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Hyperactivity and Abnormal Exploratory Activity Developing in CD-1 Male Mice under Chronic Experience of Aggression and Social Defeats

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Journal of Behavioral and Brain Science 2015年第11期5卷 478-490页

作者： Irina L. kovalenko Anna G. Galyamina Dmitry A. Smagin Natalia N. Kudryavtseva Modeling of Neuropathology Laboratory Neurogenetics of Social Behavior Sector Siberian Department of Russian Academy of Sciences Institute of Cytology and Genetics Novosibirsk Russia

Chronic social defeat stress induces diverse effects in mice of different strains and even in animals of the same strain. This paper aims to study the effect of repeated social defeats and, for contrast, repeated aggression in daily agonistic interactions on the behaviors of CD-1 male mice. The behavior of animals that have the same winning and losing track record during 3, 10, 21 days is studied in different tests. The level of aggressiveness, as estimated by the number and total time of attacks, decreases;nevertheless, direct and indirect forms of aggression demonstrated by the aggressive mice (winners) remain significantly high. The number of stereotypic behaviors (rotations and jumps) and total time of digging behaviors are significantly increased in the winners after 21 days compared to 3 and 10 days of intermale confrontations. Among the losers, chronic experience of social defeats is accompanied by the development of pronounced anxiety and a depression-like state estimated by the elevated plus-maze and the Porsolt test scores, respectively. Both groups of male mice with alternative social behaviors demonstrate abnormal locomotor and exploratory behaviors in the open-field test. This phenomenon may be viewed as hyperactivity developed under chronic agonistic interactions and specific for the outbred CD-1 mice. We believe that these animals may be potentially used for modeling the key symptoms of bipolar disorder.

关键词： Chronic Social Defeats Repeated Aggression Hyperactivity Depression Anxiety CD-1 Mice Model of Bipolar Disorder

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Synthesis of cyclic carbonates from epoxides or olefins and CO_2 catalyzed by metal-organic frameworks and quaternary ammonium salts

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Journal of Energy Chemistry 2013年第1期22卷 130-135页

作者： Olga V. Zalomaeva Nataliya V. Maksimchuk Andrey M. Chibiryaev Konstantin A. kovalenko Vladimir P. Fedin Bair S. Balzhinimaev Boreskov Institute of Catalysis pr. Akademika Lavrentieva 5 Vorozhtsov Novosibirsk Institute of Organic Chemistry pr Akademika Lavrentieva 9 Nikolaev Institute of Inorganic Chemistry pr. Akademika Lavrentieva 3

Catalytic properties of the metal-organic framework Cr-MIL-101 in solvent-free cycloaddition of CO2 to epoxides to produce cyclic carbon- ates using tetrabutylammonium bromide as co-catalyst have been explored under mild reaction conditions （8 bar CO2, 25 ~C）. Styrene and propylene carbonates were formed with high yields （95% and 82%, respectively）. Catalytic performance of Cr-MIL-101 was compared with other MOFs： Fe-MIL-101, Zn-MOF-5 and HKUST-1, The catalytic properties of different quaternary ammonium bromides, Cr-MIL-101 as well as PW12/Cr-MIL-101 composite material have been assessed in oxidative carboxylation of styrene in the presence of both tert-butyl hydroperoxide and H202 as oxidants at 8-100bar CO2 and 25-80 ~C with selectivity to styrene carbonate up to 44% at 57% substrate conversion.

关键词： carbon dioxide cyclic carbonates cycloaddition heterogeneous catalysis metal-organic framework oxidative carboxylation quaternary am-monium salts

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用于激光再制造的沸腾式送粉器仿真与控制优化

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应用激光 2013年第1期33卷 24-29页

作者：胡晓冬马磊姚建华陈智君 Volodymyr kovalenko 特种装备制造与先进加工技术教育部/浙江省重点实验室(浙江工业大学) 浙江杭州310014 浙江工业大学激光加工技术工程研究中心浙江杭州310014 乌克兰国立科技大学激光技术研究所基辅03056

设计了一种用于激光再制造的沸腾式送粉器,并基于PICF877A单片机开发了送粉器控制系统。为探索送粉器输送规律,以Fluent软件为工具,通过变化沸腾气流量值、送粉气流量值等参数,探讨气体输送流量大小、输送策略等对粉末输送特性的影响。... 详细信息

设计了一种用于激光再制造的沸腾式送粉器,并基于PICF877A单片机开发了送粉器控制系统。为探索送粉器输送规律,以Fluent软件为工具,通过变化沸腾气流量值、送粉气流量值等参数,探讨气体输送流量大小、输送策略等对粉末输送特性的影响。在仿真研究的基础上,建立控制系统的控制策略,并以所开发的控制系统为实验平台对控制规律进行实验验证。实验结果证明:该系统控制精度高、稳定性好,能够满足再制造系统的需要。

关键词：激光再制造沸腾式送粉器数值模拟控制系统

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电磁复合场协同激光熔覆制备TiB_w/Ti网状结构复合涂层

