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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia:targeted immunotherapy for acute lymphoblastic leukemia

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Frontiers of Medicine 2022年第1期16卷 139-149页

作者： Sisi Wang Lijun Peng Wenqian Xu Yuebo Zhou Ziyan Zhu yushan kong Stewart Leung Jin Wang Xiaoqiang Yan Jian-Qing Mi Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Pôle Franco-Chinois de Recherche en Sciences du Vivant et Genomique Shanghai 200025China Shanghai Blood Center Shanghai 200051China Generon Biomed Shanghai 201210China

The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic ***,several studies showed that blinatumomab has a short plasma half-life due to its low molecular weight,and thus its clinical use is ***,multiple trials have shown that approximately 30%of blinatumomab-relapsed cases are characterized by CD19 negative leukemic ***,we design and characterize two novel antibodies,A-319 and *** and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures,and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 *** in vitro,ex vivo,and in vivo experiments demonstrated that A-319 and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells,enhancing T-cell function,mediating B-cell depletion,and eventually inhibiting tumor growth in Raji xenograft *** two molecules are complementary in terms of efficacy and specificity *** activity of A-319 demonstrated superior to that of A-2019,whereas A-2019 has an additional capability to target CD20 in cells missing CD19,suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells.

关键词： B-cell acute lymphoblastic leukemia bispecific antibody trispecific antibody CD19 CD20

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肺移植术后副流感病毒性肺炎一例及文献复习

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中华器官移植杂志 2019年第7期40卷 423-427页

作者：孔育姗伍造端田科谷刚李丽娟南华大学附属南华医院衡阳421002 中日友好医院呼吸与危重症学科北京100029

目的探讨肺移植术后继发副流感病毒性肺炎的临床特点、诊治及预后.方法回顾性分析1例肺移植术后合并副流感病毒性肺炎病例的诊治经过,并总结国内外现有相关病例报道及文献复习.结果受者因慢性阻塞性肺病、肺大疱、呼吸衰竭接受序贯式双... 详细信息

目的探讨肺移植术后继发副流感病毒性肺炎的临床特点、诊治及预后.方法回顾性分析1例肺移植术后合并副流感病毒性肺炎病例的诊治经过,并总结国内外现有相关病例报道及文献复习.结果受者因慢性阻塞性肺病、肺大疱、呼吸衰竭接受序贯式双肺移植术.术后常规抗排斥治疗.术后14个月,受者因咳嗽、气促1个月余入院;术后15个月连续3次查痰细菌、真菌涂片及培养均显示副流感病毒核酸检测阳性.明确诊断为肺移植术后副流感病毒性肺炎,给予利巴韦林抗病毒治疗,以及气管插管、有创呼吸机辅助通气,后给予亚胺培南加多西环素联合抗感染治疗,更昔洛韦抗病毒治疗,反复行支气管镜吸痰灌洗治疗,受者病情无改善,并于术后16个月因呼吸衰竭、感染性休克死亡.结论肺移植术后副流感病毒感染重在预防,PCR法是快速检测病毒感染的最主要方法,但尚无确定的治疗副流感病毒感染的方法,特异性的副流感免疫球蛋白和DAS181雾化吸入可能是将来治疗肺移植受者副流感病毒感染的一种选择.

关键词：肺移植副流感病毒肺炎

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疏花水柏枝内生真菌QY-1的抗氧化活性分析

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微生物学杂志 2017年第5期37卷 53-59页

作者：蒋维秦王阁阁孔玉珊李辉薛艳红刘士平三峡大学生物与制药学院湖北宜昌443002

以从疏花水柏枝(Myricaria laxiflora)中分离的1株内生真菌QY-1为研究对象,为分析其体内及体外的抗氧化活性,对其发酵液及其提取物的活性进行了综合评价。对nr DNA内转录间隔区进行测序鉴定。分别采用总抗氧化力试剂盒、自由基清除试剂... 详细信息

以从疏花水柏枝(Myricaria laxiflora)中分离的1株内生真菌QY-1为研究对象,为分析其体内及体外的抗氧化活性,对其发酵液及其提取物的活性进行了综合评价。对nr DNA内转录间隔区进行测序鉴定。分别采用总抗氧化力试剂盒、自由基清除试剂盒和还原力测定试剂盒评价发酵液及粗提物的体外抗氧化能力活性;对发酵液提取物及其主成分进行了大肠埃希菌、人神经母瘤细胞SH-SY5Y的体内抗氧化损伤保护作用分析。结果表明QY-1是1株球毛壳菌(Chaetomium globosum),其粗提物具有很高的抗氧化活性,总抗氧化活力、自由基清除率及总还原力均接近维生素C的50%,远高于国际报道水平。且其发酵液提取物有促进细胞增殖和抗氧化保护作用,显著提高大肠埃希菌细胞和神经细胞在H2O2胁迫下的存活率。其粗提物可保护神经细胞膜的完整性,有效减低乳酸脱氢酶(LDH)的渗漏率。从粗提物中分离到一种主成分SF2,可显著抑制凋亡蛋白Caspase 3和Caspase 9的活性。结果表明内生真菌球毛壳菌QY-1不管在体内还是体外都具备较强的抗氧化能力,是一种具有潜在开发价值的天然抗氧化剂资源。

