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Design and aligner-assisted fast fabrication of a microfluidic platform for quasi-3D cell studies on an elastic polymer

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Bioactive Materials 2022年第9期7卷 288-304页

作者： Yingning He Yue Yu Yuqian Yang Yexin Gu Tianjiao Mao yang Shen Qiong Liu Ruili Liu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai200434China

While most studies of mechanical stimulation of cells are focused on two-dimensional(2D)and three-dimensional(3D)systems,it is rare to study the effects of cyclic stretching on cells under a quasi-3D microenvironment as a linkage between 2D and 3D.Herein,we report a new method to prepare an elastic membrane with topographic microstructures and integrate the membrane into a microfluidic chip.The fabrication difficulty lay not only in the preparation of microstructures but also in the alignment and bonding of the patterned membrane to other layers.To resolve the problem,we designed and assembled a fast aligner that is cost-effective and convenient to operate.To enable quasi-3D microenvironment of cells,we fabricated polydimethylsiloxane(PDMS)microwell arrays(formed by micropillars of a few microns in diameter)with the microwell diameters close to the cell sizes.An appropriate plasma treatment was found to afford a coating-free approach to enable cell adhesion on PDMS.We examined three types of cells in 2D,quasi-3D,and 3D microenvironments;the cell adhesion results showed that quasi-3D cells behaved between 2D and 3D cells.We also constructed transgenic human mesenchymal stem cells(hMSCs);under cyclic stretching,the visualizable live hMSCs in microwells were found to orientate differently from in a 3D Matrigel matrix and migrate differently from on a 2D flat plate.This study not only provides valuable tools for microfabrication of a microfluidic device for cell studies,but also inspires further studies of the topological effects of biomaterials on cells.

关键词： Microfluidic chip Biomaterials Cell-material interaction Polymer Cell stretching

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Tuning energy levels for high VOC in halide perovskite solar cells

Tuning energy levels for high VOC in halide perovskite solar...

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第九届新型太阳能材料科学与技术学术研讨会

作者： Yuqian Yang Jihuai Wu Qin Hu University of science and Technology of China School of Microelectronics

Hybrid halide perovskites hold great potential for next-generation solar cells. However, the PCE for relevant single junction devices is far away from the Shockley-Queisser limit [1-3]. Here, we tune energy levels via inducing alteration of lead-halogen bonds(Pb-I) for enhancement of open-circuit voltage(V) in triple-cation(Cs-MA-FA) perovskite solar cells. The extent of Pb-I orbital overlap relies on specific electronic environment around the lattice [4]. A phosphate salt can anchor on the perovskite lattice via coordinate with lead, which induces energy level shifts by increasing of Pb-I orbital overlap. Moreover, its functional groups further maintain the octahedral structure due to the conjugation and delocalization property. The optimized PSC exhibited power conversion efficiency of 22.8% with high open-circuit voltage(1.21 V), which maintained >80% of their initial value after 1000 hours in the dark under ambient condition.

关键词： perovskite solar cells energy level metal-halide bond open circuit voltage

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Exploring the anti-aging effects of chlorogenic acid and the underlying mechanisms based on a Caenorhabditis elegans model

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 208-217页

作者： Yuqian Yang Xu Chen Danyang Ye Chuanyu Wei Xinxin Pang Chuchu Kong Yongsheng Fang Hongliu yang Yuanyuan Zhang Yonggang Liu School of Chinese Materia Madica Beijing University of Chinese MedicineBeijing102488China Krannert Institute of Cardiology Indiana UniversityBurmingtonIndiana46517USA

Objective:To explore the anti-aging effects of chlorogenic acid(CGA)and the underlying mechanisms based on a Caenorhabditis elegans(C.elegans)model.Methods:The anti-agingactivityofCGAwasstudied basedon thebodylength,exercisebehavior,lipofuscin content,antioxidative stress ability,swallowing frequency,body-bending frequency,and head-swinging ability of C.elegans.Through DAF-16 nuclear translocation and SOD-3-GFP fluorescence experiments,the effects of CGA on ROS levels,antioxidant enzyme activities,MDA content,mutant-strain lifespan,and anti-aging molecular signaling pathways were explored,as well as the underlying mechanisms.Results:CGA improved multiple indices of the nematode:body length was increased(all P<0.001),head-swing frequency and body-bending frequency were increased(all P<0.05),nematode longevity was prolonged(P=0.0021),lipofuscin deposition in nematodes was slowed down(all P<0.001),the chemotaxis index was improved(P=0.0012),ROS levels were reduced(all P<.001),and SOD activity and MDA content were reduced(SOD:P=0.0017 between the low-concentration group and the control group,P<.001 between the high-concentration and medium-concentration groups and the control group;MDA:P=0.0135 between the low-concentration group and the control group,and P<0.001 between the high-concentration and medium-concentration groups and the control group).In addition,CGA also activated the DAF-16 transcription factor,promoted DAF-16 nuclear translocation under oxidative stress conditions(both P<0.001 between the high-concentration and medium-concentration groups and the control group),and increased SOD-3 gene expression in nematodes(all P<0.001).Conclusion:CGA plays an anti-aging role in C.elegans.The underlying mechanisms include activation of the insulin/IGF-1 signaling pathway and enhancement of DAF-16 activity.This study lays a foundation for further research into the anti-aging effects of CGA.

