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Journal of Materials Science & Technology 2006年第3期22卷 339-341页

作者： Zhengxing HUANG Zhen＇an TANG Ziqiang XU Haitao DING yuqin gu Department of Electronic Engineering Microsystem Resarch Center Dalian University of Technology Dalian 116024 China School of Mechanic Engineering Dalian University of Technology Dalian 116024 China Department of Engineering Mechanics Tsinghua University Beijing 100084 China

A genetic algorithm （GA） was studied to simultaneously determine the thermal transport properties and the contact resistance of thin films deposited on a thick substrate. A pulsed photothermal reflectance （PPR） system was employed for the measurements. The GA was used to extract the thermal properties. Measurements were performed on SiO2 thin films of different thicknesses on silicon substrate. The results show that the GA accompanied with the PPR system is useful for the simultaneous determination of thermal properties of thin films on a substrate.

关键词： Thin film Thermal transport properties Thermal contact resistance Genetic algorithm

EPON和WiMAX融合网管带宽管理模块设计实现

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光通信技术 2010年第1期34卷 18-21页

作者：顾雨沁吕淼陈雪北京邮电大学信息光子学与光通信教育部重点实验室北京100876

在EPON和WiMAX融合接入网中,为对网络带宽进行管理,需要结合WiMAX业务在EPON网络中的映射情况,对各级带宽进行配置。针对这一需求,设计实现了能够自动对带宽进行重新分配的带宽管理模块。该模块具有友好的图形化操作界面和合理的带宽配... 详细信息

在EPON和WiMAX融合接入网中,为对网络带宽进行管理,需要结合WiMAX业务在EPON网络中的映射情况,对各级带宽进行配置。针对这一需求,设计实现了能够自动对带宽进行重新分配的带宽管理模块。该模块具有友好的图形化操作界面和合理的带宽配置算法。采用了典型的C/S结构进行模块划分和设计,利用Java语言结合NetBeans等工具完成了具体功能的实现。

关键词： EPON WiMAX 融合网络带宽

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参数估计在测量热物性中的应用

工程热物理学报 1987年第1期 83-86页

作者：顾毓沁清华大学

一、前言参数估计提供了有效地利用数据去估计数学模型中的参数的方法。可如图1所示。通常的热物性测试原理都是基于导热微分方程的一个反问题,即由一定单值性条件下的解来确定方程中的某些系数,即热物性。本文以激光脉冲法为例,说明... 详细信息

一、前言参数估计提供了有效地利用数据去估计数学模型中的参数的方法。可如图1所示。通常的热物性测试原理都是基于导热微分方程的一个反问题,即由一定单值性条件下的解来确定方程中的某些系数,即热物性。本文以激光脉冲法为例,说明参数估计在测量热物性中的应用具有良好的前景。

关键词：参数估计激光脉冲法统计估计单纯形搜索法目标函数热扩散率输运过程热物性

Breaking new ground in photocatalysis: lutetium texaphyrin as a trigger for pyroptosis through biomolecular photoredox reactions

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Science China Chemistry 2025年第1期68卷 1-2页

作者： Qihang Ding Mengrong He Meijia gu Department of Chemistry Korea University Department of Ultrasound Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) School of Pharmaceutical Sciences Wuhan University

Malignant neoplasms consistently pose a significant threat to global public health [1,2]. In recent years, immunotherapy has demonstrated remarkable clinical success; however, its efficacy is limited by the scarcity of immune cell infiltration within tumor microenvironments. Cell pyroptosis, a gasdermin-mediated process characterized by cellular swelling,rupture, and the release of intracellular contents such as IL-1β, IL-18, ATP, HMGB1, plays a crucial role in this context[3,4].

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圩区一体化监控预警系统设计与应用

浙江水利科技 2021年第5期49卷 83-85页

作者：顾玉勤海盐县海塘管理所浙江海盐314300

由于圩区涉及范围广、闸站泵组多、管理难度大以及传统信息化建设资金投入大,导致很多圩区仍处于人工管理阶段,管理效率低、资源利用率低、防洪排涝能力差、安全隐患大。设计圩区一体化监控预警系统,不仅实现视频监控、水雨情监测、设... 详细信息

由于圩区涉及范围广、闸站泵组多、管理难度大以及传统信息化建设资金投入大,导致很多圩区仍处于人工管理阶段,管理效率低、资源利用率低、防洪排涝能力差、安全隐患大。设计圩区一体化监控预警系统,不仅实现视频监控、水雨情监测、设备监测、异常预警和统一调度等功能,而且安装维护方便、成本低,具有一定的推广价值。

关键词：圩区视频监控水雨情信息预警

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母婴同室管理模式的利弊与改进方法

护理研究（上旬版） 2005年第8期19卷 1482-1483页

作者：顾玉琴江苏省常州市妇幼保健院 213003

随着改革开放的深入,国外一些先进的管理模式及理念在我国被逐步应用.母婴同室作为医院一种新的管理制度,至今已广泛开展,我院于1993年开始实行母婴同室,经10年多的实践观察,感觉母婴同室确有好多好处,但并不是尽善尽美的,还潜在很多不... 详细信息

随着改革开放的深入,国外一些先进的管理模式及理念在我国被逐步应用.母婴同室作为医院一种新的管理制度,至今已广泛开展,我院于1993年开始实行母婴同室,经10年多的实践观察,感觉母婴同室确有好多好处,但并不是尽善尽美的,还潜在很多不利因素.现对母婴同室管理模式的利弊作一分析,并就如何尽量避免不利因素,谈一点自己的看法.

关键词：母婴同室管理模式利弊不利因素改革开放管理制度实践观

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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用扫描热显微镜测量微小区域热导性质的探讨

工程热物理学报 2000年第4期21卷 456-460页

作者：顾毓沁晋宏师孙晓毅陈皓明谢志刚清华大学工程力学系北京100084 清华大学现代应用物理系北京100084

随着高新技术的迅速发展，许多研究对象已进入亚微米和纳米范畴。在对这些对象的热性能和热可靠性的研究中，亚微米尺度的热物性测量已成为关键技术之一。例如：在微电子、微电子机械系统（MEMS）领域中，已使用纳米量级厚度的材质和做... 详细信息

随着高新技术的迅速发展，许多研究对象已进入亚微米和纳米范畴。在对这些对象的热性能和热可靠性的研究中，亚微米尺度的热物性测量已成为关键技术之一。例如：在微电子、微电子机械系统（MEMS）领域中，已使用纳米量级厚度的材质和做出纳米尺度线宽的器件。在材料科学、生物学、医学和化学等许多领域，高空间分辨率下的热物性测量也具有重要意义。本文经过实验；初步用扫描热显微镜判定了微小区域材料热导性质的差别，并从理论上探讨了用该仪器测量微小区域热导性质的方法原理。

关键词：扫描热显微镜热探针热导率微小区域

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli gu Kijung Sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic