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Artificial stepwise light harvesting system in water constructed by quadruple hydrogen bonding supramolecular polymeric nanoparticles

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Chinese Chemical Letters 2024年第2期35卷 370-373页

作者： Tangxin Xiao Xiuxiu Li Liangliang Zhang Kai diao Zheng-Yi Li Xiao-Qiang Sun Leyong Wang Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Stepwise energy transfer is ubiquitous in natural photosynthesis,which greatly promotes the widespread use of solar ***,we constructed a supramolecular light harvesting system based on sequential energy transfer through the hierarchical self-assembly of M,which contains a cyanostilbene core flanked by two ureidopyrimidinone motifs,endowing itself with both aggregation-induced emission behavior and quadruple hydrogen bonding *** monomer M can self-assemble into hydrogen bonded polymers and then form supramolecular polymeric nanoparticles in water through a mini-emulsion *** nanoparticles were further utilized to encapsulate the relay acceptor ESY and the final acceptor NDI to form a two-step FRET *** fluorescence including a white-light emission was successfully *** work not only shows a desirable way for the fabrication of efficient two-step light harvesting systems,but also shows great potential in tunable photoluminescent nanomaterials.

关键词： Light harvesting system Supramolecular polymer Quadruple hydrogen bonding AIE Self-assembly

Developments in the *** Party Since the 2020 Election

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Contemporary World 2024年第1期 41-43页

作者： diao Daming School of International Relations at the Renmin University of China

On November 8,2023,the Republican Party of the United States hosted its third televised debate for the presidential nomination primary in Miami,Flori*** President Donald Trump,though absent once again,still maintains a lead in all polls and is even considered highly likely to win the Republican nomination for the third time,to fight Biden again and compete for the White House *** fact,over the three years since Trump left office,and Biden came to power,the Republican Party did not get rid of the influence of the political philosophy represented by Trump,and the party’s political ecology and policy agenda inevitably by Trump’s personal influence,presenting a subtle and complex political phenomenon as Trump has never left.

关键词： likely political levis

Innovative Mn3-xO4-y@NCA design:Leveraging Mn/O vacancies and amorphous architecture for enhanced sodium-ion storage

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Journal of Energy Chemistry 2024年第10期97卷 747-756页

作者： Kaijun Xie Xin Liu Kai Xia Lipeng diao Ping Lu Mengmeng Wang Long Fang Yihui Zou Dongjiang Yang Xiaodong Zhang College of Chemistry and Chemical Engineering College of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textiles Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles Institute of Marine Biobased Materials Qingdao University Institute of Micro/Nano Materials and Devices Ningbo University of Technology

Manganese-based oxide electrode materials suffer from severe Jahn-Teller（J-T） distortion,leading to severe cycle instability in sodium ion ***,it is difficult to adjust the electron at d orbitals exactly to a low spin state to eliminate orbital degeneracy and suppress J-T distortion *** article constructed concentration-controllable Mn/O coupled vacancy and amorphous network in Mn3O4and coated it with nitrogen-doped carbon aerogel(Mn3-xO4-y@NCA).The existence of Mn/O vacancies has been confirmed by scanning transmission electron microscopy（STEM） and positron annihilation lifetime spectroscopy（PALS）.Atomic absorption spectroscopy（AAS） and X-ray photoelectron spectroscopy（XPS） determine the most optimal ratio of Mn/O vacancies for sodium ion storage is 1:*** functional theory（DFT） calculations prove that Mn/O coupled vacancies with the ratio of 1:2could exactly induce a low spin states and a d4electron configuration of Mn,suppressing the J-T distortion *** abundant amorphous regions can shorten the transport distance of sodium ions,increase the electrochemically active sites and improve the pseudocapacitance *** the synergetic effect of Mn/O coupled vacancies and amorphous regions,Mn3-xO4-y@NCA exhibits an energy density of 37.5 W h kg-1and an ultra-high power density of 563 W kg-1in an asymmetric *** sodium-ion batteries,it demonstrates high reversible capacity and exceptional cycling *** research presents a new method to improve the Na+storage performance in manganese-based oxide,which is expected to be generalized to other structural distortion.

