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Alveolar macrophage functions and DNA damage in cigarette smoke-exposed mice

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Advances in Bioscience and Biotechnology 2013年第8期4卷 1-7页

作者： yuriko hirono Yasuyuki Tanahashi Kazuma Sasaki Kenjiro Konno Yuki Shirai Kengo Kobayashi Azusa Someya Sumire Inaga Masaaki Sakura Kent E. Pinkerton Minoru Takeuchi Center for Health and the Environment University of California Davis Davis USA Department of Animal Medical Science Faculty of Life Sciences Kyoto Sangyo University Kyoto Japan Division of Genome Morphology Department of Functional Morphological and Regulatory Science Faculty of Medicine Tottori University Yonago Japan

Alveolar macrophages (AM) are known to play an essential role in lung defense through their ability to remove the foreign matters reaching the lung alveoli. Cigarette smoke (CS) is a critical risk factor for many lung diseases. CS is inhaled into the lung by respiretion and affects AM. It has been previously reported that CS induces inhibition of cytokine production, cell surface receptor expression and antigen presentation in AM. However, the relationship of immune suppression and DNA damage caused by CS in AM is still unclear. Therefore, in this study, we investigated AM immune function and DNA damage in CS-exposed mice. Mice were exposed to CS of 20 cigarettes/day during 10 days using a HambrugⅡsmoking machine. After exposure, AM were obtained by bronchoalveolar lavage. The number of AM was significantly increased in CS-exposed mice compared with non-CS-exposed mice. Phagocytic activity of AM was significantly inhibited by CS exposure. Percentage of CD11b-, CD14-, Toll-like receptor (TLR)2- or TLR4-positive cells was significantly decreased in CS-exposed mice compared with non-CS-exposed mice. Interleukin-1β mRNA expression in lipopolysaccharide-stimulated AM was significantly inhibited by CS exposure. Intracellular reactive oxygen species (ROS) (, H2O2) production of AM was significantly increased, and DNA damage was induced by CS exposure. These results suggest that impaired immune functions by CS exposure may be related to DNA damage via excessive ROS induced by CS. These alterations of AM caused by CS could be associated with infection and development of pulmonary diseases.

关键词： Alveolar Macrophages Phagocytic Activity ROS Production DNA Damage Cigarette Smoke

Cowpea NAC1/NAC2 transcription factors improve growth and tolerance to drought and heat in transgenic cowpea through combined activation of photosynthetic and antioxidant mechanisms

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Journal of Integrative Plant Biology 2023年第1期65卷 25-44页

作者： Richa Srivastava yuriko Kobayashi Hiroyuki Koyama Lingaraj Sahoo Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati Assam 781039 India Faculty of Applied Biological Sciences Gifu University 1-1 YanagidoGifu 501-1193Japan

NAC(NAM/ATAF1/2/CUC2)transcription factors are central switches of growth and stress responses in ***,unpredictable interspecies conservation of function and regulatory targets makes the well-studied NAC orthologs inapt for pulse *** knowledge of suitable NAC candidates in hardy pulses like cowpea(Vigna unguiculata(L.)Walp.)is still in infancy,hence warrants immediate biotechnological ***,we showed that overexpression of two native NAC genes(VuNAC1and VuNAC2)promoted germinative,vegetative,and reproductive growth and conferred multiple abiotic stress tolerance in a commercial cowpea *** transgenic lines displayed increased leaf area,thicker stem,nodule-rich denser root system,early flowering,higher pod production(~3.2-fold and~2.1-fold),and greater seed weight(10.3%and 6.0%).In contrast,transient suppression of VuNAC1/2 caused severe growth retardation and flower *** overexpressor lines showed remarkable tolerance to major yielddeclining terminal stresses,such as drought,salinity,heat,and cold,and recovered growth and seed production by boosting photosynthetic activity,water use efficiency,membrane integrity,Na^(+)/K^(+)homeostasis,and antioxidant *** comparative transcriptome study indicated consolidated activation of genes involved in chloroplast development,photosynthetic complexes,cell division and expansion,cell wall biogenesis,nutrient uptake and metabolism,stress response,abscisic acid,and auxin *** their orthologs,VuNAC1/2 direct synergistic transcriptional tuning of stress and developmental signaling to avoid unwanted *** overexpression governs the favorable interplay of photosynthesis and reactive oxygen species regulation to improve stress recovery,nutritional sufficiency,biomass,and *** unconventional balance of strong stress tolerance and agronomic quality is useful for translational crop research and molecular breeding of pulses.

