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Zero-Sum Continuous-Time Markov Games with One-Side Stopping

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Journal of the Operations Research Society of China 2024年第1期12卷 169-187页

作者： yurii Averboukh Laboratory of Stochastic Analysis and Its Applications National Research University Higher School of Economics(HSE)Moscow109028Russia Department of Differential Equations Krasovskii Institute of Mathematics and MechanicsYekaterinburg620108Russia

The paper is concerned with a variant of the continuous-time finite state Markov game of control and stopping where both players can affect transition rates,while only one player can choose a stopping *** dynamic programming principle reduces this problem to a system of ODEs with unilateral *** system plays the role of the Bellman *** show that its solution provides the optimal strategies of the ***,the existence and uniqueness theorem for the deduced system of ODEs with unilateral constraints is derived.

关键词： Continuous-time Markov games Dynamic programming Verification theorem Stopping time

The Value of Traditional Medicine Should not be Underestimated-Traditional Chinese Medicine in Treatment of Autoimmune Diseases

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Chinese Medicine and Culture 2024年第2期7卷 167-173页

作者： yurii O Novikov Anait p Akopyan Bashkir State Medical University Republic of BashkortostanRussia 450008

Autoimmune diseases of the nervous system(ADNS)are characterized by the formation of a pronounced neurologic deficit and often lead to *** attention of doctors and researchers is increasingly attracted by complementary medicine as adjuvant or preventive therapy for various diseases,including autoimmune *** Chinese medicine(TCM)is a combination of treatment methods that include acupuncture,herbal medicine,dietetics,physical exercises,and other methods that are often used in conjunction with recognized approaches of official medical *** article describes the application of TCM techniques in autoimmune diseases of the nervous system,and demonstrates clinical experience in the use of acupuncture,herbal medicine,diets and physical *** and complementary medicine is an important and often underestimated healthcare resource,especially in the prevention and treatment of autoimmune diseases of the nervous system.

关键词： Autoimmune diseases Traditional Chinese medicine Nervous diseases

Activating Effect of Staphylococcal Enterotoxins

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Advances in Microbiology 2024年第3期14卷 175-181页

作者： yurii V. Ezepchuk Aurora USA

The effect of enterotoxins is to induce the production of endogenous IF. St. aureus enteropathogenic proteins (enterotoxins) possess an antitumour effect. After intraperitoneal inoculation, they decrease the size and, in some cases, prevent the development of the human hypernephroma in the cheek pouch of golden hamsters. The effect of enteropathgenic proteims may possibly consist in inducing the production of endogenous immune interferon which activates the host immune system and enhances the rejection of heterologous tumour cells.

关键词： Gamma-Interferon Enterotoxins Antitumour Activity

Green synthesis of biocompatible Gd^(3+)-doped ultrasmall carbon-based nanohybrids from coffee wastes

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Carbon Resources Conversion 2024年第2期7卷 64-73页

作者： Konstantin paliienko Anna Topchylo Sergei Alekseev Alain Géloën yurii Milovanov Tetiana Lysenko Valeriy Skryshevsky Tatiana Borisova Vladimir Lysenko Department of Neurochemistry Palladin Institute of BiochemistryNational Academy of Sciences of Ukraine9 Leontovicha strKyiv 01054Ukraine Corporation Science park Taras Shevchenko University of Kyiv60 Volodymyrska Str.Kyiv 01033Ukraine Institute of High Technologies Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine Faculty of Chemistry Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine UMR Ecologie Microbienne Lyon(LEM) CNRS 5557INRAE 1418Claude Bernard University of LyonVetAgro SupResearch Team“Bacterial Opportunistic Pathogens and Environment”(BPOE)University of LyonF-69622 VilleurbanneFrance Light Matter Institute UMR-5306Claude Bernard University of Lyon/CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is *** gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carbon dots(GFCDs)can be synthesized in a domestic microwave oven according to green synthesis *** sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and *** particular,doping of the NHs with Gd^(3+)ions,up to 1.87%w/w of gadolinium per particles’weight,will allow their application for magnetic resonance imaging(MRI).Furthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of the GDNHs and in a wide concentration range 100-1000μg/ml.

