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中国医学影像技术从业人员现状和需求调查研究

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四川大学学报（医学版） 2024年第3期55卷 612-618页

作者：谭裕奇叶铮李函宇吕欣阳夏春潮李真林四川大学华西医院放射科成都610041

目的调查我国二级及以上医院放射科医学影像技术从业人员的现状和需求,为医学影像技术行业的发展和卫生行政部门相关决策的制定提供参考依据。方法采用中华医学会影像技术分会制定的调查表,由各医院放射科推荐一位影像技师填写线上问... 详细信息

目的调查我国二级及以上医院放射科医学影像技术从业人员的现状和需求,为医学影像技术行业的发展和卫生行政部门相关决策的制定提供参考依据。方法采用中华医学会影像技术分会制定的调查表,由各医院放射科推荐一位影像技师填写线上问卷。填写内容包括:医院基本信息、本院医学影像技术从业人员基本情况、日常工作、发展与晋升、科研现状及需求等。使用Mann-Whitney U检验比较技师配置人数上的差异,使用卡方检验比较不同地区或不同等级医院在需求选取人数上的差异。结果本调查获取了全国31个省份总计5 403家医院的有效问卷,其中影像技师人数共计67 481人,各医院放射科技师配置人数为[中位数(四分位间距)]9(5,16)人;男女比例为1.41∶1;20~40岁占比77.5%;博士、硕士、本科、专科、中专及以下所占比例分别为:0.6%、3.3%、60.7%、30.8%、4.6%;主任技师、副主任技师、主管技师、技师、技士及以下所占比例分别为:1.0%、4.2%、22.1%、51.8%、20.9%;影像技师整体的职业满意度较好;“与外界学习交流机会少”是影像技师工作能力提升遇到的主要问题。近5年内,59.2%的受访者未发表过学术论文,以第一作者在科学引文索引(SCI)收录期刊发表论文的技师仅占7.0%。结论我国医学影像技术从业人员平均年龄较为年轻,且从业人数大大增加,现阶段应重视影像技术的人才培养和继续教育,并进一步加强学科建设,为我国医学影像技术行业的发展提供有力的支持。

关键词：医学影像技术医学影像技师人员现状和需求人才培养

工作回报调节视角下心理疲劳对建筑工人危险感知的差异化影响研究

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项目管理技术 2024年第4期22卷 40-47页

作者：韩豫张梦月谈宇琦江苏大学管理学院江苏镇江212013 江苏大学土木工程与力学学院江苏镇江212013

为有效减少心理疲劳对危险感知的负面影响,提高建筑工人安全绩效,基于实地调研和文献梳理,研究心理疲劳不同表现形式对建筑工人危险感知的影响差异,并重点关注工作回报的调节作用。采用结构方程模型和分层回归方法,对356份来自建筑工人... 详细信息

为有效减少心理疲劳对危险感知的负面影响,提高建筑工人安全绩效,基于实地调研和文献梳理,研究心理疲劳不同表现形式对建筑工人危险感知的影响差异,并重点关注工作回报的调节作用。采用结构方程模型和分层回归方法,对356份来自建筑工人的有效问卷进行分析。结果表明:动力减少对危险侦测和危险处置的负面影响最为显著;认知衰弱对危险认知具有长期负面影响;工作回报在心理疲劳对危险感知的负向影响中发挥积极的调节作用;情绪耗竭和行为迟缓对危险感知的负面影响较弱。

关键词：工作回报心理疲劳建筑工人危险感知结构方程模型

Emergence of machine language: towards symbolic intelligence with neural networks

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National Science Review 2024年第4期11卷 27-30页

作者： yuqi Wang Xu-Yao Zhang Cheng-Lin Liu Tieniu tan Zhaoxiang Zhang State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences

Representation learning is a core issue in artificial intelligence (AI). Currently,there exists a disparity in the choice of representation between humans and machines. Humans rely on discrete language for communicati...

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Effect of Microstructural Characteristics on Fracture Toughness in Direct Energy Deposited Novel Ti-6Al-4V-1Mo Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 119-131页

作者： Chao Xia Kexin Zhao Xin Zhou yuqi He Panpan Gao Hengxin Zhang Guangrui Gao Fengying Zhang Hua tan School of Material Science and Engineering Chang’an UniversityXi’an710064China Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an710038China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China Surface Material Protection Co. LtdXi’an710018China

Meeting the damage tolerance requirements for engineering-grade titanium alloys pose a significant challenge in achieving high fracture toughness in direct energy deposition(DED)titanium alloys.This work primarily investigated the relationship between the microstructure and the fracture toughness of DED new Ti-6Al-4V-1Mo alloy.Two types of microstructures were designed via two process strategies:high-line energy density(HE)and low-line energy density(LE).Relative to LE samples,HE samples possess larger-sized microstructural characteristics(coarser grain boundaryα(α_(GB)),largerαcolonies,and coarserαlaths).Lessα/βphase boundaries were formed by coarserαlaths in the HE samples,increasing the movement of dislocations,resulting in tensile strength decreasing from 1007.1 MPa(LE)to 930.8 MPa(HE)and elongation increasing from 10.8%(LE)to 15.7%(HE).Also,HE samples exhibited an excellent fracture toughness of 114.0 MPa m^(1/2),significantly higher than that of LE samples(76.8 MPa m^(1/2)).An analysis of crack propagation paths was conducted to investigate the factors contributing to toughening.The primary factor enhancing toughness is the frequent obstruction of cracks by coarseαGB and largeαcolonies in HE samples.Particularly,the pretty large-angle deflections induced by the superposition effect of coarseαGB and largeαcolonies play a vital of significant role.These factors induced the long and tortuous high-energy pathways,which resulted in ultimately improved fracture toughness.The discovered microstructural toughening mechanisms can serve as a reference for future studies involving titanium alloys,offering insights on how to enhance fracture toughness by achieving similar characteristics.

