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中成药临床实践指南制定方法(六)——推荐意见形成与呈现

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中医杂志 2024年第2期65卷 172-177页

作者：张钰菁梁宁晏利姣胡紫腾陈雅馨张福强车前子陈昭刘玉祁王丁熠史楠楠王燕平中国中医科学院中医临床基础医学研究所北京市100700

推荐意见形成是临床实践指南制定的关键环节,其应包含确定推荐的强度和方向,推荐理由及实施推荐意见的方法。推荐意见可通过正式共识法和非正式共识法形成。判定中成药临床实践指南的推荐意见强度和方向时应综合考虑中成药的证据质量、... 详细信息

推荐意见形成是临床实践指南制定的关键环节,其应包含确定推荐的强度和方向,推荐理由及实施推荐意见的方法。推荐意见可通过正式共识法和非正式共识法形成。判定中成药临床实践指南的推荐意见强度和方向时应综合考虑中成药的证据质量、临床问题的优先性、疗效和不良反应的利弊、患者的接受度、推荐意见的可行性和资源可用性、社会公平性、经济效益等影响因素。为了更好地指导指南制定者更合理地考虑这些因素,通过结合中医药特点对每个因素进行详细的解释说明。

关键词：临床实践指南中成药推荐意见共识法

The biochemical behavior and mechanism of uranium(Ⅵ)bioreduction induced by natural Bacillus thuringiensis

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Journal of Environmental Sciences 2024年第2期136卷 372-381页

作者： Shunzhang Chen Junyuan Gong Yanxia Cheng yuqi Guo Feize Li Tu Lan Yuanyou Yang Jijun Yang Ning liu Jiali Liao Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China

For a broader understanding of uranium migration affected by microorganisms in natural anaerobic environment,the bioreduction of uranium(Ⅵ)(U(Ⅵ))was revealed in Bacillus thuringiensis,a dominant bacterium strain with potential of uranium-tolerant isolated from uranium contaminated *** reduction behavior was systematically investigated by the quantitative analysis of U(Ⅳ)in bacteria,and mechanism was inferred from the pathway of electron *** anaerobic conditions,appropriate biomass and sodium lactate as electron donor,reduction behavior of U(Ⅵ)induced by *** was restricted by the activity of lactate dehydrogenase,which was directly affected by the initial pH,temperature and initial U(Ⅵ)concentration of bioreduction *** of U(Ⅵ)was driven by the generation of nicotinamide adenine dinucleotide(NADH)from enzymatic reaction of sodium lactate with various *** transmission of the electrons from bacteria to U(Ⅵ)was mainly supported by the intracellular NADH dehydrogenase-ubiquinone system,this process could maintain the biological activity of cells.

关键词： Uranium Bacillus thuringiensis Bioreduction Electron transmission

Bi^(3+)-activated dual-wavelength emitting phosphors toward effective optical thermometry

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Chinese Chemical Letters 2024年第3期35卷 486-492页

作者： Yu Xue yuqi Chen Guixian Li Weixi Xia Qinan Mao Lang Pei Meijiao liu Liang Chu Jiasong Zhong Center of Advanced Optoelectronic Materials College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China Department of Chemistry Zhejiang Sci-Tech UniversityHangzhou 310018China

