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Ontogenetic Approach to the Study of Mechanisms of Copper-Induced Liver Fibrosis

Advances in Aging Research 2017年第3期6卷 39-54页

作者： Anatoliy I. Bozhkov Olena M. Klimova yuriy V. nikitchenko natalia I. Kurguzova Olena S. Linkevych Katherine M. Lebid Olena S. Protsenko natalya A. Remneva Ali M. M. Al-Bahadly Mohammad A. Y. Al-Begai Research Institute of Biology of V.n. Karazin Kharkov national University Kharkov Ukraine SI “Zaycev V.T. Institute of General and Urgent Surgery of national Academy of Medical Sciences of Ukraine” Kharkov Ukraine Medical Department of V.n. Karazin Kharkov national University Kharkov Ukraine

On the model of Cu-induced liver fibrosis, the relationship between the activity of prooxidant-antioxidant system, immune system parameters, liver morphology and several physiological parameters (body temperature and performance ability of the animals, taking into account their ages) was investigated. Classical biochemical, immunological, histological and physiological methods of investigation were used. The subjects of the study were male Wistar rats of 3-month (young) and 20-month (old) age. For the induction of liver fibrosis, experimental animals were successively injected with copper sulfate (three times at intervals of 24 hours at a dose corresponding to 33% of the lethal one). It was shown that after five days of sulfate copper administration inflammatory reactions in the liver, damage of the vessel epithelium, an increase in collagen content, and other morphological changes were detected. At this time, the content of lipid hydroperoxides in the liver and blood serum was increased, the activity of a number of antioxidant enzymes was reduced, and the activity of aconitase was two times less compared to values in the control group. These changes correlated with a decrease in the amount and activity of phagocytic cells in the blood of experimental animals. Inhibition of the general metabolism was accompanied by a decrease in body temperature, loss of body weight and performance ability. The relationship between a specific metabolic pattern in animals with Cu-induced fibrosis was age-dependent. The formed specific adaptive metabolic pattern is unstable, and in the future it can be realized in one of three possible adaptive strategies, the choice of which is influenced by age.

关键词： Lipid Hydroperoxides Glutathione Peroxidase Aconitase Liver Fibrosis Ontogenesis

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Source-Generated noise Suppression Using the Singular Value Decomposition

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Petroleum Science 2005年第2期2卷 57-65页

作者： yuriyK.Tyapkin naumYa.Marmalyevskyy ZenonV.Gomyak CaiGang UkrainianStateGeologicalProspectingInstitute 78AvtozavodskayaStr.04114KievUkraine northwestExplorationandDevelopmentResearchInstitute PetroChinaLanzhouGansu730020China

Source-generated noise, such as air, refracted, guided waves, near-surface multiples, and radial ground roll, is one of the most challenging problems in the land seismic method. The interference of the noise with reflection events often results in a distorted representation of the subsurface and gives rise to interpretation uncertainties. To suppress the noise, geophysicists have devised various techniques in both acquisition and processing stages. Conventional processing methods, such as high-pass, f - k and hyperbolic velocity filters, however, have certain disadvantages when handling actual seismic data. In this study, we present a new hybrid method combining singular value decomposition (SVD) with a special linear transformation of the common-shot gather. The method is aimed at effectively removing the noise while minimizing harm to the signal. As compared with other methods, the SVD-based one gives a denser approximation to source-generated noise before its subtraction from the seismic data, due to the use of more appropriate basis functions. The special transformation applied in advance to the data is intended to align the source-generated noise events horizontally and thus to benefit the subsequent SVD. The effectiveness of the method in suppressing source-generated noise is demonstrated with a synthetic data set. Emphasis is put on the comparison of the performance of the method with that of conventional f - k filtering.

关键词： Source-generated noise surface waves singular value decomposition eigenimage common-shot gather

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气相色谱法分析二氨基二苯甲烷中的微量水

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化学试剂 2016年第10期38卷 975-977,1016页

作者：裴迅田景芝郑永杰奥奇罗夫.尤里齐齐哈尔大学化学与化学工程学院黑龙江齐齐哈尔161006

利用气相色谱反吹技术,针对二氨基二苯甲烷产品的高沸点、多组分、粘度大的特点,采用热导池检测器,安装六通阀、锥形阀、电磁阀,实现气路转换、气路平衡、气路反吹功能。通过实验确定反吹时间及色谱条件,利用外标法定量分析。实验结果表... 详细信息

