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简易瞬态工况下汽油车挥发性有机物在线排放特征研究

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环境科学学报 2020年第12期40卷 4470-4482页

作者：郝钰琦沙青娥庄文辉卢仲康袁自冰赵恺辉刘元向段乐君刘学辉张立航郑君瑜邵敏袁斌李文石王日超闫宇华南理工大学环境与能源学院广州510006 暨南大学环境与气候研究院广州511486 广州华工机动车检测技术有限公司检测站广州510641 帕莫瑞科技有限公司北京100071

机动车是大气挥发性有机物(VOCs)的重要排放源之一,识别其高分辨率排放特征对于VOCs污染控制具有重要意义.针对现有研究对不同行驶状态下机动车VOCs排放特征精细化描述较为缺乏这一问题,本研究构建了在线与离线相结合的VOCs测量系统,采... 详细信息

机动车是大气挥发性有机物(VOCs)的重要排放源之一,识别其高分辨率排放特征对于VOCs污染控制具有重要意义.针对现有研究对不同行驶状态下机动车VOCs排放特征精细化描述较为缺乏这一问题,本研究构建了在线与离线相结合的VOCs测量系统,采用底盘测功机运行的简易瞬态工况(VMAS),对广州市36辆不同排放标准的汽油车尾气VOCs高分辨率排放特征开展在线测量.实时观测结果发现,随着国标加严,VOCs排放至少下降2个数量级.庚烷、丁烯、甲苯、甲醛和甲醇为各类VOCs的特征组分,各组分间的相关系数普遍在0.90~0.97之间.然而,随着国标加严,组分间的相关系数下降到0.20~0.94,醇类与其它组分出现负相关或无相关性.VOCs排放分布集中于变速阶段,高于怠速和匀速阶段所占的比重,其中,甲醛、乙醛和丙酮等含氧挥发性有机物(OVOCs)在不同变速阶段维持较高且稳定的排放.这说明在城市地区降低机动车VOCs排放,长期任务是减少因拥堵或其它因素造成的频繁启动和变速,尽可能确保行驶畅通.本研究在线与离线测试所识别的VOCs组分比对结果一致性较高,在线仪器的使用较好地弥补了离线测试识别VOCs实时排放特征的局限性.

关键词：在线测量工况变化挥发性有机物排放特征简易瞬态工况

Understanding the synergetic interaction within α-MoC/β-Mo2C heterostructured electrocatalyst

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Journal of Energy Chemistry 2019年第8期28卷 66-70,I0004页

作者： hao Zhang Haiyan Jin yuqi Yang Fanfei Sun Yang Liu Xianlong Du Shuo Zhang Fei Song Jianqiang Wang Yong Wang Zheng Jiang Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204 China University of Chinese Academy of Sciences Beijing 100100 China Advanced Materials and Catalysis Group Institute of Catalysis Zhejiang UniversityHangzhou 310028 Zhejiang China

Constructing heterostructure is an important strategy to design efficient electrocatalysts. The synergetic interaction between dissimilar materials has been considered as the origin of the activity enhancement,however, the interfacial interaction is challenging to probe, thus, the underlying mechanism remains obscure. Here, we reported a heterostructured α-MoC/β-Mo2 C electrocatalyst for hydrogen evolution in alkaline media, which shows a significant electrocatalytic activity improvement as compared to the single component. Based on extensive characterizations including high-resolution transmission electron microscopy and X-ray absorption fine structure(XAFS) spectroscopy, together with density functional theory, we unraveled the synergetic interaction between α-MoC and β-Mo2 C, implying that α-Mo C sites are beneficial for water dissociation and hydrogen prefers to release on β-Mo2 C sites.