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表面技术 2019年第5期48卷 102-107页

作者：袁莹林英华王梁张杰姚建华刘新新 Volodymyr S.kovalenko 浙江工业大学激光先进制造研究院杭州310014 哈尔滨汽轮机厂有限责任公司哈尔滨150046 乌克兰国立科技大学激光技术研究所乌克兰基辅03056

目的利用电磁复合场(EMCF)辅助激光熔覆制备TiB_w/Ti网状结构复合涂层,探索电磁场对涂层组织结构的影响。方法以TiB_2∶Ti=1∶1(摩尔比)的混合粉末为熔覆材料,TC4作为基板材料,通过外加电磁复合场进行激光熔覆试验。通过扫描电子显微镜(... 详细信息

目的利用电磁复合场(EMCF)辅助激光熔覆制备TiB_w/Ti网状结构复合涂层,探索电磁场对涂层组织结构的影响。方法以TiB_2∶Ti=1∶1(摩尔比)的混合粉末为熔覆材料,TC4作为基板材料,通过外加电磁复合场进行激光熔覆试验。通过扫描电子显微镜(SEM)观察洛伦兹力方向对熔覆层组织结构的影响,利用X射线衍射仪(XRD)和维氏显微硬度计分析施加电磁复合场前后熔覆层的相组成和硬度分布。结果未施加电磁复合场的熔覆层组织主要为细针状、粗棒状和颗粒状组织。而施加电磁复合场后,熔覆层出现了网状结构,而且方向向下的洛伦兹力可使涂层内部形成空间间距更大的网状结构。此外,单独施加稳态磁场后,熔覆层只出现细针状和粗棒状组织。电磁复合场施加前后熔覆层硬度与基体相比,均有很大的提高。但未施加电磁复合场的熔覆层硬度变化幅度较大;施加电磁复合场后,随着距熔覆层表面距离的增加,硬度的变化幅度比较平缓。结论在洛伦兹力作用下,可得到TiB_w/Ti网状结构的复合涂层,电磁复合场使TiB_w/Ti网状结构强化相均匀分布,同时提高涂层的显微硬度。

关键词：激光熔覆洛伦兹力网状结构 TiB 电磁复合场显微组织

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基于统计模型优化的铝合金激光熔覆研究

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应用激光 2010年第6期30卷 460-464页

作者：王维夫 V.kovalenko M.Anyakin 耿广刚陈智君姚建华特种装备制造与先进加工技术教育部/浙江省重点实验室(浙江工业大学) 浙江杭州310014 乌克兰国立科技大学激光技术研究所基辅03056

为了解决铝合金零件激光修复与再制造中的气孔等质量问题,以正交试验规则为基础,采用高吸收率半导体激光在铝合金表面设计了熔覆实验,并采用统计模型进行了优化。结果表明,在有效控制保护气氛的前提下,通过优化工艺参数能够显著的减少... 详细信息

为了解决铝合金零件激光修复与再制造中的气孔等质量问题,以正交试验规则为基础,采用高吸收率半导体激光在铝合金表面设计了熔覆实验,并采用统计模型进行了优化。结果表明,在有效控制保护气氛的前提下,通过优化工艺参数能够显著的减少熔覆层中的气孔缺陷。基于统计模型模拟的结果显示,适当降低扫描速度有利于减少涂层中气孔的数量。功率变化的影响相对较小,但可以显著影响涂层的成形质量。分析认为这主要与不同条件下熔覆过程中的气泡的排出行为差异有关。

关键词：铝合金激光熔覆气孔统计模型

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Application of mobile photography with smartphone cameras for monitoring of orthodontic correction with dental BRACKETS

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中国现代医学杂志 2014年第15期24卷 10-14页

作者： Godlevsky LS Bidnyuk EA Bayazitov NR Kresyun NV kovalenko AS Lyashenko AV Balykov VV

This research was to observe patients,who underwent orthodontic tooth alignment correction with dental brackets,for the purpose of early detection of white spots(early satge of caries)and dynamic measurement of distance between teeth edges based on the digital photographs taken with a smartphone Sony Xperia *** reading was realized taking into account the adjustment of color features of a standard ceramic surface(tile)that was selected during the dental brackets installation period,the photo of which was taken simultaneously during the dynamic observation *** color scale RGB was transformed into CIE L*a*b scale of color measurement with regard to the correction of RGB components of image by usage of correction coefficient for calibration tile surface RGB *** expert appraisal showed sensitivity of proposed method was between 88.7%and 96.2%(the mean 93.1%)and specificity between 68.4%and 84.2%(the mean 75.4%).The positive predictive value was between 89.5%and94.0%(the mean 91.5%);and the negative predictive value was between 72.7%and 86.7%(the mean 80.6%).The measurement of the distance between teeth edges during the first 10 days following the brackets installation was carried out using a self-scalable ruler that was calibrated,according to the standard sizes of the dental bracket system *** Android application of self-scalable ruler was developed using *** development of a pronounced pain syndrome was observed when the velocity of distance changes between teeth edges was rather high-0.051+0.004 mm/*** improvement of efficiency of the suggested method is expected due to application of illumination standards during the shooting period.

