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Mutations in foregut SOX2^+ cells induce efficient proliferation via CXCR2 pathway

Protein & Cell 2019年第7期10卷 485-495页

作者： Tomoaki Hishida Eric Vazquez-Ferrer yuriko Hishida-Nozaki Ignacio Sancho-Martinez Yuta Takahashi Fumiyuki Hatanaka Jun Wu Alejandro Ocampo Pradeep Reddy Min-Zu Wu Laurie Gerken Reuben J. Shaw Concepcion Rodriguez Esteban Christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni Castells Josep M. Campistol Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of the Chinese Academy of Sciences Beijing 100049 China Insitute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Beijing Institute for Brain Disorder Beijing 100069 China Universidad Catolica San Antonio de Murcia Campus de los Jeronimos 135 Guadalupe 30107 Spain Molecular and Cell Biology Laboratory Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Howard Hughes Medical Institute Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Integrative Genomics Core Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Division of Gastroenterology Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Abramson Cancer Center University of Pennsylvania Philadelphia PA 19104 USA Department of Traumatology and Research Unit Clinica CEMTRO Av. Ventisquero de la Condesa 42 Madrid 28035 Spain Gastroenterology Department Hospital Clinic University of Barcelona IDIBAPS CIBEREHD Barcelona 08036 Spain

Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics.

关键词： Sox2 tumor CXCR2 stratified epithelia

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Changes in Health Consciousness of Nursing Students in Japan after Acquiring Medical Care Knowledge from a Nursing School

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Open Journal of Nursing 2021年第9期11卷 794-800页

作者： yuriko Inoue Hiromitsu Ezure Junji Ito Chika Sawa Masato Yamamoto Mone Hatasa Wakatsuki Harumi Hata Akiko Sasaki Masaaki Takayanagi Takashi Takaki Mikako Tanaka Hiroshi Moriyama Naruhito Otsuka Department of Anatomy School of Medicine Showa University Tokyo Japan Department of Nursing School of Nursing and Rehabilitation Sciences Showa University Tokyo Japan Department of Chemistry Faculty of Arts and Sciences at Fujiyoshida Showa University Tokyo Japan Department of Perioperative Medicine Division of Anesthesiology School of Dentistry Showa University Tokyo Japan Center for Research and Development in Pharmacy Education School of Pharmacy Nihon University Chiba Japan Department of Pharmacology School of Medicine Showa University Tokyo Japan Saitama Prefectural University Saitama Japan Division of Electron Microscopy Showa University Tokyo Japan Department of Chemical Engineering Science Yokohama National University Yokohama Japan

Background: Health consciousness in daily life is very important because lifestyle habits, such as dietary and exercise habits, sleep, and smoking, are involved in the development and progression of lifestyle-related diseases, such as cancer, heart diseases, stroke, liver diseases, kidney diseases, and diabetes. Purpose: In this study, we surveyed to see if the health consciousness increased and what behaviors in daily life changed in students of a nursing school (Seiwa Nursing College, Tokyo, Japan) after they learned medical care knowledge required to become a nurse. Results: After learning medical care knowledge for 3 years, the students were found to have a higher level of health consciousness in the third year than they did in the first year. They applied the medical care knowledge they learned in daily life. All data were collected in 2019. Conclusions: The medical care knowledge learned in a nursing school was demonstrated to serve as information to increase the health consciousness.

关键词： Health Consciousness Nursing Students

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A Recycling Technique of Iron Phosphate Containing Sludge

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材料科学与工程：中英文A版 2015年第5期5卷 245-248页

作者： Takahashi Masaaki Takemoto Yukimasa Hukaya yuriko Yokkaichi University Faculty of Environmental and Information Science Mie 512-8512 Japan Sharp Corporation A VC Liquid Crystal Display Group Kamevama Mie 519-0169 Japan

In the processes of wastewater treatment, significant amounts of iron phosphate containing sludge is discharged. One of the recycling methods of this sludge, alkalization treatment is investigated. aq. solution of sodium hydroxide is added to the dehydrated sludge. Iron phosphate in the sludge react with sodium hydroxide, forming sodium phosphate and iron hydroxide containing-sludge at room temperature. The recovered phosphorus contained 91% of phosphorus as the form of Na3PO4, and iron hydroxide-containing residue has 93% of iron as Fe2O3.

