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Catalytic Asymmetric Reaction Using Fluorous Chiral BINAP

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Catalytic Asymmetric Reaction Using Fluorous Chiral BINAP

Detection of non-typhoid Salmonella infection by citrus and citrus extracts in Lao PDR

中国化学会第九届全国络合催化学术讨论会

作者： yutaka nakamura Seiji Takeuchi Niigata College of Pharmacy Niigata College of Pharmacy

＜正＞In 1994, Horvath and Rabai introduced a fluorous biphasic system（FBS） concept. Because it makes recovering and reusing the precious ligands very simple in homogeneous catalysis, it is attracting more and more attentions of chemists in the world wide. A number of reagents and catalysts bearing appropriate perfluoroalkyl substiruents have been prepared and used in fluorous biphase chemistry. However, only a few reports have been published on asymmetric reactions using fluorous catalysts. The main reason is probably due to the lack of chiral fluorous ligands available such as BINAP.

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 939-942页

作者： yutaka Midorikawa Satoshi nakamura Rattanaphone Phetsouvanh Manivanh Vongsouvaht Kaoru Midorikawa Suzuka University Medical Science Research Institute of National Center for Global Health and Medicine Wellcome Trust-Mahosot Hospital Oxford University Tropical Medicine Research Collaboration Department of Environmental and Molecular Medicine Mie University Graduate School of Medicine

Objective:To know the current state of non-typhoid Salmonella infection in *** examine the usefulness of new screening methods for Salmonella using ***:Non-typhoid Salmonella infection of person in Lao PDR was studied in this research(2004-2009).The site was Vientiane capital city in *** from rural villages locating suburb of Vientiane during 2005-2008 was carried *** villages in Attapu province where ethnic minorities were living was searched for this study in *** this research,to detect Salmonella strain, a new method using citrus and citrus extract named MY phenomenon that observing black ring (MIDO ring) on DHL agar was *** slice lemon and lime were used for this trial in 2004. After 2005,disk of ascorbic acid and citric acid were used for the device instead of citrus fruits ***:During this research,65 of 272 human samples(23.9%) were infected with non- typhoid ***:During this study,the method using citrus and citrus extracts was accepted for the detection of *** study shows that with citrus and citrus extract, detection of Salmonella is possible using only DHL *** suggest that infectious rate of non-typhoid Salmonella was high.

关键词： Non-typhoid Salmonella Citrus MY phenomenon MIDO ring Lao PDR

NICT/ATR Chinese-Japanese-English Speech-to-Speech Translation System

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Tsinghua Science and Technology 2008年第4期13卷 540-544页

作者： Tohru Shimizu yutaka Ashikari Eiichiro Sumita 张劲松 Satoshi nakamura Knowledge Creating Communication Research Center National Institute of Information and Communications Technology ATR Spoken Language Translation Research Laboratories 2-2-2 Keihanna Science City Kyoto 619-0288 Japan

This paper describes the latest version of the Chinese-Japanese-English handheld speech-tospeech translation system developed by NICT/ATR, which is now ready to be deployed for travelers. With the entire speech-to-speech translation function being implemented into one terminal, it realizes real-time, location-free speech-to-speech translation. A new noise-suppression technique notably improves the speech recognition performance. Corpus-based approaches of speech recognition, machine translation, and speech synthesis enable coverage of a wide variety of topics and portability to other languages. Test results show that the character accuracy of speech recognition is 82%-94% for Chinese speech, with a bilingual evaluation understudy score of machine translation is 0.55-0.74 for Chinese-Japanese and Chinese-English

关键词： speech-to-speech translation speech recognition speech synthesis machine translation large-scale corpus

Detection of Non-Typhoidal Salmonella Using a Mechanism for Controlling Hydrogen Sulfide Production

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Open Journal of Medical Microbiology 2014年第1期4卷 90-95页

