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复苏的航空业或引发惨烈价格战 006

复苏的航空业或引发惨烈价格战

Tenomodulin蛋白对血管内皮细胞增生的抑制作用

环球时报

作者： Yen Nee Lee yusuke Hinata 丁玎

美国CNBC网站8月19日文章，原题：中国的航空公司或将比同行以更快速度从疫情中复苏在多家投资机构看来，随着中国国内旅游业正以比其他国家更快的速度复苏，该国航空公司的复苏速度很可能超过众多（外国）同行。英国瀚亚投资的报告显... 详细信息

美国CNBC网站8月19日文章，原题：中国的航空公司或将比同行以更快速度从疫情中复苏在多家投资机构看来，随着中国国内旅游业正以比其他国家更快的速度复苏，该国航空公司的复苏速度很可能超过众多（外国）同行。英国瀚亚投资的报告显示，尽管落后于公路旅行的好转速度，?

关键词：航空业旅客流量价格战

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眼科研究 2010年第7期28卷 617-621页

作者：王蔚大岛佑介田野保雄首都医科大学附属北京朝阳医院眼科北京100020 日本大阪大学医学部眼科

目的研究tenomodulin(TeM)蛋白对血管内皮生长因子(VEGF)诱导的人视网膜血管内皮细胞(RECs)和人脐静脉内皮细胞(UVECs)增生及其对体外血管样结构形成的作用。方法将传代至3～6代的人RECs和人UVECs生长至融合时用含质量分数0.5%胎牛血清(... 详细信息

目的研究tenomodulin(TeM)蛋白对血管内皮生长因子(VEGF)诱导的人视网膜血管内皮细胞(RECs)和人脐静脉内皮细胞(UVECs)增生及其对体外血管样结构形成的作用。方法将传代至3～6代的人RECs和人UVECs生长至融合时用含质量分数0.5%胎牛血清(FBS)的培养基孵箱中培养6h,加入不同质量浓度的VEGF或VEGF+TeM混合物,继续培养12h,ELISA法检测TeM对VEGF诱导的血管内皮细胞增生的影响。将含10%FBS、1%FBSDMEM培养基的人RECs和人UVECs悬液分别接种于预先放置基质胶的24孔培养板表面,含1%FBS培养基的细胞培养板内分别加入VEGF(100μg/L)或VEGF+TeM混合物37℃继续培养6h,共焦显微镜下观察,图像处理分析软件量化分析TeM蛋白对毛细血管样结构形成的作用。结果随着VEGF质量浓度的增加,血管内皮细胞DNA合成增加,其吸光度(A)值呈明显上升曲线,而添加TeM组的A值比VEGF组降低,差异有统计学意义(P<0.01)。含10%FBS和1%FBS培养基的血管内皮细胞在基质胶表面形成毛细血管样结构,并连接成网状;在基质胶表面同时添加VEGF的血管内皮细胞,其毛细血管样结构明显增多,长度明显变长。添加TeM组的血管内皮细胞和其毛细血管样结构破坏,每个视野内血管内皮细胞毛细血管样结构显著破坏,管形细胞总长度明显变短。结论 TeM蛋白对血管内皮细胞的增生及体外血管样结构的形成有明显抑制作用。

关键词： Tenomodulin 血管内皮细胞增生新生血管血管内皮生长因子

Combination of genistein with ionizing radiation on andro-gen-independent prostate cancer cells

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Asian Journal of Andrology 2004年第4期6卷 285-290页

作者： Sen-XiangYan YasuoEjima RyoheiSasaki Shu-SenZheng yusukeDemizu ToshinoriSoejima KazuroSugimura DepartmentofRadiology FirstAffiliatedHospitalCollegeofmedicineZhejiangUniversityHangzhou310003China DivisionofRadiology KobeGraduateSchoolofMedicineHyogo6500017Japan