关键词： Direct energy deposition Ti-6Al-4V-1Mo Tensile properties Fracture toughness Crack propagation

Analysis of Hot Topics Regarding Global Smart Elderly Care Research—1997-2021

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China CDC weekly 2024年第9期6卷 157-161页

作者： Hongman Wang Hong Chen yuqi Wang School of Health Humanities Peking UniversityBeijingChina Center for Global Public Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?With the assistance of the internet,big data,cloud computing,and other technologies,the concept of smart elderly care has emerged.What is added by this report?This study presents information on the countries or regions that have conducted research on smart elderly care,as well as identifies global hotspots and development trends in this field.

关键词： Smart internet smart

A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei Liu Shangwen Jiang Bingbing Hao Shuyu Xie Yingluo Liu yuqi Huang Heng Xu Cheng Luo Min Huang Minjia tan Jun-Yu Xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

A new review of single-ion conducting polymer electrolytes in the light of ion transport mechanisms

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Journal of Energy Chemistry 2024年第2期89卷 543-556,I0012页

作者： yuqi Luo Lu Gao Weimin Kang State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China

With the depletion of fossil fuels and the demand for high-performance energy storage devices,solidstate lithium metal batteries have received widespread attention due to their high energy density and safety advantages.Among them,the earliest developed organic solid-state polymer electrolyte has a promising future due to its advantages such as good mechanical flexibility,but its poor ion transport performance dramatically limits its performance improvement.Therefore,single-ion conducting polymer electrolytes(SICPEs)with high lithium-ion transport number,capable of improving the concentration polarization and inhibiting the growth of lithium dendrites,have been proposed,which provide a new direction for the further development of high-performance organic polymer electrolytes.In view of this,lithium ions transport mechanisms and design principles in SICPEs are summarized and discussed in this paper.The modification principles currently used can be categorized into the following three types:enhancement of lithium salt anion-polymer interactions,weakening of lithium salt anion-cation interactions,and modulation of lithium ion-polymer interactions.In addition,the advances in single-ion conductors of conventional and novel polymer electrolytes are summarized,and several typical highperformance single-ion conductors are enumerated and analyzed in what way they improve ionic conductivity,lithium ions mobility,and the ability to inhibit lithium dendrites.Finally,the advantages and design methodology of SICPEs are summarized again and the future directions are outlined.

关键词： Lithium metal batteries Single-ion conductor Polymer electrolytes Ion transport mechanism Li-ion transport number

miR‑423 sponged by lncRNA NORHA inhibits granulosa cell apoptosis

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Journal of Animal Science and Biotechnology 2024年第2期15卷 632-644页

作者： yuqi Li Zhuofan Zhang Siqi Wang Xing Du Qifa Li College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Background Atresia and degeneration,a follicular developmental fate that reduces female fertility and is triggered by granulosa cell(GC)apoptosis,have been induced by dozens of miRNAs.Here,we report a miRNA,miR-423,that inhibits the initiation of follicular atresia(FA),and early apoptosis of GCs.Results We showed that miR-423 was down-regulated during sow FA,and its levels in follicles were negatively correlated with the GC density and the P4/E2 ratio in the follicular fluid in vivo.The in vitro gain-of-function experiments revealed that miR-423 suppresses cell apoptosis,especially early apoptosis in GCs.Mechanically speaking,the miR-423 targets and interacts with the 3’-UTR of the porcine SMAD7 gene,which encodes an apoptosis-inducing factor in GCs,and represses its expression and pro-apoptotic function.Interestingly,FA and the GC apoptosis-related lncRNA NORHA was demonstrated as a ceRNA of miR-423.Additionally,we showed that a single base deletion/insertion in the miR-423 promoter is significantly associated with the number of stillbirths(NSB)trait of sows.Conclusion These results demonstrate that miR-423 is a small molecule for inhibiting FA initiation and GC early apoptosis,suggesting that treating with miR-423 may be a novel approach for inhibiting FA initiation and improving female fertility.

关键词： Granulosa cell apoptosis miR-423 NORHA SMAD7 Sow fertility traits

Time-varying parameters estimation with adaptive neural network EKF for missile-dual control system

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Journal of Systems Engineering and Electronics 2024年第2期35卷 451-462页

作者： YUAN yuqi ZHOU Di LI Junlong LOU Chaofei School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Electronic System Engineering Beijing 100854China

In this paper, a filtering method is presented to estimate time-varying parameters of a missile dual control system with tail fins and reaction jets as control variables. In this method, the long-short-term memory(LSTM) neural network is nested into the extended Kalman filter(EKF) to modify the Kalman gain such that the filtering performance is improved in the presence of large model uncertainties. To avoid the unstable network output caused by the abrupt changes of system states,an adaptive correction factor is introduced to correct the network output online. In the process of training the network, a multi-gradient descent learning mode is proposed to better fit the internal state of the system, and a rolling training is used to implement an online prediction logic. Based on the Lyapunov second method, we discuss the stability of the system, the result shows that when the training error of neural network is sufficiently small, the system is asymptotically stable. With its application to the estimation of time-varying parameters of a missile dual control system, the LSTM-EKF shows better filtering performance than the EKF and adaptive EKF(AEKF) when there exist large uncertainties in the system model.

关键词： long-short-term memory(LSTM)neural network extended Kalman filter(EKF) rolling training time-varying parameters estimation missile dual control system