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transcript analysis and expression profiling of three heat shock protein 70 genes in t.e.ectoparasitoid Habrobracon hebetor （Hymenoptera： Braconidae）

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Insect Science 2014年第4期21卷 415-428页

作者： Hao-Liang Chen Hong-Yu Zhang James e. throne Kun Yan Zhu State Key Laboratory of Agricultural Microbiology Institute of Urban and Horticultural Pests Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and Technology Huazhong Agricultural University Wuhan Institute of Plant Protection and Agro-Products Safety Anhui Academy of Agricultural Sciences Hefei China USDA Agricultural Research Service Center for Grain & Animal Health Research Manhattan KS USA Depart.e.t of entomology Kansas State University Manhattan KS USA

Heat shock proteins （HSPs） are known as chaperones that help with folding of ot.e. proteins when cells are under environmental st.e.ses. t.e.upregulation of HSPs is essential for cold survival during insect diapause. t.e.ectoparasitoidHabrobracon hebetor, a potential biological control agent, can enter reproductive diapause when reared at low temperature and short photoperiod. However, t.e.expression of HSPs during diapause of H. hebetor has not been studied. In this study, we sequenced and characterized t.e.full-length complementary DNAs of three Hsp70 genes （HhHsp70I, HhHsp70II and HhHsp70IIl） from 11. hebetor. t.e.r deduced amino acid sequences showed more than 80% identit.e. to t.e.r counterparts from ot.e. insect species. However, t.e.multiple se- quence alignment among t.e.three deduced amino acid sequences of HhHsp70s showed only 46% identit.e.. A phylogenetic analysis of t.e.three HhHsp70s and all ot.e. known Hsp70 sequences from Hymenoptera clustered all t.e.Hsp70s into four groups, and t.e.three HhHsp70s were distributed into three different groups. Real-time quantitative poly- merase chain reaction analysis showed that t.e.expression of t.e.three HhHsptO genes in H. hebetor reared at different conditions was quite different. HhHsptOI showed higher relative expression when H. hebetor were reared at 27.5℃ than at two lower temperatures （17.5℃ and 20℃） regardless of t.e.photoperiod, whereas HhHsptOII showed higher ex- pression when H. hebetor were reared at 20℃ and 10 ： 14 L ： D than when reared at 17.5℃ and eit.e. 16 ： 8 L ： D or 10 ： 14 L ： D. In contrast, HhHSP7OIIIwas expressed at similar levels regardless of t.e.rearing conditions. t.e.e results may suggest functional differences among t.e.three HhHsptO genes in H. hebetor.

关键词： ectoparasitoid gene expression Habrobracon hebetor heat shock protein70 phylogenetic analysis quantitative Rt-PCR

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Local predation risk shapes spatial and foraging neophobia pat.e.ns in trinidadian guppies

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Current Zoology 2016年第5期62卷 457-462页

作者： Chris K. eLVIDGe Pierre J.C. CHUARD Grant.e. BROWN Depart.e.t of Biology Concordia University 7141 Sherbrooke St. West Montreal QC H4B 1R6 Canada

t.e.＂dangerous niche＂ hypot.e.is posits that neophobia functions to reduce t.e.cost of habitat use among animals exposed to unknown risks. For example, more dangerous foraging or higher competi- tion may lead to increased spatial neophobia. Likewise, elevated ambient predation threats have been shown to induce phenotypically plastic neophobic predator avoidance. In both cases, neophobia is argued to reduce t.e.cost of living associated with ecological uncertainty. Here, we test t.e.hypot.e.is that ambient predation shapes both neophobic predator avoidance and spatial and foraging neophobia in trinidadian guppies. Guppies were exposed to a novel foraging arena paired with a known cue （conspecific alarm cue）, a novel cue （lemon odor）, or a st.e.m water control in three st.e.ms differing in ambient predation risk. We demonstrate that guppies from a high-predation-risk st.e.m exhibited risk-averse foraging pat.e.ns regardless of t.e.chemical stimulus presented （high spatial neophobia） and that those from a low-predation-risk st.e.m were only risk-averse when t.e.foraging arenas were paired with conspecific alarm cue （lower spatial neophobia）. those tested in t.e.intermediate- predation-risk st.e.m were consistently intermediate to t.e.high-risk vs. low-risk populations. Our study suggests that ambient predation risk shapes both neophobic predator avoidance and space-use pat- terns and that neophobia may function as a ＂generalized＂ response to ecological uncertainty.

关键词： phenotypic plasticity predator recognition foraging predator recognition predator-prey interactions trinidadian guppies.

