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A 3D bio-printed spheroids based perfusion in vitro liver on chip for drug toxicity assays

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Chinese Chemical Letters 2022年第6期33卷 3167-3171页

作者： Tian Tian Yuhan Ho Chen Chen Hebin Sun Janan Hui Panhui Yang yuqing ge Ting Liu Jian Yang Hongju Mao Institute of Microsystem and Information Technology(SIMIT) Chinese Academy of Sciences(CAS)Shanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Industrial Technology Research Institute(SITRI) Shanghai 201800China School of Stomatology Dalian Medical UniversityDalian 116044China State Key Laboratory of component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Liver is the foremost organ of human being for drug metabolism,and it played a significant role in toxicity evaluation of *** a liver model in vitro can accelerate the process of the drug screening and new drug research and *** provide a 3D printing based hepatic sinusoid-on-a-chip microdevice that reconstitutes organ-level liver functions to create a drug screening model of toxicity evaluation on *** microfluidic device,which recapitulates the hepatic sinusoid microenvironment,consists of PET polyporous membranes which mimic the perisinusoidal space,and experience fluid flow to mimic the hepatic arterial *** PET membrane was used to separate the hepatocyte and *** endotheliocyte was cultured on the downside of the membrane and the hepatocyte were 3D seeded on the membrane via the 3D *** device was used to reproduce the in vitro liver model for drug toxicity *** expression of several biomarkers of liver was compared with the monoculture and 2D cultured conditions,and the results reveal that this organ-on-a-chip microdevice mimics the drug hepatoxicity that has not been possible by 2D cell-based and animal models,providing a useful platform for screening the drugs and developing an effective therapy in hepatopathy.

关键词： Liver-on-chip Drug screening Drug toxicity 3D-printing 3D-culture

N-glycosylation inhibitor tunicamycin suppresses the self-renewal of glioma-initiating cell

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N-glycosylation inhibitor tunicamycin suppresses the self-re...

Influence of Foaming Process on Acoustic Performance of a Vehicle with a Typical Lightweight Floor Carpet

第二届糖合成化学青年学术研讨会

作者： Yuanyan Wei Yang Xin yuqing ge 江建海 Shanghai Medical College of Fudan University 复旦大学

Glioma-initiating cells possess tumor-initiating potential and are relatively resistant to conventional chemotherapy and ***,their elimination is an essential factor for the development of efficient ***,we report that endoplasmic reticulum（ER）stress inducer tunicamycin inhibits glioma-initiating cell self-renewal as determined by neurosphere formation ***,tunicamycin decreases the efficiency of glioma-initiating cell to initiate tumor *** tunicamycin induces glioma-initiating cell apoptosis,apoptosis inhibitor z-VAD-fmk only partly abrogates the reduction in glioma-initiating cell self-renewal induced by ***,tunicamycin reduces the expression of self-renewal regulator Sox2 at translation *** of Sox2 obviously abrogates the reduction in glioma-initiating cell self-renewal induced by *** together,tunicamycin suppresses the self-renewal and tumorigenic potential of glioma-initiating cell partly through reducing Sox2 *** finding provides a cue to potential effective treatment of glioblastoma through controlling stem cells.

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Influence of Foaming Process on Acoustic Performance of a Ve...

Bulk photovoltaic effect in two-dimensional ferroelectric α-In2Se3

2021中国汽车工程学会年会暨展览会

作者： Huang Yi ge yuqing Liang Weiqiang Liu Lin Li Ding CAE Center Changan Automotive Engineering Institute NVH center Changan Automotive Engineering Institute

This article focuses on the effect of different foaming process on acoustic performance of a vehicle with a typical vehicle lightweight floor *** carpet structure difference between 2 different foaming processes was discussed firstly.A statistical energy analysis（SEA） based transmission loss model was developed to predict the sound transmission loss（STL） under different boundary *** was found that the STL of the carpet with direct foaming process is much worse than the separate foaming process carpet when the boundary condition was *** a full vehicle SEA model was developed to predict the sound pressure level（SPL） at the front-left（FL） driver’s *** parallel,a test was conducted to measure the SPL response at the same space after the floor was assembled on the *** test results showed the good agreement with the simulation results.

