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Unusual histopathological findings in appendectomy specimens:A retrospective analysis and literature review

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World Journal of Gastroenterology 2011年第15期17卷 1961-1970页

作者： Sami Akbulut Mahmut Tas Nilgun Sogutcu Zulfu Arikanoglu Murat Basbug Abdullah Ulku Heybet Semur yusuf yagmur Department of Surgery Diyarbakir Education and Research Hospital 21400 Diyarbakir Turkey Department of Emergency Medicine DiyarbakirEducation and Research Hospital 21400 Diyarbakir Turkey Department of Pathology Diyarbakir Educa-tion and Research Hospital 21400 Diyarbakir Turkey Department of Surgery Ergani State HospitalDiyarbakir Turkey

AIM: To document unusual findings in appendectomy specimens. METHODS: The clinicopathological data of 5262 patients who underwent appendectomies for presumed acute appendicitis from January 2006 to October 2010 were reviewed retrospectively. Appendectomies performed as incidental procedures during some other operation were excluded. We focused on 54 patients who had unusual findings in their appendectomy specimens. We conducted a literature review via the PubMed and Google Scholar databases of English language studies published between 2000 and 2010 on unusual findings in appendectomy specimens. RESULTS: Unusual findings were determined in 54 (1%) cases by histopathology. Thirty were male and 24 were female with ages ranging from 15 to 84 years (median, 32.2 ± 15.1 years). Final pathology revealed 37 cases of enterobiasis, five cases of carcinoids, four mucinous cystadenomas, two eosinophilic infiltrations, two mucoceles, two tuberculosis, one goblet-cell carcinoid, and one neurogenic hyperplasia. While 52 patients underwent a standard appendectomy, two patients who were diagnosed with tuberculous appendicitis underwent a right hemicolectomy. All tumors were located at the distal part of the appendix with a mean diameter of 6.8 mm (range, 4-10 mm). All patients with tumors were alive and disease-free during a mean follow-up of 17.8 mo. A review of 1366 cases reported in the English literature is also discussed. CONCLUSION: Although unusual pathological findings are seldom seen during an appendectomy, all appendectomy specimens should be sent for routine histopathological examination.

关键词： Appendicitis Carcinoid Unusual findings Goblet cell carcinoid Enterobius vermicularis Mucocele

Giant Meckel's diverticulum: An exceptional cause of intestinal obstruction

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World Journal of Gastrointestinal Surgery 2014年第3期6卷 47-50页

作者： Sami Akbulut yusuf yagmur Department of Surgery Di-yarbakir Education and Research Hospital

Meckel's diverticulum(MD) results from incomplete involution of the proximal portion of the vitelline(also known as the omphalomesenteric) duct during weeks 5-7 of foetal development. Although MD is the most commonly diagnosed congenital gastrointestinal anom-aly, it is estimated to affect only 2% of the population worldwide. Most cases are asymptomatic, and diagno-sis is often made following investigation of unexplained gastrointestinal bleeding, perforation, inflammation or obstruction that prompt clinic presentation. While MD range in size from 1-10 cm, cases of giant MD(≥ 5 cm) are relatively rare and associated with more severe forms of the complications, especially for obstruction. Herein, we report a case of giant MD with secondary small bowel obstruction in an adult male that was suc-cessfully managed by surgical resection and anasto-mosis created with endoscopic stapler device(80 mm, endo-GIA stapler). Patient was discharged on post-operative day 6 without any complications. Histopatho-logic examination indicated Meckel's diverticulitis with-out gastric or pancreatic metaplasia.

关键词： Meckel’s diverticulum Giant Meckel’ s diverticulum Intestinal obstruction Small bowel

Coexistence of abdominal cocoon, intestinal perforation and incarcerated Meckel's diverticulum in an inguinal hernia: A troublesome condition

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World Journal of Gastrointestinal Surgery 2014年第3期6卷 51-54页

作者： Sami Akbulut yusuf yagmur Mehmet Babur Department of Surgery Diyarbakir Education and Research Hospital

Sclerosing encapsulating peritonitis(SEP) is a rare dis-ease entity, in which the small intestine becomes en-cased and mechanically obstructed by a dense, fibrotic membrane. The disorder is characterized as either primary(idiopathic) or secondary to other causes. The idiopathic cases of SEP, which lack any identifiable eti-ology according to clinical, radiological and histopatho-logical findings, are also reported under the designation of abdominal cocoon syndrome. The most frequent presenting symptoms of all SEP cases are nausea, vom-iting, abdominal distention and inability to defecate, all of which are associated with the underlying intestinal obstruction. Persistent untreated SEP may advance to intestinal perforation, representing a life-threatening condition. However, preoperative diagnosis remains a particular clinical challenge, and most diagnoses are confirmed only when the typical fibrous membrane en-casing the small intestine is discovered by laparotomy. Here, we report the clinical presentation of an 87-year-old male with signs of intestinal obstruction and the ul-timate diagnosis of concurrent abdominal cocoon, rightincarcerated Meckel's diverticulum, and gastrointestinal perforation in laparotomy.