关键词： Hydrogen evolution reaction Heterostructure Molybdenum carbide Synergetic interaction Water dissociation

分级诊疗背景下康复患者双向转诊现状及对策研究

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卫生软科学 2024年第10期38卷 84-88,94页

作者：李晓轩叶睿雪王昱棋郝英姿王玉龙山东中医药大学康复医学院山东济南250355 深圳市第二人民医院康复医学科广东深圳518035

[目的]探明双向转诊的现状和患者对双向转诊态度的影响因素,为促进分级诊疗政策的有效实施提供参考。[方法]对2023年9-11月纳入深圳市5家机构中具有康复需求的门诊患者进行问卷调查,问卷内容包括社会人口学特征、医保及医疗费用情况、... 详细信息

[目的]探明双向转诊的现状和患者对双向转诊态度的影响因素,为促进分级诊疗政策的有效实施提供参考。[方法]对2023年9-11月纳入深圳市5家机构中具有康复需求的门诊患者进行问卷调查,问卷内容包括社会人口学特征、医保及医疗费用情况、诊疗情况等。[结果]共发放问卷1173份,回收有效问卷1013份,患者平均年龄(48.47±16.84)岁;47.6%的患者认可双向转诊。单因素分析结果显示患者对双向转诊的态度与年龄、下转存在问题等因素之间存在相关性(P<0.05)。多因素Logistic回归模型结果显示,患者年龄、学历、家庭年收入、是否了解下转、是否满意基层医院环境设施、是否满意基层医院医疗费用和报销水平,是患者双向转诊态度的影响因素。[结论]患者对双向转诊态度受到患者年龄、学历、家庭年收入、下转存在问题等因素的影响,针对重点人群加强分级诊疗的宣传、改善基层医院的卫生服务能力可以在一定程度上提高患者对双向转诊的认可度,有利于巩固并促进当前我国分级诊疗模式。

关键词：分级诊疗双向转诊康复患者态度影响因素

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球磨时间对MSR铜铝尖晶石的影响

炼油与化工 2024年第5期35卷 32-36页

作者：乔韦军郝敏彤王波张煜琪李红平刘通中国石油石油化工研究院大庆化工研究中心黑龙江大庆163714 兰州中石油润滑油添加剂有限公司甘肃兰州730000

采用球磨法制备了铜铝(Cu-Al)尖晶石催化剂,通过改变球磨时间(t=0、2、4、6 h),制备出Cu-Al尖晶石前驱体CAQ-t和对应催化剂CA-t,通过XRD、BET、H2-TPR和XPS一系列表征方法对催化剂及前驱体进行表征,探究球磨时间对尖晶石催化剂催化性能... 详细信息

采用球磨法制备了铜铝(Cu-Al)尖晶石催化剂,通过改变球磨时间(t=0、2、4、6 h),制备出Cu-Al尖晶石前驱体CAQ-t和对应催化剂CA-t,通过XRD、BET、H2-TPR和XPS一系列表征方法对催化剂及前驱体进行表征,探究球磨时间对尖晶石催化剂催化性能的影响。结果表明,适当的球磨时间会增加Cu-Al尖晶石及CuO的分散情况,进而影响了尖晶石相含量。当球磨时间为4 h时,制备的Cu-Al尖晶石分散情况最好,尖晶石含量最高为90.76%,将其应用在催化甲醇水蒸气重整制氢中,当反应温度为280℃时,水醇物质的量比为2。当甲醇质量空速为1.05 h^(-1)时,甲醇转化率约为76%,并且能够在50 h下保持不失活。

关键词：球磨时间甲醇水蒸气重整制氢 Cu-Al尖晶石催化性能

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双源CT双能量虚拟平扫对直肠癌壁外血管侵犯的诊断价值

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CT理论与应用研究（中英文） 2024年第1期33卷 42-48页

作者：杨振兴张宇琦刘挨师吴慧赵磊高伟施琳郝粉娥内蒙古医科大学附属医院影像诊断科呼和浩特010050 内蒙古医科大学附属医院病理科呼和浩特010050 内蒙古医科大学第一临床医学院呼和浩特010110

目的:探讨双源CT双能量虚拟平扫(VNC)对直肠癌壁外血管侵犯(EMVI)的术前诊断价值。方法:选取2019年11月至2021年12月间拟手术治疗的150例直肠癌患者术前行双源CT双能量虚拟平扫,女性64例(42.7%)、男性86例(57.3%),平均年龄为(62.3±11.8... 详细信息

