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北祁连山晚中新世以来的隆升历史——来自河道高程剖面的约束

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第四纪研究 2024年第2期44卷 338-353页

作者：苏晓倩庞建章王一舟郑德文张会平郝宇琦中国地震局地质研究所地震动力学国家重点实验室北京100029

北祁连山作为青藏高原隆升与扩展的最前缘,一直以来都是研究的热点。本研究为弥补活动构造与热年代学方法时间尺度上难以链接的不足及提供青藏高原扩展隆升机制相关证据,利用河流水力侵蚀模型的方法模拟得出北祁连山河道陡峭指数与部分... 详细信息

北祁连山作为青藏高原隆升与扩展的最前缘,一直以来都是研究的热点。本研究为弥补活动构造与热年代学方法时间尺度上难以链接的不足及提供青藏高原扩展隆升机制相关证据,利用河流水力侵蚀模型的方法模拟得出北祁连山河道陡峭指数与部分河流地质隆升历史。结果揭示出北祁连山河道陡峭指数与距断裂的距离存在显著关系,且具有从中间向东西两侧减小的特征,表现出北祁连山隆升速率大致也呈现自中向两侧减慢的特征;并通过分析处于北祁连山非沉积区白杨河、洪水坝河、丰乐河、马营河、大渚马河及洪水河这6条流域的地质隆升历史,发现在4 Ma左右,北祁连山隆升速率逐渐增加,且隆升速率大致在0.20~0.38 mm/a之间。直到0.6~1.0 Ma,隆升速率迅速加快,呈现陡增的趋势。因此,北祁连山的构造隆升并不是均匀的,而是随时间发生变化的。

关键词：北祁连山基岩河道河道陡峭指数水力侵蚀方程隆升历史

Identification of close relationship between atmospheric oxidation and ozone formation regimes in a photochemically active region

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Journal of Environmental Sciences 2021年第4期33卷 373-383页

作者： Kaihui Zhao Huihong Luo Zibing Yuan Danni Xu Yi Du Shu Zhang yuqi hao Yonghua Wu Jianping Huang Ying Wang Rongsheng Jiang School of Environment and Energy South China University of TechnologyGuangzhou 510006China The City College of New York(CCNY) New YorkNY 10031USA NOAA–Cooperative Science Center for Earth System Sciences and Remote Sensing Technologies New YorkNY 10031USA NOAA-NCEP Environmental Modeling Center and IM System Group Inc. College ParkMD 720740USA Yale-NUIST Center on Atmospheric Environment Nanjing University of Information Science&TechnologyNanjing 210044China Xianyang Meteorological Bureau Xianyang 712000China Climate Environment and Sustainability CenterNanjing University of Information Science and TechnologyNanjing 210044China

Understanding ozone(O_(3))formation regime is a prerequisite in formulating an effective O_(3)pollution control *** indicator is a simple and direct method in identifying O_(3)formation *** used indicators are derived from observations,whereas the role of atmospheric oxidation is not in consideration,which is the core driver of O_(3)***,it may impact accuracy in signaling O_(3)formation *** this study,an advanced three-dimensional numerical modeling system was used to investigate the relationship between atmospheric oxidation and O_(3)formation regimes during a long-lasting O_(3)exceedance event in September 2017 over the Pearl River Delta(PRD)of *** discovered a clear relationship between atmospheric oxidative capacity and O_(3)formation *** eastern PRD,O_(3)formation was mainly in a NO x-limited regime when HO_(2)/OH ratio was higher than 11,while in a VOC-limited regime when the ratio was lower than *** central and western PRD,an HO_(2)/OH ratio higher than 5 and lower than 2 was indicative of NO x-limited and VOC-limited regime,*** contribution,including horizontal transport and vertical transport,may pose uncertainties on the indication of O_(3)formation regime by HO_(2)/OH *** comparison with other commonly used photochemical indicators,HO_(2)/OH ratio had the best performance in differentiating O_(3)formation *** study highlighted the necessities in using an atmospheric oxidative capacity-based indicator to infer O_(3)formation regime,and underscored the importance of characterizing behaviors of radicals to gain insight in atmospheric processes leading to O_(3)pollution over a photochemically active region.