Aim: To study the effect of the combined use of genistein and ionizing radiation (IR) on prostate DU145 cancer cells. Methods: DU145, an androgen-independent human prostate cancer cell line, was used in the experiment. Clonogenic assay was used to compare the survival of DU145 cells after treatments with genistein alone and in combination with graded IR. Apoptosis was assayed by DNA ladder and TUNEL stain. Cell cycle alterations were observed by flow cytometry and related protein expressions by immunoblotting. Results: Clonogenic assay demonstrated that genistein, even at low to medium concentrations, enhanced the radiosensitivity of DU145 cells. Twenty-four hours after treatment with IR and/or genistein, apoptosis was mainly seen with genistein at high concentrations and was minimally related to IR. At 72 h, apoptosis also occurred in treatment with lower concentration of genistein, especially when combined with IR. While both IR and genistein led to G2/M cell cycle arrest, combination of them further increased the DU145 cells at G2/M phase. This Gz/M arrest was largely maintained at 72 h, accompanied by increasing apoptosis and hyperdiploid cell population. Cell-cycle related protein analysis disclosed biphasic changes in cyclin B1 and less dramatically cdc-2, but stably elevated p21cipl levels with increasing genistein concentrations. Conclusion: Genistein enhanced the radiosensitivity of DU145 prostate cancer cells. The mechanisms might be involved in the increased apoptosis, prolonged cell cycle arrest and impaired damage repair.

关键词： prostate cancer genistein ionizing radiation (IR) apoptosis cell cycle

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电子束熔炼法评定洁净钢中夹杂物

电子束熔炼法评定洁净钢中夹杂物

The Quantitative Density Measurement of Unsteady Flow around the Projectile

中国金属学会2003中国钢铁年会

作者： Takayuki Nishi Yukio Ishizaka yusuke Nakano 住友金属研发中心住友金属小仓制铁所住友金属小仓制铁所

电子束熔炼法已经被发展应用于洁净钢中夹杂物的评定。电子束熔炼法就是在超真空的条件下通过电子束的轰击使试样重新熔化,收集熔体表面的夹杂物的方法。收集到的夹杂物“漂浮物”与夹杂物的总量相关。因此这种方法有许多优点,例如对于... 详细信息

电子束熔炼法已经被发展应用于洁净钢中夹杂物的评定。电子束熔炼法就是在超真空的条件下通过电子束的轰击使试样重新熔化,收集熔体表面的夹杂物的方法。收集到的夹杂物“漂浮物”与夹杂物的总量相关。因此这种方法有许多优点,例如对于超纯净钢来说,与常规的夹杂物分析方法相比,电子束熔炼法具有快速评定、刻度标准等优点。住友金属通过应用这种方法来持续提高钢产品的质量。

关键词：电子束熔炼法夹杂物洁净钢

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Journal of Flow Control, Measurement & Visualization 2019年第2期7卷 111-119页

作者： yusuke Hirose Kazuki Ishikawa Yoshiyuki Ishimoto Takumi Nagashima Masanori Ota Shinsuke Udagawa Tatsuro Inage Kazuki Fujita Hideki Kiritani Koji Fujita Kiyonobu Ohtani Hiroki Nagai Graduate School of Engineering Chiba University Chiba Japan Aerospace Engineering Course Tokyo Metropolitan College of Industrial Technology Tokyo Japan Department of Mechanical Engineering Shonan Institute of Technology Fujisawa Kanagawa Japan Institute of Fluid Science Tohoku University Sendai Miyagi Japan

Three-dimensional density measurement of unsteady flow field around a sphere is carried out in the ballistic range at Institute of Fluid Science, Tohoku University. Simultaneous multi-angle measurement system using twelve digital cameras is installed in the test chamber of the ballistic range to achieve the three-dimensional density measurement. The Colored-Grid Background Oriented Schlieren (CGBOS) technique using colored-grid background is utilized for the reconstruction of density. The Mach number of the sphere is set to 1.5. The short pulse LEDs to illuminate the backgrounds are also installed in the chamber to capture the unsteady flow field around a flying sphere. Three-dimensional density distribution around a sphere is successfully reconstructed.