作者： yutaka Midorikawa Satoshi nakamura Rattanaphone Phetsouvanh Kaoru Midorikawa Department of Hygiene School of Medicine Mie University Tsu Japan Research Institute of National Center for Global Health and Medicine Tokyo Japan Suzuka University of Medical Science Suzuka Japan Wellcome Trust-Mahosot Hospital Oxford University Tropical Medicine Research Collaboration VientianeLaos

To know the relation between NaCl concentration and hydrogen sulfide (H2S) production by MY Phenomenon of Salmonella, we developed a method to control H2S production by Salmonella in this study. Desoxycholate-hydrogen sulfide-lactose (DHL) agar was used as the selective medium for Salmonella. Triple sugar iron (TSI) agar was used as the screening medium. Citric acid disks were placed on DHL agar. NaCl was added to both media. After 24 hours incubation, H2S production on DHL agar was stimulated by citric acid, whereas production was suppressed by adding NaCl. The color change in the bottom of the TSI medium was due to the low production of black FeS. The production of FeS was reduced by lower H2S production by Salmonella with an increasing concentration of NaCl from 0.5% to 3%. The inhibition of the black color meant that the color change due to glucose fermentation could be seen clearly in the bottom of the agar. The current method cannot detect glucose fermentation but the addition of more NaCl to the TSI medium allowed the visualization of glucose fermentation by Salmonella. Although H2S production of salmonella was promoted by citrate etc., being controlled by sodium chloride was proved in this study. Thus, we had developed a possibility of novel technique for the detection of Salmonella etc.

关键词： Salmonella H2S MY Phenomenon MIDO Ring NaCl

Symbiosis of <i>Salmonella</i>and <i>Escherichia coli</i>by MY Phenomenon

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Open Journal of Medical Microbiology 2020年第1期10卷 17-25页

作者： yutaka Midorikawa Satoshi nakamura Yusuke Wakasugi Kaoru Midorikawa Suzuka University Medical Science Suzuka Japan Graduate School of Nursing Science and Faculty of Nursing Hiroshima Bunka Gakuen University Hiroshima Japan Faculty of Child Education Suzuka University Suzuka Japan

Background: The symbiotic relationship between E. coli and Salmonella was demonstrated using hydrogen sulfide production named MY phenomenon, which is a feature of Salmonella. Methods: In order to confirm the hydrogen sulfide production of Salmonella by iron sulfide formation, deoxycholate-hydrogen sulfate-lactose agar medium having both a sulfur source and an iron source was used. The case where Salmonella was cultured alone was compared with the case co-cultured with E. coli. In the case of culture with Salmonella alone, the MY phenomenon has not occurred. When Salmonella was co-cultured with E. coli, Salmonella cultured near E. coli existing place showed a black color named MY phenomenon. When E. coli was cultured alone, it turned red due to the organic acid produced. However, when E. coli was cultured in the part where Salmonella. is inoculated on the surface of the medium, the MY phenomenon appeared there. Furthermore, hydrogen sulfide production was more active in Salmonella co-existing with E. coli. Conclusion: The study shows an important relation that E. coli is a promoting factor for Salmonella culture by NY phenomenon. The relation suggests that bacterial symbiosis relation exist in bacterial flora.

关键词： Symbiosis of Salmonella Escherichia coli Bacterial Symbiosis Bacterial Flora

Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis

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World Journal of Gastroenterology 2015年第6期21卷 1982-1988页

作者： Kenta Baba Akihiko Oshita Mohei Kohyama Satoshi Inoue Yuta Kuroo Takuro Yamaguchi Hiroyuki nakamura Yoichi Sugiyama Tatsuya Tazaki Masaru Sasaki Yuji Imamura yutaka Daimaru Hideki Ohdan Atsushi Nakamitsu Department of Surgery JA Hiroshima General Hospital Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University Department of Pathology JA Hiroshima General Hospital

A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis(CRLM),which involved the right hepatic vein(RHV)and the inferior vena cava(IVC),was referred to our *** metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and *** she had undergone laparoscopic sigmoidectomy for the original tumor,she consequently had 3 courses of modified 5-fluorouracil,leucovorin,and oxaliplatin(m FOLFOX6)plus *** tomography revealed a partial response,and the confluence of the RHV and IVC got free from cancer *** 3 additional courses of m FOLFOX6 plus cetuximab,preoperative percutaneous transhepatic portal vein embolization(PTPE)was performed to secure the future remnant liver ***,a right hemihepatectomy was *** postoperative course was *** patient was discharged from the hospital on postoperative day *** had neither local recurrence nor distant metastasis 18 mo after the last surgical *** multidisciplinary strategy,consisting of conversion chemotherapy using FOLFOX plus cetuximab and PTPE,could contribute in facilitating curative hepatic resection for initially unresectable CRLM.

