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Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival

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World Journal of Gastroenterology 2006年第1期12卷 48-53页

作者： Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka yutaka matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Department of Gastroenterology Maebashi Red Cross HospitalMaebashiGunma 371-0014Japan Department of Internal Medicine Isesaki Municipal HospitalIsesakiGunma 372-0817Japan Department of Internal Medicine Kiryu Kousei General HospitalKiryuGunma 376-0024Japan Department of Internal Medicine Tone Chuo HospitalNuraataGunma 378-0053Japan Department of Gastroenterology National Nishigunma HospitalShibukawaGumna 377-0027Japan Department of Gastroenterology Saiseikai Maebashi HospitalMaebashiGunma 371-0821Japan Department of Gastroenterology Public Tomioka General HospitalTomiokaGunma 370-2361Japan Department of Internal Medicine Fuji Heavy Industries Ltd.Health Insurance Society General Ota HospitalOtaGunma 373-0056Japan Department of Gastroenterology Shimada Memorial HospitalFujiokaGunma 375-0024Japan

AIM： To identify the clinical and prognostic features of patients with hepatocellular carcinoma （HCC） aged 80 years or more. METHODS： A total of 1310 patients with HCC were included in this study. Ninety-one patients aged 80 years or more at the time of diagnosis of HCC were defined as the extremely elderly group. Two hundred and thirty-four patients aged 〉/ 50 years but less than 60 years were regarded as the non-elderly group. RESULTS： The sex ratio （male to female） was significantly lower in the extremely elderly group （0.90：1） than in the non-elderly group （3.9：1, P〈 0.001）. The positive rate for HBsAg was significantly lower in the extremely elderly group and the proportion of patients negative for HBsAg and HCVAb obviously increased in the extremely elderly group （P〈 0.001）. There were no significant differences in the following parameters： diameter and number of tumors, Child-Pugh grading, tumor staging, presence of portal thrombosis or ascites, and positive rate for HCVAb. Extremely elderly patients did not often receive surgical treatment （P 〈 0.001） and they were more likely to receive conservative treatment （P〈 0.01）. There were no significant differences in survival curves based on the Kaplan-Meier methods in comparison with the overall patients between the two groups. However, the survival curves were significantly worse in the extremely elderly patients with stage Ⅰ/Ⅱ, stage Ⅰ/Ⅱ and Child-Pugh grade A cirrhosis in comparison with the non-elderly group. The causes of death did not differ among the patients, and most cases died of liverrelated diseases even in the extremely elderly patients. CONCLUSION： In the patients with good liver functions and good performance status, aggressive treatment for HCC might improve the survival rate, even in extremely elderly patients.

关键词： Hepatocellular carcinoma Extremely elderly patients Survival analysis Cause of death

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Review:effects of wind on trees

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Journal of Forestry Research 2004年第2期15卷 153-160,i003,i004页

作者：朱教君刘足根 matsuzaki Takeshi Gonda yutaka Gonda yutaka 中国科学院沈阳应用生态研究所沈阳110016中国中国科学院研究生院北京100039中国日本国立新泻大学农学部 950-2181新泻日本 Faculty of Agriculture Niigata UniversityNiiigata950-2181Japan

Wind not only causes extensive damages to trees in many parts of the world, it also has more subtle effects on the growth and morphology of trees and forest ecology as well. Wind damage to trees has historically been the field of silviculture, but increasing recognition of the importance and complexity of the subject has recently got people involved from many other disciplines. Due to the global climate changes, it is believed that the risk of further and stronger storms is increasing. In order to better understand the effects of wind on individual trees, forest stand and forest ecosystem, and further to practice the management of forests, it is necessary to summarize the research results related to this subject. This review was mostly based on the references from recent researches in the field, especially from the symposium volumes of some international conferences on this subject. The results indicated that there have been significant progresses in the following aspects: 1) the aerodynamic interaction between wind and trees, 2) the mechanics of trees under wind loading and adaptive growth, 3) the tree's physiological responses to wind, and 4) the risk assessment of wind damage to forest. However, there are some aspects which may need further studies: 1) wind damage to natural forests, 2) wind-driven gap formation and forest dynamics, 3) the effects of changes resulted from wind disturbances on ecological processes of forest ecosystem, and 4) management for the wind-damaged forests. Key words Wind - Wind effect - Trees/forest - Forest ecology - Disturbance CLC number S718 Document code B Foundation item: This research was supported by “the 100-Young-Researcher Project” of Chinese Academy of Sciences (BR0301) and National Natural Science Foundation (30371149).Biography: ZHU Jiao-jun (1965-), male, Ph. Doctor, Professor of Institute of Applied Ecology, Chinese Academy of Sciences, Professor of Graduate School of Chinese Academy of Sciences. China. Schola

