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Chinese Optics Letters 2024年第7期22卷 19-28页

作者： yurui pu Chaoliang Chen School of Electronic Science&Engineering Southeast UniversityNanjing 210096China

A large field of view is in high demand for disease diagnosis in clinical applications of optical coherence tomography(OCT)and OCT angiography(OCTA)*** to limits on the optical scanning range,the scanning speed,or the data processing speed,only a relatively small region could be acquired and processed for most of the current clinical OCT systems at one time and could generate a mosaic image of multiple adjacent small-region images with registration algorithms for disease *** this work,we investigated performing cross-correlation(instead of phase-correlation)in the workflow of the Fourier–Mellin transform(FMT)method(called dual-cross-correlation-based translation and rotation registration,DCCTRR)for calculating translation and orientation offsets and compared its performance to the FMT method used on OCTA images *** phantom and in vivo experiments were implemented for comparisons,and the results quantitatively demonstrate that DCCTRR can align OCTA images with a lower overlap rate,which could improve the scanning efficiency of large-scale imaging in clinical applications.

关键词： optical coherence tomography optical coherence tomographic angiography:image registration cross-correlation phase-correlation.

Extraction of Flavonoids and Polyphenols from Coronatinetreated Mulberry Leaves and Evaluation of Their Antibacterial Activity against Pseudomonas syringae

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Agricultural Biotechnology 2017年第4期6卷 51-62页

作者： Na WANG Yanliang CHU yurui pu Fu'an WU College of Biotechnology Jiangsu University of Science and Technology Sericulture Research Institute Chinese Academy of Agricultural Sciences

Flavonoids and polyphenols are the main secondary metabelites in mulberry leaves, which have multiple biological functions such as antibacterial activity, free radical scavenging activity and antioxidant activity. In this paper, the parameters for the extraction of flavonoids and palyphenols from eoronatine （ COR）- treated mulberry leaves were optimized, and the components of the extracts were analyzed by high performance liquid chromatography （ HPLC）, and their antibacterial activity against Pseudomonas syringae, which causes mulberry bacterial blight, was evaluated in vitro to explore the mechanism how COR acted as a plant immune elicitor to improve the resistance of mulberry to bacterial blight. The results showed that ethanol concentration of 70%, extraction temperature of 80 ℃, extraction duration of 6 h and solid-liquid ratio of 1 ： 40 were the optimal parameters for the extraction of flavonoids and polyphenols from mulberry leaves. Flavonoids and polyphenols were mostly distributed in ethyl acetate and n-butyl alcohol fractions which showed better antibacterial activity than petroleum ether, dichloromethane and water fractions. Meanwhile, the antibacterial activity of ethyl acetate and n-butyl alcohol fractions of COR-treated mulberry leaves were more evident than that of water-treated mulberry leaves. Scanning electron microscopy showed that flavonoids and pelyphenols inhibited the growth of pathogenic bacteria by changing cell morphology, damaging cell wall structure and unbalancing cell osmotic pressure. HPLC analysis confirmed the contents of morin, quercetin, quereitrin, kaempferol, chlorogenic acid and rutin were increased to a different extent in COR-treated mulberry leaves. So it can be concluded that the increased contents of flavonoids and polyphenols induced by COR may be one of the reasons for the enhanced resistance to mulberry bacterial blight.

关键词： Corenatine Mulberry Flavonoids Polyphenols Antibacterial activity Mulberry bacterial blight

Low-cost spectrometer design for ultra-high resolution spectral domain optical coherence tomography

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Chinese Optics Letters 2023年第10期21卷 19-23页

作者：陈朝良蒲郁蕊史伟松 Advanced Photonics Center School of Electronic Science&EngineeringSoutheast UniversityNanjing 210096China Department of Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China

In this Letter,we present a low-cost,high-resolution spectrometer design for ultra-high resolution optical coherence tomography(UHR-OCT),in which multiple standard achromatic lenses are combined to replace the expensive F-theta lens to achieve a comparable *** UHR-OCT,the spectrometer plays an important role in high-quality 3D image ***,an F-theta lens is used in spectrometers as the Fourier lens to focus the dispersed light on the sensor array,and this F-theta lens is one of the most expensive components in *** advantage of F-theta lens over the most widely used achromatic lens is that the aberrations(mainly spherical aberration,SA)are corrected,so the foci of the dispersed optical beams(at different wavelengths)with different incident angles could be placed on the sensor array *** the achromatic lens,the foci of the center part of the spectrum are farther than those on the side in the longitudinal direction,causing degradations of the spectral ***,in comparison with the achromatic lens with the same focal length,those with smaller diameters have stronger SA,but small lenses are what we need for making spectrometers compact and *** this work,we propose a simple method of using multiple long-focal-length achromatic lenses together to replace the F-theta lens,which is>8-fold cheaper based on the price of optical components from Thorlabs,*** simulations and in vivo experiments were implemented to demonstrate the performance of the proposed method.

