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Journal of Biophysical Chemistry 2016年第2期7卷 43-48页

作者： yusuke kobayashi Rina Hirai Daiki Ito Yasushi Yamamoto Keijiro Taga Zameer Shervani Department of Life Science and Material Engineering Nagoya Institute of Technology Nagoya Japan Department of Life Science and Material Engineering Nagoya Institute of Technology Nagoya Japan 2Tohoku Foods Corporation Limited Sendai Japan Tohoku Foods Corporation Limited Sendai Japan

We have investigated the morphology of novel 3, 4-bis-alkyloxycarbonyl-hexanedioic acid monolayer (alkyl chain number n = 12, 14, and 16) formed on the water surface by dropping method using Surface Tension measurement (STm) and Brewster Angle Microscopy (BAM). Surfactant of 3, 4-bis-alkyloxycarbonyl-hexanedioic acid has a gemini type structure. π-A isotherm curves (STm) of two gemini surfactants of n = 12 and 14 showed gradual increase in surface pressure, while that of n = 16 showed gradual increase, a stagnant range and finally steep increase. BAM observation showed each image corresponding to the result of STm measurement. From STm and BAM results of surfactants, it is found that surfactant of n = 12 and 14 form Liquid-Expand (LE) type monolayer, while that of n = 16 formed Liquid-Condensed (LC) type monolayer including LE-LC phase transition.

关键词： 3 4-Bis-Alkyloxycarbonyl-Hexanedioic Acid Gemini Surfactants Gemsurfs Monolayer Morphology

Surface Properties of Novel Surfactant, Dihexadecyl Gemini Phosphate, Monolayers on Water Surface by Dropping Method

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Journal of Biophysical Chemistry 2017年第4期8卷 39-50页

作者： yusuke kobayashi Takahiko Amano Keijiro Taga Yasushi Yamamoto Zameer Shervani Masato Yamamoto Department of Life Science and Applied Chemistry Graduate School of Engineering Nagoya Institute of Technology Nagoya Japan Nanomaterials Production Division Food and Energy Security Research and Product Center Sendai Japan Department of Chemistry School of Arts and Sciences Showa University Yamanashi Japan

We have synthesized first novel dihexadecyl phosphate (DHGP-n) gemini surfactants containing alkyl chain ((CnH2n);n = 3, 4, 5, and 6) spacers. Surfactants were used to form monolayers on water surface. Surface tension measurement (STm), Brewster angle microscopy (BAM), and density functional theory (DFT) calculation were used to investigate these monolayers. Surface pressure (π) and molecular area (A);π-A isotherm curves of all DHGP-n gemini surfactants showed a gradual increase in surface pressure without any break points in the curves, confirmed the formation of liquid-expand (LE) type monolayers. BAM observations also supported the STm results. Limited molecular area (A0) of these monolayers depended on the spacer of gemini surfactants without spacer n = 4. Longer alkyl chain spacer in the series had higher value of A0 in π-A isotherm plots. In the series, A0 of spacer n = 4 was smallest among A0 values of other spacers. Density functional theory (DFT) method calculation also confirmed π-A isotherm curves pattern of these surfactants. Calculation showed that both odd and even numbers and length of the alkyl chain spacer influenced the structure of DHGP-n monolayer formation on the water surface.

关键词： Dihexadecyl Gemini Phosphates Monolayers Surface Tension Measurement Brewster Angle Microscopy Density Functional Theory Calculation

Gynecological tumors in patients with Peutz-Jeghers syndrome (PJS)

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Open Journal of Genetics 2011年第3期1卷 65-69页

作者： Arisa Ueki Iori Kisu Kouji Banno Megumi Yanokura Kennta Masuda yusuke kobayashi Akira Hirasawa Daisuke Aoki Department of Obstetrics and Gynecology School of Medicine Keio University

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder characterized by the development of hamartomatous polyposis in the gastrointestinal tract and melanin-pigmented macules on the skin mucosa. The responsible gene is a tumor suppressor, STK11/LKB1, on chromosome 19p13.3. PJS complicates with benign and malignant tumors in various organs. In gynecology, there has been a particular focus on complications of PJS with sex cord tumor with annular tubules (SCTAT) and minimal deviation adenocarcinoma (MDA), which are rare diseases. Approximately 36% of patients with SCTAT are complicated with PJS and these patients are characterized by multifocal, bilateral, small and benign lesions that develop into tumors with mucinous to serous ratios of 8:1. In addition, 10% of cases of MDA are complicated with PJS and mutation of STK11, the gene responsible for PJS, has a major effect on onset and prognosis. The disease concept of lobular endocervical glandular hyper-plasia (LEGH) has recently been proposed and LEGH is thought to be a potential premalignant lesion of MDA, however, the relationship between PJS and LEGH remains unclear. Several case reports of PJS patients complicated with gynecological tumors have been published and further studies are needed to determine the underlying

