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Oocyte Cryopreservation before Tumorectomy in Gorlin-Goltz Syndrome with Recurrent Ovarian Fibroma: A Case Report

Open Journal of Obstetrics and Gynecology 2018年第10期8卷 836-846页

作者： Makoto Chihara Atsushi Fujimoto Kanna Ogi Tatsuya Ishiguro Kunihiko Yoshida Masayuki Sekine Koich Takakuwa Hiroki Fujikawa yutaka Shimomura Takayuki Enomoto Department of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Obstetrics and Gynecology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Dermatology Yamaguchi University Graduate School of Medicine Yamaguchi Japan

Background: Gorlin-Goltz syndrome is a very rare syndrome that reportedly occurs in 1 of 235,800 people in Japan. The proportion of women with Gorlin-Goltz syndrome complicated with an ovarian fibroma ranges from 12.5% to 17.0%. Some surgical cases of Gorlin-Goltz syndrome with an ovarian tumor have been reported. However, no studies have mentioned subsequent fertility preservation by using oocyte cryopreservation process. Case: In this case report, the patient with Gorlin-Goltz syndrome underwent laparotomy for bilateral ovarian fibrothecoma at 15 years of age. At 20 years of age, a recurrent ovarian tumor was detected in the remaining ovary. During the follow-up, we detected an increase in its size. As tumor torsion requiring left salpingo-oophorectomy was possible, tumorectomy was considered. However, her anti-Müllerian hormone level was low. As she was at risk for premature ovarian failure after tumorectomy, we planned to cryopreserve her oocytes to preserve her fertility before tumorectomy. Outcome: When the patient underwent surgery, the diameter of her left ovarian tumor was found to have increased to 56 mm. Egg collection was performed twice, and two oocytes were cryopreserved. Subsequently, she underwent tumorectomy of the left ovarian tumor. No recurrence has been observed. Conclusion: If a recurrent ovarian tumor is detected in patients with Gorlin-Goltz syndrome and a low anti-Müllerian hormone level, cryopreservation of oocytes before tumorectomy may be effective for preserving their fertility.

关键词： Case Reports Cryopreservation Fibroma Gorlin-Goltz Syndrome Recurrence

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Isoleucine, an Essential Amino Acid, Induces the Expression of Human <i>β</i>Defensin 2 through the Activation of the G-Protein Coupled Receptor-ERK Pathway in the Intestinal Epithelia

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Food and Nutrition Sciences 2012年第4期3卷 548-555页

作者： Youkou Konno Toshifumi Ashida Yuhei Inaba Takahiro Ito Hiroki Tanabe Atsuo Maemoto Tokiyoshi Ayabe Yusuke Mizukami Mikihiro Fujiya yutaka Kohgo Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medical University Asahikawa Japan IBD Center Sapporo Higashi Tokushukai Hospital Sapporo Japan Innate Immunity Laboratory Department of Cellular Life Science Faculty of Advanced Life Science Hokkaido University Sapporo Japan

Anti-microbial peptides are essential for the intestinal innate immunity that protects the intestinal epithelia from attacks by foreign pathogens. Human β-defensin (HBD) is one of the pivotal anti-microbial peptides that are expressed in the colonic epithelia. This study investigated the effect and the signaling mechanism of inducible β-defensin HBD2 by an essential amino acid, isoleucine (Ile) in colonic epithelial cells. Here we examined the expression level of HBD2 on induction of Ile in epithelial cells, and checked this pathway. HBD2 mRNA was induced by co-incubation with IL-1α and Ile in Caco2 cells, but not by Ile alone. An inhibitor of either ERK or Gi, a subunit of G-proteins, reduced the induction of HBD2 mRNA by Ile. The treatment with Ile also increased the intracellular calcium ion concentration, thus suggesting that the GPCR and ERK signaling pathway mediate the effects of Ile. These results indicate that an essential amino acid, Ile, enhances the expression of an inducible β-defensin, namely HBD2, by IL-1α through the activation of GPCRs and ERK signaling pathway. The administration of Ile may therefore represent a possible option to safely treat intestinal inflammation.

关键词： Isoleucine Human β-Defensin G-Protein Coupled Receptor Extracellular Signal-Regulated Kinases Pathway Inflammatory Bowel Disease Crohn’s Disease

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Efficacy of Postoperative Adjuvant Chemotherapy According to Prognostic Factor in Patients with Stage III Colon Cancer

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Journal of Cancer Therapy 2014年第8期5卷 806-816页

作者： Kiichi Sugimoto Kazuhiro Sakamoto Yuichi Tomiki Michitoshi Goto yutaka Kojima Hiromitsu Komiyama Makoto Takahashi Shun Ishiyama Koichiro Niwa Haruna Okubo Department of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan

Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: Two hundred and thirty four patients with lymph node metastases who underwent curative surgery for colon cancer between 1999 and 2005 were enrolled in the present study. Firstly, clinicopathological factors and survival data, were analyzed to determine prognostic factors related to cancer-specific survival. Secondly, we examined the effectiveness of postoperative adjuvant chemotherapy based upon these prognostic factors. Results: The multivariate analysis revealed that differentiation (P = 0.03, Hazard ratio = 2.50), lymphatic invasion (P = 0.02, Hazard ratio = 3.23) and the TNM classification, 7th?edition (P = 0.04, Hazard ratio = 1.94) were found to be significant independent prognostic factors. Among the patients classified as TNM IIIA, the recurrence-free survival rates were extremely good. Among the patients classified as IIIB and IIIC, there was no significant difference between the patients with and without postoperative adjuvant chemotherapy. Conclusion: The present study suggests that the patients with Stage IIIA colon cancer may not require postoperative adjuvant chemotherapy. The addition of oxaliplatin to 5-FU should be considered for the patients with Stage IIIB and IIIC colon cancer, for whom the prognoses are far from satisfactory.

关键词： Colorectal Cancer Postoperative Adjuvant Chemotherapy Prognostic Factor Stage III Colon Cancer TNM Classification 7th Edition

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Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature

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World Journal of Gastroenterology 2019年第15期25卷 1899-1906页

作者： Takahiro Yokose Hideaki Obara Masahiro Shinoda yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine Division of Hematology Department of Medicine Keio University School of Medicine

BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and *** This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation.

关键词： Cytomegalovirus gastrointestinal disease Colon perforation Antigenemia negative Liver transplantation Case report

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华南中生代岩浆活动研究：现状和前景

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地质学报 2013年第S1期 137-138页

作者：毛建仁叶海敏厉子龙赵希林刘凯李寄嵎 yutaka Takahashi Weon-Seo KEE 南京地质矿产研究所浙江大学地质系地球科学系台湾大学地质科学系日本产业技术研究院地质和地质情报研究所大韩民国韩国地质资源研究院

1研究现状1.1华南地质构造的复杂性华南地质构造的复杂性在于华南陆块周边存在印支陆块、华北陆块、太平洋板块和印度陆块的围限。华南是由扬子、华夏三大陆块于不同时期碰撞拼合而成,最近的研究发现华夏陆块由5-6个元古代块体拼合而成...

1研究现状1.1华南地质构造的复杂性华南地质构造的复杂性在于华南陆块周边存在印支陆块、华北陆块、太平洋板块和印度陆块的围限。华南是由扬子、华夏三大陆块于不同时期碰撞拼合而成,最近的研究发现华夏陆块由5-6个元古代块体拼合而成(许效松等,2012)。控制亚洲显生宙构造演化的三大动力体系(古亚洲洋体系,

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Novel procedure for hepatic venous outflow block after liver resection:A case report

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World Journal of Clinical Cases 2024年第29期12卷 6320-6326页

作者： Hisanobu Higashi Yuta Abe Kodai Abe yutaka Nakano Masayuki Tanaka Shutaro Hori Yasushi Hasegawa Hiroshi Yagi Minoru Kitago Yuko Kitagawa Department of Surgery National Hospital Organization Saitama HospitalWako 351-0102Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Postoperative complications like remnant hepatic vein(HV)outflow block and liver torsion can occur after right *** falciform ligament fixation is typically used to prevent liver *** report a novel procedure to manage outflow *** SUMMARY An 80-year-old man developed HV outflow block after remnant right hepatectomy,despite liver fixation and intraoperative HV flow *** had a history of cholangiocellular carcinoma and had undergone posterior segmentectomy and *** falciform ligament fixation was inadequate to maintain liver *** surgery was performed,using an omental flap and mobilized right side colon with ileocecal region to prevent liver dislocation due to intraabdominal *** postoperative course was *** This is the first report providing a novel surgical procedure when the falciform ligament is insufficient for remnant liver fixation.

关键词： Hepatectomy Postoperative complications Budd-Chiari syndrome Hepatic vein outflow block Emergency surgery Case report

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炼铁系统碳循环的可行性研究

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世界钢铁 2014年第5期14卷 1-6页

作者： Yukitaka Kato Arnoldus Lambertus Dipu yutaka Ujisawa 袁兵东京工业大学住友金属工业株式会社

一种基于碳循环的新型能源交换系统被认为是零CO2排放。这种能源系统被称为活性碳循环能源系统,简称ACRES。基于热力学对炼铁系统使用活性碳循环能源系统的可行性进行了讨论。活性碳循环能源系统包含三个部分,即CO2的回收、分离,以及从... 详细信息

一种基于碳循环的新型能源交换系统被认为是零CO2排放。这种能源系统被称为活性碳循环能源系统,简称ACRES。基于热力学对炼铁系统使用活性碳循环能源系统的可行性进行了讨论。活性碳循环能源系统包含三个部分,即CO2的回收、分离,以及从CO2中进行碳材料的再生和再生碳材料的使用。活性碳循环能源系统使用初级能源,不会释放CO2,这如同可再生能源和核能。在活性碳循环能源系统中含碳物质作为能源载体,并被重复循环使用。与使用氢能源系统相比,活性碳循环能源系统在热力学方面是可行的。CO的能量密度高于氢气,而且CO与传统炼铁工艺具有较高的兼容性。因此,在活性碳循环能源系统中,CO是适宜的循环介质。用碳作为介质的活性碳循环能源系统其可行性是基于热焓分析来评估的。CO的有效再生是建立活性碳循环能源系统的一个关键技术。评价了基于CO2氢化而获得CO再生方法的能源平衡,该再生过程需要超过800℃的热量输入。高温过程产生的800℃左右的剩余热量可用于反应。高温气体冷却反应堆可作为一种备用的初级能源。探讨了用氢还原CO2的活性碳循环能源系统在炼铁系统中应用的可行性。活性碳循环能源系统有望成为新型低CO2排放炼铁工艺的基础。

