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Conservative Evolution of Hepatitis B Virus Precore and Core Gene During Immune Tolerant Phase in Intrafamilial Transmission

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Virologica Sinica 2020年第4期35卷 388-397页

作者： yuqian luo Le Zhang Yimin Dai Yali Hu Biyun Xu Yi-Hua Zhou Department of Laboratory Medicine Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular MedicineNanjing University Medical SchoolNanjing 210008China Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China Department of Biostatistics Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing Medical UniversityNanjing 210008China

Hepatitis B virus(HBV)is characterized with high mutations,which is attributed to the lack of proof-reading of the viral reverse transcriptase and host immune *** this study,31 HBV chronic carriers from 14 families were enrolled to investigate the evolution of the same original HBV sources in different *** of pre-C and C(pre-C/C)genes were analyzed in eight pairs of HBV-infected mothers with longitudinal sera(at an interval of 6.0–7.2 years)and their children(5.5–6.7 years old),and in 15 adults(21–78 years old)from six families with known intrafamilial HBV *** pre-C/C sequences had almost no change in eight mothers during 6.0–7.2 years and their children who were in immune tolerant *** pre-C/C sequences from the 15 adults of six families,mostly in the immune-clearance phase or the low replicative phase,showed various diversified mutations between individuals from each *** to a reference stain(GQ205441)isolated nearby,the pre-C/C in individuals in immune tolerant phase showed 98.56%–99.52%homology at nucleotide level and 99.5%–100%homology at amino acid *** contrast,multiple mutations were developed in the immune-clearance phase or the low replicative phase,affecting immune epitopes in core gene and G1896 in pre-C *** results indicate that the evolution of new HBV variants is not mainly resulted from the spontaneous error rate of viral reverse transcription,but from the host immune pressure.

关键词： Hepatitis B virus(HBV) Pre-C/C gene Sequence evolution

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Variation characteristics of acid rain in Zhuzhou,Central China over the period 2011-2020

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Journal of Environmental Sciences 2024年第4期138卷 496-505页

作者： Jiahao Ren Liquan Zhu Xi Zhang yuqian luo Xuecai Zhong Bowen Li Yuwen Wang Kai Zhang State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Zhuzhou Environment Monitoring Center Zhuzhou 412000China Faculty of Environmental Engineering The University of Kitakyushu1–1 HibikinoWakamatsuKitakyushuFukuoka 808-0135Japan College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China

Zhuzhou was one of the most polluted cities in China with the serious acid *** to the implementation of air pollution control measures from 2016 to 2018,the acid rain pollution in this city has *** order to understand the recent situation,a comprehensive study on the acid rain was carried out from January 2011 to December *** pH values during the study period varied from 3.3 to 7.5,with a volume-weighted mean value of *** predominant acidic components of the precipitation were SO_(4)^(2-)and NO_(3)^(-),accounting for 89.3% of the total *** ratio of non-sea-salt SO_(4)^(2-)to NO_(3)^(-)showed a decreasing trend,revealing that the pollution type of acid rain changed from sulfuric acid type to sulfuric acid and nitric acid compound *** correlation analysis(p<0.05)showed that SO_(4)^(2-)was positively correlated with NH_(4)^(+),Ca^(2+),and Mg^(2+);hence,it predominated in precipitation as(NH_(4))_(2)SO_(4),NH_(4)HSO_(4),CaSO_(4),and MgSO_(4).Significant positive correlation of Ca^(2+)with Mg^(2+)shows that they may originated mainly from *** positive correlation between SO_(4)^(2-)and F^(-)and Cl^(-)indicate that their source may be related to the non-ferrous metal smelting industry in *** correlation analysis shows that emissions from the non-ferrous metal smelting industry in the area have a large significant on SO_(4)^(2-)and F^(-)in precipitation,while Cl^(-)may still be emitted from other anthropogenic sources.

关键词： Acid rain pH Chemical composition Neutralization factor Correlation analysis

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A statistic comparison of multi-element analysis of low atmospheric fine particles(PM_(2.5)) using different spectroscopy techniques

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Journal of Environmental Sciences 2022年第4期34卷 194-203页

作者： Minkang Zhi Kai Zhang Xi Zhang Hartmut Herrmann Jian Gao Khanneh Wadinga Fomba Wei Tang yuqian luo Huanhuan Li Fan Meng State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Faculty of Environmental Engineering The University of Kitakyushu1-1 HibikinoWakamatsuKitakyushuFukuoka 808-0135Japan Atmospheric Chemistry Department(ACD) Leibniz-Institute for Tropospheric Research(TROPOS)Leipzig 04318Germany

Over the past few decades,the metal elements(MEs)in atmospheric particles have aroused great *** well-established techniques have been used to measure particlebound ***,each method has its own advantages and disadvantages in terms of complexity,accuracy,and specific elements of *** this study,the performances of inductively coupled plasma-optical emission spectrometry(ICP-OES)and total reflection X-ray fluorescence spectroscopy(TXRF)were evaluated for quality control to analyze data accuracy and *** statistic methods(Deming regression and significance testing)were applied for intercomparison between ICP-OES and TXRF measurements for same lowloading PM_(2.5)samples in Weizhou *** results from the replicate analysis of standard filters(SRM 2783)and field filters samples indicated that 10 MEs(K,Ca,V,Cr,Mn,Fe,Ni,Cu,Zn,and Pb)showed good accuracies and precision for both *** higher accuracy tended to the higher precision in the MEs analysis *** addition,the interlab comparisons illustrated that V and Mn all had good agreements between ICP-OES and *** measurements of K,Cu and Zn were more reliable by TXRF analysis for low-loading PM_(2.5).ICP-OES was more accurate for the determinations for Ca,Cr,Ni and Pb,owing to the overlapping spectral lines and low sensitivity during TXRF *** measurements of Fe,influenced by low-loading PM_(2.5),were not able to determine which instrument could obtain more reliable *** conclusions could provide reference information to choose suitable instrument for the determination of MEs in low-loading PM_(2.5)samples.

关键词： Multielement analysis Low-loading fine particles Inductively coupled plasma-optical emission spectrometry Total reflection X-ray fluorescence spectroscopy Inter-laboratory comparison

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The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro

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Signal Transduction and Targeted Therapy 2020年第1期5卷 230-232页

作者： Huahao Fan Bixia Hong yuqian luo Qi Peng Liqin Wang Xiangshu Jin Yangzhen Chen Yunjia Hu Yi Shi Tong Li Hui Zhuang Yi-Hua Zhou Yigang Tong Kuanhui Xiang Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China Department of Laboratory Medicine Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China

Dear Editor,Since severe acute respiratory syndrome coronavirus 2(SARSCoV-2)RNA has been detected in human breastmilk,infants’safety with breastmilk feeding is of great concern for women with coronavirus disease 2019(COVID-19).1 It is known that milk has antiviral properties.2 However,little is known about the antiviral property of human breastmilk to SARS-CoV-2 and its related pangolin coronavirus(GX_P2V).Here we present for the first time that whey protein from human breastmilk effectively inhibited both SARS-CoV-2 and GX_P2V by blocking viral attachment and viral replication at entry and even post ***,human whey protein inhibited infectious virus production,as proved by the plaque *** found that whey protein from different species,such as cow and goat,also showed anti-coronavirus *** bovine formula milk also showed similar anti-SARS-CoV-2 activity.

关键词： properties inhibited acute

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Naked DNA in cells:An inducer of major histocompatibility complex molecules to evoke autoimmune responses?