关键词： cowpea enhanced photosynthetic activity improved growth improved yield legume genetic engineering multiple stress tolerance NAC transcription factor VuNAC

Novel SLC30A2 mutations in the pathogenesis of transient neonatal zinc deficiency

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Pediatric Investigation 2023年第1期7卷 6-12页

作者： Taichiro Muto yuriko Kawase Kaori Aiba Miyuki Okuma Naoya Itsumura Shuangyu Luo Namino Ogawa Tokuji Tsuji Taiho Kambe Department of Pediatrics Aichi Medical University HospitalNagakuteJapan Department of Dermatology Toshiba Central HospitalTokyoJapan Department of Pediatrics Toyohashi Municipal HospitalToyohashiJapan Department of Pediatrics Toshiba Central HospitalTokyoJapan Department of AppliedMolecular Biology Division of Integrated Life ScienceGraduate School of BiostudiesKyoto UniversityKyotoJapan

Importance:Transient neonatal zinc deficiency(TNZD)occurs in breastfed infants due to abnormally low breast milk zinc *** in the solute carrier family 30 member 2(SLC30A2)gene,which encodes the zinc transporter ZNT2,cause low zinc concentration in breast ***:This study aimed to provide further insights into TNZD ***:SLC30A2 sequencing was performed in three unrelated Japanese mothers,whose infants developed TNZD due to low-zinc milk *** effects of the identified mutations were examined using cell-based assays and luciferase reporter ***:Novel SLC30A2 mutations were identified in each *** harbored a heterozygous missense mutation in the ZNT2 zinc-binding site,which resulted in defective zinc *** other two mothers exhibited multiple heterozygous mutations in the SLC30A2 promoter,the first mutations in the SLC30A2 regulatory region reported to ***:This report provides new genetic insights into TNZD pathogenesis in breastfed infants.

关键词： Dermatology Breastfeeding Transient neonatal zinc deficiency(TNZD) Low-zinc breast milk SLC30A2/ZNT2 Promoter Zinc-binding motif

NB-IoT商业生态系统下企业国际化转型的案例研究

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NB-IoT商业生态系统下企业国际化转型的案例研究

作者： TANAKA yuriko 浙江大学

学位级别：硕士

近年来,通过专注于充分利用物联网信息管理资源,创造新顾客价值的企业与提供物联网服务的平台商相继而生。本文重点关注了源于中国的首家开展国际化业务的美格智能并考察通过研发创新的NB-IoT平台创建与NB-IoT商业生态系统的形成。目的... 详细信息

近年来,通过专注于充分利用物联网信息管理资源,创造新顾客价值的企业与提供物联网服务的平台商相继而生。本文重点关注了源于中国的首家开展国际化业务的美格智能并考察通过研发创新的NB-IoT平台创建与NB-IoT商业生态系统的形成。目的是通过作为在全球国际化过程中具有代表性的案例研究,可以获得有关IoT平台和商业生态系统研究领域中的新理论问题的线索。本文主要以美格智能企业为主要调研对象,参考依据当代企业的战略管理学理论,经过对企业发展情况、所面对的外部环境以及企业的内在资源情况等进行了调研,并运用PEST数据分析、SWOT数据分析工具等,对企业外部环境,所面临的机会与危险,对企业内部环境,所面临的优点与劣点等展开了详细剖析。并通过美格智能的财务报表与财务能力对其财务竞争力进行了评估,在此基础上,明确了公司企业国际化转型发展的定位。本文提出美格智能应该采用以SO战略为核心主要,以WO战略、ST战略与WT战略为辅助的战略组合,也就是借用本身的功能优势和外界环境的机遇,加快发展有关NB-IoT工作业务,并且对本身的劣势展开补偿,发展提升为总体规模领先、管理标准规范、经济效益良好的,首屈一指的物联网终端服务商以及无线数据网络的设计方案服务商。最后,“从加强政企合作,创新无线通信的产学研体制机制”、“强化战略联盟,实现抱团出海”、“优化公司组织结构,聚焦主业能力”、“完善人力资源吸纳与培养,强化外籍人才的引入”、“尝试属地管理,加强对境外项目的监督与评估”、“健全投资风险管控体系,及时评估纠偏纠错”等六个构成方面逐渐确定了公司国际化转型发展实行的举措手段,为该企业未来的中长期企业国际化转型发展和“十三五”发展规划的确定,供应了理论参考依据。

