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Numerical investigation of the effect of seasonal variations of depthof-closure on shoreline evolution

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International Journal of Sediment Research 2021年第1期36卷 1-16页

作者： Xuan Tinh Nguyen Minh Thanh Tran Hitoshi Tanaka Trung Viet Nguyen yuta Mitobe Cong Dien Duong Department of Civil Engineering Tohoku University

The current study presents the effects of seasonal variations in the depth-of-closure（D;） on shoreline evolution using a numerical,one-line shoreline *** erosion of the southern beach of the Nha Trang Coast,which is located in south central of Vietnam,is selected as the study *** study area is immensely influenced by the tropical monsoon climate that has a clear pattern of large waves in the northeast monsoon season and calm waves in the non-monsoon *** analysis of the long-term measured shoreline variations from a video-camera system has found a strong correlation of these variations to the monsoon-dominated wave characteristics in the Nha Trang ***,a new approach for determining the depth-of-closure with consideration of the seasonal wave climate changes is purposed in the current *** implementing this new approach into a numerical,one-line shoreline model,it is found that the seasonal variations of D;appear to better describe the periodical shoreline evolution due to the monsoon-dominated wave characteristics for the Nha Trang *** important findings are considered to commonly apply for monsoon-dominated coastal regions in *** findings are useful information not only for scientific readers but also for the coastal authorities and managers in order to make better countermeasure plans against this kind of erosion mechanism in the future.

关键词： Video camera Shoreline change One-line theory Nha Trang Beach Depth-of-closure Monsoon wave climate

Alcohol,postprandial plasma glucose,and prognosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第1期19卷 78-85页

作者： Hiroshi Abe yuta Aida Haruya Ishiguro Kai Yoshizawa Tamihiro Miyazaki Munenori Itagaki Satoshi Sutoh Yoshio Aizawa Division of Gastroenterology and Hepatology Department of Internal MedicineJikei University School of Medicine Katsushika Medical CenterTokyo 125-8506Japan

AIM:To identify factors associated with prognosis of hepatocellular carcinoma(HCC) after initial ***:A total of 377 HCC patients who were newly treated at Katsushika Medical Center,Japan from January 2000 to December 2009 and followed up for > 2 years,or died during follow-up,were *** factors related to survival were first analyzed in 377 patients with HCC tumor stage T1-T4 using multivariate Cox proportional hazards regression analysis.A similar analysis was performed in 282 patients with tumor stage ***,factors associated with the period between initial and subsequent therapy were examined in 144 patients who did not show local ***,214 HCC stage T1-T3 patients who died during the observation period were classified into four groups according to their alcohol consumption and postprandial glucose levels,and differences in their causes of death were ***:On multivariate Cox proportional hazards regression analysis,the following were significantly associated with survival:underlying liver disease stage [non-cirrhosis/Child-Pugh A vs B/C,hazard ratio(HR):0.603,95% CI:0.417-0.874,P = 0.0079],HCC stage(T1/T2 vs T3/T4,HR:0.447,95% CI:0.347-0.576,P < 0.0001),and mean postprandial plasma glucose after initial therapy(< 200 vs ≥ 200 mg/dL,HR:0.181,95% CI:0.067-0.488,P = 0.0008).In T1-T3 patients,uninterrupted alcohol consumption after initial therapy(no vs yes,HR:0.641,95% CI:0.469-0.877,P = 0.0055) was significant in addition to underlying liver disease stage(non-cirrhosis/Child-Pugh A vs B/C,HR:0649,95% CI:0.476-0.885,P = 0.0068),HCC stage(T1 vs T2/T3,HR:0.788,95% CI:0.653-0.945,P = 0.0108),and mean postprandial plasma glucose after initial therapy(< 200 mg/dL vs ≥ 200 mg/dL,HR:0.502,95% CI:0.337-0.747,P = 0.0005).In patients without local recurrence,time from initial to subsequent therapy for newly emerging HCC was significantly longer in the "postprandial glucose within 200 mg/dL group" than the "postprandial

关键词： Hepatocellular carcinoma Prognosis Alcohol consumption Diabetes mellitus Postprandial plasma glucose level Initial therapy Local recurrence Survival

Prediction of lymph node metastasis and sentinel node navigation surgery for patients with early-stage gastric cancer

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World Journal of Gastroenterology 2016年第33期22卷 7431-7439页

作者： Atsuo Shida Norio Mitsumori Hiroshi Nimura yuta Takano Taizou Iwasaki Muneharu Fujisaki Naoto Takahashi Katsuhiko Yanaga Department of Surgery Jikei University School of Medicine