关键词： Atmospheric oxidation O_(3)formation regimes WRF-CMAQ Photochemically active region

Synergistic precipitant powered self-assembly of papain for cross-linked enzyme crystals preparation

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Particuology 2024年第2期85卷 102-112页

作者： Qi hao Pan Guo Honghai Wang Min Su Chunli Li yuqi Hu Weiyi Su School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization Tianjin300130China

In this study,we prepared cross-linked enzyme crystals(CLECs)of papain to further broaden the application of the enzyme with high activity in extreme ***,papain crystals were successfully obtained based on the micro-batch,batch,and expanded batch crystallization ***,ammonium sulfate and polyethylene glycol 6000(PEG6000)were synergistically used as the precipitants,while L-cysteine was applied to enhance the activity of ***,the interaction between L-cysteine and papain was modeled by molecular docking *** was found that L-cysteine could form a hydrogen bond with aspartic acid residue(Asp)at site 158,and the electrostatic attraction with lysine residue(Lys)at site 156 was also quite *** the enzyme crystals were cross-linked by glutaraldehyde at optimized *** papain CLECs were identified by various methods,and it was found that the thermal stability and enzymatic activity both increased compared to the raw *** importantly,it could be applied at more rigorous conditions,for example,pH of 4.

关键词： Papain Cross-linked enzyme crystals L-cysteine Molecular docking Crystallization

Discharge evolution law of debris flow based on a sharp bend physical modeling test

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Journal of Mountain Science 2024年第6期21卷 1904-1915页

作者： LU Ming SUN hao LIU Jinfeng Abrar HUSSAIN SHANG yuqi FU Hang Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China

For the basins with debris flow development,its channel terrain exhibits a tortuous shape,which significantly restricts the movement of debris flows and leads to severe erosion effects on the concave ***,this study aims to analyze the shear force of debris flows within the bend *** established the relationship between the shear force and bend curvature through laboratory *** the long-term erosion by debris flows,the curvature radius of bends gradually increases,however,when this increasing trend reaches an equilibrium state with the intensity of debris flow discharge,there will be no significant change in curvature *** general,the activity pattern and discharges of debris flows would remain relatively ***,we can infer the magnitude of debris flow discharges from the terrain parameters of the bend channel.

关键词： Debris flow discharge Erosion effect Bend channel Curvature radius

RGB oralscan video-based orthodontic treatment monitoring

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Science China(Information Sciences) 2024年第1期67卷 124-139页

作者： Yan TIAN Hanshi FU hao WANG yuqi LIU Zhaocheng XU Hong CHEN Jianyuan LI Ruili WANG School of Computer Science and Technology Zhejiang Gongshang University Shining3D Tech Co. Ltd. School of Information and Technology Monash University School of Mathematical and Computational Sciences Massey University Department of Stomatology Zhejiang Provincial People's HospitalHangzhou Medical College School of Computer and Computing Science Zhejiang University City College

Orthodontic treatment monitoring involves using current images and previous 3D models to estimate the relative position of individual teeth before and after orthodontic *** process differs from image-based object 6D pose estimation due to the gingiva deformation and varying pose offsets for each tooth during *** by the fact that the poses of molars remain relatively fixed in implicit orthodontics,we design an approach that employs multiview pose evaluation and bidirectional temporal propagation for jaw pose estimation and then employs an iteration-based method for tooth *** handle changes in tooth appearance or location with weak texture across frames,we also introduce an instance propagation module that leverages positional and semantic information to explore instance relations in the temporal *** evaluated the performance of our approach using both the Shining3D tooth pose dataset and the Aoralscan3 tooth registration *** experimental results demonstrate remarkable accuracy improvements compared with existing methods.

关键词： digital dentistry object 6D pose estimation deep learning computer vision

Flexible sensors with zero Poisson's ratio

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National Science Review 2024年第5期11卷 153-169页

作者： Xin Huang Tianzhao Bu Qingyang Zheng Shaoyu Liu Yangyang Li Han Fang yuqi Qiu Bin Xie Zhouping Yin hao Wu Department of Mechanical Engineering Flexible Electronics Research Center State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and Technology Department of Electronic Science and Technology School of Integrated CircuitsHuazhong University of Science and Technology

Flexible sensors have been developed for the perception of various stimuli. However, complex deformation,usually resulting from forces or strains from multi-axes, can be challenging to measure due to the lack of independent perception of multiaxial stimuli. Herein, flexible sensors based on the metamaterial membrane with zero Poisson's ratio(ZPR) are proposed to achieve independent detection of biaxial stimuli. By deliberately designing the geometric dimensions and arrangement parameters of elements, the Poisson's ratio of an elastomer membrane can be modulated from negative to positive, and the ZPR membrane can maintain a constant transverse dimension under longitudinal stimuli. Due to the accurate monitoring of grasping force by ZPR sensors that are insensitive to curvatures of contact surfaces, rigid robotic manipulators can be guided to safely grasp deformable objects. Meanwhile, the ZPR sensor can also precisely distinguish different states of manipulators. When ZPR sensors are attached to a thermal-actuation soft robot, they can accurately detect the moving distance and direction. This work presents a new strategy for independent biaxial stimuli perception through the design of mechanical metamaterials, and may inspire the future development of advanced flexible sensors for healthcare, human–machine interfaces and robotic tactile sensing.