关键词： Initial y unresectable Colorectal liver metastasis

High-density and wide-bandwidth optical interconnects with silicon optical interposers [Invited]

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Photonics Research 2014年第3期2卷 S0001-S0007页

作者： yutaka Urino Tatsuya Usuki Junichi Fujikata Masashige Ishizaka Koji Yamada Tsuyoshi Horikawa Takahiro nakamura Yasuhiko Arakawa Institute for Photonics-Electronics Convergence System Technology(PECST) Japan Photonics Electronics Technology Research Association(PETRA) West 7 SCR16-1 OnogawaTsukubaIbarakiJapan National Institute of Advanced Industrial Science and Technology West 7 SCR16-1 OnogawaTsukubaIbarakiJapan Institute of Industrial Science The University of Tokyo4-6-1KomabaMeguroTokyoJapan

One of the most serious challenges facing exponential performance growth in the information industry is the bandwidth bottleneck in interchip *** propose a photonics–electronics convergence system in response to this *** demonstrate the feasibility of the system,we fabricated a silicon optical interposer integrated with arrayed laser diodes,spot-size converters,optical splitters,optical modulators,photodetectors,and optical waveguides on a single silicon *** this system,20 Gbps error-free data links and a 30 Tbps∕cm2 bandwidth density were *** bandwidth density is sufficient to meet the interchip interconnect requirements for the late 2010s.

关键词： optical system exponential

Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis

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World Journal of Gastroenterology 2015年第1期21卷 254-261页

作者： Nobuyuki Miyake Takafumi Ando Kazuhiro Ishiguro Osamu Maeda Osamu Watanabe yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya CityAichi 466-8550Japan Department of Gastroenterology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan

AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine ***: We retrospectively reviewed clinical records for 29 patients diagnosed with severe steroid-refractory ulcerative colitis in our hospital from August 1997 to August 2008 and treated with cyclosporine by continuous intravenous *** patients were treated with intravenous corticosteroids for more than 5 d prior to cyclosporine *** was continued for up to 21 d under serum monitoring to maintain cyclosporine levels between 400 and 600 ng/*** activity was assessed before and after cyclosporine therapy using the clinical activity index score,with a reduction of ≥ 5 considered to indicate a *** responders,we defined cases not requiring surgery for more than 5 years as exhibiting long-term efficacy of *** considered to be possibly predictive of long-term efficacy of cyclosporine were sex,age,disease duration,clinical activity index score,C-reactive protein level,hemoglobin level,disease extent,endoscopic findings,and clinical ***: Cyclosporine was not discontinued due to side effects in any ***(65.5%) of 29 patients were considered responders.A statistically significant(P = 0.004) inverseas sociation wa s observed between an endoscopic finding of "mucosal bleeding" and responsive ***(9 males,6 females) of these 19 patients were followed for 5 years or more,of whom 9(60%) exhibited long-termefficacy of *** the 10 non-responders,9(90%) underwent surgery within 6 mo of cyclosporine *** of the following factors had a significant impact on the long-term efficacy of cyclosporine: sex,age,duration of disease,clinical activity index score,C-reactive protein level,hemoglobin level,extent of disease,endoscopic findings,or clinical *** contrast,a significant association was observed for maintenance therapy with azat

关键词： Ulcerative colitis Cyclosporine Maintenance therap

NICT-ATR Chinese-Japanese-English Speech-to-Speech Translation System

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NICT-ATR Chinese-Japanese-English Speech-to-Speech Translati...