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认知参与运动对儿童抑制控制功能和前额叶脑区激活的影响:情绪的遮掩效应

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中国体育科技 2024年第5期60卷 39-49页

作者：梁煜卿王欢徐玲玲国家体育总局体育科学研究所北京100061

目的:探讨不同认知参与的急性跑步对儿童抑制控制功能、情绪及前额叶激活的影响,以及情绪在运动干预对抑制控制影响中的中介作用。方法:以90名小学四年级儿童为研究对象,随机分为认知跑步组(n=30),传统跑步组(n=30)及对照组(n=30),分别... 详细信息

目的:探讨不同认知参与的急性跑步对儿童抑制控制功能、情绪及前额叶激活的影响,以及情绪在运动干预对抑制控制影响中的中介作用。方法:以90名小学四年级儿童为研究对象,随机分为认知跑步组(n=30),传统跑步组(n=30)及对照组(n=30),分别进行20 min中等强度认知参与跑步、传统跑步或休息。采用Go/No-go范式认知任务和功能性近红外光谱技术(functional near-infrared spectroscopy,fNIRS)考察运动干预前、后15 min儿童抑制控制功能和前额叶脑区激活的变化;采用二维情绪量表(Two-Dimensional Mood Scale,TDMS)测量儿童在运动干预前、后的情绪变化。结果:1)在传统跑步和认知参与跑步后,儿童在Go/No-go认知任务中go trail的反应时均显著缩短(P<0.01),而认知参与跑显著提高了nogo trail的正确率(P<0.01);2)与传统跑步相比,认知参与跑步更有效地提升了儿童情绪的愉悦水平和唤醒水平(P<0.05),并显著提高了左背外侧前额叶的氧合血红蛋白(oxyhemoglobin,Oxy-Hb)浓度(P<0.01);3)左背外侧前额叶Oxy-Hb浓度的增加量与唤醒水平的增加量显著正相关(r=0.31,P<0.01),与反应时的增加量显著负相关(r=-0.22,P<0.05);4)情绪的唤醒水平在运动干预与抑制控制反应时之间起遮掩效应。结论:认知参与运动可以更有效改善儿童情绪,增强抑制控制功能,其神经机制可能是通过激活与情绪反应相关的左背外侧前额叶,进而增强儿童的抑制控制功能,而运动诱发的情绪唤醒水平在运动干预对抑制控制影响中表现为遮掩效应。

关键词：抑制控制情绪认知参与运动儿童功能性近红外光谱技术

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超声成像技术评估卵巢肿瘤的研究进展

影像研究与医学应用 2024年第10期8卷 4-6页

作者：梁玉清陈成彩右江民族医学院研究生学院广西百色533000 右江民族医学院附属医院超声医学科广西百色533000

早期发现并准确评判卵巢肿瘤的良恶性对临床管理及手术时机的选择极为重要。超声检查是当前临床筛查和评估卵巢肿瘤的首选技术手段,但由于卵巢肿瘤组织类型复杂多样,且超声诊断具有较强的主观依赖性,临床漏诊率和误诊率较高。随着影像... 详细信息

早期发现并准确评判卵巢肿瘤的良恶性对临床管理及手术时机的选择极为重要。超声检查是当前临床筛查和评估卵巢肿瘤的首选技术手段,但由于卵巢肿瘤组织类型复杂多样,且超声诊断具有较强的主观依赖性,临床漏诊率和误诊率较高。随着影像学技术的发展,新型超声技术提高了识别卵巢肿瘤的能力,在卵巢肿瘤诊断中的优势凸显。本文主要综述二维灰阶超声、彩色多普勒超声、超声造影以及结合超声图像的人工智能评估等技术在诊断卵巢肿瘤良恶性中的应用研究进展。

关键词：卵巢肿瘤超声检查超声造影人工智能

企业社会责任、女性高管与股价同步性——基于信息不对称视角的实证研究

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南华大学学报（社会科学版） 2024年第2期25卷 55-68页

作者：朱敏杜凤梁雨晴安徽工程大学经济与管理学院安徽芜湖241000

基于中国沪深A股上市公司2003—2022年样本数据,实证考察企业社会责任对股价同步性的影响,并检验企业高管性别特征对上述关系的调节作用。研究发现,企业社会责任与股价同步性间存在显著负向影响关系,女性高管的性别特征能够在一定程度... 详细信息

基于中国沪深A股上市公司2003—2022年样本数据,实证考察企业社会责任对股价同步性的影响,并检验企业高管性别特征对上述关系的调节作用。研究发现,企业社会责任与股价同步性间存在显著负向影响关系,女性高管的性别特征能够在一定程度上增强企业社会责任对股价同步性的抑制作用。研究从信息传递对股票价格影响的角度出发,对当前企业社会责任、高管性别特征及其对股价波动影响的研究文献进行拓展,有利于完善资本市场会计信息披露和监管,缓解企业内外部信息不对称,对于投资者了解企业特有信息,降低股价同涨同跌的大幅波动,稳定金融市场秩序具有一定的信号传递作用。

