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Concrete Compressive Strength Estimation by Means of Nondestructive Testing: A Case Study

Open Journal of Civil Engineering 2016年第4期6卷 503-515页

作者： yuri danilo lopes Leandro Vanalli Vladimir José Ferrari Universidade Estadual de Maringá Departamento de Engenharia Civil Programa de Pós-gradua&ccedil ã o em Engenharia Civil Maringá Brazil

Estimation of the mechanical properties of concrete in an existing structure is possible with the results of surface hardness and ultrasound tests (nondestructive tests (NDTs)). For both the use of correlation curves is necessary, it is established between NDT and the results of the compressive strength of test specimens or extracted from structure. The objective of this study is to produce correlations between the results of surface hardness and ultrasound NDTs and the compressive strength of the structural concrete in the bleachers of a soccer stadium in the city of Cianorte, which is located in the northwest part of the state of Paraná, Brazil. This concrete structure, which is approximately 26 years old, has some defects, such as corrosion, concrete segregation and cracks. Concrete spalling in one of the slabs has recently raised some concern. Another significant issue is the absence of records regarding concreting of the bleachers’ structure. Therefore, mapping the reinforcement was initially performed according to the results of a surface hardness test, as recommended by standard [1]. An ultrasound test was simultaneously performed according to standard [2] for the same points employed in the surface hardness test. The concrete specimens were extracted according to the recommendations of standard [1] to determine compressive strength, perform the NDT and construct the correlation curves for the results. A total of 26 concrete specimens were obtained from all structures of the bleachers. From the methodology and the results of the study, highly reliable equations were obtained from the correlation curves among the compressive strength of the concrete specimens and the values of the surface hardness index and the ultrasound wave propagation velocity.

关键词： Concrete Soccer Stadium Strength Ultrasound Surface Hardness

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In Silico Evaluation of the Potential Interference of Boceprevir, Calpain Inhibitor II, Calpain Inhibitor XII, and GC376 in the Binding of SARS-CoV-2 Spike Protein to Human Nanobody Nb20

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Open Journal of Biophysics 2023年第3期13卷 35-49页

作者： yuri Alves de Oliveira Só Marcelo lopes Pereira Junior Wiliam Ferreira Giozza Rafael Timóteo de Sousa Junior Ricardo Gargano Luiz Antônio Ribeiro Júnior Institute of Physics University of Brasília Brasília Brazil Department of Electrical Engineering University of Brasília Brasília Brazil

Virtual screening can be a helpful approach to propose treatments for COVID-19 by developing inhibitors for blocking the attachment of the virus to human cells. This study uses molecular docking, recovery time and dynamics to analyze if potential inhibitors of main protease (Mpro) of SARS-CoV-2 can interfere in the attachment of nanobodies, specifically Nb20, in the receptor binding domain (RBD) of SARS-CoV-2. The potential inhibitors are four compounds previously identified in a fluorescence resonance energy transfer (FRET)-based enzymatic assay for the SARS-CoV-2 Mpro: Boceprevir, Calpain Inhibitor II, Calpain Inhibitor XII, and GC376. The findings reveal that Boceprevir has the higher affinity with the RBD/Nb20 complex, followed by Calpain Inhibitor XII, GC376 and Calpain Inhibitor II. The recovery time indicates that the RBD/Nb20 complex needs a relatively short time to return to what it was before the presence of the ligands. For the RMSD the Boceprevir and Calpain Inhibitor II have the shortest interaction times, while Calpain Inhibitor XII shows slightly more interaction, but with significant pose fluctuations. On the other hand, GC376 remains stably bound for a longer duration compared to the other compounds, suggesting that they can potentially interfere with the neutralization process of Nb20.

关键词： SARS-CoV-2 Main protease Mpro Boceprevir Calpain Inhibitor II Calpain Inhibitor XII GC376 Nanobody Nb20 In Silico

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In Silico Evaluation of the Potential Interference of Boceprevir, Calpain Inhibitor II,Calpain Inhibitor XII, and GC376 in the Binding of SARS-CoV-2 Spike Protein to Human Nanobody Nb20

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Open Journal of Biophysics（生物物理学期刊） 2023年第3期

作者： yuri Alves de Oliveira Só Marcelo lopes Pereira Junior Wiliam Ferreira Giozza Rafael Timóteo de Sousa Junior Ricardo Gargano Luiz Antônio Ribeiro Júnior

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