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Journal of Environmental Sciences 2021年第6期33卷 113-127页

作者： yupei long Chenchen Yuan Xiaomin Wang Dongyan Jin Hong Zhou Qiongyin Wang Chenyang Lu Yuqi Chen Yanqing Cong Qi Wang Yi Zhang School of Environmental Science and Engineering Zhejiang Gongshang UniversityHangzhou310018China Ecological Environmental Science Design and Research Institute of Zhejiang Province Hangzhou310007China

Dielectric barrier discharge(DBD)plasma applied as surface treatment technology was employed for the modification of Ag_(2)O and graphitic carbon nitride(g-C_(3)N_(4))powders.Subsequently,the pretreated powders were sequentially loaded onto TiO_(2)nanorods(TiO_(2)-NRs)via electro-deposition,followed by calcination at N_(2)atmosphere.The results indicated that at the optimal plasma discharge time of 5 min for modification of g-C_(3)N_(4)and Ag_(2)O,photocurrent density of ternary composite was 6 times to bare TiO_(2)-NRs under UV-visible light irradiation.Phenol was degraded by using DBD plasma-modified g-C_(3)N_(4)/Ag_(2)O/TiO_(2)-NRs electrode to analyze the photoelectrocatalytic performance.The removal rate of phenol for g-C_(3)N_(4)-5/Ag_(2)O-5/TiO_(2)-NRs electrode was about 3.07 times to that for TiO_(2)-NRs electrode.During active species scavengers'analysis,superoxide radicals and hydroxyl radicals were the main oxidation active species for pollutants degradation.A possible electron-hole separation and transfer mechanism of ternary composite with high photoelectrocatalytic performance was proposed.

关键词： Degradation mechanism Photoelectrochemical catalysis Plasma treatment Ternary material Z-scheme structure

基于多维赋权威布尔分布的智能电表可靠性评价方法

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西南大学学报（自然科学版） 2024年第4期46卷 164-173页

作者：吴达雷梁树华陈长基于秀丽陈育培王丕适龙致远海南电网有限责任公司电能计量中心海口570100 海南电网有限责任公司海口570100 北京邮电大学自动化学院北京100876

智能电表作为电力系统中的关键组成部分,用于测量和监控电能消耗,其可靠性是确保电力系统正常运行和供电质量的重要指标.该文提出一种基于多维赋权威布尔(Weibull)分布的智能电表可靠性评价方法,结合多维赋权分析得到各个影响因素的权... 详细信息

智能电表作为电力系统中的关键组成部分,用于测量和监控电能消耗,其可靠性是确保电力系统正常运行和供电质量的重要指标.该文提出一种基于多维赋权威布尔(Weibull)分布的智能电表可靠性评价方法,结合多维赋权分析得到各个影响因素的权重和威布尔分布模型拟合故障率,构建电表的可靠性函数,实现对智能电表可靠性的准确度评价.首先,提出多维赋权分析方法,将电表的多个关键指标进行权重赋值,以反映不同指标对可靠性的重要程度;通过专家调查和层次分析法(AHP)建立权重体系,为后续的可靠性评价提供依据.其次,引入威布尔分布模型计算智能电表的故障率和使用寿命,通过拟合电表数据与威布尔分布模型得到智能电表的可靠性函数.最后,使用不同的参数分布分析模型对智能电表的可靠性进行评估,并根据Anderson-Darling调整值选择最佳拟合分布.实验结果表明,基于多维赋权威布尔分布的方法能够更准确地评估智能电表的可靠性,且相比其他算法具有更好的预测性能和稳定性.

关键词：多维赋权威布尔分布层次分析法可靠性

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智能台区低压故障定位及主动上报方法研究

微型电脑应用 2024年第5期40卷 96-99页

作者：陈育培吴达雷龙致远陈龙瑾杨娴吴定海南电网有限责任公司海南海口570100

针对传统低压台区配电网故障诊断方法存在适用范围有限、模型复杂等问题,提出一种基于计算智能的故障诊断模型。基于实时PMU数据诊断电力故障,根据故障内容上报智能控制中心,设计一种改进的多目标进化算法求解多目标故障诊断模型。实验... 详细信息

针对传统低压台区配电网故障诊断方法存在适用范围有限、模型复杂等问题,提出一种基于计算智能的故障诊断模型。基于实时PMU数据诊断电力故障,根据故障内容上报智能控制中心,设计一种改进的多目标进化算法求解多目标故障诊断模型。实验阶段,以一个故障区域电力系统接线模型为例,对所提模型进行验证。仿真结果表明,所提模型可以有效地克服单个或多个保护继电器故障的影响,从而高效确定故障组件。同时,通过交叉对比分析,所提模型故障识别平均准确率为0.9171。仿真结果进一步验证了所提模型的鲁棒性和稳定性。