关键词： Chlorogenic acid Caenorhabditis elegans Antioxidant activity Anti-aging DAF-16

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Chromium trioxide modified spiro-OMeTAD for highly efficient and stable planar perovskite solar cells

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Journal of Energy Chemistry 2021年第10期30卷 386-394,I0011页

作者： Xiaobing Wang Jihuai Wu Yuqian Yang Guodong Li Zeyu Song Xuping Liu Weihai Sun Zhang Lan Peng Gao Engineering Research Centre of Environment-Friendly Functional Materials Ministry of Education/Fujian Engineering Research Centre of Green Functional MaterialsHuaqiao UniversityXiamen 361021FujianChina Fujian Institute of Research on Structure Matter Chinese Academy ScienceCASXiamen 361021FujianChina

Hole transporting materials(HTMs)play an unparalleled role in heightening the stability and photovoltaic performance of perovskite solar cells(PSCs).The organic small molecule spiro-OMeTAD is frequently utilized for HTM in PSCs.However,the raw spiro-OMeTAD without dopant would be harmful to the development of highly efficient PSCs,due to its unsatisfied hole mobility and conductivity.Therefore,we introduce an inorganic dopant(chromium trioxide,CrO_(3))into the lithium-salt doped spiro-OMeTAD.Because of the exclamatory oxidizability of CrO_(3),it can accelerate the oxidation of spiro-OMeTAD and thereby enhancing the hole mobility of HTM.The introduction of CrO_(3) not only substantially decreases the density of defects,but also adjusts spiro-OMeTAD energy band,and thus effectively suppresses the hysteresis and improving stability of PSCs.In the end,we obtained a power conversion efficiency(PCE)as high as 22.6%after doping CrO_(3) in spiro-OMeTAD.The facile,low cost and outstanding photovoltaic performance render CrO_(3) an excellent dopant for HTMs in PSCs.

关键词： Perovskite solar cells Spiro-OMeTAD Hole transporting materials CrO_(3)

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The influence of pulsed parameters on the damage of a Darlington transistor

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Journal of Semiconductors 2018年第9期39卷 38-43页

作者： Qiankun Wang Changchun Chai yuqian Liu Yintang yang School of Microelectronics Xidian University Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices

Theoretical research on the heat accumulation effect of a Darlington transistor induced by high power microwave is conducted,and temperature variation as functions of pulse repetitive frequency（PRF）and duty cycle（DC）are studied.According to the distribution of the electronic field and the current density in the Darlington transistor,the research of the damage mechanism is carried out.The results show that for repetitive pulses with the same pulse widths and different PRFs,the value of temperature variation increases with PRF increases,and the peak temperature has almost no change when PRF is lower than 200 k Hz;while for the repetitive pulses with the same PRF and different pulse widths,the larger the pulse width is,the greater temperature variation varies.The response of the peak temperature caused by a single pulse demonstrates that there is no temperature variation when the rising time is much shorter than the falling time.In addition,the relationship between the temperature variation and the time during the rising edge time as well as that between the temperature variation and the time during the falling edge time are obtained utilizing the curve fitting method.Finally,for a certain average power,with DC increases the value of temperature variation decreases.