关键词： Background Oriented Schlieren Flow Visualization High Speed Flows Unsteady Flow Simultaneous Measurement

Comparison of percutaneous radiofrequency ablation and CyberKnife®for initial solitary hepatocellular carcinoma:A pilot study

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World Journal of Gastroenterology 2015年第48期21卷 13490-13499页

作者： Kazue Shiozawa Manabu Watanabe Takashi Ikehara Yasushi Matsukiyo Michio Kogame Yui Kishimoto yusuke Okubo Hiroyuki Makino Nobuhiro Tsukamoto Yoshinori Igarashi Yasukiyo Sumino Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Medical CenterOmori Hospital 6-11-1 Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineSaiseikai Yokohamashi Tobu Hospital Department of Radiology Saiseikai Yokohamashi Tobu Hospital

AIM To compare therapeutic outcomes and adverseevents in initial solitary hepatocellular carcinoma（HCC） treated with radiofrequency ablation （RFA） andCyberKnife？.METHODS： Seventy three consecutive patients withinitial solitary HCC treated with RFA （38 patients;RFA group） and CyberKnife （35 patients; CK group）were enrolled in this study. Background factorswere compared between the two groups. Local andintrahepatic distant recurrence control, and cumulativesurvival rates were compared between the two *** were determined using the Kaplan-Meier method,and the significance of differences was analyzed by log-rank test. The presence of more grade 3 on CTCAE ver.4.0 early and late adverse events was ***： In background factors, age was significantlyhigher （P = 0.005） and the tumor diameter wassignificantly larger （P = 0.001） in the CK group. The1-year local recurrence control rates were 97.4%and 97.1% in the RFA and CK groups, respectively （P= 0.71）; the 1-year intrahepatic distant recurrencecontrol rates were 85.6% and 86.1%, respectively （P= 0.91）; and the 1-year cumulative survival rates were100% and 95.2%, respectively （P = 0.075）, showingno significant difference in any rate between the twogroups. There were no late adverse event in the RFAgroup, but 11.4% in the CK group had late adverseevents. In the CK group, the Child-Pugh score at 12 moafter treatment was significantly higher than that in theRFA group （P = 0.003） and significantly higher than thescore before treatment （P = 0.034）.CONCLUSION： The occurrence of adverse events is aconcern, but CyberKnife treatment is likely to becomean important option for local treatment of early HCC.

关键词： Hepatocellular carcinoma Radiofrequencyablation Stereotactic body radiotherapy CyberKnife® Adverse event

Epigenetic Aberrant Hypermethylation of DNA in Endometrial Cancer: Application as a Biomarker

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Journal of Cancer Therapy 2011年第5期2卷 610-615页

作者： Asuka Ono Iori Kisu Kouji Banno Megumi Yanokura Kenta Masuda yusuke Kobayashi Kosuke Tsuji Arisa Ueki Wataru Yamagami Hiroyuki Nomura Nobuyuki Susumu Daisuke Aoki 不详

Endometrial cancer is the seventh most common cancer worldwide among females and accounts for about 40% of cancers of the uterus in Japan. An increase in incidence and a reduction in onset age of this disease are also likely, which makes it important to define the pathogenesis and develop effective treatment. However, the mechanism of canceration in the endometrium is unclear and development of endometrial cancer cannot be explained only by mutations of cancer-related genes. In contrast, epigenetic analyses have shown the importance of aberrant DNA hypermethylation in the canceration mechanism. In development of type 1 endometrial cancer, breakdown of the DNA mismatch repair system plays a large role, with changes in the human mutL homologue 1 (hMLH1) gene being of most importance. Studies to detect aberrant DNA hypermethylation of cancer cells present in microscopic amounts in vivo and to apply these data to diagnosis of cancer have been started. Epigenetic changes have also been examined as a marker of sensitivity to anticancer drugs. Aberrant hypermethylation of checkpoint with forkhead-associated and ring finger (CHFR), a mitotic phase checkpoint gene, is correlated with sensitivity to treatment with microtubule inhibitors and may be a marker for the response of endometrial cancer to anticancer drugs. Epigenetic aberrant DNA methylation of other genes may also be useful as clinical biomarkers for diagnosis and treatment of endometrial cancer.

关键词： Epigenetics Endometrial Cancer Aberrant DNA Hypermethylation hMLH1 CHFR Biomarker

Leg Atherosclerosis in Japanese COPD Patients: Prevalence of Undiagnosed Peripheral Artery Disease and Association between Leg Atherosclerosis and Clinical Indices

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Open Journal of Respiratory Diseases 2013年第1期3卷 25-30页

作者： Hirofumi Matsuoka yusuke Matsumoto Kengo Kimura Midori Koyama Towa Uzu Yasuko Koma Kensuke Fukumitsu Yoshitaka Kasai Nariyasu Nakashima Daiki Masuya Harukazu Yoshimatsu Yujiro Suzuki Department of Respiratory Medicine Shinko Hospital Kobe Japan