Optical thermometry as an important local temperature-sensing technique,has received increasing attention in scientific and industrial ***,it is still a big challenge to develop luminescent materials with self-activated dual-wavelength emissions toward high-sensitivity optical ***,a novel ratiometric thermometric strategy of Bi^(3+)-activated dual-wavelength emission band was realized in the same lattice position with two local electronic states of La_(3)Sb_(1-x)Ta_xO_(7):Bi^(3+)(0≤x≤1.0)materials based on the different temperature-dependent emission behaviors,benefiting from the highlysensitive and regulable emission to the coordination environment of Bi^(3+).The structural and spectral results demonstrate that the emission tremendously shifted from green to blue with 68 nm and the intensity was enhanced 2.6 ***,the visual dual-wavelength emitting from two emission centers was presented by increasing the Ta^(5+)substitution concentration to 20%or 25%,mainly originating from the two local electronic states around the Bi^(3+)emission ***,the dual-wavelength with different thermal-quenching performance provided high-temperature sensitivity and good discrimination signals for optical thermometry in the range between 303 and 493 *** maximum relative sensitivity reached 2.64%/K(La_(3)Sb_(0.8)Ta_(0.2)O_(7):0.04Bi^(3+)@383 K)and 1.91%/K(La_(3)Sb_(0.75)Ta_(0.25)O_(7):0.04Bi^(3+)@388 K).This work reveals a rational design strategy of different local electronic states around the singledoping multiple emission centers towards practical applications,such as luminescence thermometry and white LED lighting.

关键词： Dual-wavelength emitting Cationic substitution Two local electronic states Optical thermometry Bi^(3+)-doped phosphor

Enhanced extracellular production of alpha-lactalbumin from Bacillus subtilis through signal peptide and promoter screening

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Food Science and Human Wellness 2024年第4期13卷 2310-2316页

作者： yuqi Zhu Pengdong Sun Chunjian Li Yu Zhang Yu Wang Jingyuan Li Yanfeng liu Jian Chen Yang Deng College of Food Science and Engineering Qingdao Agricultural UniversityQingdao 266109China Key Laboratory of Special Food Processing(Co-construction by Ministry and Province) Ministry of Agriculture Rural AffairsQingdao Agricultural UniversityQingdao 266109China Qingdao Special Food Research Institute Qingdao 266109China Science Center for Future Foods Engineering Research Center of Ministry of Education on Food Synthetic BiotechnologyJiangsu Province Engineering Research Center of Food Synthetic BiotechnologyJiangnan UniversityWuxi 214122China Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Alpha-lactalbumin(α-LA)is a major whey protein found in breast milk and plays a crucial role in the growth and development of *** this study,Bacillus subtilis RIK1285 harboring AprE signal peptide(SP)was selected as the original strain for the production ofα-*** was found thatα-LA was identified in the pellet after ultrasonic disruption and centrifugation instead of in the fermentation *** original strain most likely only producedα-LA intracellular,but not *** improve the expression and secretion ofα-LA in RIK1285,a library of 173 homologous SPs from the *** 168 genome was fused with target LALBA gene in the pBE-S vector and expressed extracellularly in *** YjcN was determined to be the best signal *** in supernatant were observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and purified by nickel column to calculate the highest yield signal *** addition,different promoters(P_(aprE),P_(43),and P_(glv))were compared and *** results indicated that the strain RIK1285-pBE-P_(glv)-YjcN-LALBA had the highestα-LA yield,reaching 122.04μg/*** study demonstrates successful expression and secretion of humanα-LA in *** and establishes a foundation for simulating breast milk for infant formulas and developing bioengineered milk.

关键词： Bacillus subtilis Alpha-lactalbumin Bioengineering milk Signal peptide Promoter screening

A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei liu Shangwen Jiang Bingbing Hao Shuyu Xie Yingluo liu yuqi Huang Heng Xu Cheng Luo Min Huang Minjia Tan Jun-Yu Xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

Shanghai Autism Early Development:An Integrative Chinese ASD Cohort

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Neuroscience Bulletin 2022年第12期38卷 1603-1607页

作者： Yuan Dai yuqi liu Lingli Zhang Tai Ren Hui Wang Juehua Yu Xin liu Zilin Chen Lin Deng Minyi Tao Hangyu Tan Chu‑Chung Huang Jiaying Zhang Qiang Luo Jianfeng Feng Miao Cao Fei Li Department of Developmental and Behavioral Pediatric and Child Primary Care Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children’s Environmental HealthXinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Center for Experimental Studies and Research The First Afliated Hospital of Kunming Medical UniversityKunming 650032China Key Laboratory of Brain Functional Genomics(Ministry of Education) Afliated Mental Health CenterSchool of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China Shanghai Changning Mental Health Center Shanghai 200335China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China National Clinical Research Center for Aging and Medicine at Huashan Hospital Fudan UniversityShanghai 200433China Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenome InstituteFudan UniversityShanghai 200032China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Ministry of EducationFudan UniversityShanghai 200433China

Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,w... 详细信息

关键词： impaired Cohort ASD

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腹腔感染患者肺脏保护的管理策略

中华胃肠外科杂志 2020年第11期23卷 1032-1035页

作者：刘玉琪福建医科大学附属第二医院重症医学科福建省呼吸医学中心泉州362000

肺脏保护在腹腔感染(IAI)患者的医治过程中非常重要。本文重点分享IAI患者肺脏保护的管理策略。在实施IAI个体化呼吸保护时,良好的温湿化和胸腔物理治疗、必需的营养支持、严格的气囊管理、保持高卧体位、减轻镇痛镇静的持续时间和深度... 详细信息

肺脏保护在腹腔感染(IAI)患者的医治过程中非常重要。本文重点分享IAI患者肺脏保护的管理策略。在实施IAI个体化呼吸保护时,良好的温湿化和胸腔物理治疗、必需的营养支持、严格的气囊管理、保持高卧体位、减轻镇痛镇静的持续时间和深度,有利于保持有效的咳嗽能力和预防隐性吸入。同时,需要预防呼吸机相关机械通气的损伤,做好急性呼吸窘迫综合征小潮气量、限制平台压力、膈肌保护和右心保护性策略。在进行个体化呼吸功能状态的评估和监测时,对于行机械通气治疗的IAI患者可以使用呼吸力学指标包括气道阻力、呼吸系统顺应性、最大吸气压(MIP)和气道闭合压(P0.1);未行机械通气治疗的IAI患者可以使用床旁简易肺功能指标,包括吸气和呼气的用力肺活量、吸气和呼气峰值流速、最大吸气压力和吐气压力以及1 s量和1 s率等。在肺康复中,实施"湿、翻、拍、咳、扩、吹、动"七字原则的肺脏保护技术。

关键词：腹腔感染肺保护急性呼吸窘迫综合征预防

Effect of cyclosporine-A on electrophysiological properties of atria in tachycardia-induced atrial fibrillation

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Journal of Geriatric Cardiology 2008年第3期5卷 175-178页

作者： Lei Gao Wei Yan yuqi liu Ya Huang Qi Chen Yuxiao Zhang Peng liu Caiyi Lu Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China. Institute of Geriatric Cardiology Chinese PLA General Hospital

Objective To investigate the effects of ciyelosporine-A(CsA).a calcinenrin(CAN)inhibitor,on electrophysiological propertiesof atria in canine tachycardia-induced model of *** Eighteen healthy adult mongrel canines weighing 17.0 to 23.2 kg(rangedfrom 2 to 4 years old)were randomized to 3 groups,Sham group(no pacemaker was implanted),atrial tachypacing group(ATP group)each group at baseline and after 8 weeks' *** included atrial effective refractory period(AERP),conductionvelocity(CV),wave length(WE),atrial fibrillation load and rate-adaptability. Results After 8 weeks' atrial tachypacing,ATP andCsA groups showed significant longer duration of the P wave,shorter AERP,decreased adaptation of AERE slower CV,shorter Wland longer AF duration compared to the shamg roup (all P＜0.05).AERP of the CsA group was longer than that of ATP group (P＜0.05),but there were no differences in rate-adaptability,CV,incidence of induced AF and AF duration between CsA group and ATP *** Our results suggest that calcineurin pathway intervention by CsA have a positive effect on tachycardia-inducedelectrical remodeling of atria,but can not prevent or reverse AF.

关键词： attral fibrillation calcineurin CsA:electrophysiology electrical remodeling

Pseudorandom Code Error Monitoring Method for GNSS Signal

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Pseudorandom Code Error Monitoring Method for GNSS Signal