关键词： Amorphous network Concentration-controllable Mn/O coupled vacancies Manganese-based metal oxide Sodium ion battery Sodium ion supercapacitor

Preoperative albumin-bilirubin score predicts short-term outcomes and long-term prognosis in colorectal cancer patients undergoing radical surgery

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2096-2105页

作者： Yu-Hang diao Xin-Peng Shu Can Tan Li-Juan Wang Yong Cheng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND The albumin-bilirubin(ALBI)score is a serum biochemical indicator of liver function and has been proven to have prognostic value in a variety of *** colorectal cancer(CRC),a high ALBI score tends to be associated with poorer *** To investigate the correlation between the preoperative ALBI score and outcomes in CRC patients who underwent radical *** Patients who underwent radical CRC surgery between January 2011 and January 2020 at a single clinical center were *** ALBI score was calculated by the formula(log10 bilirubin×0.66)+(albumin×-0.085),and the cutoff value for grouping patients *** short-term outcomes,overall survival(OS),and disease-free survival(DFS)were *** A total of 4025 CRC patients who underwent radical surgery were enrolled in this study,and there were 1908 patients in the low ALBI group and 2117 patients in the high ALBI *** regression analysis revealed that age,tumor size,tumor stage,ALBI score,and overall complications were independent risk factors for OS;age,tumor stage,ALBI score,and overall complications were identified as independent risk factors for *** A high preoperative ALBI score is correlated with adverse short-term outcomes,and the ALBI score is an independent risk factor for OS and DFS in patients with CRC undergoing radical surgery.

关键词： Colorectal cancer Albumin-bilirubin score Overall survival Disease-free survival Outcomes

Nullification of GFTs fortifies bioactive folates in foxtail millet

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Journal of Integrative Plant Biology 2024年第8期66卷 1540-1543页

作者： Jianzhou Pang Wei Zhang Yanyan Zhang Shihui Zhang Yannan Wang Hui Zhi Chunyi Zhang Qiuju Liang Xianmin diao College of Life Science Hebei Normal UniversityShijiazhuang 050024China Dry Land Farming Institute of Hebei Academy of Agricultural and Forestry Sciences Key Laboratory of Crop Drought Tolerance Research of Hebei ProvinceHengshui 053000China Institute of Crop Sciences Chinese Academy of Agricultural SciencesState Key Laboratory of Crop Gene Resources and BreedingBeijing 100081China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China

Folates—tetrahydrofolate(THF)and its derivatives(also known collectively as vitamin B9)—are essential micronutrients for almost all living *** as carriers of one-carbon(C1)units,folates participate in the biosynthesis of numerous biomolecules and play central roles in cellular methylation reactions(Strobbe and Van Der Straeten,2017).

关键词： collective organisms vitamin

Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex

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Neural Regeneration Research 2024年第6期19卷 1351-1359页

作者： Afzal Misrani Sidra Tabassum Tintin Wang Huixian Huang Jinxiang Jiang Hongjun diao Yanping Zhao Zhen Huang Shaohua Tan Cheng Long Li Yang South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina Guangzhou Hongai Cultural Development Inc.GuangzhouGuangdong ProvinceChina Yinguo Health Management Team GuangzhouGuangdong ProvinceChina College of Biophotonics South China Normal UniversityGuangzhouGuangdong ProvinceChina

Tibetan singing bowls emit low-frequency sounds and produce perceptible harmonic tones and vibrations through manual *** sounds the singing bowls produce have been shown to enhance relaxation and reduce ***,the underlying mechanism remains *** this study,we used chronic restraint stress or sleep deprivation to establish mouse models of anxiety that exhibit anxiety-like *** then supplied treatment with singing bowls in a bottomless cage placed on the top of a *** found that unlike in humans,the combination of harmonic tones and vibrations did not improve anxietylike behaviors in mice,while individual vibration components ***,the vibration of singing bowls increased the level of N-methyl-D-aspartate receptor 1 in the somatosensory cortex and prefrontal cortex of the mice,decreased the level ofγ-aminobutyric acid A(GABA)receptorα1 subtype,reduced the level of CaMKII in the prefrontal cortex,and increased the number of GABAergic *** the same time,electrophysiological tests showed that the vibration of singing bowls significantly reduced the abnormal low-frequency gamma oscillation peak frequency in the medial prefrontal cortex caused by stress restraint pressure and sleep *** from this study indicate that the vibration of singing bowls can alleviate anxiety-like behaviors by reducing abnormal molecular and electrophysiological events in somatosensory and medial prefrontal cortex.

