength decreased. At a small scale （0-16 m）, all size classes showed a negative correlation and the larger the difference between tree size, the more significant the negative correlation. The number of medium, big and old trees had a significantly positive correlation with elevations, whereas the number of saplings and small trees was not significantly correlated with elevations. The numbers of saplings, small and medium trees showed a significant positive correlation with slope gradient, whereas the number of big trees was not significantly correlated, and the number of old trees was negatively correlated with gradient. With the exception of old trees, saplings, small, me- dium and big trees showed negative correlations with convexity index. The study provides a theoretical basis for the conservation, rehabilitation and sustainable management of forest ecosystems in the Tianshan Mountains.

关键词： Picea schrenkiana coniferous forest population structure spatial correlation age class topographic attribute

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预防抗精神病药物所致首发精神分裂症患者体重增加的研究现况

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四川精神卫生 2017年第2期30卷 191-195页

作者：蔡东滨杨欣湖郑伟冷传芳向应强宁玉萍李春波项玉涛吴智兵广州中医药大学第一临床医学院广州中医药大学第一附属医院广东广州510405 广州医科大学附属脑科医院广州市惠爱医院广东广州510370 首都医科大学附属北京安定医院北京100088 上海交通大学医学院附属精神卫生中心上海201100 澳门大学

抗精神病药物引起精神分裂症患者的体重增加等代谢异常是临床面临的一大问题,尤其对首发精神分裂症患者。目前有较多的干预方法,包括药物干预措施和非药物干预措施。本课题组通过检索中英文数据库中已发表的关于预防抗精神病药物所致首... 详细信息

抗精神病药物引起精神分裂症患者的体重增加等代谢异常是临床面临的一大问题,尤其对首发精神分裂症患者。目前有较多的干预方法,包括药物干预措施和非药物干预措施。本课题组通过检索中英文数据库中已发表的关于预防抗精神病药物所致首发精神分裂症患者体重增加的随机对照研究,探讨能有效控制体重增加的药物和非药物干预方法。

关键词：预防体重首发精神分裂症综述文献

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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“寒门贵子”是“补偿”还是“选拔”出来的?——对两所精英大学2018—2023年高校专项计划招生的追踪研究

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华东师范大学学报（教育科学版） 2025年第1期43卷 113-126页

作者：金文旺柳夕浪北京师范大学中国教育与社会发展研究院北京100875 山东师范大学教育学部济南250014

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总... 详细信息

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总体规模及变化趋势看,近几年高校专项计划政策力度不断加大,越来越多的寒门子弟进入精英高校。同时,精英大学高校专项计划实际招生呈现“补偿不均,选拔有余”的鲜明特点,经济欠发达、教育发展水平薄弱省域的农村学生和学校在该计划中并未获得更多优质高校入学机会的补偿,一个重要原因在于他们在高校自主选拔和高考选拔中处于劣势。为此,应调整高校专项计划招生办法及相关政策,确立“补偿为主,兼顾选拔”的价值导向并切实付诸实践,推进“实质的公平”。

关键词：高校专项计划补偿选拔教育公平精英大学

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抗精神病药物所致高催乳素血症的相关不良危害

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四川精神卫生 2018年第1期31卷 84-88页

作者：邱允郑伟李先宾杨欣湖蔡东滨胡晋卿张广平项玉涛宁玉萍广州市脑科医院、广州市惠爱医院、广州医科大学附属脑科医院广东广州510370 首都医科大学附属北京安定医院、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室北京100088 广州中医药大学第一临床医学院广东广州510405 澳门大学中国澳门

抗精神病药物所致高催乳素血症(HPRL)是临床面临的一大问题,但人们对HPRL所致不良危害的认识和关注不足。故本课题组总结了近年来国内外抗精神病药物所致HPRL的机制和发生率,从内分泌系统、生殖系统、运动系统、免疫系统、心血管系统和... 详细信息

抗精神病药物所致高催乳素血症(HPRL)是临床面临的一大问题,但人们对HPRL所致不良危害的认识和关注不足。故本课题组总结了近年来国内外抗精神病药物所致HPRL的机制和发生率,从内分泌系统、生殖系统、运动系统、免疫系统、心血管系统和神经系统等方面系统阐述HPRL的相关不良危害,旨在为HPRL所致相关不良危害的早期识别和干预提供参考。

关键词：抗精神病药物高催乳素血症不良危害综述文献

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思想政治教育数字化的价值意蕴及实践进路

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 128-136页

作者：于祥成刘成合肥工业大学安徽合肥230009 武汉大学马克思主义学院湖北武汉430064

随着数字技术的广泛应用和教育数字化转型发展,数字化变革成为思想政治教育创新发展的必然选择。面对新的时代境遇,要全面把握思想政治教育数字化的内涵和特征,深刻认识思想政治教育数字化在推动思想政治教育认知重建、资源重组、话语... 详细信息

随着数字技术的广泛应用和教育数字化转型发展,数字化变革成为思想政治教育创新发展的必然选择。面对新的时代境遇,要全面把握思想政治教育数字化的内涵和特征,深刻认识思想政治教育数字化在推动思想政治教育认知重建、资源重组、话语重构、形态重塑等方面的重要价值。同时,要秉承数字理念,构建思想政治教育数字范式;搭建数字平台,优化思想政治教育数字服务;培育数字素养,提升思想政治教育数字技能;厚植“数字土壤”,形塑思想政治教育数字生态,积极探索思想政治教育数字化实践创新路径。

关键词：思想政治教育数字化数字技术实践进路

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