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Common traditional Chinese medicine therapies for diarrhea-predominant irritable bowel syndrome: An overview of systematic reviews

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 330-339页

作者： Jun Zhao Xia Li Xiaowei Chen Hui Zheng Kun Ye Yunzhou Shi Xin Xie Jianfang Wang Min Chen Zhigang Li School of Acupuncture Moxibustion and TuinaBeijing University of Chinese MedicineBeijing102488China Department of Spleen StomachLiver and Gallbladder DiseasesDongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China The Third Hospital/Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu610075China Anorectal Disease Department Hospital of Chengdu University of Traditional Chinese MedicineChengdu610072China

Objective: To critically evaluate and summarize the methodological quality of systematic reviews(SRs)and present objective and important outcomes on the effectiveness of traditional Chinese medicine(TCM) therapies, including Chinese herbal medicine(CHM), acupuncture, and moxibustion, for diarrheapredominant irritable bowel syndrome(IBS-D).Methods: We conducted a comprehensive literature search for SRs in 7 databases until April 16, 2022.Two reviewers independently extracted data and assessed the methodological quality of the reviews according to the Assessing the Methodological Quality of Systematic Reviews 2(AMSTAR-2), the Risk of Bias in Systematic reviews(ROBIS) tool, and the Preferred Reporting Item for Systematic Review and Meta-analysis(PRISMA) statement. The Grading of Recommendations, Assessment, Development, and Evaluation(GRADE) was used to rate the quality of evidence.Results: IBS-D patients included in 12 reviews were diagnosed in accordance with the Rome criteria, 9 reviews focused on CHM, 2 articles observed moxibustion and heat-sensitive moxibustion, 1 article studied acupuncture and CHM. The outcomes of the SRs were the effectiveness rate, the total effectiveness rate,global symptom improvement, and adverse effects. Based on AMSTAR-2, which measures the quality of methodology, all of the included studies were of low or critically low quality. According to the ROBIS tool, 10 SRs(83.33%) had a high risk of bias. With the PRISMA checklist, only 3 SRs reached over 90% compliance.Based on GRADE, most evidence was of low quality, and there was a moderate quality of evidence that the effectiveness rate of modified-Tongxie Yaofang was superior to Western medicine in the treatment of IBS-D.Conclusion: Given the suboptimal reporting and methodological quality of existing SRs, more studies are needed to clarify whether TCM therapies are more effective or safe than pharmacological medicine.Future studies should combine evidence-based medicine with TCM research according to the characteristics of TCM.

关键词： Diarrhea-predominant irritable bowel syndrome Overview Traditional Chinese medicine therapies AMSTAR-2 GRADE PRISMA ROBIS

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互联网平台的犯罪风险防控责任

中国特色社会主义研究 2023年第4期 61-71页

作者：张旭史云舟吉林大学法学院

《反电信网络诈骗法》的颁布与实施为以互联网平台为代表的互联网服务提供者设置了风险防控这一犯罪预防性责任。犯罪风险防控责任来源于互联网平台在网络治理领域所承担的主体责任,并以风险防控作为责任的价值目标。根据《反电信网络... 详细信息

《反电信网络诈骗法》的颁布与实施为以互联网平台为代表的互联网服务提供者设置了风险防控这一犯罪预防性责任。犯罪风险防控责任来源于互联网平台在网络治理领域所承担的主体责任,并以风险防控作为责任的价值目标。根据《反电信网络诈骗法》的条文规定,犯罪风险防控责任由信息核检义务、特定行为禁止义务、合理注意义务以及侦查协助义务四项基本义务构成。犯罪风险防控责任需通过确立政府监督者地位、提高义务履行标准、限定责任承载范围以及完善既有评价机制的方式在电信网络诈骗犯罪治理领域予以落实。

关键词：《反电信网络诈骗法》风险防控责任犯罪预防义务互联网平台

三元乙丙橡胶汽车密封条着色污染的测试与分析

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橡胶工业 2019年第12期66卷 944-947页

作者：施云舟上汽大众汽车有限公司

研究三元乙丙橡胶(EPDM)汽车密封条对车身油漆着色污染的测试方法,分析着色污染原因。结果表明:与VDA 675242推荐方法和恒温恒湿环境模拟测试法相比,湿热交变模拟测试法能够有效判别EPDM密封条导致车身油漆黄变的潜在风险;EPDM密封条对... 详细信息