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World Journal of Translational Medicine 2016年第1期5卷 46-52页

作者： yuqian luo Aya Yoshihara Kenzaburo Oda Yuko Ishido Naoki Hiroi Koichi Suzuki Department of Clinical Laboratory Science Faculty of Medical TechnologyTeikyo University Department of Education Planning and Development Faculty of MedicineToho University Division of Diabetes Metabolism and EndocrinologyDepartment of Internal MedicineToho University

The major histocompatibility complex(MHC) is the exclusive chaperone that presents intracellular antigens,either self or foreign to T ***,aberrant expression of MHC molecules has been reported in various autoimmune target tissues such as thyroid follicular cells in Grave's ***,we review the discovery of an unexpected effect of cytosolic doublestranded DNA(ds DNA),despite its origins,to induce antigen processing and presenting genes,including MHC molecules,in non-immune ***,we highlight several recent studies that suggest cell injury endows thyroid epithelial cells with a phenotype of mature antigen presenting cells by inducing multiple antigen processing and presenting genes via releasing genomic DNA fragments into the *** discuss the possibility that such cytosolic ds DNA,in naked form without binding to histone proteins,might be involved in the development of cell damage-triggered autoimmune *** also discuss the possible molecular mechanism by which cytosolic ds DNA can induce MHC *** is reasonable to speculate that cytosolic ds DNA-induced MHC class Ⅰ is partially due to an autocrine/paracrine effect of type Ⅰ interferon(IFN).While the mechanism of cytosolic ds DNA-induced MHC class Ⅱ expression appears,at least partially,distinct from that mediated by IFN-γ.Further in-depth are required to clarify this picture.

关键词： Cytosolic double-stranded DNA Major histocompatibility complex molecules Autoimmune response Antigen presentation Tissue injury

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电力调度数据网安全传输研究

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通信电源技术 2023年第16期40卷 90-92页

作者：罗语茜国网汉中供电公司陕西汉中723000

电力调度数据是否稳定、安全、可靠,直接影响电力调度数据网的运行效果。随着经济的飞速发展,电力已经成为人们生活中不可或缺的核心能源。为确保电网正常工作,必须加大对电力调度数据网安全传输的重视,同时使用科学合理的手段,提升网... 详细信息

电力调度数据是否稳定、安全、可靠,直接影响电力调度数据网的运行效果。随着经济的飞速发展,电力已经成为人们生活中不可或缺的核心能源。为确保电网正常工作,必须加大对电力调度数据网安全传输的重视,同时使用科学合理的手段,提升网络传输效率。通过研究电力调度数据网的安全传输模式,分析其安全问题产生的主要原因,提出具有针对性的安全防护设计方法,从而促使电网保持良好的运行状态。

关键词：电力调度数据网安全传输传输效率

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“领跑未来”:以领跑者精神引领新优质学校建设

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中国基础教育 2024年第11期 73-75页

作者：叶卉罗宇茜天津港保税区文教局天津港保税区空港学校党委天津300308 天津港保税区空港学校教育集团天津300308 天津港保税区空港学校党建人事处天津300308

天津港保税区空港学校通过确立契合学校定位的教育价值观,提出融合科学知识、道德情感与人文素养的育人愿景,构建富有创新特质的学校治理体系,建设教产研融合的“领跑者”师资队伍,创建体现新型生产关系的课程建设共同体,推动了学校的... 详细信息

天津港保税区空港学校通过确立契合学校定位的教育价值观,提出融合科学知识、道德情感与人文素养的育人愿景,构建富有创新特质的学校治理体系,建设教产研融合的“领跑者”师资队伍,创建体现新型生产关系的课程建设共同体,推动了学校的加速发展。

关键词：新优质学校新学校建设领跑者精神学校治理体系课程建设共同体

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甲状腺球蛋白负反馈调节机制

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南方医科大学学报 2019年第1期39卷 125-127页

作者：陈飞汪红娟李强黎志超骆予倩南方医科大学珠江医院广东广州510280 南京大学医学院附属鼓楼医院江苏南京210008

甲状腺球蛋白(Tg)是甲状腺滤泡中最重要含量最丰富的蛋白质,临床作为甲状腺癌复发和持续状态的肿瘤标志物被广泛深入的研究。传统观点认为Tg是甲状腺激素合成的物质基础,不参与调节甲状腺激素合成分泌,甲状腺激素合成分泌受甲状腺-下丘... 详细信息

甲状腺球蛋白(Tg)是甲状腺滤泡中最重要含量最丰富的蛋白质,临床作为甲状腺癌复发和持续状态的肿瘤标志物被广泛深入的研究。传统观点认为Tg是甲状腺激素合成的物质基础,不参与调节甲状腺激素合成分泌,甲状腺激素合成分泌受甲状腺-下丘脑-脑垂体轴负反馈调节机制调控。本文阐述的甲状腺球蛋白负反馈调节机制基于实验研究结论认为:甲状腺球蛋白对甲状腺滤泡细胞合成甲状腺激素功能存在负向调控作用,可以拮抗促甲状腺激素TSH的正向调控作用,推测甲状腺滤泡细胞功能是Tg和TSH共同作用的结果,并提出滤泡周期模型揭示甲状腺滤泡异质性的原因。本文综述甲状腺球蛋白负反馈调节机制研究进展,展望了该研究的临床意义,对比甲状腺-下丘脑-脑垂体轴负反馈调节机制,说明两个理论之间的差异,加深对甲状腺两个负反馈调节机制的认识。

关键词：甲状腺球蛋白甲状腺激素合成负反馈学说滤泡周期模型

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冬季NH_(3)和液态水含量对PM_(2.5)中SNA形成的影响与敏感性分析

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环境科学研究 2021年第5期34卷 1053-1062页

作者：吕文丽张凯支敏康曹晴黎洁罗宇骞刘翰青中国环境科学研究院环境基准与风险评估国家重点实验室北京100012 贵州大学资源与环境工程学院贵州贵阳550025

为了解冬季不同污染等级下NH_(3)和AWC(Aerosol Water Content,气溶胶液态水含量)对PM_(2.5)中水溶性二次离子形成的影响,对保定市冬季颗粒物浓度、二次离子及前体物(SO_(2)、NO_(2)、NH_(3))浓度进行了分析,并利用ISORROPIA-Ⅱ计算了PM... 详细信息

为了解冬季不同污染等级下NH_(3)和AWC(Aerosol Water Content,气溶胶液态水含量)对PM_(2.5)中水溶性二次离子形成的影响,对保定市冬季颗粒物浓度、二次离子及前体物(SO_(2)、NO_(2)、NH_(3))浓度进行了分析,并利用ISORROPIA-Ⅱ计算了PM_(2.5)中的AWC和pH.结果表明:①2017—2018年冬季保定市重污染期(AQI>200)ρ(PM_(2.5))、ρ(SO_(2))、ρ(NO_(2))和ρ(NH_(3))较优良期(AQITS(总硫)浓度>TN(总氮)浓度≈TA+TS+TN浓度(同时改变相同比例的总氨、总硫、总氮浓度),随污染等级的升高,pH对TS、TA浓度变化的敏感性减弱,对TN浓度变化的敏感性增强;单独改变TS、TN、TA浓度时AWC敏感性弱,同时改变TS、TN、TA浓度时AWC敏感性较强,AWC变化与二次离子浓度密切相关.研究显示,保定市冬季污染期SNA的形成以液态水参与的液相氧化为主,NH_(3)可以维持颗粒物的高pH,保持氧化过程.

关键词： NH_(3) 气溶胶液态水含量(AWC) 污染等级 ISORROPIA-Ⅱ 敏感性

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企业人才忠诚度的影响因素及提升对策研究——以“90后”员工为例

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创新科技 2017年第12期17卷 43-45页

作者：罗煜茜张雪松蒋静河南科技大学管理学院河南洛阳471000

本文主要采取问卷调查的方式进行资料收集,旨在分析影响"90后"员工忠诚度的因素,并综合考虑"90后"员工的自身特性和忠诚度现状,探究出其在职场上的真实需求,帮助企业管理者制定适合自身的人力资源管理体系。

关键词： “90后”员工忠诚度对策研究

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