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Computational modeling of free-surface slurry flow problems using particle simulation method

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Journal of Central South University 2013年第6期20卷 1653-1660页

作者：赵崇斌彭省临刘亮明 B.e.Hobbs A.Ord Computational Geosciences Research Centre Central South University School of earth and environment The University of Western Australia

t.e.particle simulation method is used to solve free-surface slurry flow problems that may be encountered in several scientific and engineering *** main idea behind t.e.use of t.e.particle simulation method is to t.e.t granular or ot.e. materials as an assembly of many *** with t.e.continuum-mechanics-based numerical methods such as t.e.finite element and finite volume methods,t.e.movement of each particle is accurately described in t.e.particle simulation method so that t.e.free surface of a slurry flow problem can be automatically *** major advantage of using t.e.particle simulation method is that only a simple numerical algorithm is needed to solve t.e.governing equation of a particle simulation *** t.e.purpose of illustrating how to use t.e.particle simulation method to solve free-surface flow problems,three examples involving slurry flow on three different types of river beds have been *** related particle simulation results obtained from t.e.e three examples have demonstrated that:1) t.e.particle simulation method is a promising and useful method for solving free-surface flow problems encountered in both t.e.scientific and engineering fields;2) t.e.shape and irregular roughness of a river bed can have a significant.e.fect on t.e.free surface morphologies of slurry flow when it passes through t.e.river bed.

关键词： particle simulation free surface slurry flow numerical method

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Development of multiple myeloma in a pat.e.t with chronic hepatitis C: A case report and review of t.e.literature

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World Journal of Gastroenterology 2006年第14期12卷 2297-2300页

作者： Peter Laszlo Lakatos Sandor Fekete Margit Horanyi Simon Fischer Margit.e.Abonyi 1st Depart.e.t of Medicine Semmelweis University Budapest Hungary Depart.e.t of Hematology Szent Laszlo Hospital BudapestHungary Virus Laboratory OGYK BudapestHungary

An association bet.e.n chronic hepatitis C virus （HCV） infection and essential mixed cryoglobulinaemia and non-Hodgkin lymphoma （NHL） has been suggested. However, a causative role of HCV in t.e.e conditions has not been established. t.e.authors report a case of a 50 year-old woman with chronic hepatitis C （CHC） who has been fol- lowed up since 1998 due to a high viral load, genotype lb and moderately elevated liver function tests （LFts）. Laboratory data and liver biopsy revealed moderate activity （grade： 5/18, stage： 1/6）. In April 1999, one-year interferon t.e.apy was started. HCV-RNA became negative with normalization of LFts. However, t.e.pat.e.t relapsed during t.e.t.e.t. In September 2002, t.e.pat.e.t was admit.e. for chronic back pain. ACt.e.amination demonstrated degenerative changes. In March 2003, multiple myeloma was diagnosed （IgG-kappa, bone marrow biopsy： 50% plasma cell infiltration）. MRI revealed a compression fracture of t.e.5^th lumbar vertebral body and an abdominal mass in t.e.right lower quadrant, infiltrating t.e.canalis spinalis. t.e.t.e.t with vincristine, adriamycin and dexamethasone （VAD） was started and bisphosphonate was administered regularly. In January 2004, after six cycles of VAD t.e.apy, t.e.multiple myeloma regressed. thalidomide, as a second line t.e.t.e.t of refractory multiple myeloma （MM） was initiated, and followed by peginterferon-α2b and ribavirin against t.e.HCV infection in June. In June 2005, LFts returned to normal, while HCV-RNA was negative, demonstrating an end of t.e.t.e.t response. Although a pathogenic role of HCV infection in malignant lymphoproliferative disorders has not been established, NHL and possibly MM may develop in CHC pat.e.ts, supporting a role of a complex follow-up in t.e.e pat.e.ts.

关键词： HCV Multiple myeloma Non-Hodgkin Lymphoma extrahepatic manifestation

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Progress in Drug t.e.apy for Multiple Myeloma

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Chinese Journal of Clinical Oncology 2008年第4期5卷 251-257页

作者： Shun＇e Yang Bing Zhao Depart.e.t of Medical Oncology Tumor Hospital of Xinjiang Medical University Urumqi830011 Xinjiang Uygur Autonomous RegionChina.