关键词： Carbon dots from coffee waste Carbon dots for MRI Gadolinium-doped carbon dots Microwave-assisted synthesis

Human chemerin induces eryptosis at concentrations exceeding circulating levels

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BIOCELL 2024年第8期48卷 1197-1208页

作者： MARYNA TKACHENKO ANATOLII ONISHCHENKO LILIYA TRYFONYUK DMYTRO BUTOV KATERYNA KOT VIKTORIIA NOVIKOVA LIWEI FAN VOLODYMYR pROKOpIUK yurii KOT ANTON TKACHENKO Department of Internal Medicine No.2 Clinical Immunology and AllergologyKharkiv National Medical UniversityKharkiv61022Ukraine Research Institute of Experimental and Clinical Medicine Kharkiv National Medical UniversityKharkiv61022Ukraine Institute of Health National University of Water and Environmental EngineeringRivne61022Ukraine Department of Infectious Diseases and phthisiology Kharkiv National Medical UniversityKharkiv61022Ukraine Biochemistry Department V.N.Karazin Kharkiv National University Ministry of Education and Science of UkraineKharkiv61022Ukraine Department of Chemistry BiochemistryMicrobiology and Food HygieneState Biotechnological UniversityKharkiv61022Ukraine Clinical Research Innovation Lab Floor 26 Block D Qidi Technology Building 8Tsinghua Technology ParkBeijing100084China Department of Cryobiochemistry Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of UkraineKharkiv61015Ukraine

Introduction:Human chemerin is an adipokine that regulates chemotaxis,inflammation,and glucose *** addition,accumulating evidence suggests that chemerin promotes apoptosis,autophagy,and ***,there are no data on its impact on *** current study aimed to analyze the effects of human active Glu^(21)-Ser^(157) chemerin on eryptosis in *** and Methods:Human chemerin 0-2-10-50μg/mL was incubated for 24 h with human erythrocytes(hematocrit 0.4%)obtained from eight healthy *** cytometry-based determination of phospholipid scrambling,reactive oxygen species(ROS)production,and intracellular Ca^(2+)levels was *** supplement data on ROS and Ca^(2+)signaling in chemerin-mediated eryptosis,incubation in the presence or absence of antioxidants vitamin C and N-acetylcysteine and Ca^(2+)-binding agent EGTA was carried out,*** microscopy-based techniques were used to detect reactive nitrogen species(RNS)generation,involvement of caspase-3 and caspase-8,as well as the state of lipid order in cell membranes of erythrocytes exposed to human Glu^(21)-Ser^(157) ***:Our observations suggest that human Glu^(21)-Ser^(157) chemerin had no impact on eryptosis parameters at 2μg/***,chemerin stimulated phosphatidylserine externalization,ROS production,and Ca^(2+)accumulation at higher concentrations suggesting activation of ***^(2+)uptake turned out to be at least partly required for chemerin-mediated ***-mediated erythrotoxicity was additionally mediated by RNS,caspase-3,and ***,Glu^(21)-Ser^(157) chemerin promoted reduction in the liquid-ordered phase of cell membranes in ***:The present study first discloses that human chemerin can induce eryptosis via Ca^(2+)-dependent mechanisms at concentrations noticeably exceeding circulating ***,chemerin-induced eryptosis can hardly contribute to eryptosis-mediated anemia in disease

关键词： Adipokine Cell death Chemerin Oxidative stress Eryptosis

Structure and properties of micro-arc calcium phosphate coatings on pure titanium and Ti-40Nb alloy

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Transactions of Nonferrous Metals Society of China 2017年第1期27卷 125-133页

作者： yurii sharkeev Ekaterina KOMAROVA Maria SEDELNIKOVA Ze-ming SUN Qi-fang ZHU Jing ZHANG Tatiana TOLKACHEVA pavel UVARKIN Institute of Strength physics and Materials Science of Siberian Branch of Russian Academy of Sciences 2/4 Academicheskii pr.Tomsk 634055Russia 北京有色金属研究总院北京100088