目的:探讨双源CT双能量虚拟平扫(VNC)对直肠癌壁外血管侵犯(EMVI)的术前诊断价值。方法:选取2019年11月至2021年12月间拟手术治疗的150例直肠癌患者术前行双源CT双能量虚拟平扫,女性64例(42.7%)、男性86例(57.3%),平均年龄为(62.3±11.8)岁。两名高年资影像科医师独立分析术前影像资料(包括ctEMVI情况及有无局部淋巴结浸润和远处转移),判断是否存在术前EMVI。以手术病理结果为金标准,分别评价VNC诊断EMVI的敏感性、特异性、准确性、阳性预测值和阴性预测值并采用受试者操作特征(ROC)曲线下面积评价其诊断效能。结果:150例直肠癌患者中,术后病理证实56例(37.3%)为EMVI阳性,94例(62.7%)为EMVI阴性。医师1对EMVI评价准确性、敏感性、特异性、阳性预测值、阴性预测值分别为86%、80.36%、89.36%、81.82%、88.42%,AUC为0.831(95%CI 0.756~0.905);医师2的准确性、敏感性、特异性、阳性预测值、阴性预测值分别为88.67%、80.36%、93.62%、88.24%、88.89%,AUC为0.870(95%CI 0.802~0.938),医师1与医师2的评估结果一致性较高(k=0.943)。结论:双源CT双能量虚拟平扫对直肠癌EMVI术前评估具有一定的诊断价值。

关键词：双源CT 双能量虚拟平扫直肠癌壁外血管侵犯

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Effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein sleeve cardiomyocytes with atrial fibrillation

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Journal of Geriatric Cardiology 2008年第1期5卷 39-42页

作者： Yang Li Yan Huang Zongbin Li hao Wang Jianguo Song yuqi Liu Lei Gao Shiwen Wang Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china

Objective To study the effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein(PY) sleeve cardiomyocytes with atrial *** Dissociation of PVs yielded single cardiomyocytes from a Landengorff column without or with pacemaker activity from long-term rapidly atrial pacing (RAP) *** current was measured with the whole-cell patch-clamp *** Compared with the control group,the rapidly atrial pacing canine PV cardiomyocytes had spontaneous diastolic depolarization and had larger If *** (Iva,1 μM),a selective inhibitor of the If current,markedly reduced If currents in the RAP from -2.66±0.4 pA/pF to -1.58±0.1 pA/pF at the test potential of-120 mV (P＜0.01,n=12).Inhibition effect of Iva of If current showed concentration-dependent range from 0.1 to 10.0μM,with IC50 of 2.2 μ M ( 1.8-2.9 μM,95% CL).Furthermore,V1/ of steady-state activated curve was shifted from -84.3±4.9 mV to -106.9±3.4 mV and k value of steady-state activated curve was changed from 12.1+2.6 mV to 9.9±3.4 mV by the application of.1.0 μM Iva ( P＜0.01,n=12).Conclusions Our study revealed that Ivarbadine may significantly decrease If of rapidly atrial pacing pulmonary vein sleeve ceUs with atrial fibdllation.(J Geriatr Cardiol 2008;5:39-42)

关键词： ivarbadine hyperpolarization activated cation anine pulmonary vein sleeves atrial fibrillation

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

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Science China(Life Sciences) 2020年第10期63卷 1429-1449页

作者： Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu yuqi Deng hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan Deparment of Clinical Laboratory The Firs Ajiaued Hospital of USICHefei National Laborarory for Physical Sciences an Microscalethe CAS Key Laboratory of Inmate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Neurosurgery The First Afiliated Hospial of University of Science and Technology of China Hefei 230001China Key Laboratory of Regeneralive Biology of the Chinese Academy of Sciences Joint School of Life SciencesGuangzhou Medical Untiversily and Guangzhou Institutes of Biomedicine and HealhChinese Academy of SciencesGuangzhou 510530China MOE Key Laboratory of Bioinformatics School of Life SciencesTsinghua UniversiyBeiing 100084.China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Mammalian mitochondria have small genomes encoding very limited numbers of *** one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the ***,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial *** provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported *** components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein *** expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein *** and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus.

