检索结果-南通市图书馆

Polyamide Nanofiltration Membrane from Surfactant-assembly Regulated Interfacial Polymerization of 2-Methylpiperazine for Divalent Cations Removal

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2022年第3期38卷 782-789页

作者： gong Li ZHU Yuzhang DONG Dianyu ZHANG yuping GUI Liangliang JIN Jian College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123P.R.China i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123P.R.China

Removal of metal ions from water can not only alleviate the scaling problem of domestic and industrial water,but also solve the water safety problem caused by heavy metal ion pollution.Here,we fabricate a positively charged nanofiltration membrane via surfactant-assembly regulated interfacial polymerization(SARIP)of 2-methylpiperazine(MPIP)and trimesoyl chloride(TMC).Due to the existence of methyl substituent,MPIP has lower reactive activity than piperazine(PIP)but stronger affinity to hexane,resulting in a nanofiltration(NF)membrane with an opposite surface charge and a loose polyamide active layer.Interestingly,with the help of sodium dodecyl sulfate(SDS)assembly at the water/hexane,the reactivity between MPIP and TMC was obviously increased and caused in turn the formation of a positively charged polyamide active layer with a smaller pore size,as well as with a narrower pore size distribution.The resulting membrane shows a highly efficient removal of divalent cations from water,of which the rejections of MgCl_(2),CoCl_(2)and NiCl_(2)are higher than 98.8%,98.0%and 98.0%,respectively,which are better than those of most of other positively charged NF membranes reported in literatures.

关键词： Nanofiltration membrane Interfacial polymerization Surface charge Divalent cation removal

基于聚类分析黄文东后人龚雨萍主任治疗慢性非特异性溃疡性结肠炎的用药规律研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

河北中医 2017年第12期39卷 1791-1796页

作者：李超男龚雨萍上海中医药大学附属龙华医院脾胃病科上海200032

目的探讨和总结黄文东后人龚雨萍主任治疗慢性非特异性溃疡性结肠炎(CUC)的学术思想和临床用药规律。方法收集龚主任治疗CUC医案299例,对所选医案中符合纳入标准的药物运用Excel表进行收录,然后用SPSS 22.0统计软件进行聚类分析。结果 ... 详细信息

目的探讨和总结黄文东后人龚雨萍主任治疗慢性非特异性溃疡性结肠炎(CUC)的学术思想和临床用药规律。方法收集龚主任治疗CUC医案299例,对所选医案中符合纳入标准的药物运用Excel表进行收录,然后用SPSS 22.0统计软件进行聚类分析。结果 (1)共有299例医案纳入研究,共计就诊457次;共得药物224味,出现的总频次为7 420,常用中药有白术、茯苓、马齿苋、生地榆等36味。(2)聚类分析发现益气健脾、健脾温肾、健脾利湿、活血化瘀、凉血止痢药为龚主任治疗CUC的常用配伍药类。(3)四君子汤、参苓白术散、香砂六君子汤、白头翁汤等为龚主任治疗CUC的基本方药。结论龚主任治疗CUC体现出以脾胃为根本,注重辨证论治、寒热并用、标本兼顾的学术思想,聚类分析结果客观反映了龚主任临床用药规律。

关键词：结肠炎溃疡性治疗慢性病聚类分析龚雨萍

Role of the rhizosphere of a flooding-tolerant herb in promoting mercury methylation in water-level fluctuation zones

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2022年第9期34卷 139-151页

作者： Juan Wang yuping Xiang Xiaosong Tian Cheng Zhang Guiqing gong Jinping Xue Tao Jiang Dingyong Wang Yongmin Wang Interdisciplinary Research Center for Agriculture Green Development in Yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400715China Laboratory of Environmental Nanotechnology&Health Effect Chinese Academy of SciencesResearch Center for Eco-Environmental SciencesBeijing 100085China College of Resources and Safety Chongqing Vocational Institute of EngineeringChongqing 402260China Institut des Sciences Analytiques et des Physico-Chimie pour l’Environnement et les Materiaux(IPREM) UMR 5254CNRSUniversitede Pau et des Pays de l’AdourPau 64000France

The water-level fluctuation zone(WLFZ) has been considered as a hotspot for mercury(Hg) methylation. Flooding-tolerant herbs are gradually acclimated to this water-land ecotone, tending to form substantial root systems for improving erosion resistance. Accompanying rhizosphere microzone plays crucial but unclear roles in methylmercury(Me Hg) formation in the WLFZ. Thus, we conducted this study in the WLFZ of the Three Gorges Reservoir, to explore effects of the rhizosphere of a dominant flooding-tolerant herb(bermudagrass) on Me Hg production. The elevated Hg and Me Hg in rhizosphere soils suggest that the rhizosphere environment provides favorable conditions for Hg accumulation and methylation. The increased bioavailable Hg and microbial activity in the rhizosphere probably serve as important factors driving Me Hg formation in the presence of bermudagrass. Simultaneously, the rhizosphere environments changed the richness, diversity, and distribution of hgc A-containing microorganisms. Here, a typical ironreducing bacterium( Geobacteraceae) has been screened, however, the majority of hgc A genes detected in rhizosphere, near-, and non-rhizosphere soils of the WLFZ were unclassified. Collectively, these results provide new insights into the elevated Me Hg production as related to microbial processes in the rhizosphere of perennial herbs in the WLFZ, with general implications for Hg cycling in other ecosystems with water-level fluctuations.