关键词：脱水污泥回收处理技术磷酸盐含铁氢氧化钠溶液氢氧化物水处理过程 Fe2O3

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“剧场”商店

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现代装饰 2021年第4期 16-23页

作者： Haruki Oku(设计) yuriko Yagi(设计) Kazumass Takada(设计) Kenji Seo(摄影) Crazy.Inc(摄影) 范嘉苑(编译) 日本HARUKI OKU DESIGN 丹麦PAN-PROJECTS 不详

“剧场”商店位于日本东京繁华时尚的青山区(Aoyama),是一个三层建筑的全新改造项目。建筑的一层和二层是英国时装品牌店,三层是婚礼及活动策划公司的专属大厅。设计团队面临的挑战是要重新考量实体零售商店的现有功能,并设想出后疫情... 详细信息

“剧场”商店位于日本东京繁华时尚的青山区(Aoyama),是一个三层建筑的全新改造项目。建筑的一层和二层是英国时装品牌店,三层是婚礼及活动策划公司的专属大厅。设计团队面临的挑战是要重新考量实体零售商店的现有功能,并设想出后疫情时代的新商业空间模式。全球新冠疫情显著地加快了社会的数字化进程,持续的快速发展预示着未来的购物体验趋势将愈发地往虚拟世界转移。如果说人们更喜欢在线购物,那我们应该要重新思考,当实体商店从以展示及储存为主要空间功能的模式中解放出来后,它还能给用户提供哪些体验?

关键词：活动策划数字化进程时装品牌虚拟世界购物体验在线购物空间功能改造项目

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Modeling of Bridging Law for PVA Fiber-Reinforced Cementitious Composite Considering Fiber Orientation

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Journal of Civil Engineering and Architecture 2018年第9期12卷 651-661页

作者： yuriko Ozu Masaru Miyaguchi Toshiyuki Kanakubo Masaru Miyaguchi Sumitomo Mitsui Construction Co. Ltd.Chuo-kuTokyo 104-0051Japan Department of Engineering Mechanics and Energy University of TsukubaTsukuba-cityIbaraki 305-8573Japan

The authors have proposed the calculation method of bridging law,that is expressed by tensile stress–crack width relationship,considering the influence of fiber orientation in FRCC(fiber-reinforced cementitious composite).The objective of this study is to propose a new tri-linear model that expresses the bridging law considering fiber *** parameters that give the characteristic points of the tri-linear model are proposed as functions of orientation *** bending test,in which the specimens are fabricated by three different casting methods,is conducted to verify the adaptability of the proposed *** results of section analysis using the proposed model can present the difference of bending strength due to the fiber orientation.

关键词： FRCC tensile stress crack width tri-linear model fiber orientation PVA fiber bending test compacting vibrator

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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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拿什么拯救你的尊严

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财经文摘 2010年第11期 47-47页

作者： yuriko koike 齐煜（编译）

中国限制稀土出口的背后有着另一个动机：它想迫使全球高科技企业都转移到中国生产，以便让本土企业吸收前者的技术。

关键词：尊严中国生产高科技企业本土企业出口

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利用游客受雇拍摄法和云图标注应用程序接口探究均质化景观的识别与分类——以日本东京桥区河流景观为例

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景观设计学（中英文） 2021年第5期9卷 12-31页

