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Borderline resectable for colorectal liver metastases:Present status and future perspective

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 756-763页

作者： Yuki Kitano Hiromitsu Hayashi Takashi Matsumoto Shotaro Kinoshita Hiroki Sato yuta shiraishi Yosuke Nakao Takayoshi Kaida Katsunori Imai Yo-ichi Yamashita Hideo Baba Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto UniversityKumamoto 860-8556Japan

Surgical resection for colorectal liver metastases(CRLM)may offer the best opportunity to improve ***,only about 20% of CRLM cases are indicated for resection at the time of diagnosis(initially resectable),and the remaining cases are treated as unresectable(initially unresectable).Thanks to recent remarkable developments in chemotherapy,interventional radiology,and surgical techniques,the resectability of CRLM is ***,some metastases are technically resectable but oncologically questionable for upfront *** pancreatic cancer,such cases are categorized as"borderline resectable",and their definition and treatment strategies are ***,in CRLM,although various poor prognosis factors have been identified in previous reports,no clear definition or treatment strategy for borderline resectable has yet been *** the efficacy of hepatectomy for CRLM was reported in the 1970 s,multidisciplinary treatment for unresectable cases has improved resectability and prognosis,and clarifying the definition and treatment strategy of borderline resectable CRLM should yield further improvement in *** review outlines the present status and the future perspective for borderline resectable CRLM,based on previous studies.

关键词： Borderline resectable Colorectal liver metastases Adjuvant chemotherapy Hepatectomy Colorectal cancer

Safety assessment of dextrin hydrogel adhesion barrier (AdSpray®) for elective laparoscopic cholecystectomy

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 61-65页

作者： Toshiro Masuda Hiroshi Takamori Moeko Kato Chisho Mitsuura yuta shiraishi Rumi Itoyama Kenji Shimizu Ryuichi Karashima Hidetoshi Nitta Hideo Baba Department of Surgery Saiseikai Kumamoto HospitalKumamoto861-4193Japan Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto860-0811Japan

Objective:Adhesion barriers have not traditionally been used during laparoscopic cholecystectomy(lapchole),and so there are no data confirming the safety of the dextrin hydrogel adhesion barrier(AdSpray®)for the use during *** aim of this prospective study is to investigate the safety of AdSpray®for elective ***:Between July 2019 and March 2021,we conducted a prospective study at Saiseikai Kumamoto Hospital to assess the safety of applying AdSpray®around the hepatoduodenal ligament,liver surface,and port area after extraction of the gallbladder during elective *** assessed patient morbidity,mortality,and laboratory data on postoperative day 1 and at the outpatient follow-up ***:A total of 100 patients(43 men,57 women)received AdSpray®application during elective lapchole at our *** mean patient age was 56.5±14.8 y,and the mean body mass index was 25.1±4.8 kg/*** gallbladder drainage was performed in 3(3.0%)patients as conservative treatment for acute *** mean operative time was 91.7±35.1 min,and the median blood loss was 5 mL(range,5e120 mL).Intraoperative gallbladder perforation was observed in 4.0%of patients(n=4).There was no intraoperative bile duct ***(1.0%)patient had a postoperative subhepatic fluid collection without bacterial *** mean white blood cell count and C-reactive protein level was significantly elevated on postoperative day 1 but returned to preoperative levels by the time of the follow-up *** patients were successfully discharged after surgery,and the median postoperative hospital stay was 2 d(range,2e9 d).Conclusion:Applying AdSpray®during elective lap-chole is safe,with an acceptable rate of postoperative complications.

关键词： Adhesion barrier Dextrin hydrogel Laparoscopic cholecystectomy

Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

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World Journal of Hepatology 2022年第1期14卷 234-243页

作者： Takayoshi Kaida Hiromitsu Hayashi Hiroki Sato Shotaro Kinoshita Takashi Matsumoto yuta shiraishi Yuki Kitano Takaaki Higashi Katsunori Imai Yo-ichi Yamashita Hideo Baba Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Laparoscopic surgery has been introduced as a minimally invasive technique for the treatment of various ***,there are few reports that have scientifically investigated the minimally invasive nature of laparoscopic liver resection(LLR).AIM To investigate whether LLR is scientifically less invasive than open liver *** During December 2011 to April 2015,blood samples were obtained from 30 patients who treated with laparoscopic(n=10,33%)or open(n=20,67%)partial liver resection for liver *** levels of serum interleukin-6(IL-6)and plasma thrombospondin-1(TSP-1)were measured using ELISA kit at four time points including preoperative,immediate after operation,postoperative day 1(POD1)and ***,we investigated the impact of the operative approaches during partial hepatectomy on the clinical time course including IL-6 and *** Serum level of IL-6 on POD1 in laparoscopic hepatectomy was significantly lower than those in open hepatectomy(8.7 vs 30.3 pg/mL,respectively)(P=0.003).Plasma level of TSP-1 on POD3 in laparoscopic hepatectomy was significantly higher than those in open hepatectomy(1704.0 vs 548.3 ng/mL,respectively)(P=0.009),and have already recovered to preoperative level in laparoscopic *** patients with higher IL-6 Levels on POD1,plasma level of TSP-1 on POD3 was significantly lower than those in patients with lower IL-6 Levels on *** analysis showed that open approach was the only independent factor related to higher level of IL-6 on POD1[odds ratio(OR),7.48;95%confidence interval(CI):1.28-63.3;P=0.02].Furthermore,the higher level of serum IL-6 on POD1 was significantly associated with lower level of plasm TSP-1 on POD3(OR,5.32;95%CI:1.08-32.2;P=0.04)in multivariate *** In partial hepatectomy,laparoscopic approach might be minimally invasive surgery with less IL-6 production compared to open approach.

