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Impact of metabolic dysfunction-associated steatotic liver disease on the efficacy of immunotherapy in patients with chronic hepatitis B-related hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第9期21卷 813-825页

作者： Jiaxin Han Wentao Kuai Liu Yang Xuemei Taol Yuekui wang Minghui Zeng' yuqin Lil Yuqiang Mi Ningning Zhang Wei Lu Liang Xu Clinical School of the Tianjin Second People's Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People's HospitalTianjin 300192China Tianjin Institute of Hepatology Tianjin 300192China Department of Hepatobiliary Oncology Liver Cancer CenterTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Centerfor CancerTianjin300060China

Objective:To investigate the impact of metabolic dysfunction-associated steatotic liver disease(MASLD)on the efficacy of immune checkpoint inhibitor(ICI)-based therapy in patients with chronic hepatitis B(CHB)-related hepatocellular carcinoma(HCC).Methods:A total of 155 patients with CHB-related HCC who received ICI–based therapy(in the Department of Hepatology,Tianjin Second People’s Hospital and Department of Hepatobiliary Oncology,Tianjin Medical University Cancer Institute&Hospital)between April 2021 and December 2023 were *** were divided into two groups:MASLD concurrent with CHB[MASLD-CHB](n=38),and CHB(n=117).Results:The median progression-free survival(PFS,6.9 months vs.9.3 months;P=0.001),progressive disease(57.89%vs.37.61%;P=0.028),and disease control rate(42.11%vs.62.39%;P=0.028)in the MASLD-CHB group were significantly worse than the CHB *** median overall survival was not *** percentage of CD4+PD1+(17.56%vs.8.89%;P<0.001)and CD8+PD1+T cells(10.50%vs.7.42%;P=0.005)in patient samples from the MASLD-CHB group were significantly higher than the CHB *** MASLD[hazard ratio(HR)=1.921;95%CI,1.138–3.245;P=0.015]and alpha-fetoprotein levels after 3 months of treatment(HR=2.412;95%CI,1.360–4.279;P=0.003)were independent risk factors for PFS in all ***:ICI-based therapy in patients with CHB-related HCC and concurrent MASLD resulted in poorer efficacy and shorter PFS compared to patients with CHB-related HCC alone.

关键词： Metabolic dysfunction-associated steatotic liver disease chronic hepatitis B hepatocellular carcinoma immunotherapy efficacy

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Retinol is involved in the intestinal regeneration and strengthens the intestinal barrier during refeeding in broiler chickens

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Journal of Integrative Agriculture 2024年第11期23卷 3843-3859页

作者： Youli wang Huajin Zhou Jing Chen yuqin Wu Yuming Guo Bo wang Jianmin Yuan Key Laboratory of Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Utilization Ministry of Education/Key Laboratory of Sichuan Province for Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Exploitation College of Animal Science and Veterinary Medicine Southwest Minzu University State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Sichuan New Hope Liuhe Technology Innovation Co.Ltd.

Fasting is typically used before feeding metabolizable energy assessment in broilers. Previous studies have shown that fasting cause atrophy of the intestinal villus. Whether fasting affects intestinal permeability during refeeding by altering barrier function and nutrient absorption is of concern. Here, 23-d-old broilers were randomly assigned to 5 treatments, fasted for 0, 12, 24, 36, and 48 h, respectively, and then refed for 2 d, to study the impact of different duration of fasting on the intestinal regeneration and barrier function during refeeding. Results showed that the intestinal morphology in fasted birds was recovered in 2 d of refeeding at most. As fasting durations increased,enterocytes per intestinal villus were linearly and quadratically increased(both P<0.05), whereas goblet cells per intestinal villus was linearly decreased(both P<0.05). Besides, the mRNA level of lysozyme was linearly decreased as fasting durations increased during refeeding(both P<0.05), while quadratically increased mucin 2 was observed only after 1 d of refeeding(P<0.05). Linear increase effects were observed for claudin 2 and zonula occludens-1with increased fasting durations after 1 d of refeeding(all P<0.05), and linear and quadratical effects were observed for claudin 2 at 2 d of refeeding(both P<0.05). Besides, we found that intestinal permeability to creatinine, 4 and 70 kD dextran were linearly and quadratically decreased with increased fasting durations at 6 h and 1 d of refeeding(all P<0.05). Furthermore, jejunum proteomic from birds refed for 6 h showed that birds fasted for 36 h showed increased antimicrobial peptides and upregulated retinol metabolism when compared to the nonfasted birds(P<0.05).Further study showed that retinyl ester catabolism was inhibited during fasting and enhanced during *** of intestinal organoid culture showed that retinol benefits the cell proliferation and enterocyte *** conclusion, the intestinal permeability t