Accurate prediction of lymph node(LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer(EGC). However,consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search,we identified several independent variables associated with LN metastasis in EGC,which should be included in future research to assess which of these variables remain as significant predictors of LN metastasis. On the other hand,even if we use these promising parameters,we should realize the limitation and the difficulty of predicting LN metastasis accurately. The sentinel LN(SLN) is defined as first possible site to receive cancer cells along the route of lymphatic drainage from the primary tumor. The absence of metastasis in SLN is believed to correlate with the absence of metastasis in downstream LNs. In this review,we have attempted to focus on several independent parameters which have close relationship between tumor and LN metastasis in EGC. In addition,we evaluated the history of sentinel node navigation surgery and the usefulness for EGC.

关键词： Early-stage gastric cancer Sentinel node navigation surgery Prediction of lymph node metastasis

Recent advances in artificial intelligence for pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2021年第43期27卷 7480-7496页

作者： Hiromitsu Hayashi Norio Uemura Kazuki Matsumura Liu Zhao Hiroki Sato yuta Shiraishi Yo-ichi Yamashita Hideo Baba Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan

Pancreatic ductal adenocarcinoma(PDAC)remains the most lethal type of *** 5-year survival rate for patients with early-stage diagnosis can be as high as 20%,suggesting that early diagnosis plays a pivotal role in the prognostic improvement of PDAC *** the medical field,the broad availability of biomedical data has led to the advent of the“big data”*** overcome this deadly disease,how to fully exploit big data is a new challenge in the era of precision *** intelligence(AI)is the ability of a machine to learn and display intelligence to solve *** can help to transform big data into clinically actionable insights more efficiently,reduce inevitable errors to improve diagnostic accuracy,and make real-time ***-based omics analyses will become the next alterative approach to overcome this poor-prognostic disease by discovering biomarkers for early detection,providing molecular/genomic subtyping,offering treatment guidance,and predicting recurrence and *** in AI may therefore improve PDAC survival outcomes in the near *** present review mainly focuses on recent advances of AI in PDAC for *** believe that breakthroughs will soon emerge to fight this deadly disease using AI-navigated precision medicine.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Artificial intelligence Machine learning Precision medicine

Electricity Generation System with Piezoelectric Element Using Acoustic Radiation Energy

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Journal of Power and Energy Engineering 2018年第10期6卷 1-19页

作者： Hiroyuki Moriyama yuta Yamamura Department of Prime Mover Engineering Tokai University Hiratsuka Japan Course of Mechanical Engineering Graduate School of Tokai University Hiratsuka Japan

In this study, a circular plate that is installing a piezoelectric element at its center is adopted as energy-harvesting system and is subjected to a harmonic point force. Because this system cannot avoid the influence of its acoustic radiation, the influence is considered theoretically using the equation of plate motion taking into account its radiation impedance and is estimated by the electricity generation efficiency, which is derived from the ratio of the electric power in the electricity generation and the mechanical power supplied to the plate. As a result, the efficiency is suppressed by the acoustic radiation from the plate, so that the efficiencies are so different in whether to take into consideration the radiation impedance or not. Because those results are verified by the electricity generation experiment and radiation acoustic energy has a hopeful prospect for improving the performance of this system, mechanical-acoustic coupling is used to make the most of the acoustic energy. Therefore, a cylinder that has the above plates at both ends is also adopted as the electricity generation system and mechanical-acoustic coupling is caused between the plate vibrations and an internal sound field into the cylindrical enclosure by subjecting one side of each plate to a harmonic point force. Then, the effect of coupling is evaluated by comparing with the efficiencies in the electricity generation system of only plate. Specifically, because the radiation impedance increases with the plate thickness, i.e., with the natural frequency of the plate, it is demonstrated that the effect of coupling becomes remarkable with increasing the thickness on the electricity generation efficiency.

