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Synthesis and TEM structural characterization of C60-flattened carbon nanotube nanopeapods

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Nano Research 2014年第12期7卷 1843-1848页

作者： Qing Wang Ryo Kitaura yuta yamamoto Shigeo Arai Hisanori Shinohara Department of Chemistry & Institute for Advanced Research Nagoya University Nagoya 464-8602 Japan High Voltage Electron Microscope Laboratory Ecotopia Science Institute Nagoya University Nagoya 464-8602 Japan

A fully flattened carbon nanotube （FNT）, a graphene nanoribbon （GNR） analogue, provides a hollow space at edges for endohedral doping. Due to the unique shape of the hollow space of FNTs, novel types of low-dimensional arrangements of atoms and molecules can be obtained through endohedral doping into FNTs, which provides a new type of nanopeapods. FNT-based nanopeapods have been synthesized through endohedral doping of C60, and their structural characterization with transmission electron microscopy （TEM） performed. The doping of C60 into the inner hollow space of FNTs has been carried out via the gas-phase filling method, where open-ended FNTs are sealed in a glass ampoule and heated at 723-773 K for two days. TEM observations show that most of the encapsulated C60 molecules align as single molecular chains along the edges of FNTs and that some of the C60 forms two-dimensional close-packed structures inside FNTs.

关键词： carbon nanotubes nanopeapods endohedral doping electron microscopy

Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib

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Journal of Pharmaceutical Analysis 2019年第1期9卷 49-54页

作者： Rintaro Sogawa Tetsuya Saita yuta yamamoto Sakiko Kimura yutaka Narisawa Shinya Kimura Masashi Shin Department of Pharmacy Saga University Hospital Applied Life Science Department Faculty of Biotechnology and Life Science Sojo University Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University

Afatinib is an oral tyrosine kinase inhibitor(TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple quantification method for TKIs in order to facilitate therapeutic drug monitoring(TDM) in clinical settings. This study sought to develop a simple and sensitive competitive enzyme-linked immunosorbent assay(ELISA) to quantify afatinib in plasma for routine pharmacokinetic applications. An anti-afatinib antibody was obtained using(S)-N-4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)-quinazoline-4,6-diamine(CTQD), which has the same substructure as afatinib, as a hapten. Enzyme labeling of afatinib with horseradish peroxidase was similarly performed using CTQD. A simple competitive ELISA for afatinib was developed based on the principle of direct competition between afatinib and the enzyme marker for the anti-afatinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Plasma afatinib concentrations below the limit of quantification of 30 pg/mL were reproducibly measurable. Also, the values of plasma afatinib levels measured from 20 patients were comparable with those measured by high-performance liquid chromatography, and there was a strong correlation between the values determined by both methods(Y=0.976 X – 0.207, r=0.975). As indicated by its specificity and sensitivity, this newly developed ELISA for afatinib is an important tool for TDM and studies of the pharmacokinetics of afatinib.

关键词： Afatinib Enzyme-linked immunosorbent assay Therapeutic drug monitoring Tyrosine-kinase inhibitor

Comparison of strength values and laterality in various muscle contractions between competitive swimmers and untrained persons

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Health 2010年第11期2卷 1249-1254页

作者： Shinichi Demura Hiroki Aoki yuta yamamoto Shunsuke Yamaji 不详

Competitive swimmers may gain a specific training effect as the result of long term exercise in the water. This study aimed to compare isometric, non-isokinetic and isokinetic muscle strengths in competitive swimmers and untrained persons. Twelve young male adults without exercise experience for over three years and twelve swimmers with over 10 years of competitive swimming experience performed various strength tests. Non-isokinetic tests were evaluated using one repetition of maximum half squat, vertical jump, and drop jump. Isometric and isokinetic (60 and 180 deg/s) muscle strengths were measured by both legs in knee extension and flexion. There were no significant differences between non-isokinetic and isometric muscle strengths of both groups. On the other hand, all isokinetic parameters in both angular velocities were significantly larger in competitive swimmers. There was significant laterality of isokinetic strength in untrained persons, but not in competitive swimmers. In addition, right and left differences of isokinetic strength tended to be smaller in competitive swimmers. In conclusion, competitive swimmers tended to be superior only in isokinetic strength, which is a similar muscle contraction in the water, and have less right and left differences.

关键词： Lsokinetic Strength Lsometric Strength Knee Extension and Flexion Laterality

Comparison of stepping parameters and center of foot pressure properties during different tempo stepping movements

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Health 2012年第10期4卷 832-837页

作者： Shunsuke Yamaji Shinichi Demura Sohee Shin Hiroki Aoki yamamoto yuta Faculty of Medical Sciences University of Fukui Fukui Japan Graduate School of Natural Science & Technology Kanazawa University Kanazawa Japan Kanazawa College of Art Kanazawa Japan Kanazawa Gakuin High School Kanazawa Japan School of Medicine Gifu University Gifu Japan

This study was designed to examine the trial-to-trial reliability of stepping parameters and to compare the center of foot pressure (COP) when adapting to different tempos. Twenty healthy men (M age = 20.8, SD = 1.9 years) performed stepping tests to fixed tempos. The intra-class correlation coefficients of stepping and COP parameters were high (0.75 - 0.97). The time difference between foot contact time and fixed tempo and COP sway velocities of the X- and Y-axis were the largest at 40 beats per minute (bpm). At 60 and 120 bpm tempos, single support and swing times reflecting the stepping strategy correlated significantly with the root mean square and the velocity of the X-axis (r = I0.45 - 0.53I) . Because these step tempos are controlled largely by the automation of stepping, the single support and swing phases appeared to have a constant frequency. On the other hand, a stepping tempo of 40 bpm showed the largest sway velocity of X and Y and the smallest surrounding area mean path length. The above suggests that stepping at 40 bpm induced a larger sway area in relation to total path length and faster COP sway. Hence, it is inferred that the stepping task becomes more difficult at 40 bpm than at 60 and 120 bpm.