关键词： broiler chicken fasting intestinal barrier intestinal permeability retinol

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莱芜铁矿区岩溶塌陷危险性评价及生态治理对策

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地理科学进展 2008年第6期27卷 70-75页

作者：王煜琴中国矿业大学(北京)土地复垦与生态重建研究所北京100083 山东旅游职业学院济南250200

矿产资源开采带来的塌陷及其环境地质灾害已给矿区可持续发展带来严重影响,加快塌陷治理,搞好环境修复是实现自然经济和谐发展的重要前提。在对莱芜铁矿区岩溶塌陷调查的基础上,探讨了铁矿区岩溶塌陷的影响因素和形成机理,选取第四系厚... 详细信息

矿产资源开采带来的塌陷及其环境地质灾害已给矿区可持续发展带来严重影响,加快塌陷治理,搞好环境修复是实现自然经济和谐发展的重要前提。在对莱芜铁矿区岩溶塌陷调查的基础上,探讨了铁矿区岩溶塌陷的影响因素和形成机理,选取第四系厚度、第四系松散岩类孔隙水含水层厚度及其与岩溶水的水力联系、灰岩顶界面岩溶发育程度、"天窗"内塌陷坑密度5个指标对岩溶塌陷危险性进行了定性及半定量评价;根据评价依据将研究区内不同天窗进行危险性划分;并针对评估结果,提出了相应的治理方案。本文的研究结果可以为区域生态环境修复规划的编制,实现区域可持续发展提供科学的依据。同时本文提出的评估方法在类似矿山地质灾害危险性评估及治理中具有参考和借鉴价值。

关键词：岩溶塌陷危险性生态治理莱芜市

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电影录音技术发展对动画片声音的影响

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北京电影学院学报 2009年第3期 15-19页

作者：王玉琴北京电影学院动画学院

动画片声音创作受到录音技术的限制与影响,并于不同时期呈现出不同的面貌。从默片到有声片,从单声道到立体声,从传统工艺到音频工作站的出现,每一次重大的技术革命都给我们带来全新的艺术感受,同时往往带来新的形式、新的观念和新的风... 详细信息

动画片声音创作受到录音技术的限制与影响,并于不同时期呈现出不同的面貌。从默片到有声片,从单声道到立体声,从传统工艺到音频工作站的出现,每一次重大的技术革命都给我们带来全新的艺术感受,同时往往带来新的形式、新的观念和新的风格变化。录音技术的发展给我们今天动画声音的创作提供了极为广阔的空间,然而任何一个技术进步对于电影声音来说都只是多了一重手段,到底怎样使用,还要取决于影片题材、性质和声音总体设计的需要。只有合理地使用,才能使它更好地为影片创作服务。

关键词：后期配音先期录音噪声立体声

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Assessment of Serum PRL,MLT,TSH,FSH and LH Concentrations in the Goat (Capra hircus) Exposing to Different Photoperiod Regimes

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Agricultural Biotechnology 2018年第4期7卷 110-114,117页

作者： Huibin SHI Zhilong TIAN yuqin wang Zhibo WU Fang YANG Jianping wang Mingxing CHU CaiHong WEI College of Animal Science and Technology Henan University of Science and TechnologyLuoyang 471003China Mutton Sheep Breeding Engineering Technology Research Center of Henan Province Luoyang 471019China Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

In many seasonally breeding species, photoperiod is an important factor involved in reproduction. Capra hircus breeds are normally considered short-day breeders. An experiment was carried out to evaluate whether or not photoperiodic regimens influence circulating hormone levels （prolactin, melatonin, thyrotropin stimulating hormine, luteinizing hormone,follicle stimulating hormone） of Henan huai local goat exposing to different photoperiodic regimens. The results showed that plasma levels of prolactin, melatonin, thyrotropin stimulating hormine, luteinizing hormone and follicle stimulating hormone were higher in the 8 L∶ 16 D photoperiodic regimen than that in the 16 L∶ 8 D photoperiodic regimen. Levels of those hormones decreased on day 7 and day 28 when the 16 L∶ 8 D photoperiodic regimen was used continuously. It was concluded that serum concentrations of the hormones increased in summer when short day （8 L∶ 16 D） was used and decreased when the goats were transferred from short day for 42 d to long day exposure for 28 d. We suggest that in summer, levels of hormones changing may be due to short day animals. Changing of related hormones is still determined by the mechanism of internal regulation of short day animal s exposure to light changes. Shortening light may also help increase the reproductive activity of goat and thus increase productivity.