关键词： anxiety medial prefrontal cortex parvalbumin interneuron pressure somatosensory cortex Tibetan singing bowl vibration

Identifying and Managing Technical Risks in the Process of Innovative Drugs Development in China

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Asian Journal of Social Pharmacy 2024年第2期19卷 126-134页

作者： diao Yuanyuan Wu Zhiang School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China Yeehong Business School Shenyang Pharmaceutical UniversityBeijing 100055China

Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and *** The initial risk index was investigated by literature ***,the Likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in *** and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were *** key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.

关键词： innovative drug development technology risk risk management

Analytic Hierarchy Process for Technological Risks in the Process of Innovative Drug Development in China

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Asian Journal of Social Pharmacy 2024年第1期19卷 29-42页

Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in *** Expert investigation and analytic hierarchy process were used to determine the weights of different *** and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the *** the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug *** lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical *** difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical *** dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization *** biggest impact from the marketing authorization application to the approval stage was inadequate communication with *** investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.

关键词： innovative drug drug research and development risk management analytic hierarchy process weight

Dual-Defect Engineering Strategy Enables High-Durability Rechargeable Magnesium-Metal Batteries

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Nano-Micro Letters 2024年第9期16卷 449-461页

作者： Fuyu Chen Bai‑Qing Zhao Kaifeng Huang Xiu‑Fen Ma Hong‑Yi Li Xie Zhang Jiang diao Jili Yue Guangsheng Huang Jingfeng Wang Fusheng Pan National Innovation Center for Lndustry‑Education Integration of Energy Storage Technology School of Materials Science and EngineeringChongqing UniversityChongqing 400044People’s Republic of China National Magnesium Alloy Material Engineering Technology Research Center Chongqing UniversityChongqing 400044People’s Republic of China Materials and Energy Division Beijing Computational Science Research CenterBeijing 100193People’s Republic of China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044People’s Republic of China

Rechargeable magnesium-metal batteries(RMMBs)are promising next-generation secondary batteries;however,their development is inhibited by the low capacity and short cycle lifespan of *** various strategies have been devised to enhance the Mg^(2+)migration kinetics and structural stability of cathodes,they fail to improve electronic conductivity,rendering the cathodes incompatible with magnesium-metal ***,we propose a dual-defect engineering strategy,namely,the incorporation of Mg^(2+)pre-intercalation defect(P-Mgd)and oxygen defect(Od),to simultaneously improve the Mg^(2+)migration kinetics,structural stability,and electronic conductivity of the cathodes of *** lamellar V_(2)O_(5)·nH_(2)O as a demo cathode material,we prepare a cathode comprising Mg_(0.07)V_(2)O_(5)·1.4H_(2)O nanobelts composited with reduced graphene oxide(MVOH/rGO)with P-Mgd and *** Od enlarges interlayer spacing,accelerates Mg^(2+)migration kinetics,and prevents structural collapse,while the P-Mgd stabilizes the lamellar structure and increases electronic ***,the MVOH/rGO cathode exhibits a high capacity of 197 mAh g^(−1),and the developed Mg foil//MVOH/rGO full cell demonstrates an incredible lifespan of 850 cycles at 0.1 A g^(−1),capable of powering a light-emitting *** proposed dual-defect engineering strategy provides new insights into developing high-durability,high-capacity cathodes,advancing the practical application of RMMBs,and other new secondary batteries.

关键词： Rechargeable magnesium-metal batteries Dual-defect engineering Vanadium-based cathode High durability Lamellar structure