作者：施佳颖本條毅矢泽优里子古谷胜则东南大学建筑学院景观学系日本千叶大学园艺学研究科环境科学与绿地造园学系

对景观照片进行有效的分类是数据处理和环境分析中至关重要的一步。随着地理信息的收集逐渐采用众包模式,越来越多的研究开始利用带有地理标记的照片,将人们对场所的感知与互动可视化,并探究场所的美学、文化和游憩价值。近年来,图像识... 详细信息

对景观照片进行有效的分类是数据处理和环境分析中至关重要的一步。随着地理信息的收集逐渐采用众包模式,越来越多的研究开始利用带有地理标记的照片,将人们对场所的感知与互动可视化,并探究场所的美学、文化和游憩价值。近年来,图像识别机器学习算法的应用极大提高了关键词匹配的效率,并实现了大批量照片的自动分类。然而,这类方法在景观分类实践中—尤其是针对具有相似特点的均质化景观—应用仍显不足。本研究利用谷歌云视觉API和多层次聚类法,研发了一种半自动化的分类器来识别均质化景观照片,并将其应用于日本东京桥区城市河流均质化景观照片的分类中。分类器将所有河流景观划分为9个特征组,这些特征组的视觉印象与人们的直观感知一致。研究中所应用的混淆矩阵显示,分类器分类结果总体上的准确性达82.61%,表明机器分类与人工分类的结果十分相近。因此,该分类器对均质化河流景观照片的分类切实有效。这种方法可大力推动评估过程中的公众参与及城市旅游管理。

关键词：均质化景观景观特征图像标注照片分类城市河流景观机器学习聚类

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日本森林植被恢复技术——Bioblock工法(英文)

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农业科学与技术：英文版 2013年第2期14卷 340-344页

作者：季梅泽桑梓东三郎仓持寿夫尾谷百合子云南省林业科学院云南昆明650201 Bioblock技术推广联络委员会

Bioblock方法是一种仅需摆放生物组块(一套物件,包括纸育盒、土壤和1株苗木)的免作穴森林植被恢复技术,其步骤包括收集目的树种子或插条、培育苗木、准备和填充"Kaminekkon"(一种利用再循环瓦楞纸制作的纸育盒)、加工处理生物组块、现... 详细信息

Bioblock方法是一种仅需摆放生物组块(一套物件,包括纸育盒、土壤和1株苗木)的免作穴森林植被恢复技术,其步骤包括收集目的树种子或插条、培育苗木、准备和填充"Kaminekkon"(一种利用再循环瓦楞纸制作的纸育盒)、加工处理生物组块、现地种植。苗木可在不损伤根系的情况下进行种植,可种植在坚硬地面或冻土中,全年均可种植。

关键词： Bioblock Kaminekkon 组装加工处理造林

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Determination of Zn and Mg in Milk Powder Samples Using Conventional and Alternative Sample Preparations and FAAS

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Journal of Food Science and Engineering 2019年第5期9卷 171-173页

作者： Deborah Cristina Crominski da Silva Clecius Henrique Chemim Leticia yuriko Togawa Fabiano Piechotcoski Erica Roberta Lovo da Rocha Watanabe Priscilla dos Santo Gaschi Leite Eduardo Sidinei Chaves Simone Delezuk Inglez Department of Chemical Engineering Federal University of Technology-Paraná Ponta Grossa Paraná 84016-210 Brazil Department of Chemistry Federal University of Santa Catarina Florianópolis Santa Catarina 88040-900 Brazil

Conventional procedures for sample preparation, such as calcination and acid digestion, were compared with an alternative procedure: alkaline solubilization and ultrasound-assisted extraction. The procedures were evaluated by the application of the mentioned sample preparation and subsequent determination of Mg and Zn in milk powder samples by flame atomic absorption spectrometry (FAAS). The results indicated that ultrasound-assisted extraction was not suitable for Zn and Mg extraction, whereas alkaline solubilization using TMAH was efficient only for determination of Mg.

关键词： Milk powder trace elements ultrasound-assisted extraction alkaline solubilization FAAS.

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