利用气相色谱反吹技术,针对二氨基二苯甲烷产品的高沸点、多组分、粘度大的特点,采用热导池检测器,安装六通阀、锥形阀、电磁阀,实现气路转换、气路平衡、气路反吹功能。通过实验确定反吹时间及色谱条件,利用外标法定量分析。实验结果表明,选用GDX-102填充柱（2 m×4 mm）,进样口温度280℃,检测器温度250℃,柱箱温度100℃（1.0min）-60℃/min-50℃（2 min）,在1.0 min时开启反吹,保持4.5 min。水分含量在0.596~3.706 mg/m L之间呈良好线性关系,相关系数为0.994 6,水的检出限为9.43μg/m L,定量下限为26.22μg/m L,达到微量级别,样品加标回收率为82.82%~118.34%,精密度变异系数〈8.53%,实验验证反吹气路和分析方法的可行性。该方法简便、快捷、准确,减少大量检测时间,适用于工业分析。

关键词：气相色谱反吹法水分分析二氨基二苯甲烷

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Ultrafast Optomechanical Terahertz Modulators Based on Stretchable Carbon nanotube Thin Films

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Ultrafast Science 2023年第6期3卷 1-9页

作者： Maksim I.Paukov Vladimir V.Starchenko Dmitry V.Krasnikov Gennady A.Komandin yuriy G.Gladush Sergey S.Zhukov Boris P.Gorshunov Albert G.nasibulin Aleksey V.Arsenin Valentyn S.Volkov Maria G.Burdanova Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny.Russia Skolkovo Institute of Science and Technology MoscowRussia Prokhorov General Physics Institute of the Russian Academy of Sciences MoscowRussia Laboratory of Advanced Functional Materials Yerevan State UniversityYerevanArmenia Institute of Solid State Physics of the Russian Academy of Sciences ChernogolovkaRussia.

For terahertz wave applications,tunable and rapid modulation is highly *** studied by means of optical pump-terahertz probe spectroscopy,single-walled carbon nanotube(SWCnT)thin films demonstrated ultrafast carrier recombination lifetimes with a high relative change in the signal under optical excitation,making them promising candidates for high-speed ***,combination of SWCnT thin films and stretchable substrates facilitated studies of the SWCnT mechanical properties under strain and enabled the development of a new type of an optomechanical *** applying a certain strain to the SWCnT films,the effective sheet conductance and therefore modulation depth can be fine-tuned to optimize the designed *** exhibited a photoconductivity change of approximately 2 times of magnitude under the strain because of the structural modification in the SWCnT *** was used to control the terahertz signal with a modulation depth of around 100%without strain and 65%at a high strain operation of 40%.The sensitivity of modulators to beam polarization is also shown,which might also come in handy for the design of a stretchable *** results give a fundamental grounding for the design of high-sensitivity stretchable devices based on SWCnT films.

关键词： strain excitation films

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空间系绳展开过程的平滑张力控制策略

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计算机仿真 2014年第3期31卷 83-86页

作者：康俊杰王伟王长青扎伯罗特诺夫.尤里西北工业大学自动化学院陕西西安710072 萨马拉国立航空航天大学

针对空间系绳系统在太空的展开性能优化问题,通过对已有的简单张力控制律进行改进,提出了一种基于双曲正切函数的平滑张力控制算法。新算法在分两阶段展开系绳的方案下,通过分段控制律,在张力跳变时刻进行平滑切换,解决了系绳在展开过... 详细信息

针对空间系绳系统在太空的展开性能优化问题,通过对已有的简单张力控制律进行改进,提出了一种基于双曲正切函数的平滑张力控制算法。新算法在分两阶段展开系绳的方案下,通过分段控制律,在张力跳变时刻进行平滑切换,解决了系绳在展开过程中可能发生的抖动问题,保证了系绳系统的安全,实现了系绳的平稳展开。在简化的数学模型下,不考虑系绳的质量和面外运动,通过在3种不同的切换策略下的仿真对比,证实了改进算法的有效性。

关键词：空间系绳系统张力控制双曲正切函数

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空间系绳系统平衡位置建模与仿真分析

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计算机仿真 2014年第2期31卷 160-164页

作者：董哲李爱军王长青扎伯罗特诺夫.尤里西北工业大学自动化学院陕西西安710072 俄罗斯萨马拉国立航空航天大学

研究空间系绳系统控制平衡问题,针对系绳质量,形变,大气阻力摄动等因素分别对系绳和子星平衡条件进行了分析,并分别建立了系绳与子星的平衡方程。为了精确计算出空间系绳系统在轨平衡位置以及分析相关参数对系统平衡位置的影响,利用经... 详细信息