关键词： low-cost spectrometer optical coherence tomography spherical aberration suppression ultrahigh-resolution non-invasive imaging

Revealing the output power potential of bifacial monolithic all-perovskite tandem solar cells

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eLight 2022年第1期2卷 274-283页

作者： Hongjiang Li yurui Wang Han Gao Mei Zhang Renxing Lin pu Wu Ke Xiao Hairen Tan Jiangsu Key Laboratory of Artificial Functional Materials College of Engineering and Applied SciencesNational Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210023China

Bifacial monolithic all-perovskite tandem solar cells have the promise of delivering higher output power density by inheriting the advantages of both tandem and bifacial architectures ***,we demonstrate,for the first time,the bifacial monolithic all-perovskite tandem solar cells and reveal their output power *** bifacial tandems are realized by replacing the rear metal electrodes of monofacial tandems with transparent conduction oxide *** engineering is deployed to achieve current matching under various rear illumination *** bifacial tandems show a high output power density of 28.51 mW cm−2 under a realistic rear illumination(30 mW cm−2).Further energy yield calculation shows substantial energy yield gain for bifacial tandems compared with the monofacial tandems under various ground albedo for different climatic *** work provides a new device architecture for higher output power for all-perovskite tandem solar cells under real-world conditions.

关键词： Bifacial tandems All-perovskite tandem solar cells Bandgap engineering Energy yield Stability

磁共振波谱成像联合直肠指检及血清PSA在前列腺癌诊断中的价值

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第三军医大学学报 2012年第15期34卷 1548-1551页

作者：易强王庆伟车英玉张玉瑞袁璞杨小明李琦杨阳师磊宋东奎郑州大学第一附属医院泌尿外科 450052 磁共振室

目的初步探讨磁共振波谱成像(MRS)联合直肠指检(DRE)与血清前列腺特异抗原(PSA)在前列腺癌诊断中的应用。方法选取血清PSA异常84例男性患者行前列腺MRS和DRE并与病理结果对照。再分析MRS联合DRE及不同水平PSA(低危组4 ng/ml20 ng/ml)诊... 详细信息

目的初步探讨磁共振波谱成像(MRS)联合直肠指检(DRE)与血清前列腺特异抗原(PSA)在前列腺癌诊断中的应用。方法选取血清PSA异常84例男性患者行前列腺MRS和DRE并与病理结果对照。再分析MRS联合DRE及不同水平PSA(低危组4 ng/ml20 ng/ml)诊断前列腺癌的灵敏度(Se)、特异度(Sp)和准确度(AR)。结果病理证实前列腺癌41例、非前列腺癌43例(良性增生41例,炎症1例,结核1例)。单纯MRS诊断前列腺癌的Se、Sp和AR分别为85.4%、83.7%和84.5%,与病理诊断有统计学一致性(K=0.69,P<0.05);MRS联合PSA低危组、中危组和高危组诊断的Se、Sp和AR分别为75.0%、90.0%和84.4%,66.7%、73.3%和71.4%,95.7%、87.5%和93.5%;MRS联合DRE诊断Se、Sp和AR分别为88.9%、87.5%和88.6%;MRS同时联合PSA高危组及DRE诊断Se、Sp和AR分别增加至95.7%、100%和95.8%,差异均有统计学意义(P<0.05)。结论 MRS诊断前列腺癌具有无创和简便优点,其联合直肠指检及PSA有助于提高诊断的准确性。

关键词：磁共振波谱成像前列腺肿瘤前列腺特异性抗原直肠指检

尿中修饰核苷水平在膀胱移行细胞癌诊断及预测预后中的意义

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第三军医大学学报 2011年第16期33卷 1714-1717页

作者：吴辉刘宏民杨松鹏王庆伟张玉瑞袁璞易强刘刚王少敏宋东奎郑州大学第一附属医院泌尿外科郑州450052 郑州大学化学系质谱实验室郑州450052 郑州大学肿瘤分子外科研究所郑州450052 河南省高等学校临床医学重点学科开放实验室

目的探讨尿中7种修饰核苷M1A、ac4C、A、06-MeG、MTA、1-MeI、1-MeG检测在膀胱移行细胞癌(bladdertransitional cell carcinoma,BTCC)诊断及预测预后中的意义。方法选取经病理证实为膀胱移行细胞癌患者45例为膀胱癌组,其中初发32例,复... 详细信息

