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Chip 2023年第3期2卷 7-19页

作者： Takaya Sugiura Kenta Yamamura yuta watanabe Shiun Yamakiri Nobuhiko Nakano Department of Electronics and Electrical Engineering Keio UniversityYoko-hamaKanawaga223-8522Japan

In recent years,Internet of Things(IoT)has become more and more important owing to the rapid expansion of the number of computing devices and data sizes.The evolution of IoT requires low-power and self-operating devices to expand the coverage area of computing re-sources.The main components of IoT are the large-scale integration(LSI)chips,which take the function of implementing the energy har-vesters,control units and applications.They exhibit different physics or phenomena,making it difficult to understand and design the entire system.The current work reviews the various methods for IoT appli-cations by CMOS LSI chips,from the power components by energy harvesting to realistic applications with future outlooks.

关键词： Analog LSI Energy har vesting Inter net of Things Sensors

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN MASANORI KAWANO TATSUYA IWASAKI ICHRO ITONAGA yuta KUBOTA HROSHI TSUMURA KAZUHRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein.This study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 on.the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches.MiR329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell lines.Additionally,a clinical comparison study was performed using the TCGA database.Subsequently,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments.When miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic bodies.The expression of proteins that indicate apoptosis increased simultaneously.The cell cycle was arrested in the G0/G1 phase,and the G1/S transition was blocked.The introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt pathway.Xenograf experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues decreased.MiR 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in vivo.Osteosarcoma cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR 3293p.Summarizing these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcoma by inhibiting TCF7L1.

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami EriNakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki ShintaroShimozawa yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo KeikoMizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of death.The five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral therapies.There remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver disease.Furthermore,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’complications.In 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral hepatitis.Today,treatment is sufficiently able to prevent the disease from reaching advanced phases.However,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral hepatitis.This review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury

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Neural Regeneration Research 2023年第2期18卷 311-312页

作者： Tetsu Kimura yuta Horikoshi Department of Anesthesia and Intensive Care Medicine Akita University Graduate School of MedicineAkitaJapan

Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa milies.SCI frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's society.The initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.

关键词： damage injury emotional

Lepton mass matrix from double covering of A_(4) modular flavor symmetry

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Chinese Physics C 2022年第12期46卷 162-171页

作者： Hiroshi Okada yuta Orikasa Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute of Experimental and Applied Physics Czech Technical University in PragueHusova 240/511000 Prague 1Czech Republic

We study a double covering of modular A_(4)flavor symmetry.To this end,we construct lepton models for canonical and radiative seesaw scenarios.Using irreducible doublet representations,heavier Majorana fermion masses are characterized by one free parameter that would differentiate from A_(4)symmetry.symmetry.Throughχsquare numerical analysis,we demonstrate that both scenarios produce some predictions in case of normal hierarchy reproducing neutrino oscillation data.However,no solution satisfies the neutrino oscillation data in case of radiative seesaw of inverted hierarchy.

关键词： flavor physics neutrino and Lepton mass beyond the standard model

Bin-scanning:Segmentation of X-ray CT volume of binned parts using Morse skeleton graph of distance transform

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Computational Visual Media 2023年第2期9卷 319-333页

作者： yuta Yamauchi Tatsuya Yatagawa yutaka Ohtake Hiromasa Suzuki School of Engineering The University of Tokyo7–3–1HongoBunkyo-kuTokyoJapan

X-ray CT scanners,due to the transmissive nature of X-rays,have enabled the non-destructive evaluation of industrial products,even inside their bodies.In light of its effectiveness,this study introduces a new approach to accelerate the inspection of many mechanical parts with the same shape in a bin.The input to this problem is a volumetric image(i.e.,CT volume)of many parts obtained by a single CT scan.We need to segment the parts in the volume to inspect each of them;however,random postures and dense contacts of the parts prohibit part segmentation using traditional template matching.To address this problem,we convert both the scanned volumetric images of the template and the binned parts to simpler graph structures and solve a subgraph matching problem to segment the parts.We perform a distance transform to convert the CT volume into a distance field.Then,we construct a graph based on Morse theory,in which graph nodes are located at the extremum points of the distance field.The experimental evaluation demonstrates that our fully automatic approach can detect target parts appropriately,even for a heap of 50 parts.Moreover,the overall computation can be performed in approximately 30 min for a large CT volume of approximately 2000×2000×1000 voxels.