关键词： Dynamic Balance Trial-to-Trial Reliability Fall Prevention

Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： yuta Ihara Hiroshi Yamagishi Masanobu Naito Yohei yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

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Research in Astronomy and Astrophysics 2021年第5期21卷 43-70页

作者： yuta Ito Department of Physics The Graduate Center of CUNY365 Fifth AvenueNew YorkNY 10016USA Department of Physics and Astronomy The College of Staten Island of CUNY2800 Victory BoulevardStaten IslandNY 10314USA

Fitting parametric models to globular clusters’structural profiles has been essential for the study of stellar *** provides their important structural parameters,such as the concentrations and core radii of the ***,existing parametric models can apply only to non-collapsing-core clusters in the early relaxation-evolution ***,a single parametric model cannot provide globular clusters’structural parameters in both the early and late evolution *** have recently found an accurate spectral solution for the self-similar orbit-averaged Fokker-Planck(OAFP)equation to model collapsingcore clusters at the late evolution *** present work establishes a new parametric model by combining the self-similar OAFP-and *** it is a single-mass and isotropic model,the new model applies to at least fifty-five Galactic globular clusters with resolved cores in all the evolution *** a main result,we show the characteristics of the relaxation times against the concentrations of the *** also affirm that the structures of low-concentration clusters are polytropic in the Milky Way.

关键词： (Galaxy:)globular clusters:general Galaxy:kinematics and dynamics methods:numerical

Drag-reduction behavior of an unusual nonionic surfactant in a circular pipe turbulent flow

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Journal of Hydrodynamics 2014年第3期26卷 400-405页

作者：蔡书鹏 HIGUCHI yuta Institute of High Pressure Water Jet Hunan University of Technology Graduate School of Science and Technology Kobe University

The Alkyl Polyglucoside（APG） is a nonionic surfactant with no toxicity and with high biodegradability, its drag-reduction behavior in a circular pipe flow is measured, and the rheological characteristics are investigated with a rheometer with a cone-plate flow cell. From the measured results, the APG is shown to have a high drag-reduction capacity, whose shear viscosity is shear-ratedependent at high concentrations, while its solution at concentrations with drag-reduction effects is non-viscoelastic as verified by zero relaxation time in the relaxation process of the shear stress, which contradicts the general viewpoint that there is a correlation between the viscoselastic characteristics and the turbulent drag reduction for the drag-reduction surfactant. However, the APG solution is birefringent as observed through a birefringent test, which indicates that there are rod-shaped micelles in the solution under the shearing flow. The higher extensional viscosity inferred from the extensional phenomenon observed in the measurements of the shear viscosity could be responsible for the drag reduction property of this nonionic surfactant.

关键词： drag reduction shear stress relaxation relaxation time viscoelasticity

Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio

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International Journal of Oral Science 2017年第4期9卷 200-209页

作者： nanami yamamoto koji kawaguchi hisako fujihara mitsuhiko hasebe yuta kishi masaaki yasukawa kenichi kumagai yoshiki hamada department of oral and maxillofacial surgery school of dental medicinetsurumi universityYokohamaJapan department of oral hygiene tsurumi junior collegeYokohamaJapan

The autofluorescence visualization method （AVM） uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss （FVL）. In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma （SCC） were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope （VELscope）, and the iodine-staining method was then performed. After biopsy, the histopathological results and the luminance ratio between the lesion and healthy tissue were compared, and a receiver operating characteristic curve was created. The cutoff value for the objective AVM was determined; the lesion was considered FVL-positive or -negative when the luminance ratio was higher or lower than the cutoff value, respectively. The histopathological diagnoses among the 79 specimens were SCC （n = 30）, leukoplakia with dysplasia （n = 34）, and leukoplakia without dysplasia （n= 15）. The cutoff value of the luminance ratio was 1.62, resulting in 66 FVL-positive and 13 FVL-negative specimens. The luminance ratio was significantly higher in the epithelial dysplasia-positive than -negative group （P〈O.O00 1）. The objective AVM showed much higher consistency between histopathological results than did the two methods （kappa statistic = 0.656）. In conclusion, objective autofluorescence visualization has a potential as an auxiliary method for diagnosis of epithelial dysplasia.

关键词： autofluorescence epithelial dysplasia oral cancer Visually Enhanced Lesion scope

Allergic reaction to anisakis-contaminated fish after the first administration of BNT162b2 mRNA vaccine:a case report

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Gastroenterology Report 2022年第1期10卷 650-652页

作者： Fumiue Harada Kana yamamoto Tomoki Matsuda Chika yamamoto yuta Tani Mutsuko Ohnishi Morihito Takita Tetsuya Tanimoto Masahiro Kami Ryusaburo Shineha Department of Internal Medicine Soma Central HospitalSomaFukushimaJapan Department of Disaster and Comprehensive Medicine Fukushima Medical UniversityFukushimaFukushimaJapan Department of Radiation Health Management Fukushima Medical UniversityFukushimaFukushimaJapan Research Division Medical Governance Research InstituteMinatoTokyoJapan

Introduction SARS-CoV-2 vaccination is an effective means to prevent severe illness and death due to SARS-CoV-2 infection[1].Vaccine safety has been carefully monitored to be sure that the benefit outweighs the risk of adverse events(AEs).Common AEs of the BNT162b2 mRNA vaccine,for example,include fatigue(45%),headache(40%),and chills(28%)after the first administration in accordance with the adult phase Ⅲ clinical trial[1].

关键词： headache death administration