The microstructure, physical and mechanical, and chemical properties of micro-arc calcium phosphate （CAp） coatings deposited under different process voltages in the range of 150-400 V on the commercially pure titanium （Ti） and Ti-40%Nb （Ti-40Nb）（mass fraction） alloy were investigated by the SEM, TEM, XRD and EDX methods. The coating thickness, roughness, and sizes of structural elements were measured and showed similar linear character depending on the process voltage for the coatings on both substrates. SEM results showed the porous morphology with spherical shape structural elements and rough surface relief of the coatings. XRD and TEM studies exhibited the amorphous structure of the Cap coating. With increasing the process voltage to 300-400 V, the crystalline phases, such as CaHpO4 and β-Ca2p207, were formed onto the coatings. The annealing leads to the formation of complex poly-phase structure with crystalline phases： CaTi4（pO4）6, β-Ca2p2O7, Tip2O7, TiNb（pO4）3, TiO2, NbO2, and Nb2O5. The applied voltage and process duration in the ranges of 200-250 V and 5-10 min, respectively, revealed the coating formed on Ti and Ti-40Nb with optimal properties： thickness of 40-70μm, porosity of 20%-25%, roughness （Ra） of 2.5-5.0 μm, adhesion strength of 15-30 Mpa, and Ca/p mole ratio of 0.5-0.7.

关键词： calcium phosphate coating micro-arc oxidation Ti-40%Nb alloy commercially pure titanium microstructure

Towards Raman imaging of centimeter scale tissue areas for real-time opto-molecular visualization of tissue boundaries for clinical applications

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Light(Science & Applications) 2022年第6期11卷 1029-1031页

作者： Oleksii Ilchenko yurii pilhun Andrii Kutsyk Technical University of Denmark Department of Health TechnologyCenter for Intelligent Drug Delivery and Sensing Using Microcontainers and NanomechanicsKgsLyngby 2800Denmark Lightnovo ApS Birker?d 3460Denmark Taras Shevchenko National University of Kyiv Department of Quantum Radio PhysicsKyivUkraine Technical University of Denmark Department of Energy Conversion and StorageKgsLyngby 2800Denmark

Raman spectroscopy combined with augmented reality and mixed reality to reconstruct molecular information of tissue surface.

关键词： surface clinical reality

Invariant Einstein metrics on generalized Wallach spaces

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Science China Mathematics 2019年第3期62卷 569-584页

作者： Zhiqi Chen yurii Gennadievich Nikonorov School of Mathematical Sciences and LpMC Nankai University Southern Mathematical Institute of Vladikavkaz Scientific Centre of the Russian Academy of Sciences

Invariant Einstein metrics on generalized Wallach spaces have been classified except SO(k + l+ m)/SO(k) × SO(l) × SO(m). In this paper, we first give a survey on the study of invariant Einstein metrics on generalized Wallach spaces, and prove that there are infinitely many spaces of the type SO(k + l + m)/SO(k)× SO(l) × SO(m) admitting exactly two, three, or four invariant Einstein metrics up to a homothety.

关键词： compact homogeneous space generalized Wallach space symmetric space homogeneous Riemannian metric Einstein metric Ricci flow

Computation of Fisher–Gale Equilibrium by Auction

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Journal of the Operations Research Society of China 2018年第3期6卷 473-483页

作者： yurii Nesterov Vladimir Shikhman Center for Operations Research and Econometrics Catholic University of Louvain1348 Louvain-la-NeuveBelgium National Research University Higher School of Economics MoscowRussia Department of Mathematics Technische Universität Chemnitz09126 ChemnitzGermany

We study the Fisher model of a competitive market from the algorithmic *** that,the related convex optimization problem due to Gale and Eisenberg(Ann Math Stat 30(1):165–168,1959)is *** latter problem is known to yield a Fisher equilibrium under some structural assumptions on consumers’utilities,e.g.,homogeneity of degree 1,*** goal is to examine applicability of the convex optimization framework by departing from these traditional *** just assume the concavity of consumers’utility *** this case,we suggest a novel concept of Fisher–Gale equilibrium by using consumers’utility *** prices of utility transfer the utility of consumption bundle to a common numé*** develop a subgradient-type algorithm from Convex Analysis to compute a Fisher–Gale equilibrium via Gale’s *** order to decentralize prices,we additionally implement the auction design,i.e.,consumers settle and update their individual prices and producers sell at the highest offer *** price adjustment is based on a tatonnement procedure,i.e.,the prices change proportionally to consumers’individual excess *** averages of consumption are shown to clear the market of *** algorithm is justified by a global rate of *** the worst case,the number of price updates needed to achieve anε-tolerance is proportional to 1/ε^(2).

关键词： Fisher equilibrium Computation of equilibrium price adjustment Convex optimization Subgradient methods Decentralization of prices Auction