检索结果-南通市图书馆

Accumulation, transportation, and distribution of tetracycline and cadmium in rice

Journal of Environmental Sciences 2023年第4期126卷 58-69页

作者： Chunfeng He Jini Zhou Chen Yang Zhiyi Song Junheng He Ziqing Huang yurong deng Jinling Wang Yu Xiong Zhi Dang College of Environment and Energy South China University of TechnologyGuangzhou 510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou 510006China Department of Environmental Sciences The State University of New JerseyRutgers UniversityNew BrunswickNJ 08901USA Guangdong Institute of Ecological Environment and Soil Guangzhou 510650China

Co-exposure to heavy metal and antibiotic pollution might result in complexation and synergistic interactions,affecting rice growth and further exacerbating pollutant enrichment.Therefore,our study sought to clarify the influence of different Tetracycline (TC) and Cadmium(Cd) concentration ratios (both alone and combined) on rice growth,pollutant accumulation,and transportation during the tillering stage in hydroponic system.Surprisingly,our findings indicated that the interaction between TC and Cd could alleviate the toxic effects of TC/Cd on aerial rice structures and decrease pollutant burdens during root elongation.In contrast,TC and Cd synergistically promoted the accumulation of TC/Cd in rice roots.However,their interaction increased the accumulation of TC in roots while decreasing the accumulation of Cd when the toxicant doses increased.The strong affinity of rice to Cd promoted its upward transport from the roots,whereas the toxic effects of TC reduced TC transport.Therefore,the combined toxicity of the two pollutants inhibited their upward transport.Additionally,a low concentration of TC promoted the accumulation of Cd in rice mainly in the root tip.Furthermore,a certain dose of TC promoted the upward migration of Cd from the root tip.Laser ablation-inductively coupled plasma mass spectrometry demonstrated that Cd mainly accumulated in the epidermis and stele of the root,whereas Fe mainly accumulated in the epidermis,which inhibited the absorption and accumulation of Cd by the rice roots through the generation of a Fe plaque.Our findings thus provide insights into the effects of TC and Cd co-exposure on rice growth.

关键词： Laser ablation-inductively coupled plasma mass spectrometry Tetracycline Cadmium Accumulation Distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assembly-enhanced triplet-triplet annihilation upconversion in the aggregation formed by Schiff-base Pt(Ⅱ) complex grafting-permethyl-β-CD and 9,10-diphenylanthracence dimer

引用

Chinese Chemical Letters 2019年第11期30卷 1979-1983页

作者： Hongxia Lai Ting Zhao yurong deng Chunyin Fan Wanhua Wu Cheng Yang Key Laboratory of Green Chemistry & Technology College of Chemistry and Healthy Food Evaluation Research CenterSichuan Univerity

Water-soluble triplet sensitizer with permethyl-β-cyclodextrin(PMCD)grafting on a Schiff-base Pt(II)complex(Pt-2),in which PMCD unit serves as a host for binding the acceptors and the Schiff-base Pt(II)complex serves as a triplet sensitizer,was synthesized to investigate the effect of supramolecular complexation and assembly on the triplet-triplet annihilation upconversion emission in water.9,10-Diphenylanthracence(DPA)carboxylate(A-1)and its dimer(A-2)in which two DPA carboxylate were covalently linked with an alkyl chain were synthesized as triplet acceptors which also play a role of guest molecules for PMCD.A-1 and A-2 showed high affinity with PMCD,and A-2 can readily aggregate in water and form micron sized assemblies due to the hydrophobic effect andπ-πstacking of anthracene core in A-2.The efficiency of TTA-UC was demonstrated to be enhanced by a synergistic effect of host-guest complexation of Pt-2 with A-2 and the self-aggregation of the acceptor A-2,which facilitated the energy transfer and energy fusion among donor and acceptor.

关键词： Triplet-triplet annihilation upconversion Host-guest interactions Self-aggregation Permethyl-β-CD

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preventing HIV Epidemic in China:Policy Evolution and Coordination Mechanisms in the Past Four Decades

引用

China CDC weekly 2023年第48期5卷 1084-1091页

作者： Yanli Liu yurong Zhang Xiaoxin Xu Zhidi deng Xiaobo Wang Duozhen Yuan Zelin Xue Xiulan Zhang School of Law Politics and Public AdministrationHebei Normal UniversityShijiazhuangHebei ProvinceChina School of Social Development and Public Policy Beijing Normal UniversityBeijingChina Faculty of Medicine and Dentistry University of AlbertaEdmontonCanada.