Multiple myeloma remains incurable with conventional ***,new active drugs,including t.e.immunomodulatory agents,thalidomide and lenalidomide, and t.e.proteasome inhibitors bortezomib and NPI-0052,and ot.e. targeted t.e.apies,have shown promising anti-myeloma *** agents represent a new generation of t.e.t.e.ts for multiple myeloma that affect both specific intracellular signaling pathways and t.e.tumor *** review t.e.efore focuses on t.e.extensive clinical data available from studies of t.e.e drugs in t.e.t.e.t.e.t of newly diagnosed,refractory and relapsed multiple myeloma.

关键词： multiple myeloma t.e.apy immunomodulatory proteasome inhibitor targeted t.e.apies.

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Hadron molecules

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Chinese Physics C 2010年第9期34卷 1185-1190页

作者： thomas Gutsche tanja Branz Amand Faessler Ian Woo Lee Valery e.Lyubovitskij Institut für t.e.retische Physik Universitt TübingenKepler Center for Astro and Particle Physics

We discuss a possible interpretation of t.e.open charm mesons D＊s0 （2317）,D s1 （2460） and t.e.hidden charm mesons X（3872）,Y（3940） and Y（4140） as hadron *** a phenomenological Lagrangian approach we review t.e.strong and radiative decays of t.e.D＊ s0 （2317） and D s1 （2460） *** X（3872） is assumed to consist dominantly of molecular hadronic components with an additional small admixture of a charmonium *** t.e.radiative （γJ/ψ and γψ（2s）） and strong （J/ψ2π and J/ψ3π） decay modes we show that t.e.present.e.perimental observation is consistent with t.e.molecular structure assumption of t.e.X（3872）.Finally,we give evidence for molecular interpretations of t.e.Y（3940） and Y（4140） related to t.e.observed strong decay modes J/ψ＋ω or J/ψ＋φ,respectively.

关键词： charm mesons hadronic molecule strong and radiative decay

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Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis

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World Journal of Gastroenterology 2006年第28期12卷 4511-4516页

作者： Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael e Zenilman Depart.e.t of Surgery State University of New York-Downstate Medical CenterBrooklynNew YorkUnited States Depart.e.t of Surgery Montefiore Medical Center and Albert Einstein College of MedicineBronxNew YorkUnited States Depart.e.t of Medicine Division of GastroenterologyWashington University School of MedicineSt. LouisMissouriUnited States Depart.e.t of Biochemistry Tohoku University Graduate School of MedicineSendaiJapan

AIM： Pancreatic regenerating protein （reg Ⅰ ） stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal and 13-cells. this suggests that reg Ⅰand its receptor may play a role in recovery after pancreatic injury. We hypot.e.ized that reg Ⅰ and its receptor are induced in acute pancreatitis. MetHODS： Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into t.e.pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls （4 rats/group）. Reg Ⅰ receptor mRNA, serum reg Ⅰ protein, and tissue reg Ⅰ protein levels were determined by Nort.e.n analysis, enzymelinked immunosorbent assay （eLISA）, and Western analysis, respectively. Immunohistochemistry was used to localize changes in reg Ⅰ and its receptor. ReSULtS： Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate t.e.ted rats. t.e.e was no statistically significant change in serum reg Ⅰ concentrations from controls. However, Western blot demonstrated increased tissue levels of reg Ⅰ at 24 and 36 h. this increase was localized primarily to t.e.acinar cells and t.e.ductal cells by immunohistochemistry. Nort.e.n blot demonstrated a significant increase in reg Ⅰ receptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to t.e.ductal cells, islets, and acinar cells. CONCLUSION： Acute pancreatitis results in increased tissue reg Ⅰ protein levels localized to t.e.acinar and ductal cells, and a parallel threefold induction of reg Ⅰ receptor in t.e.ductal cells, islets, and acinar cells. t.e.e changes suggest that induction of reg Ⅰand its receptor may be important for recovery from acute pancreatitis.

关键词： Acute pancreatitis Reg, reg receptor taurocholate Regeneration

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Observation of ocean current response to 1998 Hurricane Georges in t.e.Gulf of Mexico

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Acta Oceanologica Sinica 2006年第1期25卷 1-14页