关键词： Photoperiod PRL MLT TSH FSH LH Goat Introduction

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The tomato 2-oxoglutarate-dependent dioxygenase gene SlF3HL is critical for chilling stress tolerance

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Horticulture Research 2019年第1期6卷 1153-1164页

作者： Tixu Hu yuqin wang Qiqi wang Ningning Dang Ling wang Chaochao Liu Jianhua Zhu Xiangqiang Zhan State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture Northwest A&F UniversityNo.3Taicheng Road712100 YanglingShaanxiChina School of Biotechnology Jiangsu University of Science and TechnologyZhenjiangJiangsuChina Department of Plant Science and Landscape Architecture College of Agriculture and Natural ResourcesUniversity of MarylandCollege ParkMD 20742USA

Low temperature is a major stress that severely affects plant development,growth,distribution,and ***,we examined the function of a 2-oxoglutarate-dependent dioxygenase-encoding gene,SlF3HL,in chilling stress responses in tomato(Solanum lycopersicum *** Craig[AC]).Knockdown(KD)of SlF3HL(through RNA interference)in tomato led to increased sensitivity to chilling stress as indicated by elevated levels of electrolyte leakage,malondialdehyde(MDA)and reactive oxygen species(ROS).In addition,the KD plants had decreased levels of proline and decreased activities of peroxisome and superoxide *** expression of four cold-responsive genes was substantially reduced in the KD ***,seedling growth was significantly greater in AC or SlF3HLoverexpression plants than in the KD plants under either normal growth conditions with methyl jasmonate(MeJA)or chilling stress ***3HL appears to positively regulate JA accumulation and the expression of JA biosynthetic and signaling genes under chilling ***,these results suggest that SlF3HL is a positive regulator of chilling stress tolerance and functions in the chilling stress tolerance pathways,possibly by regulating JA biosynthesis,JA signaling,and ROS levels.

关键词： elevated stress chilling

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The stray laser light simulation and optimized design of beam dump for Thomson scattering system in HL-2M tokamak

The stray laser light simulation and optimized design of bea...

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第二十届全国光散射学术会议（CNCLS20）

作者： Chunhua LIU Yuan HUANG Zhen FENG yuqin wang Zhipei HOU Southwestern Institute of Physics

Laser beam dump is one of the critical components of Thomson scattering（TS） system to decrease stray laser light to an acceptable *** compact beam dumps are needed to absorb residual laser energy of HL-2 M TS *** will be installed at the inner wall of the HL-2 M vacuum vessel in the low field side,and the other will be set up in the divertor *** beam dump has a compact structure,and the lifetime of which manufactured by molybdenum materials,under the harsh thermal and electromagnetic loads could meet the demand of TS system in ITER [1],as well as TS system in the central region and divertor region of HL-2 *** compared with a beam dump that is set up outside the machine,the stray laser light caused by an inside beam dump maybe much stronger to seriously influence the scattered light measurement,and there is no references discussed the problem *** it is important to simulate the stray laser light caused by the chevron beam *** order to analyze its mechanical structure and simulate the stray laser light caused by it,bi-directional reflection distribution function（BRDF） of molybdenum is measured by scatterometer（Fraunhofer IOF） in 532 *** the surface properties of Mo material are loaded into the ray-tracing software to simulate the stray laser light emitting from the beam *** light source parameters are the same as that of the TS system on HL-2 *** light absorbing threshold is 1 *** 1（a） shows the beam dump structure and ray-tracing results,and it is obvious that the stray laser light emits in the cone angle α1 of about 65 *** results show that increasing the height of the entrance port could not decrease effectively the cone angle α.But after a reflecting cover is added in front of the beam dump as shown in figure 1（b）,the stray laser light emits in the cone angle α2=23 *** this condition,the strength of stray laser light directly entering into collection widow becomes *** the optimiz

关键词： Thomson scattering system HL-2M beam dump stray laser light simulation

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Behavioral Observations on Introduced Hu Sheep in Henan Province,China

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Agricultural Science & Technology 2017年第5期18卷 848-853,861页

作者： yuqin wang Zhilong TIAN Huibin SHI Qiujue WU Fang YANG Yuanxiao LI Xiaohui ZHANG Jianping wang Mingxing CHU College of Animal Science and Technology Henan University of Science and Technology Luoyang 471003 China Mutton Sheep Breeding Engineering Technology Research Center of Henan Province Luoyang 471003 China Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100193 China

