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Good efficacy and safety profile of abrocitinib in Chinese adult patients with atopic dermatitis:A case series study

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Chinese Medical Journal 2024年第6期137卷 740-742页

作者： yuqing Hu Yan Zhao Houmin Li Cheng Zhou Cong Yu Zhanglei Mu Xue Chen Yuxin Wang Jianzhong Zhang Department of Dermatology Peking University People’s HospitalBeijing 100044China

To the Editor:Atopic dermatitis(AD)is a chronic,relapsing inflammatory dermatosis with impairment of skin barrier function and immune dysfunction that affects both children and *** is characterized by eczematous lesions,pruritus,sleep disturbance,and diminished quality of *** of mild AD relies on emollients,topical corticosteroids,topical calcineurin inhibitors,and phototherapy,while systemic corticosteroids,immunosuppressive agents,and biologics are used for severe refractory cases.^([1])Systemic corticosteroids and immunosuppressants have many undesirable side *** with moderate-to-severe AD who do not respond adequately to topical therapies have few effective treatment options.

关键词： dermatitis impairment patients

Identifying the origin of porous evolution of microsized bismuth in potassium-ion batteries

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Science China Chemistry 2024年第7期67卷 2234-2239页

作者： Shenxu Chu Kaixiang Lei Qian Yang Jiaxin Li yuqing Zhao mengjia Gu Lin Li Xing Hu Yu Zhang Zhuo Chen Shuo Shi Shulei Chou Shijian Zheng Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Institute for Carbon Neutralization Technology College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Microsized bismuth(Bi)with in-situ constructed three-dimensional(3D)porous network has been considered as a promising anode for high-performance potassium-ion batteries(PIBs).However,the mechanism of the in-situ porous evolution of microsized Bi during the charge/discharge process is still ***,various electrolytes are employed to disclose the origin of porous evolution of microsized Bi in *** and theoretically,the 3D porous network originates from the uniform interfacial charge distribution on the Bi surface in the linear ether-based *** addition,the universality of the interfacial charge distribution mechanism was verified by microsized Sn and *** in-situ constructed 3D porous network of Bi enables a superior potassium storage performance in a wide temperature range from-40 to 40℃.More importantly,the K_(0.9)Mn_(0.7)Ni_(0.3)O_(2)||Bi full cell delivers excellent cycling stability(a high capacity retention of 88.44%even after 2,000 cycles)and good temperature *** work gives a distinct clarification of the origin of the porous evolution of microsized Bi during cycling,which is critical for developing high-performance PIBs.

关键词： potassium-ion batteries microsized Bi porous evolution linear ether-based electrolyte interfacial charge distribution

乡村振兴视域下牛郎织女传说的景观叙事研究:以湖北郧西为考察中心

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长江大学学报（社会科学版） 2023年第6期46卷 14-20页

作者：余红艳孟宇卿江苏大学文学院江苏镇江212013

牛郎织女传说根植于中国传统农耕文明,其在发展过程中逐渐定型的五大核心情节具有基于现实生活的农桑景观叙事、充满生命哲思的河桥景观叙事两大基因。湖北郧西作为牛郎织女传说的发源地之一,通过采取天河景观命名、七夕景观聚集等景观... 详细信息

牛郎织女传说根植于中国传统农耕文明,其在发展过程中逐渐定型的五大核心情节具有基于现实生活的农桑景观叙事、充满生命哲思的河桥景观叙事两大基因。湖北郧西作为牛郎织女传说的发源地之一,通过采取天河景观命名、七夕景观聚集等景观叙事策略,一方面强化了传说与地方的内在关联,另一方面也为探索传说资源助力乡村振兴提供了参考。牛郎织女传说景观叙事与景观生产应立足传说内涵和地方资源,讲好乡村农商故事、农旅故事和爱情故事,充分发挥经典传说的民俗经济功能、文旅融合禀赋,以及乡村治理价值,赋能乡村经济文化建设,积极思考中华优秀传统文化的创造性转化与创新性发展路径。

关键词：乡村振兴牛郎织女传说景观叙事农桑河桥

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Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma

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Genes & Diseases 2024年第5期11卷 81-84页

作者： Zhiyi Wang Shuang Chen Dongxiao Li Hui Xu Siyuan Weng Yuyuan Zhang yuqing Ren Chunguang Guo Xiuling Li Zaoqu Liu Xinwei Han Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Gastroenterology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhouHenan 450004China Center of Reproductive Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100730China

Hepatocellular carcinoma(HCC)is a highly heterogeneous tumor,with dynamic equilibrium and complex interplay between its intricate tumor nature and ambient tumor immune microenvironment(TIME).1 Elegant research has indicated that cancer stem cells,a small subset of neoplastic cells confined within dedicated niches,display stem cell-like properties and interact with cells in TIME,thereby imparting an indelible impact on stemness regulation,tumor heterogeneity,and cancer cell plasticity.2 Previous taxonomies solely from the perspective of stemness or TIME may introduce some degree of bias in the comprehension of HCC carcinogenesis,3,4 and thus it is of paramount importance to systematically consider tumor stemness and TIME as a whole to truly portray the biological landscape of HCC.