关键词：电力系统低压台区故障诊断优化模型多目标进化算法

新高考改革选科的自我—他人决策差异:责任感的中介作用

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教育测量与评价 2024年第3期 57-67页

作者：张湘一刘玉佩陈锡友丁道群湖南师范大学教育科学学院长沙410081 中国科学院大学心理学系

以X省Y市4所普通高中的883名高一学生为对象,考察新高考改革选科中是否存在自我—他人决策差异,以及责任感在这一差异中所起的作用。研究发现:新高考改革选科中存在自我—他人决策差异,责任感在这一差异中起着中介作用;相较于为自我选科... 详细信息

以X省Y市4所普通高中的883名高一学生为对象,考察新高考改革选科中是否存在自我—他人决策差异,以及责任感在这一差异中所起的作用。研究发现:新高考改革选科中存在自我—他人决策差异,责任感在这一差异中起着中介作用;相较于为自我选科,学生为他人选科时感知到的责任感较小,更倾向于为他人选择高兴趣—高难度的科目;学生自我选科时感知到的责任感较大,更倾向于为自己选择低兴趣—低难度的科目。因此,社会各界尤其是学校和家长应深入了解高中生选科现状,树立“远景性”的选科导向,重视学生兴趣与潜能的发掘;科学认识选科责任,各方协同,助力学生合理选科;正视自我—他人选科差异,聚力优化选科决策。

关键词：新高考改革自我—他人决策差异高考选科调节聚焦理论责任感

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铁死亡在不同肝脏疾病的研究进展

海南医学院学报 2024年第6期30卷 463-468页

作者：刘晓萍毛德文林玉培廖莹莹莫世聪罗银冰李飞燕广西中医药大学广西南宁530001 广西中医药大学第一附属医院肝病科广西南宁530023

长期以来,肝脏疾病造成的死亡率一直偏高,已成为一个全球性的健康问题。肝细胞损伤促进了各种肝脏疾病的进展,故了解肝细胞是如何死亡的成为一个关键的研究领域。铁死亡是一种新发现的非凋亡形式的细胞死亡,其特征是铁依赖性脂质过氧化... 详细信息

长期以来,肝脏疾病造成的死亡率一直偏高,已成为一个全球性的健康问题。肝细胞损伤促进了各种肝脏疾病的进展,故了解肝细胞是如何死亡的成为一个关键的研究领域。铁死亡是一种新发现的非凋亡形式的细胞死亡,其特征是铁依赖性脂质过氧化。近来研究发现,铁死亡在许多疾病的发生和发展中起着重要的调节作用,特别是肝脏疾病。对铁死亡的研究可能为各种肝脏疾病发病机制提供新的认识,并显示了铁死亡靶向治疗肝脏疾病的巨大潜力。本文简述了铁死亡的概念和启动机制,并讨论了铁死亡在各种肝脏疾病中的诱导或抑制作用。

关键词：铁死亡细胞死亡肝脏疾病铁负荷脂质过氧化

Real-world study of surgical treatment of pancreatic cancer in China: annual report of China Pancreas Data Center (2016-2020)

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Journal of Pancreatology 2022年第1期5卷 1-9页

作者： Wenming Wu Yi Miao Yinmo Yang Wenhui Lou yupei Zhao Department of General Surgery State Key Laboratory of Complex and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBejing Department of General Surgery Pancreas Centerthe First Afiliated Hospital of Nanjing Medical UniversityNanjingJiangsu Province Department of General Surgery Peking University First HospitalBejing Department of Pancreatic Surgery Zhongshan HospitalFudan UniversityShanghaiChina