关键词：企业社会责任股价同步性女性高管股权结构

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Antibacterial biomaterials for skin wound dressing

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 353-384页

作者： yuqing liang Yongping liang Hualei Zhang Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human *** bacterial contamination could significantly menace the wound healing *** the sophisticated wound healing process,novel strategies for skin tissue engineering are focused on the integration of bioactive ingredients,antibacterial agents included,into biomaterials with different morphologies to improve cell behaviors and promote wound ***,a comprehensive review on antibacterial wound dressing to enhance wound healing has not been *** this review,various antibacterial biomaterials as wound dressings will be *** kinds of antibacterial agents,including antibiotics,nanoparticles(metal and metallic oxides,lightinduced antibacterial agents),cationic organic agents,and others,and their recent advances are *** selection and fabrication of biomaterials with different structures and forms,including films,hydrogel,electrospun nanofibers,sponge,foam and three-dimension(3D)printed scaffold for skin regeneration,are elaborated *** challenges and the future perspectives are presented in thismultidisciplinary *** envision that this review will provide a general insight to the elegant design and further refinement of wound dressing.

关键词： Antibacterial activity Wound healing Wound dressing Skin tissue engineering Biomaterials

Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

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Nano-Micro Letters 2022年第11期14卷 256-274页

作者： yuqing liang Huiru Xu Zhenlong Li Aodi Zhangji Baolin Guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Hydrogels with multifunctionalities,including sufficient bonding strength,injectability and self-healing capacity,responsive-adhesive ability,fault-tolerant and repeated tissue adhesion,are urgently demanded for invasive wound closure and wound *** by the adhesive mechanism of mussel and brown algae,bioinspired dynamic bonds cross-linked multifunctional hydrogel adhesive is designed based on sodium alginate(SA),gelatin(GT)and protocatechualdehyde,with ferric ions added,for sutureless *** dynamic hydrogel cross-linked through Schiff base bond,catechol-Fe coordinate bond and the strong interaction between GT with temperature-dependent phase transition and SA,endows the resulting hydrogel with sufficient mechanical and adhesive strength for efficient wound closure,injectability and self-healing capacity,and repeated closure of reopened ***,the temperature-dependent adhesive properties endowed mispositioning hydrogel to be removed/repositioned,which is conducive for the fault-tolerant adhesion of the hydrogel adhesives during ***,the hydrogels present good biocompatibility,near-infrared-assisted photothermal antibacterial activity,antioxidation and repeated thermo-responsive reversible adhesion and good hemostatic *** in vivo incision closure evaluation demonstrated their capability to promote the post-wound-closure and wound healing of the incisions,indicating that the developed reversible adhesive hydrogel dressing could serve as versatile tissue sealant.

关键词： Bioinspired injectable hydrogel Tissue sealant Temperature-dependent adhesion Reversible adhesion Wound healing

Porous photothermal antibacterial antioxidant dual–crosslinked cryogel based on hyaluronic acid/polydopamine for non-compressible hemostasis and infectious wound repair

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Journal of Materials Science & Technology 2022年第26期121卷 207-219页

作者： Chunbo Wang yuqing liang Ying Huang Meng Li Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Cryogel dressings with good absorption ability and photothermal antibacterial properties for preventing wound infections and treating infected wounds have attracted widespread *** this work,a series of cryogels with macroporous structure,antioxidant and photothermal properties were prepared based on adipic dihydrazide modified hyaluronic acid(HA-ADH),and dopamine(DA).The antioxidant properties,hemostatic properties,near infrared(NIR)assisted photothermal antibacterial ability provided by polydopamine,recyclable compression mechanical properties,and cytocompatibility were *** results demonstrated that the HA-ADH/DA cryogels have stable mechanical properties,great antibacterial properties against ***(EC)and methicillin-resistant ***(MRSA).The high swelling ratio due to the high water retention of HA equipped the cryogels with the capability of absorbing exuded blood and excessive tissue fluid in the infected full-thickness skin defect model of *** cryogels demonstrated good cytocompatibility and antioxidant performance through cell tests and 1,1-diphenyl-2-methylbenzohydrazino(DPPH)scavenging efficiency *** cryogels showed enhanced blood-clotting index(BCI)and better hemostatic ability in the mouse liver trauma model and the rat deep noncompressible liver defect model compared with gauze and gelatin ***,compared with commercial TegadermTMdressing in vivo,the HA-ADH/DA cryogels could greatly promote infected skin wound healing in a full-thickness infected skin defect wound *** summary,the macroporous HAADH/DA cryogels with good antioxidant,high swelling ratio,photothermal antibacterial property,and biocompatibility are a promising hemostatic material and wound healing dressing.