关键词： Electricity Generation System Piezoelectric Element Radiation Impedance Coupling

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI KAWANO TATSUYA IWASAKI ICHIRO ITONAGA yuta KUBOTA HIROSHI TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Robust Optimum Design of Thrust Hydrodynamic Bearings for Hard Disk Drives

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Applied Mathematics 2012年第10期3卷 1368-1379页

作者： Hiromu Hashimoto yuta Sunami Department of Mechanical Engineering Tokai University Hiratsuka Japan

This paper describes the robust optimum design which combines the geometrical optimization method proposed by Hashimoto and statistical method. Recently, 2.5″ hard disk drives (HDDs) are widely used for mobile devices such as laptops, video cameras and car navigation systems. In mobile applications, high durability towards external vibrations and shocks are essentials to the bearings of HDD spindle motor. In addition, the bearing characteristics are influenced by manufacturing error because of small size of the bearings of HDD. In this paper, the geometrical optimization is carried out to maximize the bearing stiffness using sequential quadratic programming to improve vibration characteristics. Additionally, the bearing stiffness is analyzed considering dimensional tolerance of the bearing using statistical method. The dimensional tolerance is assumed to distribute according to the Gaussian distribution, and then the bearing stiffness is estimated by combining the expectation and standard deviation. As a result, in the robust optimum design, new groove geometry of bearing can be obtained in which the bearing stiffness is four times higher than the stiffness of conventional spiral groove bearing. Moreover, the bearing has lower variability compared with the result of optimum design neglecting dimensional tolerance.

关键词： Robust Optimum Design Hard Disk Drive Hydrodynamic Bearing Tolerance Statistical Method

Polyarteritis nodosa diagnosed by surgically resected jejunal necrosis following acute abdomen

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World Journal of Gastroenterology 2013年第18期19卷 2830-2834页

作者： yuta Hiraike Makoto Kodaira Munetaka Sano Yasuyuki Terazawa Shingo Yamagata Syuzo Terada Masaharu Ohura Ken Kuriki Department of Gastroenterology Yaizu City Hospital Yaizu City Shizuoka 425-8505 Japan Department of Nephrology Yaizu City Hospital Yaizu City Shizuoka 425-8505 Japan Department of Pathology Yaizu City Hospital Yaizu City Shizuoka 425-8505 Japan

The differential diagnosis of acute abdomen is typically extremely broad in range, with vasculitis posing a rare but potentially life-threatening cause of acute abdomen. Here, we report a case of acute abdomen with bowel wall thickening limited to jejunum, accompanied by unexplained renal dysfunction. Later, the patient was diagnosed as having polyarteritis nodosa based on surgically resected jejunal necrosis. Despite aggressive treatment, including the use of steroid pulse therapy and continuous hemodiafiltration, the patient died. Although polyarteritis nodosa is extremely rare in patients with acute abdomen, acute abdomen is relatively common manifestation of that. And it is reported that involvement of small intestine suggests poorer prognosis. Our case highlights the importance of vasculitis as a differential diagnosis of patients with atypical acute abdomen. In this report, we not only review possible clues that might have led to an earlier diagnosis in this case, but also attempt to draw some lessons for treating similar cases in the future.

关键词： Acute abdomen Polyarteritis nodosa Jejunal necrosis

Long-term dexamethasone treatment diminishes store-operated Ca^(2+) entry in salivary acinar cells

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International Journal of Oral Science 2019年第1期11卷 25-32页

作者： Yuichiro Kusuda Yusuke Kondo yuta Miyagi Takashi Munemasa Yusuke Hori Fumiko Aonuma Shintaro Tsuka Taro Mukaibo Chihiro Masaki Ryuji Hosokawa Division of Oral Reconstruction and Rehabilitation Kyushu Dental University

Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gland function. This study aimed to evaluate the effects of dexamethasone on mouse submandibular gland function to gain insight into the mechanism of dexamethasone-induced salivary hypofunction. The muscarinic agonist carbachol(CCh) induced salivary secretion and was not affected by short-term dexamethasone treatment but was decreased following long-term dexamethasone administration. The expression levels of the membrane proteins Na^+-K^+-2 Cl-cotransporter, transmembrane member 16 A, and aquaporin 5 were comparable between the control and long-term dexamethasone treatment groups. The CCh-induced increase in calcium concentration was significantly lower in the presence of extracellular Ca^(2+) in the long-term dexamethasone treatment group compared to that in the control group. Furthermore, CCh-induced salivation in the absence of extracellular Ca^(2+) and Ca^(2+) ionophore A23187-induced salivation was comparable between the control and long-term dexamethasone treatment ***, salivation induced by the Ca^(2+) -ATPase inhibitor thapsigargin was diminished in the long-term dexamethasone treatment group. In summary, these results demonstrate that short-term dexamethasone treatment did not impair salivary gland function, whereas long-term dexamethasone treatment diminished store-operated Ca^(2+) entry, resulting in hyposalivation in mouse submandibular glands.

关键词： Corticosteroids carbachol(CCh)induced