关键词： Wind Wind effect Trees/forest Forest ecology Disturbance

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Wind profiles in and over trees

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Journal of Forestry Research 2004年第4期15卷 305-312页

作者： ZHU Jiao-jun LI Xiu-fen Gonda yutaka matsuzaki Takeshi Institute of Applied Ecology Chinese Academy of SciencesShenyang110016P.R.China Gratuate School Chinese Academy of Sciences Beijing100039P.R.China Faculty of Agriculture Niigata UniversityNiigata950-2181Japan

One of the most important and frequently studied variable in forests and the most basic element in governing transport processes of airflow is wind speed. The study of wind profile, defined as the change of wind velocity with height, and wind ve-locity are important because of tree physiological and developmental responses. Generally, wind profiles above the ground or at a canopy surface follow classical logarithm law, but wind profiles in a single tree and in a forest stand are not logarithmic. This paper summarizes the results of wind profile studies within a single tree, in a forest stand, above the forest canopy and in a forest area from recent research in a coastal pine forest. The results demonstrate that: 1) wind profiles with in a single conifer tree crown showed an exponential function with height, 2) wind profiles in forest stands were able to be expressed by attenuation coefficient of wind, 3) wind profiles over a forest canopy could be determined using profile parameters (friction velocity, rough-ness length and displacement), and 4) for a forest area, the extreme wind speed could be predicted reasonably using the methods developed for the design of buildings. More research will be required to demonstrate: 1) relationships between wind profiles and tree or stand characteristics, 2) the simple methods for predicting wind profile parameters, and 3) the applications of wind profile in studies of tree physiology, forest ecology and management, and the detail ecological effects of wind on tree growth.

关键词： Wind Wind profile Trees Forest ecology

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Effects of thinning on wind damage in Pinus thunbergii plantation ——Based on theoretlcal derlvation of risk—ratios for assessing wind damage

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Journal of Forestry Research 2003年第1期14卷 1-8页

作者： ZHUJiao-jun LIFeng-qin Condayutaka Takeshimatsuzaki MasashiYamamoto InstituteofAppliedEcology ChineseAcademyofSciencesShenyang110016P.R.China FacultyofAgriculture NiigataUniversityNiiigata950-2181Japan

Based on paper of "Theoretical derivation of risk-ratios for assessing wind damage in coastal forest",wind damage in the pine coasteal forest,which was thinned at four levels in December of 1997,was investigated for four successive growing *** wind damage,the wind profiles outside and inside the coastal forest stand and the distributions of optical stratification porosity (OSP) were also *** on these data,risk-ratios of wind damage for both individual trees and stands were estimated according to the methods developed in "Theoretical derivation of risk-ratios for assessing wind damage in a coastal forest".The results showed that risk-ratios of wind damage,which were calculated from the meen height and diameter only and from the combination of wind and stand sructure profiles,accurately predicted wind damage in the *** between different thinning ratios and incidence of wind damage showed that stand stability decreased soon after the *** was due to the immediate effects of thinning on increasing the canopy roughness and wind load,and on decreasing the sheltering effects from surrounding ***,thinning strategies could improve the stability by long-term effects on growthand development of trees against extreme *** canopy damage was recorded during the experimental period,no stem damage was found,even though the maximum 10-min wind speed outside the coastal forest attained 30.2m s^-*** results obtained in this study indicate that thinning is the most effective silvicultural strategy available for managing coastal forest despite the increased probability of wind damage soon after thinning.

关键词：黑松林风害风险系数理论沿海防护林防风效益

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