目的探讨尿中7种修饰核苷M1A、ac4C、A、06-MeG、MTA、1-MeI、1-MeG检测在膀胱移行细胞癌(bladdertransitional cell carcinoma,BTCC)诊断及预测预后中的意义。方法选取经病理证实为膀胱移行细胞癌患者45例为膀胱癌组,其中初发32例,复发13例;组织学分级:Ⅰ级22例,Ⅱ级16例,Ⅲ级7例;浸润性癌16例,非浸润癌29例。选取16例正常人为对照组。应用高效液相色谱/电喷雾-四极杆-飞行时间质谱技术(HPLC/ESI-Q-TOF-MS)检测膀胱癌组和对照组尿液中M1A、ac4C、A、06-MeG、MTA、1-MeI、1-MeG 7种修饰核苷水平(核苷含量/肌酐)。结果 BTCC组尿液M1A、ac4C、06-MeG和1-MeI水平[分别为(4.61±1.82)、(0.63±0.29)、(0.46±0.35)和(12.28±9.74)],均显著高于对照组[(2.85±0.68)、(0.35±0.15)、(0.21±0.11)和(5.39±2.41),PM1A>ac4C>06-MeG,且1-MeI与M1A联合检测可达到对膀胱癌最高的灵敏度和特异性,分别为92.45%和87.50%。BTCC组织学分级之间以及浸润性与非浸润性之间尿液修饰核苷水平差异均无统计学意义(P>0.05)。复发患者尿液M1A和ac4C水平分别为(6.74±1.23)、(0.83±0.41),均显著性高于初发患者[(3.93±1.43)、(0.57±0.20),P<0.05],M1A与其复发时间呈负相关(r=-0.895,P<0.01)。结论尿液M1A联合1-MeI检测在膀胱移行细胞癌诊断中意义重大,M1A和ac4C有助于预测膀胱移行细胞癌患者预后。

关键词：膀胱移行细胞癌修饰核苷高效液相色谱/电喷雾-四极杆-飞行时间质谱技术

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爱普铁矿巷道围岩稳定性评价

金属矿山 2012年第2期41卷 57-59页

作者：缪玉松张义平左宇军杨玉蕊贵州大学矿业学院贵州非金属矿产资源综合利用重点实验室

应用RMR分析了岩石的稳定性,同时应用普氏理论对巷道围岩坚固性进行运算,最后运用phase2有限元分析模拟巷道周围应力的分布情况,结合以上三者得出的结果进行比较,得出爱普铁矿巷道稳定性的综合评价,并对巷道维护提出了合理的建议。结果... 详细信息

应用RMR分析了岩石的稳定性,同时应用普氏理论对巷道围岩坚固性进行运算,最后运用phase2有限元分析模拟巷道周围应力的分布情况,结合以上三者得出的结果进行比较,得出爱普铁矿巷道稳定性的综合评价,并对巷道维护提出了合理的建议。结果表明,合理的巷道围岩压力分析和模拟,能够正确地反映围岩的分布特征,对今后预测评价巷道稳定有着重要作用。

关键词：稳定性 RMR 普氏坚固性系数 phase2

2020年兰州市8~10岁儿童碘营养状况调查分析

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中国预防医学杂志 2023年第4期24卷 363-367页

作者：李盛姚国爱赵玉锐郑艳妮李普朱东升李昕蓉冯亚莉杨露王金玉甘肃省兰州市第一人民医院公共卫生科甘肃兰州730050 甘肃中医药大学公共卫生学院甘肃省白银市第二人民医院兰州大学基础医学院

目的了解兰州市儿童的碘营养状况,为兰州市儿童科学补碘提供理论依据。方法采用多阶段随机抽样的方法抽取兰州市各(县、区)的8~10岁儿童作为研究对象,收集儿童的尿样和家中食用盐盐样,采用《制盐工业通用试验方法碘的测定》(GB/T 13025... 详细信息

目的了解兰州市儿童的碘营养状况,为兰州市儿童科学补碘提供理论依据。方法采用多阶段随机抽样的方法抽取兰州市各(县、区)的8~10岁儿童作为研究对象,收集儿童的尿样和家中食用盐盐样,采用《制盐工业通用试验方法碘的测定》(GB/T 13025.7)测定儿童碘盐含量,采用《尿中碘的砷铈催化分光光度测定方法》(WS/T 107)测定儿童尿碘含量。结果8个县(区)共采集儿童家中食用盐样品1610份,其中碘盐1601份,非碘盐9份,合格碘盐1460份,碘盐覆盖率为99.44%(1601/1610),碘盐合格率为91.19%(1460/1601),合格碘盐食用率为90.68%(1460/1610)。共采集儿童尿样1610份,尿碘中位数为208.95μg/L。结论2020年兰州市8~10岁儿童碘营养水平总体适宜,但部分县(区)的盐碘合格率较低,应普及碘盐相关知识,提高这部分县区的盐碘合格率,预防碘相关疾病,从而提高居民整体的健康状况。

关键词：儿童尿碘盐碘营养状况