关键词： NB-IoT 物联网生态系统物联网平台商业生态系统

STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrientmanagement

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Molecular Plant 2021年第10期14卷 1615-1617页

作者： Hiroyuki Koyama Liujie Wu Raj Kishan Agrahari yuriko Kobayashi Molecular PlantApplied Biological Sciences Gifu University501-1193 GifuJapan School of Environment and Life Science Nanning Normal UniversityNanning530001 GuangxiP.R.China.

Transcriptional regulation plays a crucial role in plant adaptation to diverse *** transcription factors(TFs),the so-called master switch TFs or hub TFs,regulate various genes critical for adaptation to different ***1(SENSITIVE TO PROTON RHIZOTOXICITY 1),a zinc-finger TF of Arabidopsis(Arabidopsis thaliana),is one such master/hub TF that transcriptionally regulates multiple stress tolerance(Sadhukhan et al.,2021).STOP1 plays a critical role in tolerance to acid soil syndrome(i.e.,H+and Al3+tolerance)(Iuchi et al.,2007)and hypoxia tolerance(Enomoto et al.,2019),and negatively regulates drought tolerance(Sadhukhan et al.,2019).In addition,Tian et al.

关键词： STOP1 stress Arabidopsis

Attempts to remodel the pathways of gemcitabine metabolism: Recent approaches to overcoming tumours with acquired chemoresistance

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Cancer Drug Resistance 2020年第4期3卷 819-831页

作者： yuriko Saiki Shuto Hirota Akira Horii Department of Molecular Pathology Tohoku University School of MedicineSendaiMiyagi 980-8575Japan Office of Medical Education Tohoku University School of MedicineSendaiMiyagi 980-8575Japan Saka General Hospital ShiogamaMiyagi 985-0024Japan

Gemcitabine is a cytidine analogue frequently used in the treatment of various ***,the development of chemoresistance limits its *** resistance is regulated by various factors,including aberrant genetic and epigenetic controls,metabolism of gemcitabine,the microenvironment,epithelial-to-mesenchymal transition,and acquisition of cancer stem cell *** many situations,results using cell lines offer valuable lessons leading to the first steps of important *** this review,we mainly discuss the factors involved in gemcitabine metabolism in association with chemoresistance,including nucleoside transporters,deoxycytidine kinase,cytidine deaminase,and ATP-binding cassette transporters,and outline new perspectives for enhancing the efficacy of gemcitabine to overcome acquired chemoresistance.

关键词： Gemcitabine chemoresistance deoxycytidine kinase human equilibrative nucleoside transporter 1 cytidine deaminase ATP-binding cassette transporters metabolism

Strip-loaded waveguide-based optical phase shifter for high-efficiency silicon optical modulators

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Photonics Research 2016年第6期4卷 222-226页

作者： yuriko Maegami Guangwei Cong Morifumi Ohno Makoto Okano Koji Yamada National Institute of Advanced Industrial Science and Technology (AIST)

We propose a novel silicon optical phase shifter structure based on heterogeneous strip-loaded waveguides on a photonic silicon on insulator(SOI) platform. The features of an etchless SOI layer and loaded strip would enhance the performance and uniformity of silicon optical modulators on a large-scale wafer. We implemented the phase shifter by loading an amorphous silicon strip onto an SOI layer with a vertical PN diode structure. Compared to the conventional lateral PN phase shifter based on half-etched rib waveguides, this phase shifter shows a >1.5 times enhancement of modulation efficiency and provides >20 GHz high-speed operation.

