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国外数字化工厂网络安全保障机制研究——以洛克希德·马丁公司为例

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网络安全与数据治理 2024年第5期43卷 11-17页

作者：杜洪涛李云志国家工业信息安全发展研究中心北京100040

数字化工厂是融合新一代信息技术和先进制造技术的关键工业设施,也是推进我国制造业数字化转型、增强国家科技和经济竞争力的重要载体。由于数字化工厂的网络化、智能化和开放性等特点,传统的网络集成式安全架构难以适应更复杂的业务流... 详细信息

数字化工厂是融合新一代信息技术和先进制造技术的关键工业设施,也是推进我国制造业数字化转型、增强国家科技和经济竞争力的重要载体。由于数字化工厂的网络化、智能化和开放性等特点,传统的网络集成式安全架构难以适应更复杂的业务流、供应链和不断变化的业态模式,成为制造业数字化转型的重大挑战。如何保障其安全稳定运行,成为各国政府和工业界关注的焦点。以洛克希德·马丁公司数字化工厂建设为例,研究该企业数字化转型战略、工厂数字化架构,并分析其工业物联网设备的连接通信框架(智能工厂框架),以及在云平台、无线物联网、网络安全治理、研发运营等多方面的安全措施。在此基础上,对我国如何强化重点行业数字化工厂网络安全保障机制建设,提出多角度的综合性建议。

关键词：数字化工厂网络安全架构智能工厂框架数字化转型安全治理

富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响

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标记免疫分析与临床 2024年第7期31卷 1292-1297页

作者：田越花琛李蕴志烟台市烟台山医院儿童保健科山东烟台264001

目的探讨富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响。方法前瞻性选取2020年1月至2023年6月烟台市烟台山医院收治100例的营养不良的患儿,按照随机数字方法分为对照组及研究组,各50例。研究组在营养支持基础上口... 详细信息

目的探讨富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响。方法前瞻性选取2020年1月至2023年6月烟台市烟台山医院收治100例的营养不良的患儿,按照随机数字方法分为对照组及研究组,各50例。研究组在营养支持基础上口服富马酸亚铁,对照组采用单纯营养支持,连续治疗4周。比较两组患儿治疗后临床疗效及不良反应,以及营养指标、血液指标及免疫指标水平。结果研究组患儿临床有效率(86.00%)明显高于对照组(68.00%),差异有统计学意义(χ^(2)=4.574,P=0.033)。治疗后,研究组患儿体质量指数(BMI)、转铁蛋白(TRF)及前清蛋白(PAB)、白蛋白、前白蛋白、血清铁(SI)、血红蛋白(Hb)及网织红细胞(Ret)水平明显高于对照组(P0.05)。结论富马酸亚铁联合营养支持可显著提高营养不良患儿营养状态及免疫功能,改善铁代谢障碍及提高血红蛋白含量,且不良反应少,安全性较高,值得应用。

关键词：儿童营养不良富马酸亚铁营养支持免疫球蛋白营养不良反应

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面向制造型企业的数据质量管控研究

新型工业化 2024年第7期14卷 116-123页

作者：张士存李云志刘众博中车青岛四方机车车辆股份有限公司青岛266111 国家工业信息安全发展研究中心北京100040

制造型企业的数据管理能力相对较弱,是目前普遍存在的问题,而提高数据管理能力的核心在于数据质量管控。本文介绍了制造型企业数据分布的特点,分析了制造业数据质量的特性要求及管控准则,并基于数据全生命周期的角度提出了制造业数据质... 详细信息

制造型企业的数据管理能力相对较弱,是目前普遍存在的问题,而提高数据管理能力的核心在于数据质量管控。本文介绍了制造型企业数据分布的特点,分析了制造业数据质量的特性要求及管控准则,并基于数据全生命周期的角度提出了制造业数据质量管控的建议,从多方面入手建立科学、规范的数据管理流程及数据质量提升方案,保证数据的规范性、完整性、准确性和一致性等质量特性,为企业的决策和管理提供更好的支持。

关键词：制造业数据质量数据管理

两个家蚕CPFL表皮蛋白基因的鉴定与表达分析

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山东农业科学 2024年第3期56卷 139-144页

作者：刘惠芬华丽峰刘文光娄齐年衣葵花李云芝郭光山东省蚕业研究所山东烟台264002

昆虫CPFL表皮蛋白是一类重要的结构蛋白。本研究通过生物信息学分析从家蚕基因组中鉴定出2个CPFL基因,命名为BmHCP1和BmHCP2。氨基酸序列分析发现,2个蛋白在羧基末端均具有CPFL表皮蛋白典型的保守结构序列YGW以及重复序列AAH、AAPA、AAP... 详细信息