关键词： Sclerosing encapsulating peritonitis Cocoon syndrome Perforation Meckel’ s diverticulum

Gastrointestinal perforation due to incarcerated Meckel's diverticulum in right femoral canal

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World Journal of Clinical Cases 2014年第6期2卷 232-234页

作者： yusuf yagmur Sami Akbulut Mehmet Ali Can Department of Surgery Diyarbakir Education and Research Hospital

Meckel's diverticulum is a very common congenital anomaly of the gastrointestinal tract but many cases remain asymptomatic and are diagnosed incidentally during laparoscopic or other surgical procedures. Cases of femoral hernia involving Meckel's diverticulum are rare, with less than 50 cases reported in the literature since Littre published the first description of this coincident condition over 300 years ago. While all true "Littre's hernias" contain a Meckel's diverticulum, the involved anatomical sites are various, the most common being the inner groin(inguinal), the outer groin(femoral), and the belly button(umbilical). Complications of Littre's hernias include incarceration, strangulation, necrosis, and perforation. Herein, we describe a case of Littre's hernia that involved an incarcerated Meckel's diverticulum in a femoral hernia that was diagnosed upon investigation of symptomology manifesting from perforation and was successfully managed by surgical resection with stapler devices.

关键词： Meckel’s diverticulum Incarceration Littre Hernia Gastrointestinal perforation

The use of fluoroscopy for detecting hypertensive lung edema due to prosthetic valve dysfunction: a case report

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World Journal of Emergency Medicine 2024年第4期15卷 313-315页

作者： yusuf Kantar Necmi Baykan Emergency Department Akçaabat Haçkalibaba State HospitalTrabzon 61060Turkiye Emergency Department Kayseri City HospitalKayseri 38080Turkiye

Heart valve diseases affect more than one hundred million people around the world,which are a serious cause of illness and mortality.[1]Among the valve diseases,mitral valve insufficiency ranks second in the list of valve diseases requiring surgical repair in Europe.[2]Prosthetic valve replacement is the standard treatment in cases where repair is not sufficient for valve diseases.[3]Mechanical and bioprosthetic valves can be preferred for replacement,mechanical valves are more durable and require lifelong use of *** disadvantage of bioprosthetic valves is early degeneration,and infective reoperation is required due to the formation of endocarditis.[4-5]The risk of thromboembolism,lifetime anticoagulant use and complications related to anticoagulation remain disadvantages of valve surgery.[3]The most important complication requiring urgent intervention is valve dysfunction due to *** usually occurs due to inappropriate use of the anticoagulants.[6]Surgical treatment is used for severe obstructions,such as thrombi larger than 10 *** therapy can be applied in small thrombi and in cases where surgical intervention is risky.

关键词： valve disadvantage lifetime

Metabologenomics and network pharmacology to understand the molecular mechanism of cancer research

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World Journal of Clinical Cases 2024年第3期12卷 474-478页

作者： yusuf Tutar Department of Basic Pharmaceutical Sciences Faculty of PharmacyDivision of BiochemistryUniversity of Health SciencesIstanbul 34668Turkey Health Sciences Faculty Recep Tayyip Erdogan UniversityRize 53350Turkey Molecular Oncology Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey Molecular Medicine Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey

In this editorial I comment on the article“Network pharmacological and molecular docking study of the effect of Liu-Wei-Bu-Qi capsule on lung cancer”published in the recent issue of the World Journal of Clinical Cases 2023 November 6;11(31):*** all living forms are able to manufacture particular chemicals-metabolites that enable them to differentiate themselves from one another and to overcome the unique obstacles they encounter in their natural *** methods for chemical warfare,communication,nutrition acquisition,and stress prevention are made possible by these specialized *** is a popular technique for collecting direct mea-surements of metabolic activity from many biological ***,con-fusing metabolite identification is a typical issue,and biochemical interpretation is frequently constrained by imprecise and erroneous genome-based estimates of enzyme *** annotation and gene integration uses a biochemical reaction network to obtain a metabolite-gene association so called *** network uses an approach that emphasizes metabolite-gene consensus via biochemical *** metabolomics and genomics data is ***,computer networking proposes that using meta-bolomics data may improve annotations in sequenced species and provide testable hypotheses for specific biochemical *** The genome and metabolites of biological organisms are not fully characterized with current ***,increasing high-throughput metabolomics and genomics data provide promising generation of paired data sets to understand the molecular mechanism of biochemical processes as well as determining targets for pharmaceutical drug *** network infrastructures to integrate omics analysis can provide molecular mechanism of biochemical ***,clinical data may be integrated to gene expression–metabolite expression by system genetics appr