关键词： Gynecologic Tumor Minimal Deviation Adenocarcinoma Peutz-Jeghers Syndrome Sex Cord Tumor STK11/LKB1

Total Laparoscopic Hysterectomy for Diagnosis and Treatment of Cervical Cystic Lesions: A Case Series

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Open Journal of Obstetrics and Gynecology 2020年第3期10卷 357-364页

作者： Tohru Morisada Kohsei Tanaka Tomoko Iijima Azumi Nishizawa Hiroshi Nishio yusuke kobayashi Masaru Nakamura Shigenori Hayashi Fumio Kataoka Takashi Iwata Daisuke Aoki Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo Japan

Objective: Cervical cystic lesions are often observed in gynecological clinical practice. Many are caused by benign diseases such as lobular endocervical glandular hyperplasia (LEGH), and it is important to differentiate these lesions from those due to malignant diseases such as minimal deviation adenocarcinoma (MDA). In cases in which fertility preservation is not a concern, the final pathology is often confirmed by hysterectomy. To investigate the feasibility and safety of laparoscopic surgery for cervical cystic lesions, we retrospectively examined cases in which total laparoscopic hysterectomy (TLH) was performed for diagnosis and treatment. Methods: The subjects were 28 women who underwent TLH from April 2012 to March 2017 at Keio University Hospital. The pre- and post-operative courses of these patients were examined. Results: The average age was 49.4 (range 39 - 65) years and the mean body mass index was 21.7 (16.8 - 30.5) kg/m2. The average operation time was 159 (101 - 314) min and the average bleeding volume was 106.8 (0 - 600) g. There were no severe perioperative complications. The average hospital stay was 8.4 (7 - 14) days. In postoperative pathological diagnosis, 13 cases had benign diseases such as Nabot cysts, there were 14 cases of LEGH, and one patient was diagnosed with MDA. In the MDA case, additional bilateral salpingo-oophorectomy and pelvic lymph node dissection were performed at a later date. No metastasis was observed in these excised specimens. Conclusions: Our results suggest that TLH for cervical cystic lesions can be performed safely. However, it is important to consider the TLH indication before surgery based on the possibility of malignant disease.

关键词： Lobular Endocervical Glandular Hyperplasia Minimum Deviation Adenocarcinoma Total Laparoscopic Hysterectomy Uterine Cervix

Metformin: A possible drug for treatment of endometrial cancer

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Open Journal of Obstetrics and Gynecology 2012年第1期2卷 1-6页

作者： Kosuke Tsuji Iori Kisu Kouji Banno Megumi Yanokura Arisa Ueki Kenta Masuda yusuke kobayashi Wataru Yamagami Hiroyuki Nomura Nobuyuki Susumu Daisuke Aoki Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan

Metformin is a widely used first-line drug for treatment of type 2 diabetes mellitus. In recent years, it has been reported that administration of metformin can reduce carcinogenic risk and inhibit proliferation of cancer cells including those from glioma and breast cancer. The underlying mechanism is thought to involve increased LKB-1 phosphorylation induced by metformin, followed by LKB-1 phosphorylation and activation of AMP-activated protein kinase (AMPK), which then inhibits the mammalian target of rapamycin (mTOR) pathway and results in inhibition of cell proliferation. In endometrial cancer, metformin causes cell cycle arrest in vitro, reduces hTERT mRNA, inhibits the mTOR pathway via AMPK, and is involved in inhibition of phosphorylation of S6 ribosomal protein (S6RP). Metformin promotes expression of progesterone receptor by an action opposite to that of insulin-like growth factor-2 (IGF-2) when used in combination with medroxyprogesterone acetate. This enhances the antitumor effect and this approach may be applicable in a clinical setting.

关键词： Metformin Endometrial Cancer Type 2 Diabetes Mellitus Mammalian Target of Rapamycin (mTOR) Progesterone Receptor (PR)

Epigenetic Aberrant Hypermethylation of DNA in Endometrial Cancer: Application as a Biomarker

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Journal of Cancer Therapy 2011年第5期2卷 610-615页

作者： Asuka Ono Iori Kisu Kouji Banno Megumi Yanokura Kenta Masuda yusuke kobayashi Kosuke Tsuji Arisa Ueki Wataru Yamagami Hiroyuki Nomura Nobuyuki Susumu Daisuke Aoki 不详