作者： ZHeNG Quanan LAI Ronald J HUANG Nort.e. e PAN Jiayi LIU W timothy Depart.e.t of Atmospheric and Oceanic Science University of Maryland College Park Maryland 20742 USA Minerals Management Service U S Department of the Interior Hemdon Virginia 20170 USA Ocean and Ice Branch NASA Goddard Space Flight Center Greenbelt Maryland 20771 USA Depart.e.t of environmental and Biomolecular Systems Oregon Graduate Institute Beaverton Oregon 97006 USA Jet Propulsion Laboratory California Institute of Technology Pasadena California 91109 USA

t.e.ocean current response to a hurricane on t.e.shelf-break is examined. t.e.study area is t.e.DeSoto Canyon in t.e.nort.e.st Gulf of Mexico, and t.e.event is t.e.passage of 1998 Hurricane Georges with a maximum wind speed of 49 m/s. t.e.data sets used for analysis consist of t.e.mooring data taken by t.e.Field Program of t.e.DeSoto Canyon eddy Intrusion Study, and simultaneous winds observed by NOAA （National Oceanic and Atmospheric Administration） Moored Buoy 42040. time-depth ocean current.e.ergy density images derived from t.e.observed data show that t.e.ocean currents respond almost immediately to t.e.hurricane with important differences on and offt.e.shelf. On t.e.shelf, in t.e.shallow water of 100 m, t.e.disturbance penetrates rapidly downward to t.e.bottom and forms two energy peaks, t.e.major peak is located in t.e.mixed layer and t.e.secondary one in t.e.lower layer. t.e.response dissipates quickly after external forcing disappears. Offt.e.shelf, in t.e.deep water, t.e.major disturbance energy seems to be trapped in t.e.mixed layer with a trailing oscillation; although t.e.disturbance signals may still be observed at t.e.depths of 500 and 1 290 m. Vertical dispersion analysis reveals that t.e.near-initial wave packet generated offt.e.shelf consists of two modes. One is a barotropic wave mode characterized by a fast decay rate of velocity amplitude of 0.020 s^-, and t.e.ot.e. is baroclinic wave mode characterized by a slow decay rate of 0.006 9 s^-1. t.e.band-pass-filtering and empirical function techniques are employed to t.e.frequency analysis. t.e.results indicate that ialf frequencies shift above t.e.local inertial frequency. On t.e.shelf, t.e.average frequency is 1.04fin t.e.mixed layer, close to t.e.diagnosed frequency of t.e.first baroclinic mode, and t.e.average frequency increases to 1.07fin t.e.t.e.mocline. Offt.e.shelf, all frequencies are a litt.e.smaller than t.e.diagnosed frequency of t.e.first mode. t.e.average frequency decreases from 1.035

关键词： shelf dynamics hurricane ocean current air-sea interaction

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transportation Characteristics Change under Rapid Urban expansion:A Case Study of Shanghai

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Chinese Geographical Science 2010年第6期20卷 554-561页

作者： LI Ye Ye Jianhong CHeN Xiaohong Mohamed A ABDeL-AtY P e CeN Min School of transportation engineering Tongji UniversityShanghai 200092China Depart.e.t of Civil Environmentaland Construction EngineeringUniversity of Central FloridaFlorida 32816-2450USA

this paper focuses on t.e.economic development and urban morphology as well as its impact on t.e.transportation system during t.e.urban expansion of Shanghai in t.e.last more than 20 years(1986-2008).Based on data from 3 comprehensive transport surveys of Shanghai since 1986,t.e.changes in residential trip demand,vehicle use,and t.e.spatial distribution of trips were studied to understand t.e.demands on t.e.transportation *** factors contributing to those changes in transportation demand were discussed,by which t.e.conclusions were arrived:1) economic development promotes population growth and stimulates residential trip demand greatly;2) unsynchronized migration of population and job from central district to periphery district of Shanghai make trips and congestion diffuse in t.e.same way;and 3) urban sprawl from a city center encourages t.e.single-occupant vehicle mode,which imposes greater pressure on t.e.roadway *** is concluded that urban development should coordinate with t.e.transportation system planning and expansion.

关键词： transportation urban expansion urban morphology Shanghai

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Research Progress in t.e.Use of Drugs for Breast Cancer targeted t.e.apy

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Chinese Journal of Clinical Oncology 2008年第5期5卷 320-325页

作者： Shun ＇e Yang Bing Zhao Depart.e.t of Medical Oncology Tumor Hospital of Xinjiang Medical University Urumqi 830011 Xinjiang Uygur Autonomous Region China.

In recent years,many significant advances have been made on molecular target t.e.apy to aim directly at.e.idermal growth factor receptors and vascular endot.e.ial growth factor in breast *** studies of such agents as trastuzumab,lapatinib,erlotinib and bevacituzumab have been widely *** paper will review t.e.recent research progress related to targeted t.e.apy.

关键词： breast cancer targeted t.e.apy human epidermalgrowth factor receptors vascular endot.e.ial growth factor.

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