关键词： Laparoscopic surgery Liver resection Hepatectomy Minimal invasiveness Interleukin-6 Thrombospondin-1

Water-resistant organic thermoelectric generator with >10μW output

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Carbon Energy 2023年第4期5卷 55-67页

作者： Shinichi Hata Kanto Maeshiro Misaki shiraishi Soichiro Yasuda yuta Shiozaki Koudai Kametani Yukou Du Yukihide shiraishi Naoki Toshima Department of Applied Chemistry Faculty of EngineeringSanyo‐Onoda City UniversityYamaguchiJapan Graduate School of Engineering Sanyo‐Onoda City UniversityYamaguchiJapan College of Chemistry Chemical Engineeringand Materials ScienceSoochow UniversitySuzhouPeople's Republic of China

Flexible p–n thermoelectric generator(TEG)technology has rapidly advanced with power enhancement and size *** achieve a stable power supply and highly efficient energy conversion,absolute chemical stability of n-type materials is essential to ensuring large temperature differences between device terminals and ambient *** the aim of improving the long-term stability of the n-type operation of carbon nanotubes(CNTs)in air and water,this study uses cationic surfactants,such as octylene-1,8-bis(dimethyldodecylammonium bromide)(12-8-12),a gemini surfactant,to stabilize the nanotubes in a coating,which retains the n-doped state for more than 28 days after exposure to air and water in *** with 10 p-n units of 12-8-12/CNT(n-type)and sodium dodecylbenzene sulfonate/CNT(p-type)layers are manufactured,and their water stability is *** initial maximum output of 16.1μW(75 K temperature difference)is retained after water immersion for 40 days without using a sealant to prevent TEG module *** excellent stability of these CNT-based TEGs makes them suitable for underwater applications,such as battery-free health monitoring and information gathering systems,and facilitates the development of soft electronics.

关键词： gemini surfactant n-type carbon nanotube surfactant doping thermoelectric properties water-resistant generators water stability

Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis

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World Journal of Gastroenterology 2006年第39期12卷 6325-6330页

作者： Toshihito Kosaka Junji Yoshino Kazuo Inui Takao Wakabayashi Kazumu Okushima Takashi Kobayashi Hironao Miyoshi yuta Nakamura Shigekazu Hayashi Taizou shiraishi Masatoshi Watanabe Takayuki Yamamoto Ai Nakahara Takahiko Katoh Department of Internal Medicine Second Teaching Hospital Fujita Health University School of Medicine 3-6-10 Otobashi Nakagawaku Nagoya 454-8509 Japan Department of Gastroenterology Nagoya Ekisaikai Hospital 4-66 Shounencho Nakagawaku Nagoya 454-8502 Japan Department of Pathologic Oncology Mie University Graduate School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501 Japan Inflammatory bowel disease centre and department of surgery Yokkaichi Social Insulance Hospital 10-8 Hazuyamacho Yokkaichi Mie Japan Department of Public Health Miyazaki Medical College University of Miyazaki 5200 Kihara Miyazaki 889-1692 Japan

AIM： To examine the influence of lipoprotein lipase （LPL） gene polymorphism in ulcerative colitis （UC） patients.METHODS： Peripheral blood was obtained from 131 patients with UC and 106 healthy controls for DNA extraction. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as Hind Ⅲ and Pvu Ⅱ polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clinical features in UC patients. Genotype frequencies for LPL polymorphisms were also compared between UC patients and controls.RESULTS： In patients with onset at age 20 years or younger, C/G and G/G genotypes for Ser447stop polymorphism were more prevalent than C/C genotype （OR = 3.13, 95% CI = 0.95-10.33）. Patients with H^＋/- or H^-/- genotype for Hind Ⅲ polymorphism also were more nu merous than those with H^＋/＋ genotype （OR = 2.51, 95% CI = 0.85-7.45）. In the group with H^＋/＋ genotype for Hind Ⅲ polymorphism, more patients had serum triglyceride concentrations over 150 mg/dL than patients with H^＋/- or H^- genotype （P 〈 0.01, OR = 6.46, 95% CI = 1.39-30.12）. Hypertriglycemia was also more prevalent in patients with P^＋/＋ genotypes for Pvu Ⅱ polymorphism （P 〈 0.05, OR = 3.0, 95% CI = 1.06-8.50）. Genotype frequency for LPL polymorphism did not differ significantly between UC patients and controls.

关键词： Ulcerative colitis Lipoprotein lipase Lipid metabolism Triglyceride