Endometrial cancer is the seventh most common cancer worldwide among females and accounts for about 40% of cancers of the uterus in Japan. An increase in incidence and a reduction in onset age of this disease are also likely, which makes it important to define the pathogenesis and develop effective treatment. However, the mechanism of canceration in the endometrium is unclear and development of endometrial cancer cannot be explained only by mutations of cancer-related genes. In contrast, epigenetic analyses have shown the importance of aberrant DNA hypermethylation in the canceration mechanism. In development of type 1 endometrial cancer, breakdown of the DNA mismatch repair system plays a large role, with changes in the human mutL homologue 1 (hMLH1) gene being of most importance. Studies to detect aberrant DNA hypermethylation of cancer cells present in microscopic amounts in vivo and to apply these data to diagnosis of cancer have been started. Epigenetic changes have also been examined as a marker of sensitivity to anticancer drugs. Aberrant hypermethylation of checkpoint with forkhead-associated and ring finger (CHFR), a mitotic phase checkpoint gene, is correlated with sensitivity to treatment with microtubule inhibitors and may be a marker for the response of endometrial cancer to anticancer drugs. Epigenetic aberrant DNA methylation of other genes may also be useful as clinical biomarkers for diagnosis and treatment of endometrial cancer.

关键词： Epigenetics Endometrial Cancer Aberrant DNA Hypermethylation hMLH1 CHFR Biomarker

Atypical Polypoid Adenomyoma (APAM) of the Uterine: Relationship with Endometrial Cancer

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Journal of Cancer Therapy 2011年第4期2卷 458-462页

作者： Iori Kisu Kouji Banno Megumi Yanokura yusuke kobayashi Arisa Ueki Asuka Ono Kennta Masuda Wataru Yamagami Hiroyuki Nomura Akira Hirasawa Nobuyuki Susumu Daisuke Aoki Department of Obstetrics and Gynecology Keio University School of Medicine

Atypical polypoid adenomyoma (APAM) is a rare polypoid tumor that generally occurs in women of reproductive age who have abnormal genital bleeding. The tumor was reported as a new disease concept by Mazur in 1981. Pathologically, APAM consist of irregularly proliferated endometrial gland cells and interlacing bundles of smooth muscle cells within the stroma, and have a similar form to adenocarcinoma, adenofibroma, adenosarcoma, and carcinosarcoma. Therefore, differential diagnosis is required in many cases. APAM is pathologically classified as a benign lesion and clinically has a comparatively favorable outcome. However, treatment and follow-up observation should be performed carefully because recurrence and residual lesions occur in many patients after conservative treatment. Concomitant development of endometrial adenocarcinoma also occurs in many cases and it is difficult to differentiate this disease from APAM. Thus, diagnosis of APAM should be made carefully, particularly since the number of cases of endometrial adenocarcinoma has increased in recent years. Furthermore, APAM tends to develop during a woman’s reproductive years, and fertility sparing treatment should be considered. Here, we review the clinicopathological characteristics of APAM, including the difficulty of diagnosis as a benign or malignant uterine tumor, and we examine the relationship between APAM and endometrial cancer.

关键词： Atypical Polypoid Adenomyoma Endometrial Adenocarcinoma Atypical Endometrial Hyperplasia Transcervical Resectoscope Fertility Sparing

Gynecological tumors in patients with Peutz-Jeghers syndrome (PJS)

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Phase Behavior and Crystal Structure of Perovskite-Type Rare Earth Complex Oxides

Open Journal of Genetics 2011年第3期

作者： Arisa Ueki Iori Kisu Kouji Banno Megumi Yanokura Kenta Masuda yusuke kobayashi Akira Hirasawa Daisuke Aoki

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Journal of Rare Earths 2006年第6期24卷 668-672页

作者： Migaku kobayashi Ryoko Katsuraya Tsubasa Nara yusuke Tomita Hiromi Nakano Naoki Kamegashira Department of Chemistry and Biochemistry Numazu College of Technology 3600 Ooka Numazu 410-8501 Japan Ryukoku University Seta Otsu 520-2194 Japan Department of Materials Science Toyohashi University of Technology Tempaku-cho Toyohashi 441-8580 Japan

Several compounds of rare earth complex oxides containing manganese and titanium were synthesized in Ar, and their crystal structures were analyzed by powder X-ray diffraction data and Rietveld method. Structures of A0.67Ln0.33 Mn0.33Ti0.6703（A = Ca or Sr and Ln = rare earth） were found to have orthorhombic symmetry with the space group Pnrna, and their interatomic distances and bond angles were obtained. This space group was also derived from electron microscopic study. Electrical conductivity of Cao.67Ln0.33Mn0.33Ti0.6703 for several rare earth elements showed a semiconducting property with the activation energy of 0.4 eV. Some of these compounds of the strontium system show the antiferromagnetic properties below 10 K.

关键词： perovskite crystal structure X-ray diffraction alkaline earth rare earth manganese titanium oxide

Epigenetic Aberrant Hypermethylation of DNA in Endometrial Cancer: Application as a Biomarker

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