Hu Sheep is a local sheep breed in the plain of Taihu, China. Due to the natural conditions in Taihu and human domestication, Hu Sheep is gradually featured with high adaptability, fast growth rate, early maturity and high productivity, which make them to be a unique and rare breed of sheep. In the present study, an experiment was conducted by means of instantaneous scan sampling, focal animal sampling and all-occurrence sampling to learn about Hu Sheep's behavior and activity pattern under certain feeding management and ecological condition. The result showed that the activity time budgets for several behaviors were different between rams and ewes, with respect to feeding (rams 30.60% vs. ewes 33.23%), ruminating (33.43% vs.35.30%); sleeping (19.92% vs. 13.69%), standing (4.13% vs. 5.26%), moving (8.10% vs. 7.46%), and other behaviors (3.86% vs.5.06%). A circadian activity rhythm was shown in some behaviors; e.g., total feeding time was greater in the daytime than at night, whereas resting time showed the opposite tendency. Moving mostly occurred in the daytime, and ruminating mainly occurred at night. Additionally, feeding activity occurred 32.22 times per day in rams and 31.73 times per day in ewes, whereas ruminating activity after feeding occurred 19.83 times per day in rams and 24.34 times per day in ewes. For each food bolus,the average ruminating time was 51.22 s in rams and 49.52 s in ewes, with 68.22 bouts of rumination per day in rams and57.35 bouts of rumination in ewes. By conducting the experiment, we studied and grasped the local Hu Sheep's main behavior and regularity which are of great significance on improving the feeding management and reducing diseases.

关键词： Hu sheep Ecological behavior Feeding management

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WTAP regulates postnatal development of brown adipose tissue by stabilizing METTL3 in mice

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Life Metabolism 2022年第3期1卷 270-284页

作者： yuqin wang Xinzhi Li Cenxi Liu Liying Zhou Lei Shi Zhiguo Zhang Long Chen Ming Gao Lanyue Gao Yuanyuan Xu He Huang Jin Li Zheng Chen HIT Center for Life Sciences School of Life Science and TechnologyHarbin Institute of TechnologyHarbinHeilongjiang 150001China School of Life Science State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Department of Cardiology The First Hospital of Jilin UniversityChangchunJilin 130021China The Key Laboratory of Liaoning Province on Toxic and Biological Effects of Arsenic School of Public HealthChina Medical UniversityShenyangLiaoning 110122China

Brown adipocyte maturation during postnatal development is essential for brown adipose tissue(BAT)to protect animals against *** maturation of brown adipocytes leads to cold ***,the molecular mechanisms that determine the maturation of brown adipocytes during postnatal development are not fully ***,we identify Wilms’tumor 1-associating protein(WTAP)as an essential regulator in the postnatal development and maturation of ***-specific knockout of Wtap(Wtap-BKO)severely impairs maturation of BAT in vivo by decreasing the expression of BAT-selective genes,leading to the whitening of interscapular BAT(iBAT).Single nucleus RNA-sequencing analysis shows the dynamic changes of cell heterogeneity in iBAT of Wtap-BKO *** mice with WTAP deficiency in BAT display hypothermic and succumb to acute cold ***,WTAP deficiency decreases m6A mRNA modification by reducing the protein stability of ***-specific overexpression of Mettl3 partially rescues the phenotypes observed in Wtap-BKO *** data demonstrate that WTAP/METTL3 plays an essential role in iBAT postnatal development and thermogenesis.

关键词： WTAP BAT m6A postnatal development METTL3 PRDM16

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Al含量对Mg-xAl-1Zn-1Si合金组织与力学性能的影响

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铸造技术 2014年第12期35卷 2841-2844页

作者：王玉琴陕西理工学院土木工程与建筑学院陕西汉中723000

研究了Al含量对Mg-x Al-1Zn-1Si(x=4,6,8,wt%)合金显微组织和力学性能的影响。结果表明,合金主要由α-Mg、β-Mg17Al12和Mg2Si相组成。随着Al含量的增加,α-Mg基体晶粒尺寸先减小后增大;呈网状分布于晶界上的Mg17Al12相的体积分数逐渐增... 详细信息

研究了Al含量对Mg-x Al-1Zn-1Si(x=4,6,8,wt%)合金显微组织和力学性能的影响。结果表明,合金主要由α-Mg、β-Mg17Al12和Mg2Si相组成。随着Al含量的增加,α-Mg基体晶粒尺寸先减小后增大;呈网状分布于晶界上的Mg17Al12相的体积分数逐渐增大;Mg2Si相由原来粗大的汉字状逐渐转变为相对细小的杆状。Al含量从4%增加到6%和8%时,α-Mg基体晶粒的平均尺寸分别为30、20和40μm,合金硬度逐渐提高;其室温与150℃抗拉强度、屈服强度和伸长率先升高后下降;合金拉伸断裂形式为准解理脆性断裂。

关键词： Mg-Al-Zn-Si合金 Al含量显微组织力学性能

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