关键词： thereby landscape stem

Antioxidant and anti-HepG2 cell activities of a novel bioactive peptide from cowhide collagen in vitro

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未来食品学报(英文) 2024年第3期4卷 248-257页

作者： Zhike Xie Yuhan Zhai yuqing Zhang Ming He Xuguang Wang Shaoxuan Yu Haifang Xiao Yuanda Song School of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049China State Key Laboratory of Food Science and Resources Nanchang 330047China

In the present study,the antioxidant and anti-human liver cancer(HepG2)cells effects of bioactive peptides from cowhide collagen(BPCC)were *** exhibited significant scavenging effect on l,1-diphenyl-2-picrylhydrazyl(DPPH)radicals((60.09±3.51)%),2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)radicals((77.40±3.10)%)and hydroxyl radicals((56.00±2.30)%)as well as strong reducing power(0.320士0.025).Meanwhile,BPCC effectively protected biomacromolecules including proteins,lipids and DNA from oxidative damage induced by Cu^(2+)H_(2)O_(2)and 2,2'-azobis(2-methylpropionamidine)dihydrochloride(AAPH).Moreover,BPCC significantly inhibited cell viability of HepG2 cells in a dose-dependent manner with an estimated IC_(50)of 7.61 mg/*** results of 4',6-diamidino-2-phenylindole(DAPI)and acridine:orange/ethidium bromide(AO/EB)staining demonstrated the apoptotic morphological changes and cell mediated death in BPCC treated HepG2 *** addition,BPCC induced decrease of mitochondrial membrane potential(MMP)in HepG2 ***,the present finding proved that BPCC encompasses significant antioxidant activity and anticancer property on HepG2 cells and can be used as alternative food antioxidants for cancer prevention benefits.

关键词： Cowhide collagen peptide Antioxidant activity Oxidative damage Anticancer activity

Coercivity mechanism of high-performance anisotropic heterostructure SmCo5 magnets

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Journal of Rare Earths 2024年第10期42卷 1882-1888页

作者： Yuan Teng yuqing Li Weiqiang Liu Xiaochang Xu Zhanjia Wang Jianjun Yang Dongtao Zhang Hongguo Zhang Qingmei Lu Qiong Wu Weixing Xia Ming Yue Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of Technology School of Mechanical and Electrical Engineering Henan Institute of Science and Technology School of Mechanical Engineering Anyang Institute of Technology Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of Sciences

Due to its large magnetocrystalline anisotropy field and high Curie temperature,SmCo-based magnets are irreplaceable in high-temperature applications,The hot-deformed SmCo-based magnets are especially attractive for their excellent corrosion resistance,making them more suitable for harsh ***,it is still challenging for hot-deformed SmCo-based magnets to obtain high magnetization and high coercivity ***,it is necessary to analyze the relationship between its microstructure and magnetic properties and explore its magnetic hardening mechanism to guide the further improvement of magnetic *** this paper,the anisotropic heterostructure SmCo5magnet was prepared by combining large height-reduction and introducing a nano-grained Smrich *** c-axis texture,（BH）m of 16.1 MGOe,and Hciof 9.6 kOe were obtained via the heterostructure with SmCo5micron-grain and Sm-rich nano-scale *** magnetic domain observation and technical magnetization analysis demonstrate that the coe rcivity mechanism is dominated by *** results also show that the smooth and Sm-rich precipitated grain boundary provides weak pinning *** provides a reference for the development of high-pe rformance nanocrystalline SmCo5magnets.

关键词： Permanent magnet Heterostructure Rare earths Coercivity mechanism Hot-deformed SmCo magnet

Investigating the impact of dynamic structural changes of Au/rutile catalysts on the catalytic activity of CO oxidation

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Carbon Energy 2024年第4期6卷 222-232页

作者： Xiaochun Hu Qianwenhao Fan Mingwu Tan yuqing Luo Xianyue Wu Manoel Y.Manuputty Jie Ding Tej S.Choksi Markus Kraft Rong Xu Zhiqiang Sun Wen Liu School of Energy Science and Engineering Central South UniversityChangshaChina School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingaporeSingapore Cambridge Centre for Advanced Research and Education SingaporeSingapore Institute of Sustainability for Chemicals Energy and EnvironmentJurong IslandSingapore College of Chemistry and Chemical Engineering Central South UniversityChangshaChina Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUK

The surface properties of oxidic supports and their interaction with the supported metals play critical roles in governing the catalytic activities of oxide‐supported metal *** metals are supported on reducible oxides,dynamic surface reconstruction phenomena,including strong metal–support interaction(SMSI)and oxygen vacancy formation,complicate the determination of the structural–functional relationship at the active ***,we performed a systematic investigation of the dynamic behavior of Au nanocatalysts supported on flame‐synthesized TiO_(2),which takes predominantly a rutile phase,using CO oxidation above room temperature as a probe *** analysis conclusively elucidated a negative correlation between the catalytic activity of Au/TiO_(2) and the oxygen vacancy at the Au/TiO_(2) *** the reversible formation and retracting of SMSI overlayers have been ubiquitously observed on Au/TiO_(2) samples,the catalytic consequence of SMSI remains *** functional theory suggests that the electron transfer from TiO_(2) to Au is correlated to the presence of the interfacial oxygen vacancies,retarding the catalytic activation of CO oxidation.

关键词： CO oxidation electronic metal-support interactions flame‐synthesis metal-support interactions oxygen vacancy strong metal-support interaction

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三义寨灌区灌溉水有效利用系数影响因素分析

人民黄河 2016年第11期38卷 140-144页

作者：刘翠赵海滨靳晓颖孟玉清黄河水利职业技术学院水土资源利用研究中心河南开封475004 河南省豫东水利工程管理局三义寨分局河南兰考475300

针对三义寨灌区灌溉水有效利用系数低的问题,首先基于多元线性回归,分析影响灌区灌溉水有效利用系数的主要因素,结果表明:在选取的8个影响因子中,对灌溉水有效利用系数影响程度从高到底顺序为配套设施完好率>渠道衬砌率>节水工程投资>... 详细信息

针对三义寨灌区灌溉水有效利用系数低的问题,首先基于多元线性回归,分析影响灌区灌溉水有效利用系数的主要因素,结果表明:在选取的8个影响因子中,对灌溉水有效利用系数影响程度从高到底顺序为配套设施完好率>渠道衬砌率>节水工程投资>实际灌溉面积>渠道长度>实际引水量>降水量>地下水资源模数。然后结合三义寨灌区的实际状况,依据回归分析的结果,提出完善现有的灌溉工程、改进现有的灌溉技术、制定合理的灌溉管理制度、继续加大节水工程投资等提高灌区灌溉水有效利用系数的有效途径。

关键词：灌溉水有效利用系数多元线性回归分析影响因素对策三义寨灌区

身体成分与儿童血压关系的系统评价/Meta分析

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中国循证儿科杂志 2024年第3期19卷 183-189页

作者：张杰肖雨晴吴梦刘琴重庆医科大学公共卫生学院医学与社会发展研究中心重庆400016

背景身体成分是体内各种成分的含量,其与儿童血压的关联存在争议。目的探讨身体成分与儿童血压的关联性。设计系统综述/Meta分析。方法计算机检索中国生物医学数据库、维普中文科技期刊数据库、中国知网期刊数据库、万方数据在线知识服... 详细信息

背景身体成分是体内各种成分的含量,其与儿童血压的关联存在争议。目的探讨身体成分与儿童血压的关联性。设计系统综述/Meta分析。方法计算机检索中国生物医学数据库、维普中文科技期刊数据库、中国知网期刊数据库、万方数据在线知识服务平台4个中文数据库和PubMed、Web of Science和EBSCO 4个外文数据库,检索起止时间均为各数据库建库至2023年8月8日。纳入身体成分与儿童血压关系的队列研究。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,对结果进行定量和定性归纳总结。主要结局指标身体成分与儿童高血压的相关性。结果共纳入9项身体成分与儿童舒张压和收缩压的纵向队列研究,其中7个队列报告了脂肪质量相关指标与儿童舒张压和收缩压的相关性,儿童期脂肪质量百分比与儿童舒张压和收缩压呈正相关,其他脂肪质量指标研究结论仍不一致。2个队列报告了非脂肪质量指标与儿童血压的相关性,研究结论不统一。3个队列报告了脂肪质量与儿童期血压偏高和高血压的发生呈正相关,但新生儿脂肪质量与6岁时高血压的风险可能为负相关。结论儿童期脂肪质量百分比与儿童舒张压和收缩压呈正相关,身体成分对儿童血压有一定影响。

关键词：儿童身体成分脂肪含量骨骼肌质量血压系统评价