昆虫CPFL表皮蛋白是一类重要的结构蛋白。本研究通过生物信息学分析从家蚕基因组中鉴定出2个CPFL基因,命名为BmHCP1和BmHCP2。氨基酸序列分析发现,2个蛋白在羧基末端均具有CPFL表皮蛋白典型的保守结构序列YGW以及重复序列AAH、AAPA、AAPV。进化树分析显示,2个蛋白与鳞翅目昆虫艺神袖蝶(Heliconius erato)和柑橘凤蝶(Papilio xuthus)具有较高同源性。荧光定量PCR分析显示,BmHCP1和BmHCP2存在组织、时相特异性表达,幼虫期在头部、中肠、表皮等组织中表达量较高;蛹期除翅原基、血淋巴、触角和足等组织外均有较高表达量;成虫期在足、触角、翅原基、表皮等组织中表达量较高;蛹期在大多数组织的表达量明显高于幼虫期和成虫期。研究结果为进一步探明家蚕表皮蛋白基因的功能奠定了基础。

关键词：家蚕 CPFL表皮蛋白序列分析表达分析荧光定量PCR

Molecular dynamics simulations of hydrogen-bond dynamics and far-infrared spectra of hydration water around mixed monolayer-protected Au nanoparticle

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Molecular dynamics simulations of hydrogen-bond dynamics and...

中国化学会第十二届全国量子化学会议

作者： yunzhi li Guobing Zhou Zhen Yang College of Chemistry and Chemical Engineering Jiangxi Normal University

Recently,the mixed monolayer-protected Au nanoparticles（MPANs）have received much attention due to their potential applications in biosensing,catalysis,drug delivery,and molecular recognition,since more desired properties of mixed MPANs can be achieved not only by varying the size of Au core and ligand length but also by changing the composition and relative position of mixed ligands.A comprehensive understanding of the physical and chemical properties of mixed MPANs is significantly favorable to design and synthesize various MPANs with tailored *** of the most crucial properties is the structure and dynamics of hydrogen-bond（HB）network in the hydration layer of mixed MPANs,which play an important role in determining the interfacial properties of functionalized *** this end,a series of molecular dynamics（MD）simulations have been carried out here to deep investigate the HB dynamics and far–infrared spectra of hydration water around mixed MPANs[Au140（SH（CH2）12（NH3+）x（COO–）1-x）62]（x=0.25,0.50,and 0.75,respectively）with Na+（or Cl–）counterions in aqueous environment,as described by the recent experiments.[1]Our simulation results indicated clearly that the strength of H2O–H2O HBs around mixed MPANs is obvious enhanced for all the compositions of mixed ligands,which is also observed for the charged homo-ligand MPAN.[2]Meanwhile,the vibration mode in far-infrared spectra of HBs between hydration H2O around the mixed MPANs have been calculated for the first time,which undergoes a significantly blue shift behavior as a result of the enhanced H2O–H2O HB *** simulation demonstrated distinctly that the mixed ligand compositions have little influence on the H2O–H2O HB lifetime,while such blue shift should be mainly caused by the stronger HB strength formed by the H2O molecules and terminal groups（i.e.,the H2O–NH3+,and the H2O–COO–）.The detailed HB dynamics and far-infrared spectra of hydration water studied in this work are of great benefit for ex

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几种芸苔素类农药对家蚕的毒性试验

北方蚕业 2024年第1期45卷 10-13页

作者：华丽峰董亚茹李云芝娄齐年张凤林刘惠芬山东省蚕业研究所山东烟台264002

芸苔素是植物生长调节剂。本文研究了14-羟基芸苔素甾醇、24-表芸苔素内酯和28-表高芸苔素内酯3种芸苔素对家蚕的毒性及对茧质的影响。结果表明:稀释1 000~16 000倍的14-羟基芸苔素甾醇和24-表芸苔素内酯药液对2-5龄家蚕未见毒性。添食... 详细信息

芸苔素是植物生长调节剂。本文研究了14-羟基芸苔素甾醇、24-表芸苔素内酯和28-表高芸苔素内酯3种芸苔素对家蚕的毒性及对茧质的影响。结果表明:稀释1 000~16 000倍的14-羟基芸苔素甾醇和24-表芸苔素内酯药液对2-5龄家蚕未见毒性。添食稀释16 000倍的28-表高芸苔素内酯药液48 h, 2龄家蚕出现中毒症状;添食稀释4 000倍的28-表高芸苔素内酯药液24 h, 2龄和3龄家蚕出现中毒症状,48 h后4龄家蚕出现中毒症状;添食稀释1 000倍、2 000倍、3 000倍的28-表高芸苔素内酯药液24 h, 5龄家蚕出现中毒症状,但在改用正常桑叶饲喂后,中毒症状逐渐减轻并消失。稀释4 000~16 000倍的3种芸苔素药液,仅28-表高芸苔素内酯对家蚕结茧有一定影响。在农作物“一喷三防”工作中,建议使用14-羟基芸苔素甾醇和24-表芸苔素内酯。

关键词：杀虫剂芸苔素家蚕毒性

Theoretical prediction of low-lying structures of [CH3NH3NO3]n(n = 1–20) protic ionic liquid clusters

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Theoretical prediction of low-lying structures of [CH3NH3NO3...

