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Nanowire Arrays Restore Vision in Blind Mice

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Nanowire Arrays Restore Vision in Blind Mice

Preweaning period is a critical window for rumen microbial regulation of average daily gain in Holstein heifer calves

中国神经科学学会第十二届全国学术会议

作者： Nan Qin Jing Tang Yan Chong yupu diao Tian Xue Min Jiang Jiayi Zhang Gengfeng Zheng Institutes of Brain Science State Key Laboratory of Medical NeurobiologyCollaborative Innovation Center of Brain ScienceLaboratory of Advanced MaterialsCollaborative Innovation Center of Chemistry for Energy Materials Fudan University School of Life Sciences and Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China

The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we developed artificial photoreceptors based on gold nanoparticle-decorated titania（Au-Ti O2） nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light（visible to mouse, insects and birds） responses in the retinal ganglion cells（RGCs） were restored with a spatial resolution approaching or better than 100 μm. Light ON responses in RGCs can be blocked by glutamatergic antagonists, suggesting selective photo-activation in the retina without disrupting the processing of visual information through the remaining retinal circuits. Moreover, neurons in the primary visual cortex responded to light after subretinal implant of nanowire arrays into blind mice. Improvement in pupillary light reflex suggested the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal implants and prosthetic devices.

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来源： cnki会议评论

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Journal of Animal Science and Biotechnology 2024年第1期15卷 396-411页

作者： Shengyang Xu Chong Jiao Qiyu diao Yan Tu Beijing Key Laboratory for Dairy Cow Nutrition Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081People’s Republic of China

Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and *** study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different *** calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host *** During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this ***,no significant differences were observed in rumen fermentation parameters and serum indices between the two *** The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.

关键词： Average daily gain Calves Preweaning period Rumen microbiota

Molecular mechanisms of stress resistance in sorghum: Implications for crop improvement strategies

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Journal of Integrative Agriculture 2024年第3期23卷 741-768页

作者： Hongxiang Zheng Yingying Dang Xianmin diao Na Sui Shandong Provincial Key Laboratory of Plant Stress/College of life Sciences Shandong Normal UniversityJinan 250014China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Abiotic stresses, such as drought, salt, extreme temperatures, and heavy metal pollution, are the main environmental factors that limit crop growth and yield. Sorghum, a C4 grass plant with high photosynthetic efficiency, can grow in adverse environmental conditions due to its excellent stress resistance characteristics. Therefore, unraveling the stress-resistance mechanism of sorghum could provide a theoretical basis for developing and cultivating various stress-resistant crops. This understanding could also help to create a conducive environment for using marginal soil in agriculture and ensuring food security. In this review, we discuss the adaptation mechanisms of sorghum under drought, salinity, temperature, and soil heavy metal stresses, the specific response to stress, the screening of sorghum-resistant germplasm, and the identification and functional analysis of the relevant genes and quantitative trait loci(QTL). In addition, we discuss the application potential of different stress-tolerant sorghum germplasms reported to date and emphasize the feasibility and potential use in developing and promoting highly stress-tolerant sorghum in marginal soil.

关键词： abiotic stress C4 plants QTL sorghum stress resistance yield stability

Graph neural network based method for robot path planning

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Biomimetic Intelligence & Robotics 2024年第1期4卷 80-87页

作者： Xingrong diao Wenzheng Chi Jiankun Wang Shenzhen Key Laboratory of Robotics Perception and Intelligence Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China Robotics and Microsystems Center School of Mechanical and Electric EngineeringSoochow UniversitySuzhou 215021China Jiaxing Research Institute Southern University of Science and TechnologyJiaxing 314000China

Sampling-based path planning is widely used in robotics,particularly in high-dimensional state *** the path planning process,collision detection is the most time-consuming ***,we propose a learning-based path planning method that reduces the number of collision *** develop an efficient neural network model based on graph neural *** model outputs weights for each neighbor based on the obstacle,searched path,and random geometric graph,which are used to guide the planner in avoiding *** evaluate the efficiency of the proposed path planning method through simulated random worlds and real-world *** results demonstrate that the proposed method significantly reduces the number of collision checks and improves the path planning speed in high-dimensional environments.

关键词： Graph Neural Network(GNN) Collision detection Sampling-based path planning

Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi Cai Long Qiu Zhenying diao Lintao Cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

A theoretical study on gaseous pollutant flushing of natural ventilation driven by buoyancy forces in industrial buildings

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Building Simulation 2024年第4期17卷 575-589页

作者： Jiawei Zhuang Genyang Chen Rumeng Yang Kun Han Dongdong Tian Yongfa diao Henggen Shen School of Urban Construction Changzhou UniversityChangzhou213164China School of Petroleum and Natural Gas Engineering School of EnergyChangzhou UniversityChangzhou213164China College of Environmental Science and Engineering Donghua UniversityShanghai201620China School of Architecture and Urban Planning Nanjing UniversityNanjing210093China

The acceleration of industrialization worsening indoor environments of industrial buildings has drawn more attention in recent *** ventilation can improve indoor air quality(IAQ)and reduce carbon *** evaluate gaseous pollutant levels in industrial buildings for the development of buoyancy-driven natural ventilation,two theoretical models of pollutant flushing(Model I and Model II)are developed based on the existing thermal stratification theory in combination with the mixing characteristics of lower *** results show that indoor pollutant flushing is mainly dependent on the pollution source intensity and effective ventilation *** mixing characteristics of lower pollutant has an important effect on pollutant stratification and evolution during ventilation,but it does not change the prediction results at steady *** the dimensionless pollution source intensity is larger than 1,the pollution source should be cleaned up or other ventilation methods should be used instead to improve *** addition,the comparisons between Model I and Model II on instantaneous pollutant concentration are significantly influenced by the pollution source intensity,and the actual pollutant concentration is more likely to be between the predicted values of Model I and Model *** reduce pollutant concentration to a required level,the pollution source intensity should be in a certain *** theoretical models as well as the necessary conditions for ventilation effectiveness obtained can be used for the ventilation optimization design of industrial buildings.