关键词：疏花水柏枝,内生真菌,抗氧化,凋亡蛋白,分子鉴定

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Multi-Scale Fusion Algorithm for AUVs Integrated Navigation Systems

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Journal of Beijing Institute of Technology 2019年第4期28卷 725-730页

作者： yushan Sun Fanyu Wu Yuqi Wang Guocheng Zhang Bin kong Science and Technology on Underwater Vehicle Laboratory Harbin Engineering UniversityHarbin 150001China Key Laboratory of System Control and Information Processing Shanghai Jiao Tong UniversityShanghai 200030China Wuhan Second Ship Design and Research Institute Wuhan 430205China

To deal with the low location accuracy issue of existing underwater navigation technologies in autonomous underwater vehicles(AUVs),a distributed fusion algorithm which combines the model's analysis method with a multi-scale transformation method is proposed for integrated navigation system based on ***,integrated navigation system theory and system error sources are introduced in ***,a navigation system's observation equation on the original scale is decomposed into different scales by the discrete wavelet transform method,and noise reduction is performed by setting the wavelet de-noising *** last,the dynamic equation and observation equations are fused on different scales by the wavelet transformation and Kalman *** results show that the proposed algorithm has smaller navigation error and higher navigation accuracy.

关键词： autonomous underwater vehicles(AUVs) integrated navigation system wavelet transform multi-scale transform Kalman filter

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内生真菌MG-9的主物质麦角甾醇的分离鉴定及抗氧化活性分析

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三峡大学学报（自然科学版） 2017年第2期39卷 108-112页

作者：秦王阁阁孔玉珊蒋维李辉薛艳红刘呈雄刘士平三峡大学生物与制药学院湖北宜昌443002

从疏花水柏枝中的一株内生真菌MG-9的粗提物中重结晶出一种主物质,采用NMR、MS等现代波谱学技术鉴定这种主物质为麦角甾醇.以LDH(乳酸脱氢酶)、SOD(超氧化物歧化酶)、caspase 3、caspase 9的酶活表达情况为指标,研究了MG-9主物质对神经... 详细信息

从疏花水柏枝中的一株内生真菌MG-9的粗提物中重结晶出一种主物质,采用NMR、MS等现代波谱学技术鉴定这种主物质为麦角甾醇.以LDH(乳酸脱氢酶)、SOD(超氧化物歧化酶)、caspase 3、caspase 9的酶活表达情况为指标,研究了MG-9主物质对神经细胞SH-SY5Y的毒害作用及抗氧化保护作用机理.结果表明:麦角甾醇在6.25-25μg/mL时对神经细胞SH-SY5Y毒性的量效关系不明显,而在6.25μg/mL时对神经细胞SH-SY5Y的氧化损伤保护具有更好的效果,将神经细胞SH-SY5Y在H_2O_2(800μmol/L)胁迫下的相对存活率提高了74.5%.并且麦角甾醇可通过抑制凋亡蛋白caspase 3的活性来达到对神经细胞SH-SY5Y的抗氧化保护作用.

关键词：内生真菌麦角甾醇神经细胞保护抗氧化活性

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秦巴山区低产老茶园改造技术

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现代农业科技 2021年第5期 37-38页

作者：顿耀元孔瑜珊王小丽余永松张玥黄进孙琦十堰市农业科学院湖北十堰442000

低产老茶园改造不仅可以进一步提升茶叶的品质和产量,还可以延长茶叶的获益周期和产值,是一项重要的茶叶栽培技术。本文阐述了低产老茶园改造的意义,介绍了对秦巴山区低产老茶园改造技术,包括园相与园貌改造、土壤改良、台刈、除草、病... 详细信息

低产老茶园改造不仅可以进一步提升茶叶的品质和产量,还可以延长茶叶的获益周期和产值,是一项重要的茶叶栽培技术。本文阐述了低产老茶园改造的意义,介绍了对秦巴山区低产老茶园改造技术,包括园相与园貌改造、土壤改良、台刈、除草、病虫害防治等方面内容,以供种植户参考。

关键词：低产老茶园改造技术秦巴山区

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十堰地区无性系良种茶树建园技术

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现代农业科技 2021年第18期 30-32页

作者：孙琦张玥余永松黄进孔瑜珊王小丽顿耀元十堰市农业科学院湖北十堰442000 十堰市果茶研究所湖北十堰442000

茶产业是十堰市的优势特色产业,是农民增收的重要手段。目前,十堰地区无性系良种茶园的建设存在管理粗放、标准不一等问题。本文针对十堰地区的环境特点,提出一套无性系茶园建园技术,包括茶园规划及选址、园地整理、苗木定植、幼龄茶园... 详细信息