关键词： zero Poisson's ratio metamaterials independent perception of multiaxial stimuli flexible sensor

A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei Liu Shangwen Jiang Bingbing hao Shuyu Xie Yingluo Liu yuqi Huang Heng Xu Cheng Luo Min Huang Minjia Tan Jun-Yu Xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

Strain-specific effect of Streptococcus thermophilus consumption on host physiology

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Food Science and Human Wellness 2024年第5期13卷 2876-2888页

作者： Peng Yu Yang Jiang yuqi Pan Min Guo Bo Yang Xiaoming Liu Jianxin Zhao hao Zhang Wei Chen State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Laboratory for Pharmabiotics&Antibiotic Resistance Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China National Engineering Research Centre for Functional Food Wuxi 214122China

Streptococcus thermophilus is one of the most prevalent species in stool samples of westernized populations due to continuous exposure to fermented dairy ***,few studies have explored the effect on host physiology by multiple *** strains and considered the inter-strain differences in regulating *** the present study,we investigated how four *** strains influenced the gut microbiota,mucin changes,and host metabolism after 28 days of intervention in conventional *** results indicated that the consumption of *** affected the host with strain *** four *** strains,DYNDL13-4 and DQHXNQ38M61,especially DQHXNQ38M61,had more effect on host physiology by modulating gut microbiota and host metabolism than LMD9 and *** of strains DYNDL13-4 and DQHXNQ38M61 resulted in more remarkable changes in amino acid metabolism and lipid metabolism than that of strains LMD9 and 4M6,which may be related to the elevation of intestinal Bifidobacterium by DYNDL13-4 and *** enriched Coriobacteriaceae UCG-002,Rikenellaceae RC9 gut group,and Lactobacillus only in the DQHXNQ38M61 group,had a close relationship with the prominent effect of DQHXNQ38M61 on regulating amino acid and lipid *** addition,DQHXNQ38M61 had a strong influence on degrading colonic mucin fucose by decreasedα-fucosidase activity in feces,and improving mucin sulfation by upregulated Gal3ST2 *** genomic analysis revealed that the four *** strains belonged to different branches in the phylogenetic tree,and DYNDL13-4 and DQHXNQ38M61 had more genes involved in carbohydrate metabolism,amino acid metabolism,membrane transport,and signal transduction,which may confer the capacity of nutrient utilization and gastrointestinal adaptation of the strains and be associated with their strong regulation in *** study provides valuable information for understanding the regulation of host metabolism aft

关键词： Streptococcus thermophilus Intestinal microbiota Metabolome Comparative genomics

Carbon dots-incorporated CuSeO_(3)rationally regulates activity and selectivity of the hydrogen species via light-converted electrons

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Chinese Chemical Letters 2024年第1期35卷 332-337页

作者： yuqi Ren Hongxu Zhang Caihong hao Qing Chang Ning Li Jinlong Yang Shengliang Hu Research Group of New Energy Materials and Devices North University of ChinaTaiyuan 030051China State Key Laboratory of New Ceramics and Fine Processing Tsinghua UniversityBeijing 100084China

The chemoselective hydrogenation of structurally diverse nitroaromatics is a challenging ***,catalyst activity tends to decrease when excellent selectivity is *** here present a novel photocatalyst combining amino-functionalized carbon dots(N-CDs)with copper selenite nanoparticles(N-CDs@CuSeO_(3))for simultaneously improving selectivity and *** visible light irradiation,the prepared N-CDs@CuSeO_(3)exhibits 100%catalytic selectivity for the formation of 4-aminostyrene at full conversion of 4-nitrostyrene in aqueous solvent within a few *** excellent photocatalytic performance is mainly attributed to the precise control of the hydrogen species released from the ammonia borane by means of light-converted electrons upon N-CDs@CuSeO_(3).Besides,the defect states at the interface of N-CDs and CuSeO_(3)enable holes to be trapped for promoting separation and transfer of photogenerated charges,allowing more hydrogen species to participate in catalytic reaction.

关键词： Heterostructure Carbon dots Photocatalysis Chemoselective hydrogenation Copper selenite