关键词： X-ray computed tomography(CT) volume segmentation graph matching non-destructive inspection

Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： yuta Ihara Hiroshi Yamagishi Masanobu Naito Yohei Yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large datasets.Here,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical space.For constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were collected.The dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector machine.Thereby,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation behavior.The predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular volume.Furthermore,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the trend.The extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

High-throughput study of the anomalous Hall effect

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npj Computational Materials 2023年第1期9卷 767-774页

作者： JakubŽelezný yuta Yahagi Carles Gomez-Olivella Yang Zhang Yan Sun Institute of Physics Czech Academy of SciencesCukrovarnická1016200 Praha 6Czech Republic Department of Applied Physics Tohoku UniversitySendaiMiyagiJapan Department of Physics and Astronomy University of Tennessee KnoxvilleKnoxvilleTN 37996USA Min H.Kao Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Despite its long history,the anomalous Hall continues to attract attention due to its complex origins,its connection to topology,and its use as a probe of magnetic order.In this work we investigate the anomalous Hall effect in 2871 ferromagnetic materials using an automatic high-throughput calculation scheme.We analyze general properties of the effect,such as its reliance on spin-orbit coupling strength and magnetization.In materials with the largest anomalous Hall effect,we find that symmetry-protected band degeneracies in the non-relativistic electronic structure,such as mirror symmetry-protected nodal lines,are typically responsible for the large effect.Furthermore,we examine the dependence of the anomalous Hall effect on magnetization direction and demonstrate deviations from the commonly assumed expression j^(AHE)~M×E.

关键词： effect symmetry protected

地闪回击电磁场受建筑物宽度和相对位置的影响分析

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江西科学 2024年第3期42卷 648-653页

作者：王荣珠赖悦李玉塔夏雪江西省气候中心南昌330046 北京市气象探测中心北京100089

在雷电监测预警工作中,由于地形限制,雷电监测系统通常布置于建筑物顶部,会导致系统反演的雷电参数误差较大,因此,通过仿真模拟手段定量分析影响程度,为定位结果的校正提供参考。基于时域有限差分法(FDTD),研究了建筑物的宽度和相对位... 详细信息

在雷电监测预警工作中,由于地形限制,雷电监测系统通常布置于建筑物顶部,会导致系统反演的雷电参数误差较大,因此,通过仿真模拟手段定量分析影响程度,为定位结果的校正提供参考。基于时域有限差分法(FDTD),研究了建筑物的宽度和相对位置对闪电回击电磁场的影响,绘制了建筑物的宽度与垂直电场增大比例之间的关系式以及拟合曲线。结果表明,垂直电场的增量M在建筑物宽度增加时减少,当建筑物宽度增加到一定程度时,仍保持在较小范围内;当建筑物与闪电通道之间的距离d增加到3.22 km时,建筑物的宽度对建筑物顶部垂直电场值影响可忽略不计。研究结果对提高雷电定位系统精度有一定参考价值。

关键词：建筑物宽度相对位置回击电磁场

The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

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Oncology Research 2023年第5期31卷 631-643页

作者： MASANORI KAWANO KAZUHIRO TANAKA ICHIRO ITONAGA TATSUYA IWASAKI yuta KUBOTA HIROSHI TSUMURA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5593Japan

Heat shock protein(HSP)90 plays a crucial role in correcting the misfolded three-dimensional structure of proteins,assisting them in folding into proper conformations.HSP90 is critical in maintaining the normal functions of various proteins within cells,as essential factors for cellular homeostasis.Contrastingly,HSP90 simultaneously supports the maturation of cancer-related proteins,including mesenchymal epithelial transition factor(MET)within tumor cells.All osteosarcoma cell lines had elevated MET expression in the cDNA array in our possession.MET,a tyrosine kinase receptor,promotes proliferation and an anti-apoptotic state through the activation of the MET pathway constructed by HSP90.In this study,we treated osteosarcoma cells with an HSP90 inhibitor,17-demethoxygeldanamycin hydrochloride(17-DMAG),and assessed the changes in the MET signaling pathway and also the antitumor effect of the drug.The cell cycle in osteosarcoma cells administered 17-DMAG was found to be halted at the G2/M phase.Additionally,treatment with 17-DMAG inhibited cell proliferation and induced apoptosis.Inhibition of tumor cell proliferation was also observed in an in vivo model system,mice that were treated with 17-DMAG.Based on the results of this study,we were able to confirm that 17-DMAG promotes inhibition of osteosarcoma cell proliferation and induction of apoptosis by inhibition of MET,a protein highly expressed in osteosarcoma cells.This approach may be useful for the establishment of a new treatment strategy for patients resistant to the standard treatment for osteosarcoma.

关键词： Osteosarcoma MET HSP90 17-DMAG