China has achieved commendable success in stabilizing human immunodeficiency virus(HIV)prevalence at a relatively low level of transmission(1).Nevertheless,the total number of people living with HIV in China rose to approximately 1.05 million,with cumulative reported acquired immune deficiency syndrome(AIDS)-related fatalities reaching 351,000 by the end of 2020(2).Since the initial infiltration of HIV into China in 1982(3),the nation has enacted over 471 national policies through 2021 to combat the epidemic.Initially,the outbreak was perceived primarily as a healthcare issue rather than the complex societal challenge that it manifested into.The Ministry of Health(MOH,now known as National Health Commission)was initially tasked with HIV prevention,issuing the nation’s first HIV/AIDS-related policy in 1984,which aimed to ban HIV-infected products and individuals from entry.Regrettably,this approach proved inadequate as significant HIV outbreaks unfolded.At this juncture,the State Council Research Office recognized the HIV epidemic as a grave societal and public health issue,posing a threat to the“Survival of the Chinese Nation”(4).Engagement at a higher governmental level became imperative to coordinate an effective response across diverse administrative agencies.

关键词： prevention initially primarily

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肌骨共生相关信号通路研究进展

引用

协和医学杂志 2024年第1期15卷 147-152页

作者：刘晏东邓强张彦军李中锋彭冉东郭铁峰王雨榕陈博甘肃中医药大学兰州730030 甘肃省中医院兰州730050

骨质疏松症是一种以骨量降低、骨组织微结构损坏、骨脆性增加、易发生骨折为特征的全身代谢性骨病,而肌少症是以进行性全身肌量减少和功能减退为主要特征的综合征。基于二者共同的病理生理机制及密切相关性,逐渐衍生出“肌少-骨质疏松... 详细信息

骨质疏松症是一种以骨量降低、骨组织微结构损坏、骨脆性增加、易发生骨折为特征的全身代谢性骨病,而肌少症是以进行性全身肌量减少和功能减退为主要特征的综合征。基于二者共同的病理生理机制及密切相关性,逐渐衍生出“肌少-骨质疏松症”这一概念,以描述肌肉与骨骼同时发生衰减的现象。信号通路作为肌肉与骨骼之间重要的信号传递途径,如发生异常,则会导致肌少-骨质疏松症的发生。因此,本文就Hedgehog、Hippo、mTOR和MAPK等成骨与成肌相关信号通路进行综述,以期为肌少-骨质疏松症的靶向治疗提供新思路。

关键词：成肌成骨信号通路肌少-骨质疏松症

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于T2WI的ResNet深度学习模型术前预测膀胱癌病理分级的研究

引用

磁共振成像 2024年第1期15卷 125-131页

作者：黄翔曹康养邹玉坚邓磊张蔚菁杨水清张坤林朱玉容李建鹏南方医科大学第十附属医院(东莞市人民医院)放射科东莞523000 深圳大学医学部生物医学工程学院人工智能实验室深圳518000 中山大学肿瘤防治中心影像科广州510000 南方医科大学第十附属医院(东莞市人民医院)病理科东莞523000

目的本研究旨在构建并验证基于T2加权成像(T2-weighted imaging, T2WI)的50层深度残差网络(50-layer deep residualnetwork,ResNet-50)深度学习(deeplearning,DL)模型术前预测膀胱癌(bladder cancer, BCa)病理分级的效能。材料与方法回顾性分析来自南方医科大学第十附属医院(中心1)和中山大学肿瘤防治中心(中心2)共169名BCa患者的211个肿瘤病灶数据。以病理组织学诊断作为金标准,以肿瘤病灶为单位进行分析,其中高级别尿路上皮癌(high grade urothelial carcinoma, HGUC)为111个,低级别尿路上皮癌(low grade urothelial carcinoma, LGUC)为100个。采用DL模型的ResNet-50方法,基于中心1内部训练集构建模型,所得出的模型在中心1的内部测试集中测试后筛选出最优模型,随后在中心2的外部测试集上进行独立验证。采用受试者工作特征(receiver operating characteristic, ROC)曲线下面积(area under the curve, AUC)、准确率、敏感度和特异度对模型性能进行评估,并进行特征可视化展示。结果 DL模型在内部测试集的AUC为0.856(95%CI:0.723~0.941),准确率为80.9%(95%CI:69.6%~92.1%),敏感度为77.8%(95%CI:65.9%~89.7%),特异度为82.8%(95%CI:72.0%~93.6%);在外部测试集的AUC为0.814 (95%CI:0.686~0.906),准确率为78.2%(95%CI:67.3%~89.1%),敏感度为77.3%(95%CI:66.2%~88.3%),特异度为81.8%(95%CI:71.6%~92.0%)。特征可视化结果显示DL模型较高激活区域与BCa病灶基本重叠,可正确识别BCa靶区域,同时对HGUC与LGUC的特征有一定区分度。结论本研究首次采用DL方法在术前建立基于T2WI的BCa病理分级预测模型,并在双中心进行验证。该模型无创、客观,泛化性及可重复性强,具有较高的预测准确性,有助于临床术前更精准地诊断。