关键词： Network pharmacology Metabologenomics Genome Pathways Cancer

Deciphering the implications of MAFLD and MASLD definitions in the NAFLD population:results from a single-center biopsy study

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Chinese Medical Journal 2024年第5期137卷 616-618页

作者： Eda Kaya yusuf Yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochum 44892Germany Institute of Gastroenterology Marmara Universityİstanbul 34840Turkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRize 53100Turkey

To the Editor:The nomenclature for steatotic liver disease has been a topic of debate since *** conventional expression,non-alcoholic fatty liver disease(NAFLD),was introduced in 1980 to describe the occurrence of steatosis in the absence of other hepatic ***,in recent years,there has been a growing movement to phase out and retire this *** 2020,Eslam et al^([1])proposed a new definition—metabolic(dysfunction)associated fatty liver disease(MAFLD)—redefining the disease to include hepatic steatosis along with other factors such as diabetes,obesity,overweight,or meeting the criteria for metabolic dysfunction.

关键词： NAFLD liver MAF

A Comparative Study of Metaheuristic Optimization Algorithms for Solving Real-World Engineering Design Problems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1039-1094页

作者： Elif Varol Altay Osman Altay yusuf Ovik Department of Software Engineering Manisa Celal Bayar UniversityManisa45400Turkey

Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to *** design problems are widely experienced in many engineering fields,such as industry,automotive,construction,machinery,and interdisciplinary ***,there are established optimization techniques that have shown effectiveness in addressing these types of *** research paper gives a comparative study of the implementation of seventeen new metaheuristic methods in order to optimize twelve distinct engineering design *** algorithms used in the study are listed as:transient search optimization(TSO),equilibrium optimizer(EO),grey wolf optimizer(GWO),moth-flame optimization(MFO),whale optimization algorithm(WOA),slimemould algorithm(SMA),harris hawks optimization(HHO),chimp optimization algorithm(COA),coot optimization algorithm(COOT),multi-verse optimization(MVO),arithmetic optimization algorithm(AOA),aquila optimizer(AO),sine cosine algorithm(SCA),smell agent optimization(SAO),and seagull optimization algorithm(SOA),pelican optimization algorithm(POA),and coati optimization algorithm(CA).As far as we know,there is no comparative analysis of recent and popular methods against the concrete conditions of real-world engineering ***,a remarkable research guideline is presented in the study for researchersworking in the fields of engineering and artificial intelligence,especiallywhen applying the optimization methods that have emerged *** research can rely on this work for a literature search on comparisons of metaheuristic optimization methods in real-world problems under similar conditions.

关键词： Metaheuristic optimization algorithms real-world engineering design problems multidisciplinary design optimization problems

On the interaction phenomena to the nonlinear generalized Hietarinta-type equation

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Journal of Ocean Engineering and Science 2024年第1期9卷 89-97页

作者： Usman Younas T.A.Sulaiman Jingli Ren A.yusuf State Key Laboratory of Power Grid Environmental Protection/Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Faculty of Science Federal University DutseJigawaNigeria Department of Computer Engineering Biruni University IstanbulTurkey

In this paper,we describe the nonlinear behavior of a generalized fourth-order Hietarinta-type equa-tion for dispersive waves in(2+1)*** various wave formations are retrieved by using Hirota’s bilinear method(HBM)and various test function *** Hirota method is a widely used and robust mathematical tool for finding soliton solutions of nonlinear partial differential equa-tions(NLPDEs)in a variety of disciplines like mathematical physics,nonlinear dynamics,oceanography,engineering sciences,and others requires bilinearization of nonlinear *** different wave structures in the forms of new breather,lump-periodic,rogue waves,and two-wave solutions are *** addi-tion,the physical behavior of the acquired solutions is illustrated in three-dimensional,two-dimensional,density,and contour profiles by the assistance of suitable *** on the obtained results,we can assert that the employed methodology is straightforward,dynamic,highly efficient,and will serve as a valuable tool for discussing complex issues in a diversity of domains specifically ocean and coastal *** have also made an important first step in understanding the structure and physical be-havior of complex structures with our findings *** believe this research is timely and relevant to a wide range of engineering *** results obtained are useful for comprehending the fundamental scenarios of nonlinear sciences.

关键词： Hirota’s bilinear method Lump-periodic solutions Breather waves Rouge waves Multi-waves