关键词： Three Gorges Reservoir Water-level fluctuation zone Rhizosphere soil Methylmercury Mercury methylator

Treated dentin matrix induces odontogenic differentiation of dental pulp stem cells via regulation of Wnt/β-catenin signaling

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第1期7卷 85-97页

作者： Sirui Liu Jingjing Sun Shuai Yuan Yanyu Yang Yuping Gong Ying Wang Runying Guo Xue Zhang Yiming Liu Hongyan Mi Meiyue Wang Mengzhe Liu Rui Li Department of Stomatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Academy of Medical Sciences at Zhengzhou University ZhengzhouChina College of Materials Science and Engineering Zhengzhou University ZhengzhouHenan 450001China

Treated dentin matrix(TDM)is an ideal scaffold material containing multiple extracellular matrix factors.The canonical Wnt signaling pathway is necessary for tooth regeneration.Thus,this study investigated whether the TDM can promote the odontogenic differentiation of human dental pulp stem cells(hDPSCs)and determined the potential role of Wnt/β-catenin signaling in this process.Different concentrations of TDM promoted the dental differentiation of the hDPSCs and meanwhile,the expression of GSK3βwas decreased.Of note,the expression of the Wnt/β-catenin pathway-related genes changed significantly in the context of TDM induction,as per RNA sequencing(RNA seq)data.In addition,the experiment showed that new dentin was visible in rat mandible cultured with TDM,and the thickness was significantly thicker than that of the control group.In addition,immunohistochemical staining showed lower GSK3βexpression in new dentin.Consistently,the GSK3βknockdown hDPSCs performed enhanced odotogenesis compared with the control groups.However,GSK3βoverexpressing could decrease odotogenesis of TDM-induced hDPSCs.These results were confirmed in immunodeficient mice and Wistar rats.These suggest that TDM promotes odontogenic differentiation of hDPSCs by directly targeting GSK3βand activating the canonical Wnt/β-catenin signaling pathway and provide a theoretical basis for tooth regeneration engineering.

关键词： Dental pulp stem cells Treated dentin matrix GSK3β Odontogenic differentiation Wnt/β-catenin signaling pathway

Initial chemotherapy option for pancreatic ductal adenocarcinoma in patients with adequate performance status

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pancreatology 2023年第4期6卷 196-201页

作者： Jiazhang Xing yuping Ge Xiaolei gong Yuan Liu Yuejuan Cheng Department of Medical Oncology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina

Pancreatic ductal adenocarcinoma(PDAC)is a highly progressive lethal malignancy,with chemotherapy being the primary treatment modality.This article provides a review of the initial chemotherapy options for PDAC patients with adequate performance status,comparing FOLFIRINOX(oxaliplatin,irinotecan,5-fluorouracil,and leucovorin)or modified FOLFIRINOX and gemcitabine plus nab-paclitaxel(GEM-NabP)regimens.The availability of limited evidence from randomized trials restricts a direct comparison between the 2 regimens.Based on our review,(m)FOLFIRINOX yields superior survival outcomes compared to GEM-NabP in metastatic PDAC.For locally advanced PDAC,either(m)FOLFIRINOX or GEM-NabP can be considered initial chemotherapy.In the neoadjuvant setting for borderline resectable PDAC,both regimens have demonstrated promising results in achieving feasible resection rates.However,mFOLFIRINOX remains the preferred choice for adjuvant chemotherapy.The selection of initial chemotherapy for PDAC depends on the disease stage,patients’performance status,and tumor molecular alterations.Further research and clinical trials are necessary to optimize treatment approaches for PDAC patients.

关键词： FOLFIRINOX Gemcitabine plus nab-paclitaxel Pancreatic ductal adenocarcinoma

Calcium Ion Coordinated Polyamide Nanofiltration Membrane for Ultrahigh Perm-selectivity Desalination

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2021年第5期37卷 1101-1109页

作者： BIAN Xiangying ZHANG yuping gong Li ZHU Yuzhang JIN Jian i-Lab and CAS Key Laboratory of Nano-Bio Interface CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123P.R.China College of Chemistry Chemical Engineering and Materials Science&Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou215123P.R.China

Improving the permeate flux but retaining the rejection of thin-film composite(TFC)polyamide nanofiltration(NF)membrane is a high requirement for desalination.In this work,a calcium ion(Ca^(2+))coordinated polyamide(PA)NF membrane was prepared by directly adding CaCl_(2) to the piperazine(PIP)aqueous solution during the interfacial polymerization process.Due to the coordination interaction between Ca^(2+)and the amide bond in PA active layer.