研究三元乙丙橡胶(EPDM)汽车密封条对车身油漆着色污染的测试方法,分析着色污染原因。结果表明:与VDA 675242推荐方法和恒温恒湿环境模拟测试法相比,湿热交变模拟测试法能够有效判别EPDM密封条导致车身油漆黄变的潜在风险;EPDM密封条对车身油漆的着色污染以高湿度环境中水抽提污染为主;高着色性促进剂的残留和析出是导致EPDM密封条着色污染的关键因素。

关键词：三元乙丙橡胶汽车密封条油漆着色污染促进剂

Facile Preparation of Water-Soluble and Cytocompatible Small-Sized Chitosan-Polydopamine Nanoparticles

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Chinese Journal of Chemistry 2017年第6期35卷 931-937页

作者： yunzhou Ni Feng Chen Leilei shi Gangsheng Tong Jie Wang Huimei Li Chunyang Yu Yongfeng Zhou School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China Instrumental Analysis Center Shanghai Jiao Tong University Shanghai 200240 China

In this paper, a kind of novel water-soluble chitosan-polydopamine （CHT-PDA） nanoparticles with a hydrody- namic diameter （Dh） around 10 nm were reported by the combination of self-polymerization of PDA and electro- static complexation between PDA and CHT in water/DMSO （W/D） mixture at the molar fraction of DMSO （XDMSO =0.37）. The preparation method was efficient with a yield of 98% around. The as-prepared water-soluble CHT-PDA nanoparticles exhibited effective UV-screen ability, enhanced visible-light transmittance and good cyto- compatibility via MTT assay, which might be used in transparent formulation for UV protection usage, especially in biological field including sun care application.

关键词： chitosan polydopamine nanoparticles UV-screen visible-light transmittance

(Salen)osmium (Ⅵ) nitrides catalyzed glutathione depletion in chemotherapy

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Chinese Chemical Letters 2023年第10期34卷 185-190页

作者： Wanqiong Huang Chen Pan Yongliang Huang Tao Huang Xiaonan Dong yunzhou Chen Huatian shi Taichu Lau Wailun Man Wenxiu Ni Department of Medicinal Chemistry Shantou University Medical CollegeShantou 515041China Department of Chemistry Hong Kong Baptist UniversityHong KongChina Department of Chemistry City University of Hong KongHong KongChina Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063China

Glutathione depletion provides a promising strategy for the design of non-platinum anticancer drugs.Here we report a series of electrophilic (salen)osmium(Ⅵ) nitrides that react with glutathione to generate (salen)osmium(Ⅲ) ammine compounds.In vitro studies indicate that these osmium(VI) nitrides show comparable cytotoxicity to cisplatin against various carcinoma.Mechanistic studies with the representative compound[OsⅥ(N)(LH)(OH_(2))](PF6)(1,LH=N,N’-bis(salicylidene)-o-cyclohexyldiamine dianion) suggest that 1 induces glutathione depletion,reactive oxygen species generation,endoplasmic reticulum stress,and in turn triggers death receptor-mediated apoptosis and autophagy in lung cancer cells.In vivo evaluations show that 1 can inhibit tumor xenograft growth effectively with no body weight drop.

关键词： Chemotherapy Osmium complex Glutathione depletion Apoptosis Autophagy

秩序生成视域下非法经营罪异化扩张研究——基于批判性观点的省思

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青少年犯罪问题 2023年第2期 60-71页

作者：张旭史云舟吉林大学

通过文献计量法量化既有关涉非法经营罪扩张的理论研究成果,以此描摹针对非法经营罪扩张的批判性观点占据主导地位的研究现状;进一步明晰针对非法经营罪扩张否定性观点出现取向惯性与常态的滥觞;对其中批判性观点予以总结与提炼,深度复... 详细信息

通过文献计量法量化既有关涉非法经营罪扩张的理论研究成果,以此描摹针对非法经营罪扩张的批判性观点占据主导地位的研究现状;进一步明晰针对非法经营罪扩张否定性观点出现取向惯性与常态的滥觞;对其中批判性观点予以总结与提炼,深度复盘内在逻辑与思维进路;厘清非法经营罪扩张中的肆意延展与异化扩张,以此弥合存在于理论与实际间的负向评价与正向需求之“裂痕”,进而完成基于非法经营罪批判性观点的省思。

关键词：非法经营罪秩序生成理论罪刑法定异化扩张

Technical development of operational in-situ marine monitoring and research on its key generic technologies in China

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Acta Oceanologica Sinica 2023年第10期42卷 117-126页

作者： yunzhou Li Juncheng Wang College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266061China School of Ocean Technology Sciences Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266061China Laoshan Laboratory Qingdao 266237China

In China,operational in-situ marine monitoring is the primary means of directly obtaining hydrological,meteorological,and oceanographic environmental parameters across sea areas,and it is essential for applications such as forecast of marine environment,prevention and mitigation of disaster,exploitation of marine resources,marine environmental protection,and management of transportation safety.In this paper,we summarise the composition,development courses,and present operational status of three systems of operational in-situ marine monitoring,namely coastal marine automated network station,ocean data buoy and voluntary observing ship measuring and reporting system.Additionally,we discuss the technical development in these in-situ systems and achievements in the key generic technologies along with future development trends.