研究空间系绳系统控制平衡问题,针对系绳质量,形变,大气阻力摄动等因素分别对系绳和子星平衡条件进行了分析,并分别建立了系绳与子星的平衡方程。为了精确计算出空间系绳系统在轨平衡位置以及分析相关参数对系统平衡位置的影响,利用经典四阶龙格库塔法解算系绳和子星的平衡方程得到系绳系统的平衡位置。在仿真分析中,分别针对系绳释放长度一定子星质量变化以及子星质量一定释放系绳长度变化两种情况下系统平衡位置以及系绳张力变化趋势进行了分析和对比。仿真结果对于系绳系统在未来空间应用时系统相关参数的选择提供一定参考。

关键词：大气阻力空间系绳系统平衡位置

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统计预测中的鲁棒性

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国外科技新书评介 2014年第9期 4-4页

作者： yuriy Kharin 张志斌不详中国科学院计算技术研究所

统计预测在包括工程、经济、金融、医药、环境等很多应用领域有着广泛的应用。对于多数的统计方法来说，评价效果的标准一般是基于预测与真实结果之间的平方差。因此在研究一种新的统计预测方法时往往是基于最小化平方差来进行设计。然... 详细信息

统计预测在包括工程、经济、金融、医药、环境等很多应用领域有着广泛的应用。对于多数的统计方法来说，评价效果的标准一般是基于预测与真实结果之间的平方差。因此在研究一种新的统计预测方法时往往是基于最小化平方差来进行设计。然而，在现实中的真实数据往往会偏离我们的理论假设。比如观测误差有可能不是高斯分布，数据中可能包含着异常值或者有缺失等等。

关键词：统计预测方法鲁棒性统计方法高斯分布观测误差平方差最小化异常值

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Objective Assessment in Continual Medical Education (CME) Medical Objective Assessment in System Control

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Journal of Integrative Medicine（双语） 2018年第2期7卷 7-11页

作者： yuriy V. Voronenko Ozar P. Mintser Dmytro D. Ivanov Larysa Yu. Babintseva Shupyk national Medical Academy of Postgraduate Education Kiev Ukraine

Existing examinations in postgraduate education and continuing medical education (CME) are not perfect. Modern assessment does not reflect disadvantages of older responders, for whom more time for reply is needed. Specialists with wide clinical experience may choose more than one correct answer in alternative questions. Reduced ability to remember in older people restricts examination without additional sources of information. We offer an individualised system for testing doctors. It provides personalised choice of examination questions using multiple choice questions with weight characteristics and absence of distractors, interactive cooperation in case of negative answers and the final decision of an expert in relation to the person tested. A special algorithm is proposed for typical questions that combines the advantages of known approaches to testing. The questioning system is complex for the creators of tests, but is more convenient and objective than existing ones for medical doctors.

关键词： Postgraduate education Continuing medical education Examinations in medicine Multiple choice questions based on weight answers Weight of the question Individual approach for medical testing Personalised examination

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Carbon Fiber Modified with Carbon nanotubes and Fullerenes for Fibrous Composite Application

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材料科学与工程（中英文A版） 2013年第11期3卷 725-731页

作者： Urvanov Sergey Alekseyevich Alshevskiy yuriy Lvovich Karaeva Aida Razimovna Mordkovich Vladimir Zalmanovich Chernenko Dmitriy nikolaevich Beyilina natalya Yuryevna Technological Institute for Superhard and novel Carbon Materials Troitsk Moscow 142190 Russia Joint Stock Company "nIIgrafit" Moscow 11152 Russia

The use of carbon fiber in composite materials is limited due to poor adhesion between the fiber and polymer matrix. Carbon fibers was modified by growing carbon nanotubes on the fibers" surface or by coating the fibers with fullerenes. In the case of nanotubes, the modification provides the interfacial contact improvement in the composites. In the case of fullerene, we use fullerene as a "defect healer" for carbon fiber. The investigation was done with the use of conventional epoxy-based polymer matrix and, also, with the use of alternative matrices based on elastomers such as derivatives of natural rubber. Carbon nanotubes were grown on the carbon fiber surface by chemical vapor deposition with the use of iron catalysts deposited on the fiber surface by different methods. The resulting nanostructured carbon coating was studied by scanning electron microscopy and by Raman spectroscopy. The effect of modifications on mechanical properties of both carbon fibers and composite materials based on these carbon fibers was studied. It was found that modifications increase adhesive strength of interaction between fiber and matrix.

关键词：纤维复合碳纳米管碳纤维富勒烯应用程序修饰复合材料界面扫描电子显微镜

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