关键词：膀胱癌深度学习磁共振成像肿瘤分级

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

藜麦SOD家族基因的鉴定及其对混合盐碱胁迫的响应

引用

中国农业科技导报 2024年第1期26卷 28-39页

作者：邓玉荣韩联王金龙韦兴翰王旭东赵颖魏小红李朝周甘肃农业大学生命科学技术学院兰州730070 甘肃农业大学甘肃省作物遗传改良与种质创新重点实验室甘肃省干旱生境作物学重点实验室兰州730070

超氧化物歧化酶(superoxide dismutase,SOD)是植物抗氧化系统的关键酶,在保护植物免受生物和非生物胁迫方面发挥重要作用。以拟南芥SOD为基础,通过序列比对在藜麦基因组中鉴定出12个SOD基因,分别定位于细胞核、微体及线粒体,在11条染色... 详细信息

超氧化物歧化酶(superoxide dismutase,SOD)是植物抗氧化系统的关键酶,在保护植物免受生物和非生物胁迫方面发挥重要作用。以拟南芥SOD为基础,通过序列比对在藜麦基因组中鉴定出12个SOD基因,分别定位于细胞核、微体及线粒体,在11条染色体上不均匀分布,其编码蛋白质三级结构显示Cu/Zn-SODs与Fe-SODs为同源二聚体,Mn-SODs为同源四聚体。CqSOD基因内含子/外显子分布模式不尽相同,内含子数介于4~7个,保守基序差异明显。系统发育关系显示,SOD蛋白可分为Cu/Zn-SODs、Fe-SODs及Mn-SODs 3个亚族。此外,所有的CqFe-SODs及CqMn-SODs启动子区都含有脱落酸激素反应顺式元件,CqSOD12与11个CqSOD蛋白及4个CqCAT蛋白存在相互作用。表达谱分析表明,12个CqSOD基因对混合盐碱及硝普钠均有较强响应。研究结果为SOD基因在植物发育和胁迫响应中的作用及分子机制研究奠定基础。

关键词：藜麦 SOD家族基因盐碱胁迫生物信息学分析表达分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AkT/mTOR/Wnt/β-catenin/BMP信号通路的肌骨共生作用及其中药干预研究进展

引用

中国骨质疏松杂志 2024年第6期30卷 900-904,920页

作者：刘晏东邓强张彦军李中锋彭冉东王雨榕陈博杨军杜健强甘肃中医药大学甘肃兰州730000 甘肃省中医院甘肃兰州730050

如果肌肉和骨骼同时发生衰减,则预示着生命出现不良结局的风险增高,将这种疾病称为肌少-骨质疏松症,而其对人体的危害远远大于单纯的肌肉衰减或骨质流失。虽然学术界对肌骨串扰和肌骨共减展开了较多的研究,但临床中仍然严重缺乏安全可... 详细信息

如果肌肉和骨骼同时发生衰减,则预示着生命出现不良结局的风险增高,将这种疾病称为肌少-骨质疏松症,而其对人体的危害远远大于单纯的肌肉衰减或骨质流失。虽然学术界对肌骨串扰和肌骨共减展开了较多的研究,但临床中仍然严重缺乏安全可靠的直接疗法以同时靶向肌肉和骨骼。鉴于该病对人类健康的巨大威胁,开发出具有肌骨共生作用的药物已刻不容缓。中药作为中国传统医学防病治病的主要手段,被广泛运用于各种慢性疾病。其中,一些中药不仅能调控肌肉系统,而且对骨骼系统也有显著的影响。该文基于AkT/mTOR/Wnt/β-catenin/BMP信号通路探讨既成肌又成骨的中药及其活性成分在该领域的作用和应用。

关键词：肌少-骨质疏松症肌骨共生中药活性成分信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ascorbic acid derived carbon dots promote circadian rhythm and contribute to attention deficit hyperactivity disorder

引用

Nano Research 2022年第9期15卷 8247-8254页

作者： Jian Huang Yun Wang Zhaomin Zhong yurong Ma Keru deng Changhong Liu Hui Huang Yang Liu Xin Ding Zhenhui Kang School of Biology&Basic Medical Science Soochow UniversitySuzhou 215123China Institute of Functional Nano and Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Division of Neonatology Children’s Hospital of Soochow UniversitySuzhou 215003China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