关键词： marine observation technology operational in-situ marine monitoring C-MAN station ocean data buoy VOS measuring and reporting system achievements in the key technologies development trend

Systematic Review and Meta-analysis of Randomized Controlled Trials on Manual Therapy for the Treatment of Gastroesophageal Reflux Disease

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Chinese Medicine and Natural Products 2023年第4期3卷 143-157页

作者： Mengdie Yan Yunzhou Shi Yanqin Liu Yue shi Mengzhu Zhang Dongnan Chen Senlin Ye shiyin Li Yue Feng College of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengduSichuanChina Department of Massage Pidu District Hospital of Traditional Chinese MedicineChengduSichuanChina

Objective The objective of our study was to systematically evaluate the clinical efficacy and safety of manual therapy in the treatment of gastroesophageal reflux disease(GERD),providing a reference value for clinical decision-making.Method Studies of randomized controlled trials(RCTs)evaluating the efficacy of manual therapy in patients with GERD were searched through Chinese National Knowledge Infrastructure,Wanfang,ViP China Science and Technology Journal Database,China Biology Medicine Database,PubMed,The Cochrane Library,OviD Medline,and Embase.Two researchers independently reviewed the literature,extracted data,and performed a risk of bias analysis using the Cochrane risk of bias assessment tool,and conducted meta-analysis analysis and publication bias evaluation,the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)tool 26 was used to rate the caliber of the data in this meta-analysis.Results This study included 11 RCTs.Meta-analysis showed that the manual therapy group had a higher total effective rate(odds ratio[OR]=4.63,95%confidence interval[Cl;3.01,7.14],p<0.00001)and better Reflux Disease Questionnaire scores[weighted mean difference(WMD)=-1.59,95%CI[-2.85,-0.33],p=0.01]than the control group.The subgroup analysis showed significant differences in improving the total effective rate in manual therapy versus Western medicine,manual therapy versus Chinese medicine decoction,manual therapy+Western medicine versus Western medicine,and manual therapy+conventional treatment versus conventional treatment groups.Among the 11 trials,5 reported adverse events,and all RCTs had the possibility of publication bias.Subgroup analysis shows that the differences in age could significantly influence heterogeneity;The GRADE analysis revealed that the overall quality of evidence for all outcome indicators was low and did not support our recommendation for the outcome.Conclusion Manual therapy is more effective than medication therapy alone in relieving GERD symptoms.Furthermore,conventional therapy c

关键词： gastroesophageal reflux disease manual therapy tuina massage systematic review meta-analysis

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从热病五十九俞探讨“同功穴”

辽宁中医杂志 2017年第9期44卷 1946-1947页

作者：石云舟王富春长春中医药大学针灸推拿学院吉林长春130117

目的:从《黄帝内经》热病五十九俞出发,从腧穴所属经脉,所在部位以及与针灸诊治的关系三方面探讨热病五十九俞"同功穴"。方法:手工检索《黄帝内经》及《黄帝内经》王冰、张介宾考注。结果:研究发现热病五十九俞在所属经脉上多集中于足... 详细信息

目的:从《黄帝内经》热病五十九俞出发,从腧穴所属经脉,所在部位以及与针灸诊治的关系三方面探讨热病五十九俞"同功穴"。方法:手工检索《黄帝内经》及《黄帝内经》王冰、张介宾考注。结果:研究发现热病五十九俞在所属经脉上多集中于足太阳膀胱经、督脉、足阳明胃经、足少阳胆经等阳经经脉;所在部位上多分布于头部、腰背部;针灸证治上与温热病三焦证治关系密切。结论:由于其所属经脉,所在部位的不同,热病五十九俞具有清诸阳之热、胸中之热、胃中之热、四肢之热、五脏之热等不同的清热作用。据此,可为针灸临证治疗热病选取"同功穴"配伍,提供选穴思路。

关键词：针灸热病五十九俞同功穴