关键词： mitochondria circRNA mecciRNA mitochondrial protein import

基于网络药理学及分子对接探究黄杞苷治疗银屑病的潜在靶点和机制预测

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黑龙江八一农垦大学学报 2024年第5期36卷 104-111页

作者：李宇琦王璇陈倩李爽申雪牛文琦郝美晗宋博翠黑龙江八一农垦大学生命科学技术学院大庆163319

基于网络药理学及分子对接,探究黄酮苷类化合物黄杞苷对治疗银屑病的潜在靶点及作用机制。首先,通过TCMSP等数据库获取药物与疾病潜在靶点;其次,构建黄杞苷-银屑病交集靶点蛋白质互作网络,并获取关键靶点。采用Metascape数据库对交集靶... 详细信息

基于网络药理学及分子对接,探究黄酮苷类化合物黄杞苷对治疗银屑病的潜在靶点及作用机制。首先,通过TCMSP等数据库获取药物与疾病潜在靶点;其次,构建黄杞苷-银屑病交集靶点蛋白质互作网络,并获取关键靶点。采用Metascape数据库对交集靶点进行GO功能富集分析和KEGG通路富集分析,最终选取关键靶点与黄杞苷进行分子对接。结果显示,黄杞苷治疗银屑病潜在靶点共66个,涉及炎症反应的调节、对外源性刺激的反应等生物进程,并且可能通过调控PI3K/Akt等多条信号通路发挥治疗作用。分子对接结果显示,黄杞苷与核心靶点结合活性较好,并阐明了黄杞苷通过多靶点、多途径来治疗银屑病,为研发新的治疗银屑病药物提供了理论基础。

关键词：黄杞苷银屑病网络药理学分子对接

Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple

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Horticulture Research 2020年第1期7卷 1525-1535页

作者： Dali Geng Xiaoxia Shen Yinpeng Xie Yusen Yang Ruiling Bian yuqi Gao Pengmin Li Liying Sun hao Feng Fengwang Ma Qingmei Guan Laboratory of Apple College of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China

MdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought *** this study,using a metabolomic approach,we identified differentially accumulated phenylpropanoid and flavonoid metabolites in MdMYB88/124 transgenic RNAi plants under control and long-term drought stress conditions in apple *** confirmed the regulation of phenylalanine by MdMYB88 and MdMYB124 via UPLC-MS in apple roots under both control and drought *** Electrophoretic Mobility Shift Assay(EMSA)and ChIPquantitative PCR(qPCR)analyses,we found that MdMYB88 positively regulates the MdCM2 gene,which is responsible for phenylalanine biosynthesis,through binding to its promoter *** long-term drought conditions,MdMYB88/124 RNAi plants consistently accumulated increased amounts of H2O2 and MDA,while MdMYB88 and MdMYB124 overexpression plants accumulated decreased amounts of H2O2 and *** also examined the accumulation of metabolites in the phenylpropanoid biosynthesis pathway in the leaves of MdMYB88 and MdMYB124 transgenic apple plants after long-term drought *** found that metabolites responsible for plant defense,including phenylpropanoids and flavonoids,accumulated less in the RNAi plants but more in the overexpression plants under both control and drought *** further demonstrated that MdMYB88/124 RNAi plants were more sensitive to Alternaria alternata *** and Valsa mali,two pathogens that currently severely threaten apple *** contrast,MdMYB88 and MdMYB124 overexpression plants were more tolerant to these *** cumulative results of this study provided evidence for secondary metabolite regulation by MdMYB88 and MdMYB124,further explained the molecular roles of MdMYB88 and MdMYB124 in drought resistance,and provided information concerning molecular aspects of their roles in disease resistance.

关键词： drought resistance roots