茶产业是十堰市的优势特色产业,是农民增收的重要手段。目前,十堰地区无性系良种茶园的建设存在管理粗放、标准不一等问题。本文针对十堰地区的环境特点,提出一套无性系茶园建园技术,包括茶园规划及选址、园地整理、苗木定植、幼龄茶园管理及病虫害防治等方面内容,以提高茶树成活率,提升茶园品质。

关键词：茶树无性系建园技术湖北十堰

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On Eigen-Matrix Translation Method for Classification of Biological Data

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Journal of Systems Science & Complexity 2015年第5期28卷 1212-1230页

作者： JIANG Hao QIU yushan CHENG Xiaoqing CHING Waiki Department of Mathematics School of Information Renmin University of China Advanced Modeling and Applied Computing Laboratory Department of Mathematics The University of Hong Kong

Driven by the challenge of integrating large amount of experimental data, classification technique emerges as one of the major and popular tools in computational biology and bioinformatics research. Machine learning methods, especially kernel methods with Support Vector Machines(SVMs)are very popular and effective tools. In the perspective of kernel matrix, a technique namely Eigenmatrix translation has been introduced for protein data classification. The Eigen-matrix translation strategy has a lot of nice properties which deserve more exploration. This paper investigates the major role of Eigen-matrix translation in classification. The authors propose that its importance lies in the dimension reduction of predictor attributes within the data set. This is very important when the dimension of features is huge. The authors show by numerical experiments on real biological data sets that the proposed framework is crucial and effective in improving classification accuracy. This can therefore serve as a novel perspective for future research in dimension reduction problems.

关键词： Classification dimension reduction eigen-matrix translation glycan data kernel method(KM) support vector machine(SVM)

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Density functional theory calculations on 2H-MoS_(2) monolayer for HCHO degradation:Piezoelectric-photocatalytic synergy

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Chinese Chemical Letters 2023年第5期34卷 337-342页

作者： yushan Zhu Weina Zhao Binghua Jing Junhui Zhou Bihai Cai Didi Li Zhimin Ao Guangzhou Key Laboratory Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyKowloonHong Kong 99977China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Formaldehyde(HCHO)is a common indoor gaseous pollutant,and long-term exposure to it may cause serious damage to the human immune *** degradation of HCHO is a promising ***,most photocatalysts have the disadvantage of rapid recombination of photo-generated electron-hole *** this work,the recombination of photogenerated electron holes was proposed to inhibit through the piezoelectric effect.A two-dimensional(2D)piezoelectric material,2H-MoS_(2),was selected to investigate the catalytic performance for HCHO degradation by the synergy of the piezoelectric and photocatalysis *** results show that the piezoelectric effect can induce the polarization in 2H-MoS_(2) and inhibit the recombination of photogenerated electron-hole pairs,thus improving the photogeneration of hydroxyl radicals for HCHO ***,the piezoelectric-photo-catalysis synergistic effect based on density functional theory(DFT)calculation was proposed to elucidate the HCHO degradation *** work could provide important guidance for the development of effective catalysts for HCHO degradation and the application of 2D piezoelectric materials.

关键词： Piezoelectricity Photocatalysis 2H-MoS_(2) HCHO Degradation

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Construction of Ru/WO3 with hetero-interface structure for efficient hydrogen evolution reaction

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Journal of Energy Chemistry 2023年第8期83卷 150-157,I0006页

作者： Xin Xie Yunxiao Fan Wanyu Tian Meng Zhang Jialin Cai Xingang Zhang Jie Ding yushan Liu Siyu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001HenanChina College of Material Henan Key Laboratory of Aeronautical Materials and Application TechnologyZhengzhou University of AeronauticsZhengzhou 4500oHenanChina

Water electrolysis is considered as one most promising technique for hydrogen *** high efficiency electrocatalyst is the key to accelerating the sluggish kinetics of the hydrogen evolution reaction(HER) in alkaline *** this work,an efficient HER electrocatalyst with hetero-interfacial metal-metal oxide structure was constructed through a redox solid phase reaction(SPR) *** the annealing process under Ar atmosphere,RuO_(2) and WS_(2)in RuO_(2)/WS_(2)precursor were converted to Ru nanoparticles(NPs) and WO3in situ,where tiny Ru NPs and oxygen vacancies were uniformly distributed onto the newly formed *** characterization techniques were adopted to confirm the successful formation of Ru/WO_(3)electrocatalyst(RWOC).The optimized RWOC sample annealed at 400℃ exhibited the low overpotential value of 13 mV at a current density of 10 mA cm^(-2)and strong durability under the alkaline *** functional theoretical calculations further revealed that the promoted adsorption/desorption rate of reaction intermediates and the accelerated kinetics of HER process were deduced to the synergistic effect between Ru and WO_(3)in *** work provides a feasible method to fabricate highly efficient HER electrocatalysts.

关键词： Ru WO_(3) Hetero-interface Hydrogen evolution reaction Electrocatalyst

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