Objective: In 2015, the Chinese Pancreatic Association of the Chinese Society of Surgery of the Chinese Medical Association launched a national multicenter online system for registration of surgical treatment of pancreatic cancer in China, called China Pancreas Data Center (CPDC). With continued effort, the CPDC has developed over time. Herein, we report the general results of the CPDC from January 2016 to January 2020 to present the real-world situation of surgical treatment of pancreatic cancer in China.Methods: The data of the CPDC from January 2016 to January 2020 were retrieved and analyzed in this real-world study, including the data on patient demographics, comorbidities, diagnostic modalities, neoadjuvant treatment, surgical procedures, postoperative complications and treatment, pathological examinations, postoperative adjuvant treatment, survival, and risk factors.Results: A total of 13,595 cases from 70 centers in 28 provinces were retrieved for analysis. This study reported the largest cohort of patients who underwent surgical treatment for pancreatic cancer in China to date. More cases were derived from the Eastern regions, among which Shanghai, Beijing, and Zhejiang ranked in the top three. The peak age of the patients ranged from 60 to 69 years. The ratio of males to females was 1.5:1. Overall, 64.3% of the tumors were located in the head and neck of the pancreas, and 35.7% in the body and tail of the pancreas. Of the patients, 23.0% underwent positron-emission tomography-computed tomography, 21.6% underwent endoscopic ultrasound, and 4.8% underwent preoperative biopsy. Two percent of the patients underwent neoadjuvant treatment, while 68.9% underwent R0 surgical resection (margin free of tumor cells). Of the latter, 78.6% of the operations were open procedures, 12.6% were laparoscopic procedures, 2.9% were robotic procedures, and 3.7% were converted to open procedures. The in-hospital mortality rate after surgery was 0.4%. The incidence of grade 2 and grade 3 postoperative pancreatic fistulas was 2

关键词： Chemotherapy China Pancreas Data Center Overall survival Pancreatic cancer Pancreatic surgery Registration study

A PIF7-CONST ANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering

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Molecular Plant 2019年第12期12卷 1587-1597页

作者： Renshan Zhang Chuanwei Yang yupei Jiang Lin Li State Key Laboratory of Genetic Engineering and Institute of Plant Biology School of Life SciencesFudan UniversityShanghai 200438People's Republic of China

To compete with their neighbors for light and escape shaded environments,sun-loving plants have devel-oped the shade-avoidance syndrome(SAS),a set of responses including alteration of plant architecture and initiation of early flowering and seed set.Previous studies on SAS mainly focused on dissecting molec-ular basis of hypocotyl elongation in seedlings under shade light;however,the molecular mechanisms underlying shade-accelerated flowering in adult plants remain unknown.In this study,we found that CONSTANS(CO)and PHYTOCHROME-INTERACTING FACTOR 7(PIF7)have an additive effect on shade-induced flowering,but that long HYPOCOTYL IN FAR-RED1(HFR1)represses early flowering by binding to CO and PIF7 and preventing the binding of CO to the promoter of FLOWERING LOCUS T(FT)and the binding of PIF7 to the promoter of pri-MIR156E/F.Under shade,de-phosphorylated PIF7 and accumulated CO,balanced by HFR1,upregulate the expression of FT,TSF,SOC1,and SPLs to accelerate flowering.Moreover,we found that the function of PIF7 in flowering time is independent of phyA.Collectively,these regulatory interactions establish a crucial link between the light signal and genetic network that regulates flowering transition under shade.

关键词： flowering time shade avoidance response PIF7 CO HFR1

Pancreatic head cancer: Open or minimally invasive pancreaticoduodenectomy?

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Chinese Journal of Cancer Research 2019年第6期31卷 862-877页

作者： Mengyu Feng Zhe Cao Zhiwei Sun Taiping Zhang yupei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Clinical Immunology Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Pancreatic head cancer still represents an insurmountable barrier for patients and pancreatic surgeons.Pancreaticoduodenectomy(PD)continues to be the operative standard of care and potentially curative procedure for pancreatic head cancer.Despite the rapid development of minimally invasive techniques,whether the efficacy of minimally invasive pancreaticoduodenectomy(MIPD)is noninferior or superior to open pancreaticoduodenectomy(OPD)remains unclear.In this review,we summarized the history of OPD and MIPD and the latest staging and classification information for pancreatic head cancer as well as the proposed recommendations for MIPD indications for patients with pancreatic head cancer.By reviewing the MIPD-vs.OPD-related literature,we found that MIPD shows noninferiority or superiority to OPD in terms of safety,feasibility,enhanced recovery after surgery(ERAS)and several short-term and long-term outcomes.In addition,we analyzed and summarized the different MIPD outcomes in the USA,Europe and China.Certain debates over MIPD have continued,however,selection bias,the large number of low-volume centers,the steep MIPD learning curve,high conversion rate and administration of neoadjuvant therapy may limit the application of MIPD for pancreatic head cancer.