关键词： floor carpet lightweight foaming process acoustic simulation SEA STL

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Science China(Information Sciences) 2025年第2期68卷 285-292页

作者： Huiting WANG Shuaiqin WU Yan CHEN Qianru ZHAO Jinhua ZENG Ruotong YIN yuqing ZHENG Chang LIU Shukui ZHANG Tie LIN Hong SHEN Xiangjian MENG Jun ge Xudong WANG Junhao CHU Jianlu WANG State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan University Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Frontier Institute of Chip and System Fudan University

Non-centrosymmetric material systems can generate spontaneous photocurrent without a p-n junction under uniform illumination, which is known as the bulk photovoltaic effect（BPVE）. It has garnered significant attention for its application potential in the fields of energy harvesting and photoelectric detection. In this study, we report the BPVE observed in twodimensional ferroelectric α-In2Se3multilayer flakes. The reversal in spontaneous photocurrent polarity is observed and associated with the out-of-plane ferroelectric polarization direction. The spontaneous photocurrent originating from the shift current is also polarization-sensitive. The amplitude of spontaneous photocurrent is further increased by one order of magnitude through vacuum annealing. Our results provide a further application potential for new-generation photodetectors based on BPVE with low power consumption and multi-dimensional optoelectronic detection.

关键词： bulk photovoltaic effect 2D ferroelectrics 3R $\alpha$-In$_2$Se$_3$ shift current self-powered photodetection

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基于二硫化钼的电容式土壤湿度传感器

智慧农业（中英文） 2024年第1期6卷 28-35页

作者：李露葛玉卿赵建龙中国科学院上海微系统与信息技术研究所传感技术联合国家重点实验室上海200050 中国科学院大学材料与光电研究中心北京100049 中国科学院大学北京100039

[目的/意义]土壤中含水率直接影响农作物生长状态和产量。开发出一种可靠、高效的土壤湿度传感器对实施农田科学灌溉具有重要指导意义。[方法]本研究提出一种基于微加工工艺制备的二硫化钼电容式土壤湿度传感器,通过叉指电极上同一平面... 详细信息

[目的/意义]土壤中含水率直接影响农作物生长状态和产量。开发出一种可靠、高效的土壤湿度传感器对实施农田科学灌溉具有重要指导意义。[方法]本研究提出一种基于微加工工艺制备的二硫化钼电容式土壤湿度传感器,通过叉指电极上同一平面上的金电极阵列实现数个电容并联,表面修饰二硫化钼作为敏感层实现对土壤湿度的测量。通过计算及使用COMSOL Multiphysics多物理场仿真软件研究电极参数对电容敏感度的影响,最终确定电极参数使用10μm间距、75对叉指。[结果和讨论]在保证测量精度的前提下,大大缩小了传感器的体积,可以实现土壤湿度的原位动态监测。在室温下相对湿度值从11%变化到96%时,电容式土壤湿度传感器在200 Hz频率下的电容输出为12.13 pf~187.42 nF;当土壤含水量由8.66%增加到42.75%时,传感器的电容输出在200 Hz频率下由119.51 nF增长到377.98 nF,显示出较高的湿度灵敏度及较宽的敏感范围。[结论]本研究提出的土壤水分传感器有望实现原位长期监测电容式土壤传感器的电容变化,从而监测土壤湿度的变化。

关键词：土壤传感器二硫化钼电容式传感器微机电系统

水稻叶片质膜H^+-ATPase对酸雨胁迫的适应机制

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环境化学 2013年第6期32卷 964-967页

作者：葛玉晴吕霞梁婵娟江南大学环境与土木工程学院无锡214122

采用水培法研究酸雨胁迫对水稻叶片质膜H+-ATPase活性的影响,结果表明,高强度酸雨(pH 2.5和pH 3.0组)胁迫下,pH 2.5组质膜H+-ATPase活性显著受抑,胞内pH降低,POD活性受抑,pH3.0组质膜H+-ATPase活性上升,胞内pH降低,POD活性升高,质膜透性... 详细信息

采用水培法研究酸雨胁迫对水稻叶片质膜H+-ATPase活性的影响,结果表明,高强度酸雨(pH 2.5和pH 3.0组)胁迫下,pH 2.5组质膜H+-ATPase活性显著受抑,胞内pH降低,POD活性受抑,pH3.0组质膜H+-ATPase活性上升,胞内pH降低,POD活性升高,质膜透性和MDA含量均增加,Fv/Fm和叶鲜重降低;低强度酸雨(3.0