中国化学会第十二届全国量子化学会议

作者： Hao lin yunzhi li Zhen Yang College of Chemistry and Chemical Engineering Jiangxi Normal University

The low-lying structures of[CH3NH3NO3]n protic ionic liquid clusters up to 20 ion-pairs have been explored by the combination of empirical OPLS-AA force field and high-level M06-2X ***,a series of independent molecular dynamics(MD)simulations with the empirical force field are carried out at different temperatures to produce at least 105 conformations for n>***,these MD conformations are optimized through a low-storage nonlinear optimization method to create a large database of local minima structures at the level of empirical force ***,single-point energy calculations at M06-2X/6-31G(d)are performed for the lowest 500 local ***,the lowest 10 structures obtained from the M06-2X/6-31G(d)energies are as starting points for full geometry optimizations at the same *** calculations demonstrate clearly that the low-lying structures of[CH3NH3NO3]n clusters begin to form the cubic cage structure at n=*** the cluster size increases up to n=7,10,and 13,one-,two-,and three-centered cage structures can be formed with the interior anions(NO3–),***,a four-centered cage structure embedded with one cation and three anions is found at n=16 while three five-centered cage structures embedded with one cation and four anions are found at n≥*** analysis,we find that the anions prefer to locate in the inner region compared to the cations owing to the smaller size and lower surface energy of ***,these cage structures mainly consist of four-and six-membered rings through the hydrogen-bond(HB)network between cations and anions and few odd-membered rings can be found for all low-lying *** addition,the relevant HBs and relative stabilities of[CH3NH3NO3]n clusters are also discussed in detail.

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Understanding the hydrogen bonds in protic ionic liquids and their correlations with the relevant structure and dynamics from molecular dynamics simulations

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Understanding the hydrogen bonds in protic ionic liquids and...

中国化学会第十二届全国量子化学会议

作者： Guobing Zhou yunzhi li Zhen Yang College of Chemistry and Chemical Engineering Jiangxi Normal University

In this work,a series of molecular dynamics simulations have been carried out to investigate the structure and dynamics properties of protic ionic liquid（IL）ethylammonium nitrate（EAN）at various *** simulation results showed that the temperature has a considerable influence on the dynamics properties of EAN rather than its structure *** temperature can significantly accelerate the translational and rotrational motions of cations and *** found that the ion-pair lifetime of protic EAN can be up to several nanoseconds at 300K and the corresponding structural relaxation time can reach up to several tens of nanoseconds,which are one order of magnitude greater than the counterparts of aprotic IL[bmim][PF6]in the previous work.[2]Such differences can be attributed to the stronger hydrogen bonds（HBs）between cations and anions in protic *** comparison,we found that both the lifetime and structural relaxation time of HBs in protic EAN are obviously longer than those in aprotic[bmim][PF6],especially for the HB structural relaxation time of protic EAN also up to several nanoseconds at 300K,which can be comparable with the ion-pair *** simulations reveal clearly that the HBs play a more important role in determing the dynamics properties of protic ILs compared to the aprotic ILs.

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Understanding Polymorphism-Dependent Emission Properties of Molecular Crystals with a Refined QM/MM Approach

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Understanding Polymorphism-Dependent Emission Properties of ...

第十三届全国量子化学会议

作者： yunzhi li Guoqiang Wang Wei li Yue Wang Shuhua li School of Chemistry and Chemical Engineering Key Laboratory of Mesoscopic Chemistry of Ministry of EducationInstitute of Theoretical and Computational ChemistryNanjing University State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin University

An efficient quantum mechanical/molecular mechanics（QM/MM） approach is developed for investigating polymorphism-dependent emission properties of molecular crystals. In this approach, we proposed a simple and effective way of automatically building cluster models（as the QM region） for the general QM/MM approach to deal with the excited states of molecular crystals. This approach is then applied to understand the polymorphism-dependent emission properties of two organic crystals comprised of 3（5）-（9-anthryl）pyrazole and its isomeride. Our results demonstrated that a monomer model for QM/MM calculations is suitable for describing the emission spectra of the crystal without the π…π stacking *** for the crystal with the notable intermolecular π…π stacking interaction, the most stable trimer model（or at least the most stable dimer model） should be used for accurately describing the corresponding emission spectra. The effect of the π…πstacking interaction on the emission properties of crystals can be understood by the fact that the intermolecular π…π interactions can significantly reduce the energy gap between frontier molecular orbitals of molecular clusters（dimers or trimers）. The results from the present work provide useful guidelines for understanding and designing the luminescent materials.

关键词： Organic polymorphs emission energies time-dependent density functional theory quantum mechanics/molecular mechanics method generalized energy-based fragmentation method