Introduction: Several studies have suggested that decreased FEV1 is associated with cardiovascular risk in COPD patients. Objective: To identify the prevalence of undiagnosed peripheral artery disease (PAD) and the relationship between leg atherosclerosis and clinical indices, which predict COPD mortality in Japanese COPD patients. Methods: We performed a cross-sectional study in 51 COPD patients and 51 age-matched, healthy control smokers. We measured ankle-brachial index (ABI) as a marker of atherosclerosis of the legs, pulmonary function, body mass index, modified Medical Research Council (MMRC) dyspnea scale, and smoking pack-years. We also calculated the ADO index (Age, Dyspnea, and Obstruction), an established predictor of mortality in COPD patients. Co-morbidities including diabetes mellitus, hypertension, and hypercholesterolemia were identified from blood laboratory tests and medical records. Results: Five subjects (9.8%) had an ABI 0.9. ABI was significantly lower in the COPD patients than in the healthy control smokers (p 0.05). The prevalence of PAD was marginally higher in COPD patients than in control smokers (p = 0.09), with the prevalence of ABI 1.0 being significantly higher in COPD patients than in control smokers (p = 0.04). In the COPD patients, ABI showed significant correlations with age (p = 0.006), FEV1 (p = 0.004), smoking pack-years (p = 0.047), MMRC dyspnea scale (p = 0.0005), SaO2 (p = 0.001), andADOindex (p 0.001). Multiple linear regression modeling showed the factors associated independently with ABI were age, FEV1, smoking pack-years, MMRC dyspnea scale, and SaO2. Conclusion: The risk of leg atherosclerosis in Japanese COPD patients is higher than in smokers without COPD. Leg atherosclerosis in COPD patients is associated with clinical indices that predict COPD mortality.

关键词： COPD Peripheral Artery Disease Leg Atherosclerosis Ankle-Brachial Index

Usefulness of serum lipase for early diagnosis of post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2019年第9期11卷 477-485页

作者： Masayoshi Tadehara Kosuke Okuwaki Hiroshi Imaizumi Mitsuhiro Kida Tomohisa Iwai Hiroshi Yamauchi Toru Kaneko Rikiya Hasegawa Eiji Miyata yusuke Kawaguchi Hironori Masutani Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

BACKGROUND Post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP)is new onset acute pancreatitis after *** complication is sometimes *** such,PEP should be diagnosed early so that therapeutic interventions can be carried *** lipase(s-Lip)is useful for diagnosing acute ***,its usefulness for diagnosing PEP has not been sufficiently *** This study aimed to retrospectively examine the usefulness of s-Lip for the early diagnosis of *** We retrospectively examined 4192 patients who underwent ERCP at our two hospitals over the last 5 *** primary outcomes were a comparison of the areas under the receiver operating characteristic(ROC)curves(AUCs)of s-Lip and serum amylase(s-Amy),s-Lip and s-Amy cutoff values based on the presence or absence of PEP in the early stage after ERCP via ROC curves,and the diagnostic properties[sensitivities,specificities,positive predictive values(PPV),and negative predictive value(NPV)]of these cutoff values for PEP *** Based on the eligibility and exclusion criteria,804 cases were *** the entire course,PEP occurred in 78 patients(9.7%).It occurred in the early stage after ERCP in 40 patients(51.3%)and in the late stage after ERCP in 38 patients(48.7%).The AUCs were 0.908 for s-Lip[95%confidence interval(CI):0.880-0.940,P<0.001]and 0.880 for s-Amy(95%CI:0.846-0.915,P<0.001),indicating both are useful for early *** comparing the AUCs,s-Lip was found to be significantly more useful for the early diagnosis of PEP than s-Amy(P=0.023).The optimal cutoff values calculated from the ROC curves were 342 U/L for s-Lip(sensitivity,0.859;specificity,0.867;PPV,0.405;NPV,0.981)and 171 U/L for s-Amy(sensitivity,0.859;specificity,0.763;PPV,0.277;NPV,0.979).CONCLUSION S-Lip was significantly more useful for the early diagnosis of *** s-Lip after ERCP could help diagnose PEP earlier;hence,therapeutic interventions can be provided earlier.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Pancreatitis Lipase Amylase