关键词： SOI Strip-loaded waveguide-based optical phase shifter for high-efficiency silicon optical modulators high PN

Genome-wide Association Study Reveals that the Aquaporin NIP1;1 Contributes to Variation in Hydrogen Peroxide Sensitivity in Arabidopsis thaiiana

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Molecular Plant 2017年第8期10卷 1082-1094页

作者： Ayan Sadhukhan yuriko Kobayashi Yuki Nakano Satoshi luchi Masatomo Kobayashi Lingaraj Sahoo Hiroyuki Koyama Faculty of Applied Biological Sciences Gifu University Gifu 501-1193 Japan Experimental Plant Division RIKEN BioResource Center Tsukuba Ibaraki 305-0074 Japan Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati India

Hydrogen peroxide （H202） is a reactive oxygen species that affects cell signaling in various plant defense responses and induces programmed cell death. To identify the new components associated with H202 signaling and tolerance, we conducted a genome-wide association study （GWAS） on the root growth of 133 Arabidopsis thaliana accessions grown in the presence of toxic H2O2 levels. The most significant SNPs were associated with a cluster of chromosome 4 genes encoding an aquaporin NODULIN 26-LIKE INTRINSIC PROTEIN 1; 1 （NIP1;1）, an NB-ARC domain-containing disease resistance protein （AT4G19050）, and a putative membrane lipoprotein （AT4G19070）. The expression level of NIP1;1 was relatively high in A. thaliana accessions sensitive to H2O2. Additionally, overexpression of NIP1;1 in a tolerant accession （e.g., Col-0） increased the sensitivity of transgenic plants to H2O2. An in planta β-glucuronidase reporter assay revealed that variations in the NIP1;1 promoter were responsible for the differences of its expression level in H2O2-tolerant and -sensitive accessions. Cell death was extensive and H2O2 levels were high in the roots of H2O2-sensitive and NIP1;1-overexpressing accessions. Together, our results indicate that the aquaporin NIP1;1 is a key determinant of the sensitivity ofA. thaliana to H2O2, and contributes to the phenotypic variations detected by our GWAS.

关键词： aquaporin GWAS hydrogen peroxide programmed cell death root length signaling

aflak:Visual programming environment enabling end-to-end provenance management for the analysis of astronomical datasets

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Visual Informatics 2019年第1期3卷 1-8页

作者： Malik Olivier Boussejra Rikuo Uchiki yuriko Takeshima Kazuya Matsubayashi Shunya Takekawa Makoto Uemura Issei Fujishiro Keio University 3-14-1 HiyoshiKouhoku-kuYokohamaKanagawaJapan Tokyo University of Technology 1404-1 KatakuramachiHachi¯ojiTokyoJapan Kyoto University 3037-5 HonjoKamogataAsakuchiOkayamaJapan Nobeyama Radio Observatory National Astronomical Observatory of Japan462-2 NobeyamaMinamimakiMinamisaku-gunNaganoJapan Hiroshima University 1-3-2 KagamiyamaHigashi-HiroshimaHiroshimaJapan

This paper describes an extendable graphical framework,aflak,which provides a visualization and provenance management environment for the analysis of multi-spectral astronomical *** its node editor interface,aflak allows the astronomer to compose transforms on input datasets queryable from public astronomical data repositories,then to export the results of the analysis as Flexible Image Transport System(FITS)files,in a manner such that the full provenance of the output data be preserved and reviewable,and that the exported file be usable by other common astronomical analysis *** is the standard of data interchange in *** embedding aflak’s provenance data into FITS files,we both achieve interoperability with existing software and full reproducibility of the process by which astronomers make discoveries.

关键词： Astronomy Provenance Visual programming Visualization