关键词： industrial buildings buoyancy-driven natural ventilation gaseous pollutants evolution model pollution sources

Emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate obtained by Corolase PP under high hydrostatic pressure

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Food Science and Human Wellness 2024年第3期13卷 1271-1278页

作者： Haining Guan Chunmei Feng Min Ren Xiaojun Xu Dengyong Liu Xiaoqin diao College of Food Science and Technology Bohai UniversityJinzhou 121013China

Enzymatic hydrolysis of proteins can enhance their emulsifying properties and antioxidant ***,the problem related to the hydrolysis of proteins was the generation of the bitter ***,high hydrostatic pressure(HHP)treatment has attracted much interest and has been used in several studies on protein ***,the study aimed to investigate the effects of enzymatic hydrolysis by Corolase PP under different pressure treatments(0.1,100,200,and 300 MPa for 1-5 h at 50℃)on the emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate(SPIH).As observed,the hydrolysate obtained at 200 MPa for 4 h had the highest emulsifying activity index(47.49 m^(2)/g)and emulsifying stability index(92.98%),and it had higher antioxidant activities(44.77%DPPH free radical scavenging activity,31.12%superoxide anion radical scavenging activity,and 61.50%copper ion chelating activity).At the same time,the enhancement of emulsion stability was related to the increase of zeta potential and the decrease of mean particle *** addition,the hydrolysate obtained at 200 MPa for 4 h had a lower bitterness value and showed better *** study has a broad application prospect in developing food ingredients and healthy foods.

关键词： Soybean protein isolate High hydrostatic pressure Emulsification Antioxidant Bitter taste

A Review of the Application of Artificial Intelligence in Orthopedic Diseases

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Computers, Materials & Continua 2024年第2期78卷 2617-2665页

作者： Xinlong diao Xiao Wang Junkang Qin Qinmu Wu Zhiqin He Xinghong Fan Department of Electrical Engineering Guizhou UniversityGuiyangChina

In recent years,Artificial Intelligence(AI)has revolutionized people’s *** has long made breakthrough progress in the field of ***,the research on the application of AI in orthopedics is still in the exploratory *** paper first introduces the background of AI and orthopedic diseases,addresses the shortcomings of traditional methods in the detection of fractures and orthopedic diseases,draws out the advantages of deep learning and machine learning in image detection,and reviews the latest results of deep learning and machine learning applied to orthopedic image detection in recent years,describing the contributions,strengths and weaknesses,and the direction of the future improvements that can be made in each ***,the paper also introduces the difficulties of traditional orthopedic surgery and the roles played by AI in preoperative,intraoperative,and postoperative orthopedic surgery,scientifically discussing the advantages and prospects of AI in orthopedic ***,the article discusses the limitations of current research and technology in clinical applications,proposes solutions to the problems,and summarizes and outlines possible future research *** main objective of this review is to inform future research and development of AI in orthopedics.

关键词： Artificial intelligence orthopedics image detection deep learning machine learning diagnostic disease robotics

Probing the interseismic locking state of the Xianshuihe fault based on a viscoelastic deformation model

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Science China Earth Sciences 2024年第1期67卷 134-145页

作者： Yage ZHU Faqi diao Fei CHEN Yuebing WANG Zhigang SHAO Rongjiang WANG Xiong XIONG Hubei Subsurface Multi-Scale Imaging Key Laboratory School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China China Earthquake Networks Center Beijing 100045China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China

The interseismic locking state of tectonic faults is essential for regional seismic hazard ***,it is challenging to obtain this parameter reliably due to the weak deformation and complex model *** better probe the fault locking state,more reliable physical models and well-covered observations are *** we investigate the locking state of the Xianshuihe fault based on a new-developed viscoelastic deformation ***,we combine GPS velocities from 13 new near-field stations and existing stations in this region to improve the spatial *** to the theoretical predictions,our results indicate that the elastic model will clearly overestimate the fault locking depth and seismic moment accumulation rate,and the fault slip rate inferred from the elastic model is slightly lower than that from the viscoelastic *** on the locking distribution inferred from the viscoelastic model,we identify four potential asperities on the Xianshuihe *** importantly,we find a clear spatial correlation between the fault locking distribution and the rupture extent of historical earthquakes,which indicates that the fault locking state may control the rupture extent and thus the magnitude of *** addition,our results show that the 2022 M6.8 Luding earthquake only ruptured the south part of a potential asperity,and the accumulated energy in the northern unruptured area is equivalent to an Mw6.9 earthquake,where the seismic hazard deserves special attention.

关键词： Fault kinematics Viscoelastic relaxation effect GPS observations Seismic hazard The 2022 M6.8 Luding earthquake