关键词： Feasibility minimally invasive pancreaticoduodenectomy open pancreaticoduodenectomy pancreatic head cancer safety

Integrated analysis of gene expression and methylation profiles of novel pancreatic cancer cell lines with highly metastatic activity

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Science China(Life Sciences) 2019年第6期62卷 791-806页

作者： Gang Yang Huanyu Wang Mengyu Feng Lei You Lianfang Zheng Taiping Zhang Lin Cong yupei Zhao Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Nuclear Medicine Peking Union Medical Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Clinical Immunology Center Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Pancreatic cancer is one of the most lethal human malignancies, partly because of its propensity for metastasis. However, highly metastatic human pancreatic cancer cell lines suitable for studies of metastasis are currently lacking. Here we established two highly metastatic human pancreatic cancer cell lines, MIA PaCa-2 In8 and Panc-1 In8, by Matrigel induction assay. The cell lines were further characterized both in vitro and in vivo. MIA PaCa-2 In8 and Panc-1 In8 cells demonstrated increased migration and invasion compared with their respective parental cells. Following injection into nude mice, MIA PaCa-2 In8 and Panc-1 In8 cells resulted in more pulmonary metastases compared with the parental cells. Furthermore, analyses of m RNA, long non-coding RNA, micro RNA, and methylation profiling revealed that these factors were aberrantly regulated in the highly metastatic cells,indicating that they probably affected metastasis. We thus established and characterized two highly metastatic human pancreatic cell lines that could be used as valuable tools for future investigations into the pathogenesis, metastasis, and potential treatment of human pancreatic cancer.

关键词： pancreatic cancer high metastatic activity gene expression methylation

长链非编码RNA SNHG16通过微小RNA-455-3p/Nocth2对鼻咽癌细胞增殖、凋亡和周期的影响

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中华实验外科杂志 2022年第10期39卷 1964-1967页

作者：李萍刁玉佩宋春霞新乡市中心医院新乡医学院第四临床学院耳鼻咽喉头颈外科 453000

目的探讨长链非编码RNA(lncRNA)SNHG16通过微小RNA(miR)-455-3p/Nocth2对鼻咽癌细胞增殖、凋亡和周期的影响及其机制。方法选取2017年6月到2021年6月新乡市中心医院收治的51例鼻咽癌及其癌旁组织作为研究对象,采用荧光定量聚合酶链反应(... 详细信息

目的探讨长链非编码RNA(lncRNA)SNHG16通过微小RNA(miR)-455-3p/Nocth2对鼻咽癌细胞增殖、凋亡和周期的影响及其机制。方法选取2017年6月到2021年6月新乡市中心医院收治的51例鼻咽癌及其癌旁组织作为研究对象,采用荧光定量聚合酶链反应(PCR)分析肿瘤组织和癌旁组织lncRNA SNHG16和miR-455-3p表达水平。采用慢病毒建立lncRNA SNHG16敲降稳定细胞系SNHG16 KD组和对照组,采用细胞计数试剂盒(CCK-8)分析两组细胞增殖能力和体内成瘤能力。采用流式细胞术分析两组细胞凋亡水平;采用流式细胞术分析细胞周期变化;采用生物信息学和生物信息学和双荧光素酶报告基因分析lncRNA SNHG16靶基因。组间数据比较采用t检验。结果癌旁组织lncRNA SNHG16表达水平(0.89±0.09)明显低于鼻咽癌组织lncRNA SNHG16表达水平(2.11±0.22),差异有统计学意义(t=36.260,P<0.05)。对照组细胞吸光度(A)值(1.93±0.06)明显高于SNHG16 KD组(1.27±0.06),差异有统计学意义(t=18.350,P<0.05)。对照组细胞在裸鼠体内成瘤体积[(904.94±39.53)mm^(3)]明显高于SNHG16 KD组细胞成瘤体积[(742.82±97.80)mm^(3)],差异有统计学意义(t=4.860,P<0.05)。对照组细胞成瘤重量[(4.70±0.46)g]明显高于SNHG16 KD组细胞[(2.22±0.18)g],差异有统计学意义(t=15.960,P<0.05)。对照组细胞凋亡比例[(4.07±1.34)%]明显低于SNHG16 KD组细胞[(26.79±5.16)%],差异有统计学意义(t=10.430,P<0.05)。对照组细胞G0/G1期比例[(31.56±3.27)%]明显高于SNHG16 KD组细胞[(45.96±1.72)%],差异有统计学意义(t=9.5201,P<0.05)。lncRNA SNHG16是miR-455-3p的海绵。对照组细胞miR-455-3p表达水平(1.19±0.10)明显低于SNHG16 KD组细胞(2.15±0.15),差异有统计学意义(t=13.040,P<0.05)。对照组细胞Notch2表达水平(0.93±0.05)明显高于SNHG16 KD组细胞(0.44±0.06),差异有统计学意义(t=13.040,P<0.05)。结论lncRNA SNHG16海绵吸附miR-455-3p,进而调控Nocth2表达水平,调节鼻咽癌细胞增殖、凋亡和周期。

关键词：长链非编码RNA SNHG16 微小RNA-455-3p Nocth2 鼻咽癌