关键词：碳循环二氧化碳还原一氧化碳氢气炼铁工艺

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Patterns of Blood Supply and Venous Drainage in Pediatric Intralobar Pulmonary Sequestration: A Retrospective Analysis of 30 Pediatric Cases from a Single Center

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Open Journal of Pediatrics 2016年第4期6卷 274-279页

作者： Toshiko Takezoe Kazunori Tahara Toshihiko Watanabe Michinobu Ohno Kazuteru Kawasaki Masataka Higuchi Motomi Matsuo Shunsuke Nosaka Osamu Miyazaki Yoshiyuki Tsutsumi yutaka Kanamori Division of Surgery Department of Surgical Specialties National Center for Child Health and Development Tokyo Japan Division of Pulmonology Department of Medical Subspecialties National Center for Child Health and Development Tokyo Japan Department of Radiology National Center for Child Health and Development Tokyo Japan

Purposes: Intralobar pulmonary sequestration is a rare congenital anomaly that causes nonspecific respiratory symptoms. This report presented our surgical experience for pediatric cases of intralobar pulmonary sequestration in our institute. Methods: Between 2002 and 2014, 30 pediatric patients with intralobar pulmonary sequestration underwent lobectomy. The clinical characteristics of patients were retrospectively analyzed using medical records and imaging data. Results: The median age at operation was 23 months. The sequestered lung was situated in the right lower lung in 15 cases and in the left lower lung in 15 cases. Eight cases were prenatally diagnosed by fetal ultrasound and magnetic resonance imaging. One aberrant artery was seen in 26 cases and two aberrant arteries in 4 cases. The drainage vein from the sequestered lung was: 1) the pulmonary vein in 27 cases;2) the inferior vena cava in 1 case;and 3) the azygos vein and the pulmonary vein in 2 cases. All patients underwent lower lobectomy of the affected side without postoperative early and long-term complications. Conclusion: Due to the increased rate of prenatal diagnoses, the age at operation has decreased. With respect to safety, it is vital to ascertain the number of aberrant arteries and the venous drainage route before lobectomy.

关键词： Intralobar Pulmonary Sequestration Aberrant Artery Prenatal Diagnosis

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低温等离子体轰击法对薄膜高分子聚合体表面特性影响的研究

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实用口腔医学杂志 2008年第4期24卷 525-528页

作者：魏建华 Masao Yoshinari 马威张浚睿封兴华刘宝林 yutaka Oda 西安第四军医大学口腔医学院颌面外科 710032 日本东京齿科大学·齿科理工学讲座第四军医大学口腔医学院口腔种植科

目的:研究使用氧和氮等离子体轰击法对六甲基二硅氧烷(硅醚)聚合体表面特性的影响。方法:使用薄膜等离子体聚合法在圆形盖玻片表面生成六甲基二硅氧烷薄膜聚合体,然后用低温氧和氮等离子体轰击聚合体表面,测量不同轰击时间对薄膜聚合体... 详细信息

目的:研究使用氧和氮等离子体轰击法对六甲基二硅氧烷(硅醚)聚合体表面特性的影响。方法:使用薄膜等离子体聚合法在圆形盖玻片表面生成六甲基二硅氧烷薄膜聚合体,然后用低温氧和氮等离子体轰击聚合体表面,测量不同轰击时间对薄膜聚合体表面润湿性、粗糙度、表面形貌的影响,用XPS检测表面基团组成的变化。结果:六甲基二硅氧烷薄膜聚合体表面经过氧及氮低温等离子体轰击后,随着轰击时间的延长,聚合体表面接触角显著降低,XPS结果表明O/C比例显著上升,显示COOH基团增多。结论:氧和氮等离子体轰击法可以明显增加六甲基二硅氧烷薄膜聚合体表面亲水基团的含量,表现为表面润湿性显著增高。

关键词：表面特性等离子体聚合物接触角等离子体轰击法

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Correction to: Performance Evaluation and Social Optimization of an Energy-Saving Virtual Machine Allocation Scheme within a Cloud Environment

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Journal of the Operations Research Society of China 2023年第4期11卷 981-981页

作者： Wang, Xiushuang Zhu, Jing Jin, Shunfu Yue, Wuyi Takahashi, yutaka School of Information Science and Engineering Yanshan University Qinhuangdao China Department of Intelligence and Informatics Konan University Kobe Japan Graduate School of Informatics Kyoto University Kyoto Japan

The authors would like to correct the style of their names in the original publication. The correct style of author names is provided in this correction.

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