关键词： Darlington transistor high power microwave pulse repetitive frequency duty cycle

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Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1227-1245页

作者： Shouyue Zhang Jin Zhang yang An Xiaoxi Zeng Ziyi Qin yuqian Zhao Heng Xu Bo Liu State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China Department of Laboratory Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Division of Plastic Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115USA West China Biomedical Big Data Center West China HospitalSichuan UniversityChengdu 610041China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China

Autophagy is a critical cellular homeostatic mechanism,and its dysfunction is linked to invasive breast carcinoma(BRCA).Recently,several omics methods have been applied to explore autophagic regulators in BRCA;however,more reliable and robust approaches for identifying crucial regulators and druggable targets remain to be discovered.Thus,we report here the results of multi-omics approaches to identify potential autophagic regulators in BRCA,including gene expression(EXP),DNA methylation(MET)and copy number alterations(CNAs)from The Cancer Genome Atlas(TCGA).Newly identified candidate genes,such as SF3 B3,TRAPPC10,SIRT3,MTERFD1,and FBXO5,were confirmed to be involved in the positive or negative regulation of autophagy in BRCA.SF3 B3 was identified firstly as a negative autophagic regulator,and siRNA/shRNA-SF3 B3 were shown to induce autophagyassociated cell death in in vitro and in vivo breast cancer models.Moreover,a novel small-molecule activator of SIRT3,1-methylbenzylamino amiodarone,was discovered to induce autophagy in vitro and in vivo.Together,these results provide multi-omics approaches to identify some key candidate autophagic regulators,such as the negative regulator SF3 B3 and positive regulator SIRT3 in BRCA,and highlight SF3 B3 and SIRT3 as new druggable targets that could be used to fill the gap between autophagy and cancer drug development.

关键词： Invasive breast carcinoma Multi-omics approach SIRT3 SF3B3 Autophagic regulator Anti-proliferation Migration Druggable target

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A study on service capacity of primary medical and health institutions for cervical cancer screening in urban and rural areas in China

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Chinese Journal of Cancer Research 2019年第5期31卷 838-848页

作者： yang Li Li Ma Chunxia yang Zhangya Chen yuqian Zhao Le Dang Jinghe Lang Youlin Qiao Department of Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Division of Health Information Dissemination Institute of Medical InformationChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Epidemiology Dalian Medical UniversityDalian 116027China Department of Epidemiology and Biostatistics West China School of Public Health and West fourth HospitalSichuan UniversityChengdu 610041China Executive office Taiyuan Health SupervisionTaiyuan 030001China Office of Cancer Prevention and Treatment Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science&Technology of ChinaChengdu 610041China Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical College(CAMS/PUMC)Beijing 100730China

Objective: To provide a decision-making basis for sustainable and effective development of cervical cancer screening.Methods: This cross-sectional study assesses the service capacity to conduct cervical cancer screening with a sample of 310 medical staff, medical institutions and affiliated township health centers from 20 countylevel/district-level areas in 14 Chinese provinces in 2016.Results: The county-level/district-level institutions were the main prescreening institutions for cervical cancer screening. More medical staff have become engaged in screening, with a significantly higher amounts in urban than in rural areas(P<0.05). The number of human papillomavirus(HPV) testers grew the fastest(by 225% in urban and 125% in rural areas) over the course of the project. HPV testing took less time than cytology to complete the same number of screening tasks in both urban and rural areas. The proportion of mid-level professionals was the highest among the medical staff, 40.0% in urban and 44.7% in rural areas(P=0.406), and most medical staff had a Bachelor’s degree, accounting for 76.3% in urban and 52.0% in rural areas(P<0.001). In urban areas, 75.0% were qualified medical staff, compared with 68.0% in rural areas, among which the lowest proportion was observed for rural cytology inspectors(22.7%). The medical equipment for cervical pathology diagnosis in urban areas was better(P<0.001). HPV testing equipment was relatively adequate(typing test equipment was 70% in urban areas, and non-typing testing equipment was 70% in rural areas).Conclusions: The service capacity of cervical cancer screening is insufficient for the health needs of the Chinese population. HPV testing might be an optimal choice to fill the needs of cervical cancer screening given current Chinese medical health service capacity.

关键词： China cervical cancer screening health service capacity appropriate technology cytology testing HPV testing

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突发公共卫生事件中基层政府的预警困境与治理对策

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南京社会科学 2022年第5期 75-82页

作者：李玉倩李扬南京晓庄学院教师教育学院南京211171 江苏现代信息社会研究基地江苏省社会科学院南京210004 江苏省社会科学院区域现代化研究院

基层政府位于突发公共卫生事件监测、预警和报告的最前端,提高其在突发公共卫生事件中的预警能力,有助于为整体防控赢得宝贵时间。然而政治承包责任制、理性官僚制和知识—权力制的三重委托—代理,给突发公共卫生事件预警带来了现实困境... 详细信息