关键词：酸雨水稻质膜H+-ATPase 质膜过氧化

基于Ethernet/IP协议的交通灯控制系统设计及实现

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微型电脑应用 2010年第8期26卷 61-64页

作者：葛毓青罗克韦尔自动化系统与解决方案事业部

基于Ethernet/IP协议,采用Rockwell Automation的MicroLogix控制器和软件,对多个交通路口的交通灯控制进行了设计及实现。该系统为城市交通灯的规划设计起到一定程度的参考借鉴。

关键词： Ethernet/IP协议控制器网络通讯逻辑编程远程监控

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牛茄子叶绿体全基因组特征及系统发育分析

中草药 2024年第12期55卷 4150-4158页

作者：龚秋怡董姝洁许琴葛宇清浙江中医药大学附属第一医院中心实验室浙江杭州310005 浙江中医药大学药学院浙江杭州310053

目的以牛茄子Solanum capsicoides新鲜叶片为材料,对叶绿体基因组序列进行组装、注释和分析,探究牛茄子的序列特征和同属其他物种的系统发育关系。方法基于Illumina HiSeq高通量测序,获得牛茄子完整叶绿体基因组序列,利用生物信息学方... 详细信息

目的以牛茄子Solanum capsicoides新鲜叶片为材料,对叶绿体基因组序列进行组装、注释和分析,探究牛茄子的序列特征和同属其他物种的系统发育关系。方法基于Illumina HiSeq高通量测序,获得牛茄子完整叶绿体基因组序列,利用生物信息学方法进一步对其功能及特征、密码子偏好性、IR区域边界、核苷酸多样性、系统发育关系进行分析。结果牛茄子叶绿体基因组全长为155465 bp,为典型的四分体结构,总GC含量为37.85%,其中大单拷贝区、小单拷贝区和反向重复序列的长度分别为88265、18462、24369 bp;共编码131个基因,包括86个蛋白编码基因、37个tRNA基因、8个rRNA基因。简单重复序列检测表明,叶绿体基因组包括51个SSR位点,其中以A和T组成的单核苷酸重复次数最多,占45.1%。密码子偏好性分析表明,亮氨酸是使用频率最高的氨基酸,AUU是使用次数最多的密码子,密码子偏向使用A/U结尾。属内叶绿体基因组比较分析显示,IR边界区域相对保守,但仍存在部分基因扩张和收缩等现象;核苷酸多样性分析获得了4个高突变热点:trnQ-psbK、psbF-psbE、clpP、ycf1,可作为物种鉴定和遗传多样性研究的潜在特征。系统发育分析显示牛茄子和喀西茄的亲缘关系更近,存在姐妹关系。结论牛茄子叶绿体基因组的组装和系统发育分析,为茄属植物的分类和群体间遗传多样性的研究提供理论依据。

关键词：牛茄子茄属叶绿体基因组序列特征密码子偏好性系统发育分析

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肝脏疾病的体外细胞模型研究进展

生物医学工程学杂志 2021年第1期38卷 178-184页

作者：刘婷葛玉卿袁敏熊巧(综述) 赵建龙(审校) 上海理工大学医疗器械与食品学院上海200093 中国科学院上海微系统与信息技术研究所传感技术联合国家重点实验室上海200050 海军军医大学附属长海医院泌尿外科上海200433

不健康的饮食、作息和滥用药物会引起多种肝脏疾病,包括脂肪性肝炎、肝纤维化、肝硬化和肝癌等,严重影响人体健康。构筑体外细胞模型在研究肝病及其药物开发中具有重要意义。目前,国内外研究者已经开发出多种体外肝脏疾病模型。本文概... 详细信息

不健康的饮食、作息和滥用药物会引起多种肝脏疾病,包括脂肪性肝炎、肝纤维化、肝硬化和肝癌等,严重影响人体健康。构筑体外细胞模型在研究肝病及其药物开发中具有重要意义。目前,国内外研究者已经开发出多种体外肝脏疾病模型。本文概括了体外肝脏病理模型构建的常用策略,并从原料、方法、指标等方面介绍了四种典型肝病相关的体外细胞模型,期望可为肝病模型相关研究人员提供参考。

关键词：肝脏疾病体外模型微环境肝功能标志蛋白