Attention deficit hyperactivity disorder(ADHD)is one of the most prevalent psychiatric disorders in children,and ADHD patients always display circadian abnormalities.While,the ADHD drugs currently used in clinic have strong side effects,such as psychosis,allergic reactions,and heart problems.Here,we demonstrated carbon dots derived from the ascorbic acid(VCDs)could strongly rescue the hyperactive and impulsive behaviour of a zebrafish ADHD disease model caused by per1b mutation.VCDs prolonged the circadian period of zebrafish for more than half an hour.In addition,the amplitude and circadian phase were also changed.The dopamine level was specifically increased,which may be caused by stimulation of the dopaminergic neuron development in the midbrain.Notably,it was found that the serotonin level was not altered by VCDs treatments.Also,the gene transcriptome effects of VCDs were discussed in present work.Our results provided the dynamic interactions of carbon dots with circadian system and dopamine signaling pathway,which illustrates a potential application of degradable and bio-safe VCDs for the treatment of the attention deficient and hyperactive disorder through circadian intervention.

关键词： carbon dots circadian rhythm dopamine attention deficit hyperactivity disorder(ADHD) zebrafish

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Point mass filter based matching algorithm in gravity aided underwater navigation

引用

Journal of Systems Engineering and Electronics 2018年第1期29卷 152-159页

作者： HAN yurong WANG Bo deng Zhihong FU Mengyin School of Automation Beijing Institute of TechnologyBeijing 100081China Nanjing University of Science and Technology Nanjing 210094China

Gravity-aided inertial navigation is a hot issue in the applications of underwater autonomous vehicle(UAV). Since the matching process is conducted with a gravity anomaly database tabulated in the form of a digital model and the resolution is 2’ × 2’,a filter model based on vehicle position is derived and the particularity of inertial navigation system(INS) output is employed to estimate a parameter in the system model. Meanwhile, the matching algorithm based on point mass filter(PMF) is applied and several optimal selection strategies are discussed. It is obtained that the point mass filter algorithm based on the deterministic resampling method has better practicability. The reliability and the accuracy of the algorithm are verified via simulation tests.

关键词： gravity-aided inertial navigation system(INS) navigation point mass filter(PMF) deterministic resampling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protective Effects of Flavonoids from Pteridium aquilinum on CCl_(4)-induced Acute Liver Injury in Mice

引用

Medicinal Plant 2022年第6期13卷 35-39页

作者： Junyue ZHANG Xiang HAN Qi ZHANG yurong ZHU Haowei deng Hongyang LIU Shuangli LIU Xiaohui WANG College of Traditional Chinese Medicine Jilin Agricultural UniversityChangchun 130118China Research Center of Agricultural Environment and Resources Jilin Academy of Agricultural SciencesChangchun 130033China

[Objectives]To explore the protective effects of flavonoids from Pteridium aquilinum(PAFL)on carbon tetracholoride(CCl_(4))-induced acute liver injury in mice and its potential mechanism.[Methods]All mice were randomly divided into four groups(n=10 in each),normal group,CCl_(4)group,CCl_(4)+PAFL groups[treated with PAFL(50 or 200 mg/kg)].Animal treatment was continued for 7 consecutive days.The blood was collected after injection of CCl_(4)for 24 h,and the liver tissue was removed from the mice and stored at-80℃.[Results]The PAFL(50 and 200 mg/kg)significantly inhibited the increase of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)levels in serum caused by CCl_(4)treatment.PAFL administration not only increased the activity of antioxidant enzymes superoxide dismutase(SOD),Glutathione(GSH)and catalase(CAT)in mice,but also reduced the level of malondialdehyde(MDA).Meanwhile,PAFL administration decreased the expression of nuclear factor-kappa B(NF-κB)and Cyclooxygenase-2(COX-2)proteins and inhibited the release of pro-inflammatory factors tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and interleukin 6(IL-6).In addition,PAFL(200 mg/kg)treatment down-regulated extracellular regulated protein kinases(ERK)and c-Jun N-terminal kinase(JNK)protein levels in liver tissue.[Conclusions]These findings clearly indicate that the protective effects of PAFL on CCl_(4)-induced acute liver injury is related to its antioxidant and anti-inflammatory activity,which may be mediated by NF-κB and MAPKs signaling pathways.

关键词： Flavonoids from Pteridium aquilinum(PAFL)(PAFL) Carbon tetracholoride(CCl_(4)) Acute liver injury Inflammation Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：