基层政府位于突发公共卫生事件监测、预警和报告的最前端,提高其在突发公共卫生事件中的预警能力,有助于为整体防控赢得宝贵时间。然而政治承包责任制、理性官僚制和知识—权力制的三重委托—代理,给突发公共卫生事件预警带来了现实困境,并且博弈分析证实了消极预警通常是优先策略。针对突发公共卫生事件预警的压力和结构性张力,需要遵循建设责任型政府和提高突发公共卫生事件治理能力两条基本路径,实现绩效型政府与责任型政府的统一,优化基层政府治理绩效评估机制,进一步完善突发公共卫生事件预警机制,优化突发公共卫生事件预警的知识—权力结构。

关键词：基层政府预警能力委托代理责任型政府

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A green method for synthesizing novel nanoparticles and their application in flexible conductive patterns

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Journal of Materiomics 2020年第2期6卷 300-307页

作者： Wei Li Qiongying Cen Wenjiang Li Zihan Zhao Wenlong yang yuqian Li Minfang Chen Guang yang Jinjun yang School of Materials Science and Engineering Tianjin Key Lab for Photoelectric Materials&DevicesNational Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin300384China Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology School of Environmental Science and Safety EngineeringTianjin University of TechnologyTianjin300384China

A general and unified approach to synthesize Ag,Cu and Au nanoparticles(NPs)is developed at room temperature in air atmosphere under ultrasonication in poly(N-vinylpyrrolidone)(PVP)solutions with ascorbic acid and glucose as the reducing and nucleation agents,respectively.XRD,TEM,and HR-TEM analysis of the Ag,Cu,and Au NPs confirm purity and average diameters of 15.5±2.0 nm,50±3.0 nm,and 10±1.0 nm,respectively.An ultrasonic-assisted mechanism,wherein reduction occurs readily and produces anti-oxidation particles,is proposed and discussed.Fast infrared sintering was used to avoid damaging the substrate of conductive patterns whose resistivity at 10 W(~50℃)sintering power for less than 6 min reached up to 10±0.5 μΩ cm,40±3.0 μΩ cm,and 280±5 μΩ cm for Ag,Cu,and Au patterns,respectively.Paper-based electrodes were produced successfully and exhibited excellent flexibility and good conductivity.The potential of this method for large scale production is discussed.

关键词： Novel nanoparticles Conductivity Ultrasonic-assisted Infrared sintering

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基于5 μm厚向列相液晶的高效圆极化相控阵系统的设计、校准和实验验证

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Engineering 2024年第1期32卷 69-81页

作者： Xin Yu Wu Fengshuo Wan Hongyuan Feng Shichao Jin Chong Guo Yu Wei Dunge Liu Yuqian Yang Longzhu Cai Zhi Hao Jiang Wei Hong State Key Laboratory of Millimeter Waves School ofInformation Sdence and Engineering Southeast UniversityNanjing 210096China State Key Laboratory of Space-Ground Integrated Information Technology Beijing Institute of Satellite Information Engineering Beijing 100095China Research Institute of Millimeter-Wave and Terahertz Technology(RIMMATT) Nanjing 211111China

This paper presents a systematic investigation and demonstration of a K-band circularly polarized liquid-arystal-based phased array(LCPA),including the design,over-the-air(OTA)in-array calibration,and experimental validation.The LCPA contains 16 phase-shifting radiating channels,each consisting of a cir-cularly polarized stacked patch antenna and a liquid-crystal-based phase shifter(LCPS)based on a loaded differential line structure.Thanks to its slow-wave properties,the LCPS exhibits a maximum phase-shifting range of more than 360°with a figure of merit of 78.3(°)·dB^(-1)based on a liquid crystal layer with a thickness of only 5μm.Furthermore,an automatic OTA calibration based on a state ergodic method is proposed,which enables the extraction of the phase-voltage curve of every individual LCPA channel.The proposed LCPA is manufactured and characterized with a total profile of only 1.76 mm,experimentally demonstrating a scanned circularly polarized beam from-40°to+40°with a measured peak gain of 12.5 dBic and a scanning loss of less than 2.5 dB.The bandwidth of the LCPA,which satisfies the require-ments of port reflection(|S_(11)|)<-15 dB,an axial ratio(AR)<3 dB,beam squinting<3°,and a gain vari-ation<2.2 dB,spans from 25.5 to 26.0 GHz.The total efficiency is about 34%,which represents a new state of the art.The use of the demonstrated low-profile LCPA to support circularly polarized scanning beams,along with the systematic design and calibration methodology,holds potential promise for a vari-ety of millimeter-wave applications.

关键词： Circularly polarized Liquid crystal Liquid-crystal based phased array(LCPA) Phase shifter Over-the-air(OTA)calibration

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