关键词：牙科口腔卫生牙齿治疗方法

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Effects of the Novel Anti-Asthenic Drug Ladasten on Behavior and T-Cell Subsets Alterations in a Social Defeat Animal Model of Depression

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Pharmacology & Pharmacy 2014年第1期5卷 4-10页

作者： Anna V. Tallerova Larisa P. kovalenko Iosif B. Tsorin Andrey D. Durnev Sergey B. Seredenin Federal State Budgetary Institution “Research Zakusov Institute of Pharmacology” under the Russian Academy of Medical Science Moscow Russia Federal State Budgetary Institution “Research Zakusov Institute of Pharmacology” under the Russian Academy of Medical Science Moscow Russia.

The aim of the present study was to investigate the effects of the anti-asthenic drug ladasten on behavioral patterns and T-cell subsets in blood, spleen, and thymus in socially stressed male C57Bl/6 mice. Mice subjected to social defeat stress (SDS) for 25 days developed a depressive-like phenotype. The submissive SDS animals were assigned to one of two treatment groups: one group was treated with ladasten (30 mg/kg, i.p.) for up to 5 days, and the other one was administered vehicle as a control. Twenty four hours after the last injection, behavioral parameters were tested, and trunk blood and tissue samples were collected. SDS mice from the vehicle-treated group showed a subordinate and passive avoidance behavior with significantly decreased spontaneous locomotor activity (SLA) and exhibited impaired parameters in the forced swimming test (FST). Changes in behavioral status were correlated with an increase spleen weight, a decrease in thymic index and a shift in the CD4/CD8 balance toward T-cytotoxic cells. The behavior parameters were reversed in the group treated with ladasten compared to the untreated SDS group and were similar to those of unstressed mice. Treatment of socially stressed mice with ladasten normalized the amount of T-lymphocyte cells in the blood, spleen, and thymus. These findings support the notion that depression is accompanied by cell-mediated immune activation and that targeting this pathway may be a new therapeutic approach for treatment. Furthermore, our data support further investigations of ladasten as a potent anti-depressive drug which can be used alone as well as in combination with other anti-depressants.

关键词： Ladasten Social Defeat Stress Depression Cytokines T-Cells

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Modelling One-Pot Method for Synthesis of 2,3-Dihydro-1<i>H</i>-pyrrolo[2,1-<i>c</i>][1,4]benzothiazine 5,5-Dioxides and Their Homologues

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International Journal of Organic Chemistry 2013年第2期3卷 125-135页

作者： Oleksandr Yu Grevtsov Oleg V. Zaremba Anna B. Bondarenko Oleksandr G. Drushlyak Sergiy M. kovalenko Valentyn P. Chernykh National University of Pharmacy Kharkiv Ukraine

A facile method for synthesis of 2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzothiazines by interaction of methylenactive (2-fluorophenyl)sulfones with homologues of either 5-methoxy-3,4-dihydro-2H-pyrrole or 5-(methylthio)-... 详细信息

关键词： Sulfones Lactims Cyclization Heterocycles Nucleophilic Aromatic Substitution

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热障涂层后处理技术研究进展

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材料研究与应用 2022年第1期16卷 48-56页

作者：李灿锋张盼盼姚建华张群莉 Volodymyr kovalenko 浙江工业大学激光先进制造研究院浙江杭州310023 浙江工业大学高端激光制造装备省部共建协同创新中心浙江杭州310023 浙江工业大学机械工程学院浙江杭州310023 乌克兰国立科技大学激光技术研究所基辅03056

热障涂层是一种降低航空发动机热端部件表面温度、提高发动机推力和效率的热防护技术,但其服役于高温、高压、高交变应力等恶劣环境而易脱落失效.对热障涂层的后处理技术进行了阐述,论述了真空热处理、热等静压处理、激光重熔、激光上... 详细信息

热障涂层是一种降低航空发动机热端部件表面温度、提高发动机推力和效率的热防护技术,但其服役于高温、高压、高交变应力等恶劣环境而易脱落失效.对热障涂层的后处理技术进行了阐述,论述了真空热处理、热等静压处理、激光重熔、激光上釉、激光熔覆等后处理技术的方法和原理,并对比了不同工艺的优缺点.最后,展望了激光表面改性技术的应用前景和未来发展趋势.

关键词：热障涂层涂层后处理真空热处理激光重熔激光表面改性技术

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系统方法在形成乌克兰工程教育学中的应用

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江苏技术师范学院学报 2005年第6期11卷 1-6页

作者：欧琳娜.科瓦莲科乌克兰工程师范学院乌克兰哈尔克夫61003

把教育过程作为一个系统, 并对其核心、组成和发展的基本规则以及教育活动的核心作一个深度的理论分析。本文主要论述乌克兰教育学在高等教育中对工程教师的职业培训。

关键词：工程教育教育活动职业培训系统

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