关键词： process selectivity retaining

An intra-articular injectable phospholipids-based gel for the treatment of rheumatoid arthritis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2023年第1期18卷 120-131页

作者： yuping Yang Shiqin Luo Xiong Peng Ting Zhao Qin He Mengying Wu Wei Zhang Tao gong Zhirong Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Department of Pharmacy West China Hospital Sichuan University Jintang HospitalChengdu 610000China

Rheumatoid arthritis(RA)is a chronic inflammatory and destructive arthropathy with a high deformity rate.Despite numerous studies and clinical trials,no curative treatment is available for large weight-bearing joints.Intra-articular(IA)injections could deliver high concentrations of drug to the afflicted joint and improve the drug efficacy while reducing systemic toxicity.However,free drugs are rapidly cleared from synovial fluid and do not significantly halt the progression of joint disease.Herein,a phospholipids-based controlledrelease gel was prepared for sustained IA delivery of celastrol(CEL)and the therapeutic efficiencywas evaluated in a rheumatoid arthritis rabbitmodel.The CEL-loaded gel(CEL-gel)contained up to 70%phospholipids yetwas easy to inject.After injecting into the joint cavity,CEL-gel achieved sol to gel phase transition without special stimuli and gelling agent.In vitro release and in vivo pharmacokinetic studies evidenced the stable and sustained release action of CEL-gel.A single IA injection of CEL-gel could maintain therapeutic efficiency for about 25 d and showed much better anti-arthritic efficacy compared to repeated injections of free drug solution(CEL-sol).Furthermore,the IA injection of CEL-gel greatly reduced the systemic toxicity of CEL.With good biocompatibility and biodegradability,CEL-gel might be a promising IA drug delivery system.

关键词： Celastrol Rheumatoid arthritis Phospholipids-based controlled release gel Intra-articular drug delivery

实时超声心动图与平板运动心电图诊断冠心病的ROC曲线分析

在线全文

学校读者我要写书评

暂无评论

影像科学与光化学 2019年第6期37卷 598-603页

作者：龚玉萍王洋三峡大学中医医院·宜昌市中医医院功能科湖北宜昌443000 三峡大学人民医院·宜昌市第一人民医院老年医学科湖北宜昌443000

本文对实时超声心动图(RTE)与平板运动心电图(TET)诊断冠心病(CHD)的价值进行了研究与分析。选取2016年6月~2018年6月疑似CHD患者100例,所有患者均给予RTE、TET检查,并以冠脉造影(CAG)作为金标准,采用受试者工作特征(ROC)曲线分析RTE与... 详细信息

本文对实时超声心动图(RTE)与平板运动心电图(TET)诊断冠心病(CHD)的价值进行了研究与分析。选取2016年6月~2018年6月疑似CHD患者100例,所有患者均给予RTE、TET检查,并以冠脉造影(CAG)作为金标准,采用受试者工作特征(ROC)曲线分析RTE与TET对CHD的诊断价值。CAG结果显示,100例疑似CHD患者中,CHD患者40例(40.00%)、非CHD患者60例(60.00%);ROC曲线分析结果显示,在诊断CHD敏感度、特异度、准确度、曲线下面积中,RTE为85.00%、86.67%、86.00%、0.837,TET为80.00%、76.67%、78.00%、0.768,RTE与TET联合为100.00%、96.67%、98.00%、0.924,明显高于RTE、TET,差异有统计学意义(P0.05)。本文证实了RTE、TET是诊断CHD重要的方法,且RTE与TET联合的诊断敏感度、特异度、准确度、曲线下面积更高。

关键词：实时超声心动图平板运动心电图诊断冠心病受试者工作特征曲线

在线全文

学校读者我要写书评

暂无评论

论物理概念与规律的认知机制:深化与发展

课程．教材．教法 2022年第3期42卷 124-130页

作者：邢红军赵玉萍龚文慧首都师范大学教师教育学院北京100048 首都师范大学教育学院北京100048

在教学中使学生形成、理解物理概念,进而掌握物理规律,并使学生的物理学科能力得到发展,是中学物理教学的核心议题。研究发现,目前我国中学物理概念与规律的教学一直停留在创设物理情境、进行思维加工、理解物理意义和运用概念规律的经... 详细信息

在教学中使学生形成、理解物理概念,进而掌握物理规律,并使学生的物理学科能力得到发展,是中学物理教学的核心议题。研究发现,目前我国中学物理概念与规律的教学一直停留在创设物理情境、进行思维加工、理解物理意义和运用概念规律的经验层面,未能真正厘清学生形成物理概念与规律的认知机制,在一定程度上影响了中学物理教学的发展。为此,本文基于爱因斯坦的概念形成与发展理论、物理学知识—能力结构以及皮亚杰的认知理论,进一步深化与发展了物理概念与规律的教学理论,为在中学物理教学中落实物理学科核心素养提供了有益启示。

关键词：认知机制科学方法物理概念物理规律教学过程