关键词： Dopamine-hyaluronic acid-based cryogels Antioxidant Photothermal antibacterial Wound healing Hemostasis

ZnO:Na纳米晶室温表面光电压气敏机理的研究

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材料工程 2024年第2期52卷 218-226页

作者：隆小芹哈万•阿仁王展梁玉卿平特伍沙王子强孙翼飞余飞袁欢西南民族大学电子信息学院成都610041 电子科技大学光电科学与工程学院成都610054

采用简单溶胶凝胶法在溅射有Au/Ti叉指电极的PET柔性基底上制备出不同Na掺杂浓度的ZnO纳米晶。通过对样品的微结构和光学性质表征,探究光辅助室温NO_(2)气敏机理与表面光电压之间的联系。X射线衍射(XRD)结果显示所有样品均为六方纤锌矿... 详细信息

采用简单溶胶凝胶法在溅射有Au/Ti叉指电极的PET柔性基底上制备出不同Na掺杂浓度的ZnO纳米晶。通过对样品的微结构和光学性质表征,探究光辅助室温NO_(2)气敏机理与表面光电压之间的联系。X射线衍射(XRD)结果显示所有样品均为六方纤锌矿结构,Na的掺杂并没有出现Na及其氧化物的衍射峰。室温气敏测试结果显示Na掺杂ZnO纳米晶具有优良的室温气敏性能,能够检测到0.94 mg/m^(3)浓度的NO_(2),相对于纯ZnO纳米晶体气敏响应明显提高。表面光电压谱(SPV)和紫外可见分光光度计(UV-Vis)实验结果表明掺杂ZnO样品的室温气敏性可能与其表面缺陷含量和缺陷能级有关。Na掺杂能够显著增强光生电荷的分离,同时也引入了更多的氧空位(Vo)和活性位点,促进了NO_(2)气体与表面吸附电离氧缺陷的反应。另外光学带隙的蓝移和新产生的缺陷能级也进一步提高了对NO_(2)气体的灵敏度。

关键词： ZnO 掺杂表面光电压谱气敏叉指电极

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation:A novel approach to atherosclerosis therapy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3667-3681页

作者： Xiaohong Cen Baoqu Wang yuqing liang Yanlin Chen Yu Xiao Shaohua Du Kutty Selva Nandakumar Hang Yin Shuwen Liu Kui Cheng Guangdong Provincial Key Laboratory of New Drug Screening and State Key Laboratory of Organ Failure Research School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Musculoskeletal Oncology the Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510642China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesTsinghua UniversityBeijing 100084China

Toll-like receptor 3(TLR3),as an important pattern recognition receptor(PRR),dominates the innate and adaptive immunity regulating many acute and chronic inflammatory *** is proved as an inflammatory disease,and inflammatory events involved in the entire process of initiation and ***,the contribution of TLR3 to atherosclerosis remains ***,we identified the clinical relevance of TLR3 upregulation and disease processes in human ***,activation of TLR3 also directly led to significant expression of atherogenic chemokines and adhesion ***,silencing TLR3 inhibited the uptake of oxLDL by macrophages and significantly reduced foam cell *** the aberrance in TLR3 functions on atherosclerosis progression,we hypothesized that TLR3 could serve as novel target for clinical atherosclerosis ***,we developed the novel ellipticine derivative SMU-CX24,which specifically inhibited TLR3(IC_(50)=18.87±2.21 nmol/L).In vivo,atherosclerotic burden was alleviated in Western diet fed ApoE^(−/−)mice in response to SMU-CX24 treatment,accompanying notable reductions in TLR3 expression and inflammation infiltration within atherosclerotic ***,for the first time,we revealed that pharmacological downregulation of TLR3 with specific inhibitor regenerated inflammatory environment to counteract atherosclerosis progression,thereby proposing a new strategy and probe for atherosclerosis therapy.

关键词： Toll-like receptor 3 Atherosclerosis Small molecule Inflammation Macrophage

Design of Support Effect in the Catalytic Application of Ligand-Protect Gold Clusters

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Chinese Journal of Chemistry 2024年第1期42卷 73-86页

作者： Shuohao Li Shenguang Fu yuqing Gong Nuojie Wu Lei Wang liang Wang School of Safety Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China Schoolof Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsu 225009 Jiangsu Key Laboratory of Coal-based Greenhouse Gas Control and Utilization China University of Mining and Technology XuzhouJiangsu 221008China

Ligand-protected gold(Au_(n))clusters sometimes need the removal of organic ligands to expose more active sites and reduce steric hindrance in catalytic reactions,and large amount of organic and inorganic materials usually need to be employed as supports to anchor Aun clusters through different interaction ***,less comprehensive summaries have been provided about the crucial contribution of various supports to the catalytic performance of the supported Aun ***,this review firstly summarizes synthesis methods(e.g.,impregnation and encapsulation processes)for the supported Aun cluster catalysts,and then mainly points out specific contributions of support effect in a great diversity of catalytic reactions,as well as deep interaction ***,opportunities and challenging issues will be stated towards supported Aun clusters,in terms of improving catalytic performance and structural stability of Aun clusters inthedemand of catalysis.

关键词： Gold clusters Synthesis Support effect Catalytic performance Interaction